eLife

Latest preprint reviews

1. Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex

   This article has 5 authors:

   1. Sara Ibañez
   2. Nilapratim Sengupta
   3. Jennifer I Luebke
   4. Klaus Wimmer
   5. Christina M Weaver

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports a valuable computational study of the effects of axon de-myelination and re-myelination on action potential speed and propagation failure. The manuscript presents solid evidence for the effects of de- and re-myelination in different models of working memory, with potential implications in disorders such as multiple sclerosis. The exposition of the manuscript is targeted for researchers interested in biophysical models of cognitive deficits.

   Reviewed by eLife

2. A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

   This article has 5 authors:

   1. Marina Chan
   2. Yuqi Kang
   3. Shannon Osborne
   4. Michael Zager
   5. Taranjit S Gujral

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes an important web resource for kinases connected to cytokines. The compelling information will be used by researchers across a number of fields including analysts, modelers, wet lab experimentalists and clinician-researchers, who are looking to improve our understanding of pathologies and means to correct them through modulating the immune response.

   Reviewed by eLife

3. Acetylcholine modulates the precision of prediction error in the auditory cortex

   This article has 4 authors:

   1. David Pérez-González
   2. Ana Belén Lao-Rodríguez
   3. Cristian Aedo-Sánchez
   4. Manuel S Malmierca

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The findings of this study are valuable as they provide new insights into the role of acetylcholine in modulating sensory processing in the auditory cortex. This paper reports a systematic measurement of cell activity in the auditory cortex before and after the microiontophoretic application of Ach during an oddball and cascade sequence of auditory stimuli. The evidence presented is convincing, as the study used a rigorous experimental design and statistical analysis. The manuscript will interest researchers in auditory neuroscience and neuromodulation, as well as clinicians and individuals with auditory processing disorders.

   Reviewed by eLife

4. Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

   This article has 6 authors:

   1. Andrew S Blaeser
   2. Jun Zhao
   3. Arthur U Sugden
   4. Simone Carneiro-Nascimento
   5. Mark L Andermann
   6. Dan Levy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study explored the impact of migraine-related cortical spreading depression (CSD) on the firing of nerves innervating the coverings of the brain that are considered the putative source of migraine-related pain. Using convincing approaches they show that these responses are altered in response to mechanical deformation of the brain coverings. Given that migraine is characterized by worsening head pain in response to movement, the findings offer a potential mechanism that may explain this clinical phenomenon.

   Reviewed by eLife

5. A spatial threshold for astrocyte calcium surge

   This article has 8 authors:

   1. Justin Lines
   2. Andres Baraibar
   3. Carmen Nanclares
   4. Eduardo D Martin
   5. Juan Aguilar
   6. Paulo Kofuji
   7. Marta Navarrete
   8. Alfonso Araque

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment:

     This study presents valuable findings that add to our understanding of cortical astrocytes, which respond to synaptic activity with calcium release in subcellular domains that can proceed to larger calcium waves. The proposed concept of a spatial "threshold" is based on solid evidence from in vivo and ex vivo imaging data and the use of mutant mice. Details of the specific threshold must be taken with caution and are necessarily incomplete, but may be supported by additional experiments with higher resolution in space and time in the future.

   Reviewed by eLife

6. Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

   This article has 11 authors:

   1. Wayne Mitchell
   2. Ludger JE Goeminne
   3. Alexander Tyshkovskiy
   4. Sirui Zhang
   5. Julie Y Chen
   6. Joao A Paulo
   7. Kerry A Pierce
   8. Angelina H Choy
   9. Clary B Clish
   10. Steven P Gygi
   11. Vadim N Gladyshev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports comprehensive multi-omics data on the changes induced in young and aged male mouse tail fibroblasts after treatment with chemical reprogramming factors. The authors provide solid evidence to support their claim that chemical reprogramming factors induce changes consistent with a reduction of cellular 'biological' age (e.g., correlations with established aging markers in whole tissues).

   Reviewed by eLife

7. Energy conservation by collective movement in schooling fish

   This article has 2 authors:

   1. Yangfan Zhang
   2. George V Lauder

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors provide an important series of metabolic measurements characterizing group dynamics in fish, rationalizing that schooling behavior presents several benefits. The strength of evidence supporting this conclusion is solid, but the specific methodological and analytical approaches taken should be considered for further interpretation.

   Reviewed by eLife

8. A suite of selective pressures supports the maintenance of alleles of a Drosophila immune peptide

   This article has 6 authors:

   1. Sarah R Mullinax
   2. Andrea M Darby
   3. Anjali Gupta
   4. Patrick Chan
   5. Brittny R Smith
   6. Robert L Unckless

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates evolutionary aspects around a single amino acid polymorphism, known to be under long-term balancing selection, in an immune peptide of Drosophila melanogaster. Using alleles with different substitutions, the investigators demonstrate that while one allele provides better survival after systemic infections by a bacterial pathogen, the alternative allele endows its carriers with a longer lifespan under certain conditions. The authors suggest that these contrasting fitness effects of the two alleles contribute to balancing their long-term evolutionary fate. While the work is very interesting, the strength of the provided evidence is still incomplete, and the study would benefit from more rigorous approaches.

   Reviewed by eLife

9. Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2

   This article has 2 authors:

   1. Ibtisam Ibtisam
   2. Alexei F Kisselev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents important findings regarding a transcription-independent component of the early recovery of proteasome activity from a short pulse of proteasome inhibitor treatment, which has not been appreciated before and which is independent of the DDI2-NRF2 axis. While the evidence is in principle solid, with recapitulation in several cell line models, the proposed alternative underlying mechanism, namely regulation at the level of proteasome assembly, lacks experimental support, and at this point remain speculative.

   Reviewed by eLife

10. Seasonally migratory songbirds have different historic population size characteristics than resident relatives

    This article has 2 authors:

    1. Kevin Winker
    2. Kira Delmore

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is a valuable study of the role that life history differences might play in determining population size and demography. While concerns about generation times and population structure leave the evidence for the claims in parts incomplete, the work is of considerable interest to anyone who tries to understand evolutionary consequences of life history changes.

    Reviewed by eLife