eLife

Latest preprint reviews

1. Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies

   This article has 5 authors:

   1. Christian Galicia
   2. Giambattista Guaitoli
   3. Marcus Fislage
   4. Christian Johannes Gloeckner
   5. Wim Versées

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The fundamental study by Galicia C. et al. captured the GTP-bound active structure of CtRoco, a homolog of human LRRK2, using conformation-specific nanobodies. This convincing body of work reports the first structure of a GTP-bound ROCO protein, illustrating how GTP facilitates the dimer-to-monomer transition of CtRoco and functional activation.

   Reviewed by eLife

2. Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers

   This article has 4 authors:

   1. Javier I Ottaviani
   2. Virag Sagi-Kiss
   3. Hagen Schroeter
   4. Gunter GC Kuhnle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study, using three bioactive compounds as a model, demonstrates that estimating the intake of food components based on food composition databases and self-reported dietary data is highly unreliable. The authors present convincing data showing the differences in the estimated quantile of intake of three bioactive compounds between biomarker and 24-hour dietary recall with food-composition database. The work will be of broad interest to the clinical nutrition research community.

   Reviewed by eLife

3. Tumor purity-related genes for predicting the prognosis and drug sensitivity of DLBCL patients

   This article has 6 authors:

   1. Zhenbang Ye
   2. Ning Huang
   3. Yongliang Fu
   4. Rongle Tian
   5. Liming Wang
   6. Wenting Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a predictive scoring system in DLBCL based on the expression of three tumour microenvironment-related genes. Such a scoring system seems useful for predicting tumour purity levels in DLBCL. The provided evidence showing an association between worse DLBLC prognosis and high-risk score is solid, but it is incomplete to draw a clear conclusion about the links between risk score and drug sensitivity.

   Reviewed by eLife

4. Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

   This article has 4 authors:

   1. Yan Chen
   2. Ruizhi Yang
   3. Bin Qi
   4. Zhao Shan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Supported by convincing data, this valuable study demonstrates that the Chitinase 3-like protein 1 (Chi3l1) interacts with gut microbiota and protects animals from intestinal injury in laboratory colitis model. The revised manuscript sufficiently addressed the reviewers' comments. The work will be of interest to scientists studying crosstalk between gut microbiota and inflammatory diseases.

   Reviewed by eLife

5. Ocular dominance-dependent binocular combination of monocular neuronal responses in macaque V1

   This article has 5 authors:

   1. Sheng-Hui Zhang
   2. Xing-Nan Zhao
   3. Dan-Qing Jiang
   4. Shi-Ming Tang
   5. Cong Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Overall, the reviewers found the significance of the work valuable to the field of visual neuroscience, particularly given the large data set and strength of the method used that allowed for spatial analysis of neuronal responses in macaque V1. The evidence was deemed compelling, owing in part to the consistency of responses across animals and the fitness of modeling. The authors have addressed the major comments from reviewers and improved the manuscript through relation to prior literature and addressing specific limitations of the method used.

   Reviewed by eLife

6. Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

   This article has 18 authors:

   1. Apostolos Papandreou
   2. Nivedita Singh
   3. Lorita Gianfrancesco
   4. Dimitri Budinger
   5. Katy Barwick
   6. Alexander Agrotis
   7. Christin Luft
   8. Ying Shao
   9. An-Sofie Lenaerts
   10. Allison Gregory
   11. Suh Young Jeong
   12. Penelope Hogarth
   13. Susan Hayflick
   14. Serena Barral
   15. Janos Kriston-Vizi
   16. Paul Gissen
   17. Manju A Kurian
   18. Robin Ketteler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript reports alterations in autophagy present in dopaminergic neurons differentiated from iPSCs of patients with WDR45 mutations. The authors identified compounds that improved the defects present in mutant cells by generating isogenic iPSC without the mutation and performing an automated drug screening. The methodological approaches are solid, but the claims still need to be completed; showing the effects of the identified compounds on iron-related alterations is crucial. The effects of these drugs in vivo would be a great addition to the study.

   Reviewed by eLife

7. Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits

   This article has 13 authors:

   1. Samyogita Hardikar
   2. Bronte Mckeown
   3. H Lina Schaare
   4. Raven Star Wallace
   5. Ting Xu
   6. Mark Edgar Lauckener
   7. Sofie Louise Valk
   8. Daniel S Margulies
   9. Adam Turnbull
   10. Boris C Bernhardt
   11. Reinder Vos de Wael
   12. Arno Villringer
   13. Jonathan Smallwood

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     These are important findings that support a link between low-dimensional brain network organisation, patterns of ongoing thought, and trait-level personality factors, making it relevant for researchers in the field of spontaneous cognition, personality, and neuropsychiatry. While this link is not entirely new, the paper brings to bear a rich dataset and a well-conducted study, to approach this question in a novel way. The evidence in support of the findings is convincing.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2302.14157

9. Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

   This article has 41 authors:

   1. Trang H Pham
   2. Kanika Bajaj Pahuja
   3. Thijs J Hagenbeek
   4. Jason Zbieg
   5. Cameron L Noland
   6. Victoria C Pham
   7. Xiaosai Yao
   8. Christopher M Rose
   9. Kristen C Browder
   10. Ho-June Lee
   11. Mamie Yu
   12. May Liang-Chu
   13. Scott Martin
   14. Erik Verschueren
   15. Jason Li
   16. Marta H Kubala
   17. Rina Fong
   18. Maria Lorenzo
   19. Paul Beroza
   20. Peter Hsu
   21. Sayantanee Paul
   22. Elisia Villemure
   23. Wendy Lee
   24. Tommy K Cheung
   25. Saundra Clausen
   26. Jennifer Lacap
   27. Yuxin Liang
   28. Jason Cheng
   29. Steve Schmidt
   30. Zora Modrusan
   31. Michael Cohen
   32. James Crawford
   33. Heinrich Jasper
   34. Alan Ashworth
   35. Jennie R Lill
   36. Shiva Malek
   37. Joachim Rudolph
   38. Ingrid E Wertz
   39. Matthew T Chang
   40. Xin Ye
   41. Anwesha Dey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes two findings: first, that TEAD is subject to turnover by the ubiquitin-proteasome system involving RNF146 and Parylation, and second, the development of a pan-TEAD heterobifunctional degrader that is used to inhibit growth of a YAP-dependent cancer cell line and to characterize TEAD binding sites in the genome. Convincing evidence supports the development and specificity of the degrader. This article will be of relevance to cancer biologists and scientists interested in proteostasis, cellular signaling, and post-translation modification of proteins.

   Reviewed by eLife

10. Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease

    This article has 6 authors:

    1. Vibhavari Aysha Bansal
    2. Jia Min Tan
    3. Hui Rong Soon
    4. Norliyana Zainolabidin
    5. Takaomi Saido
    6. Toh Hean Ch'ng

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study focuses on nuclear pore complex dysfunction in a mouse model of Alzheimer's disease related Aβ pathology. If future revisions can adequately respond to the reviewer comments, the findings may eventually be useful in supporting the idea that nuclear cytoplasmic transport defects occur prior to plaque deposition in this disease model and may be caused by Alzheimer's disease pathology. However, even after revision, the work suffers from overinterpretation of some of the data and remains incomplete in several respects.

    Reviewed by eLife