eLife

Latest preprint reviews

1. S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

   This article has 2 authors:

   1. Daniel M Williams
   2. Andrew A Peden

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper implicates S-acylation of Cys-130 in recruitment of the inflammasome receptor NLRP3 to the Golgi, and it provides convincing evidence that S-acylation plays a key role in response to the stress induced by nigericin treatment. While Cys-130 does seem to play a previously unappreciated role in membrane association of NLRP3, further work will be needed to clarify the details of the mechanism.

   Reviewed by eLife

2. Mitosis sets nuclear homeostasis of cancer cells under confinement

   This article has 6 authors:

   1. Malèke Mouelhi
   2. Alexis Saffon
   3. Morgane Roinard
   4. Hélène Delanoë-Ayari
   5. Sylvain Monnier
   6. Charlotte Rivière

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes the new observation that nuclear volume responds to confinement in a manner that requires transit through mitosis. The authors present solid evidence demonstrating that nuclear volume decreases upon nuclear envelope reformation under confinement in a manner that reestablishes a homeostatic state of nuclear envelope tension. Additional experimental support could provide a more complete case for the proposed underlying mechanisms governing this response. The work will be of broad interest to cell biologists and those interested in cell and organismal scaling.

   Reviewed by eLife

3. The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

   This article has 26 authors:

   1. Benita Martin-Castaño
   2. Patricia Diez-Echave
   3. Jorge García-García
   4. Laura Hidalgo-García
   5. Antonio Jesús Ruiz-Malagon
   6. José Alberto Molina-Tijeras
   7. María Jesús Rodríguez-Sojo
   8. Anaïs Redruello-Romero
   9. Margarita Martínez-Zaldívar
   10. Emilio Mota
   11. Fernando Cobo
   12. Xando Díaz-Villamarin
   13. Marta Alvarez-Estevez
   14. Federico García
   15. Concepción Morales-García
   16. Silvia Merlos
   17. Paula Garcia-Flores
   18. Manuel Colmenero-Ruiz
   19. José Hernández-Quero
   20. Maria Nuñez
   21. Maria Elena Rodriguez-Cabezas
   22. Angel Carazo
   23. Javier Martin
   24. Rocio Moron
   25. Alba Rodríguez Nogales
   26. Julio Galvez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This potentially valuable work characterizes the changes in the microbial composition of the nasal and fecal microbiomes in COVID-19 patients based on disease severity. This study enhances the understanding of COVID-19 severity predictors by identifying changes in bacterial species abundance in nasopharyngeal and fecal samples as a biomarker for predicting disease severity. The methods and statistics used appear to be solid and in line with the standards of the field.

   Reviewed by eLife

4. Sibling chimerism among microglia in marmosets

   This article has 11 authors:

   1. Ricardo C.H. del Rosario
   2. Fenna M. Krienen
   3. Qiangge Zhang
   4. Melissa Goldman
   5. Curtis Mello
   6. Alyssa Lutservitz
   7. Kiku Ichihara
   8. Alec Wysoker
   9. James Nemesh
   10. Guoping Feng
   11. Steven A. McCarroll

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study substantially advances our understanding of sibling chimerism in marmosets by demonstrating that chimerism is limited to hematopoietic cells. The evidence supporting these findings is compelling, demonstrated through comprehensive analyses, including single-cell RNA-seq data from multiple individuals and tissues. The work will be of broad interest to many fields of biology.

   Reviewed by eLife

5. Boosting biodiversity monitoring using smartphone-driven, rapidly accumulating community-sourced data

   This article has 6 authors:

   1. Keisuke Atsumi
   2. Yuusuke Nishida
   3. Masayuki Ushio
   4. Hirotaka Nishi
   5. Takanori Genroku
   6. Shogoro Fujiki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents findings of great practical value, offering fresh insights into natural species distributions across Japan. By combining multiple data sources (including those from non-academic sectors, aka citizen scientists), the manuscript also presents a compelling new tool that can be used to aid conservation agendas, detect species distribution changes, and testing of ecological theories.

   Reviewed by eLife

6. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.15352

7. Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

   This article has 5 authors:

   1. Kanako Shinno
   2. Yuri Miura
   3. Koichi M Iijima
   4. Emiko Suzuki
   5. Kanae Ando

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteomics. Neuronal overexpression of eIF2β phenocopied aspects of neuronal dysfunction observed when axonal transport of mitochondria was compromised. Conversely, lowering eIF2β expression suppressed aspects of neuronal dysfunction. While these are intriguing and useful observations, technical weaknesses limit the interpretation. On balance, the evidence supporting the current claims is suggestive but incomplete, especially concerning the characterization of the eIF2 heterotrimer and the data regarding translational regulation.

   Reviewed by eLife

8. Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

   This article has 10 authors:

   1. Duilio M Potenza
   2. Xin Cheng
   3. Guillaume Ajalbert
   4. Andrea Brenna
   5. Marie-Noelle Giraud
   6. Aurelien Frobert
   7. Stephane Cook
   8. Kirsten D Mertz
   9. Zhihong Yang
   10. Xiu-Fen Ming

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides fundamental information on how Arg-II participates in cardiac aging. The phenotypic data provide convincing evidence of non-cell-autonomous contributions to aging-related pathologies. Overall, the study highlights the importance of intercellular signaling in maintaining cardiac health during aging.

   Reviewed by eLife

9. Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

   This article has 3 authors:

   1. Rashmi Sukumaran
   2. Achuthsankar S Nair
   3. Moinak Banerjee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides a useful analysis of the variation of the burden of strokes across geographic regions, finding differences in the relationship between strokes and their comorbidities. This dataset and the correlations found within will be a resource for directing the focus of future investigations. The results are technically solid, but there are cases where statistical analyses are yet to be carried out to support statements of statistical significance.

   Reviewed by eLife

10. Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

    This article has 18 authors:

    1. Zhongying Han
    2. Sabrina Panhans
    3. Sophie Brameyer
    4. Ecenaz Bilgen
    5. Marija Ram
    6. Anna Herr
    7. Alessandra Narducci
    8. Michael Isselstein
    9. Paul D Harris
    10. Oliver Brix
    11. Pazit Con
    12. Kirsten Jung
    13. Don C Lamb
    14. Eitan Lerner
    15. Douglas Griffith
    16. Thomas R Weikl
    17. Niels Zijlstra
    18. Thorben Cordes

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study combines a comprehensive range of biophysical, kinetic, and thermodynamic techniques, together with high-quality experimental and computational analysis, to carry out a series of well-designed experiments to explore whether glutamine-binding protein binds glutamine via an induced fit or a conformational selection process. The evidence supporting the major conclusion of the work is compelling. The work will be of broad interest to biochemists and biophysicists.

    Reviewed by eLife