eLife

Latest preprint reviews

1. A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

   This article has 8 authors:

   1. Fan Zhang
   2. Annie Lee
   3. Anna V Freitas
   4. Jake T Herb
   5. Zong-Heng Wang
   6. Snigdha Gupta
   7. Zhe Chen
   8. Hong Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study's findings substantially advance our understanding of an important aspect of mitochondrial metabolism. The data are compelling and the study is well executed. The work is relevant to all who are interested in the biogenesis of mitochondria.

   Reviewed by eLife

2. Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

   This article has 8 authors:

   1. Giuseppe Deganutti
   2. Ludovico Pipito
   3. Roxana Maria Rujan
   4. Tal Weizmann
   5. Peter Griffin
   6. Antonella Ciancetta
   7. Stefano Moro
   8. Christopher Arthur Reynolds

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study describes an improved adaptive sampling approach, multiple-walker Supervised Molecular Dynamics (mwSuMD), and its application to G protein-coupled receptors (GPCRs), which are the most abundant membrane proteins and key targets for drug discovery. The manuscript provides solid evidence that the mwSuMD approach can assist in the sampling of complex binding processes, leading to useful findings for GPCR activity, including resolution of interactions not seen experimentally. The method has the potential to have broad applicability in structural biology and pharmacology.

   Reviewed by eLife

3. An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli

   This article has 6 authors:

   1. Irina Kalita
   2. Ira Alexandra Iosub
   3. Lorna McLaren
   4. Louise Goossens
   5. Sander Granneman
   6. Meriem El Karoui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Combining experimental and computation approaches, this manuscript provides convincing evidence for a post-transcriptional mechanism that provides robust control over the protein expression level of RecB in E. coli. In addition to uncovering how DNA damage drives higher levels of RecB protein, this work also reveals important tenets for how broader mechanisms that suppress noise and underlie responsive tuning of protein levels can be achieved.

   Reviewed by eLife

4. LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

   This article has 23 authors:

   1. Xianghong Xie
   2. Mingyue Gao
   3. Wei Zhao
   4. Chunmei Li
   5. Weihong Zhang
   6. Jiahui Yang
   7. Yinliang Zhang
   8. Enhui Chen
   9. Yanfang Guo
   10. Zeyu Guo
   11. Minglong Zhang
   12. Ebenezeri Erasto Ngowi
   13. Heping Wang
   14. Xiaoman Wang
   15. Yinghan Zhu
   16. Yiting Wang
   17. Xiaolu Li
   18. Hong Yao
   19. Li Yan
   20. Fude Fang
   21. Meixia Li
   22. Aijun Qiao
   23. Xiaojun Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful evidence substantiating a role for long noncoding RNAs in liver metabolism and organismal physiology. Using murine knockout and knock-in models, the authors invoke a previously unidentified role for the lncRNA Snhg3 in fatty liver. The revised manuscript has improved and most studies are backed by solid evidence but the study was found to be incomplete and will require future studies to substantiate some of the claims.

   Reviewed by eLife

5. Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

   This article has 17 authors:

   1. Morgane Djebar
   2. Isabelle Anselme
   3. Guillaume Pezeron
   4. Pierre-Luc Bardet
   5. Yasmine Cantaut-Belarif
   6. Alexis Eschstruth
   7. Diego López-Santos
   8. Hélène Le Ribeuz
   9. Arnim Jenett
   10. Hanane Khoury
   11. Joelle Veziers
   12. Caroline Parmentier
   13. Aurélie Hirschler
   14. Christine Carapito
   15. Ruxandra Bachmann-Gagescu
   16. Sylvie Schneider-Maunoury
   17. Christine Vesque

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study analyzes the role of rpgrip1l encoding a ciliary transition zone component in the development of neuroinflammation and scoliotic phenotypes in zebrafish. Through proteomic and experimental validation in vivo, the authors demonstrated increased Annexin A2 expression and astrogliosis in the brains of scoliosis fish. Anti-inflammatory drug treatment restored normal spine development in these mutant fish, thus providing additional convincing evidence for the role of neuroinflammation in the development of scoliosis in zebrafish.

   Reviewed by eLife

6. Clearance of protein aggregates during cell division

   This article has 7 authors:

   1. Shoukang Du
   2. Yuhan Wang
   3. Bowen Chen
   4. Shuangshuang Xie
   5. Kuan Yoow Chan
   6. David C Hay
   7. Ting Gang Chew

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     How misfolded proteins are segregated and cleared is a significant question in cell biology, since clearance of these aggregates can protect against pathologies that may otherwise arise. The authors discover a cell cycle stage-dependent clearing mechanism that involves the ER chaperone BiP, the proteosome, and CDK inactivation, but is curiously independent of the anaphase promoting complex (APC). These are valuable and interesting new observations, and the evidence supporting these claims is solid.

   Reviewed by eLife

7. Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells

   This article has 13 authors:

   1. Amélie-Rose Boudjema
   2. Rémi Balagué
   3. Cayla E Jewett
   4. Gina M LoMastro
   5. Olivier Mercey
   6. Adel Al Jord
   7. Marion Faucourt
   8. Alexandre Schaeffer
   9. Camille Noûs
   10. Nathalie Delgehyr
   11. Andrew J Holland
   12. Nathalie Spassky
   13. Alice Meunier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, Boudjema et al. use cell culture models and advanced microscopic imaging to provide detailed analyses of the cellular events underlying centriole amplification, apical migration, and assembly of hundreds of motile cilia in multi-ciliated cells. This largely descriptive work provides a better understanding of this process that is of interest to cell biologists studying centrioles and cilia. Most of the claims are supported by the data, but the study would benefit from additional analyses regarding the roles of microtubules, which are currently incomplete, and from text editing to improve accessibility and readability, especially for a wider audience.

   Reviewed by eLife

8. Superoxide dismutases maintain niche homeostasis in stem cell populations

   This article has 4 authors:

   1. Olivia Majhi
   2. Aishwarya Chhatre
   3. Tanvi Chaudhary
   4. Devanjan Sinha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this work, the authors intend to assess the existence of a redox potential across germline stem cells and neighbouring somatic stem cells in the Drosophila testis. Some aspects of the manuscript are convincing, like the clear effect of SOD KD on cyst cell differentiation state. Other conclusions of the work, such as the non-autonomous effect of this KD on germ cells are not sufficiently supported by the data. This remains true even with the revised version of the paper, as the effect of redox state of the soma on the germline is a major point of the paper, and this remains a critical flaw. The work could be potentially useful if the critiques of the reviewers were fully addressed; the strength of the evidence of the manuscript as it stands is still inadequate. Readers should use their own judgment about the validity and meaningfulness of different findings.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2307.05304v2

10. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination

    This article has 19 authors:

    1. Hideo Fukuhara
    2. Kohei Yumoto
    3. Miyuki Sako
    4. Mizuho Kajikawa
    5. Toyoyuki Ose
    6. Mihiro Kawamura
    7. Mei Yoda
    8. Surui Chen
    9. Yuri Ito
    10. Shin Takeda
    11. Mwila Mwaba
    12. Jiaqi Wang
    13. Takao Hashiguchi
    14. Jun Kamishikiryo
    15. Nobuo Maita
    16. Chihiro Kitatsuji
    17. Makoto Takeda
    18. Kimiko Kuroki
    19. Katsumi Maenaka

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The manuscript presents valuable findings, using solid techniques and approaches, that shed additional light into how the canine distemper virus (CDV) hemagglutinin might engage cellular receptors and how that engagement impacts host tropism. The structural data and their analysis were thorough and well-presented. The HS-AFM data, which indicate that homodimers may dissociate into monomers - and thus have significant implications for the model of fusion triggering - are very exciting, but require further validation, perhaps by alternate approaches, to bolster the current molecular model of the CDV fusion triggering.

    Reviewed by eLife