Latest preprint reviews

  1. Specific Sensitivity to Rare and Extreme Events: Quasi-Complete Black Swan Avoidance vs Partial Jackpot Seeking in Rat Decision-Making

    This article has 5 authors:
    1. Mickaël Degoulet
    2. Louis-Matis Willem
    3. Christelle Baunez
    4. Stéphane Luchini
    5. Patrick A Pintus
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study represents an important contribution to the study of decision-making under risk, bringing an interdisciplinary approach spanning economic theory, behavioral neuroscience, and computational modeling to test how choice preference is influenced by rare and extreme events. The authors aim to test whether rats are indeed sensitive to these rare and extreme events despite their infrequent occurrence, and to isolate behavioral evidence for avoidance of "Black Swans" - rare and extreme losses. The evidence for specific sensitivity to rare and extreme events however remains incomplete, owing in part to the difficulty of isolating the effect of these events beyond that arising from risk preferences more generally in both task design and in the computational modeling of the choice behavior. Despite this, and given the approach here brings a relatively novel and highly interdisciplinary perspective, this paper will be of broad interest to those seeking to understand animal behavior through the lens of economic choice and decision theory.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  2. Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

    This article has 8 authors:
    1. Ellie I James
    2. David W Baggett
    3. Edcon Chang
    4. Joel Schachter
    5. Thomas Nixey
    6. Karoline Choi
    7. Miklos Guttman
    8. Abhinav Nath
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides a valuable contribution to the development of small molecules that inhibit the aggregation of tau, a protein involved in several neurodegenerative diseases. The authors present convincing evidence that analogs of the plant alkaloid tryptanthrin can prevent the formation of larger aggregates by targeting the early stages of tau oligomerization. Nevertheless, further studies are needed to elucidate the precise mechanisms of action and to provide a detailed kinetic analysis. This work will be of interest to biochemists and biophysicists focused on designing small molecules to inhibit fibril formation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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