eLife

Latest preprint reviews

1. Time to Eat - A Personalized Circadian Eating Schedule Leads to Weight Loss Without Imposing Calorie Restriction: A Randomized Controlled Pilot Study

   This article has 6 authors:

   1. Isabell Wilming
   2. Jana Tuschewski
   3. Jessie M Osterhaus
   4. Theresa JG Bringmann
   5. Anisja Hühne-Landgraf
   6. Dominic Landgraf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigates a dietary intervention that employs a smartphone app to promote meal regularity, findings that have theoretical or practical implications for a subfield and may be clinically useful. The intervention to entice participants to adhere to specific meal times represents a restrictive diet (even though it does not ask to limit caloric intake) similar to a time-restricted feeding diet, while the control subjects are not experiencing or adhering to dietary restrictions. The authors report significant weight loss but did not rigorously assess caloric intake which remains a weakness of this study as food diaries are notoriously unreliable. While the concept is very interesting, the study is considered incomplete, and the rigor of the results should be strengthened in follow-up studies to add more stringent methods to assess caloric intake. Additionally, the study hypothesizes that the intervention resets the circadian clock. However, the study needs an objective method for assessing circadian rhythms, such as actigraphy, in addition to a subjective questionnaire.

   Reviewed by eLife

2. Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

   This article has 13 authors:

   1. Sujeethkumar Prithiviraj
   2. Alejandro Garcia Garcia
   3. Karin Linderfalk
   4. Bai Yiguang
   5. Sonia Ferveur
   6. Ludvig Nilsén Falck
   7. Agatheeswaran Subramaniam
   8. Sofie Mohlin
   9. David Hidalgo Gil
   10. Steven J Dupard
   11. Dimitra Zacharaki
   12. Deepak Bushan Raina
   13. Paul E Bourgine

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents a potentially valuable approach to genetically modify cells to produce extracellular matrices with altered compositions, termed cell-laid, engineered extracellular matrices (eECM). The evidence supporting the authors' conclusions regarding the utility of eECM for endogenous repair is solid, although there are some disagreements on the chondrogenicity of lyophilized constructs which was viewed as lacking robust evidence for endochondral ossification.

   Reviewed by eLife

3. A single-cell atlas of the miracidium larva of Schistosoma mansoni reveals cell types, developmental pathways, and tissue architecture

   This article has 10 authors:

   1. Teresa Attenborough
   2. Kate A Rawlinson
   3. Carmen L Diaz Soria
   4. Kirsty Ambridge
   5. Geetha Sankaranarayanan
   6. Jennie Graham
   7. James A Cotton
   8. Stephen R Doyle
   9. Gabriel Rinaldi
   10. Matthew Berriman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study in which the authors provide an expression profile of the human blood fluke, Schistosoma mansoni. A strength of this solid study is in its inclusion of in situ hybridisation to validate the predictions of the transcript analysis.

   Reviewed by eLife

4. Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

   This article has 13 authors:

   1. Phaedra C Ghazi
   2. Kayla T O'Toole
   3. Sanjana Srinivas Boggaram
   4. Michael T Scherzer
   5. Mark R Silvis
   6. Yun Zhang
   7. Madhumita Bogdan
   8. Bryan D Smith
   9. Guillermina Lozano
   10. Daniel L Flynn
   11. Eric L Snyder
   12. Conan G Kinsey
   13. Martin McMahon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a mechanistic study showing the effect of combining inhibition of autophagy (through ULK1/2) and KRAS (using sotorasib) on KRAS mutant NSCLC making the study valuable to cancer biologists and more broadly in a clinical setting. The evidence generated by GEM mouse models and cell lines is solid but could be further strengthened by increasing the mouse cohort size. This study holds translational relevance beyond NSCLC to other indications that carry KRAS mutations.

   Reviewed by eLife

5. An evaluation of the tumor microenvironment through CALR, IL1R1, IFNB1, and IFNG to assess prognosis and immunotherapy response in bladder cancer patients

   This article has 12 authors:

   1. Lilong Liu
   2. Zhenghao Liu
   3. Lei Fan
   4. Zhipeng Yao
   5. Junyi Hu
   6. Yaxin Hou
   7. Yang Li
   8. Yuhong Ding
   9. Yingchun Kuang
   10. Ke Chen
   11. Yi Hao
   12. Zheng Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents useful findings that explore the prognostic and immunotherapeutic relevance of specific immune-related genes (CALR, IL1R1, IFNB1, and IFNG) in the bladder cancer tumor microenvironment. While the analysis highlights potentially meaningful associations with survival and treatment response, the strength of evidence is incomplete, as some claims lack sufficient experimental or mechanistic validation. Further refinement and validation of the predictive models would enhance the impact and generalizability of the conclusions.

   Reviewed by eLife

6. Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

   This article has 7 authors:

   1. Kyle Spinler
   2. Michael Hamilton
   3. Jeevisha Bajaj
   4. Yutaka Shima
   5. Emily Diaz
   6. Marcie Kritzik
   7. Tannishtha Reya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents important findings on the role of MSI2-HOXA9 translocation in chronic myeloid leukemia. The authors provide convincing evidence supporting the role of this translocation in leukemogenesis by using elegant mouse modeling and in vitro mechanistic studies. Consistent with the reviews, the studies can be strengthened with further murine and cell line experiments.

   Reviewed by eLife

7. Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

   This article has 15 authors:

   1. Jiro Yoshino
   2. Sonali S Mali
   3. Claire R Williams
   4. Takeshi Morita
   5. Chloe E Emerson
   6. Christopher J Arp
   7. Sophie E Miller
   8. Chang Yin
   9. Lydia Thé
   10. Chikayo Hemmi
   11. Mana Motoyoshi
   12. Kenichi Ishii
   13. Kazuo Emoto
   14. Diana M Bautista
   15. Jay Z Parrish

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is important work and provides a significant advance in our understanding of mechanosensation in the epidermis. The evidence presented is convincing and, barring a few minor weaknesses, strongly implicates activation of epidermal cells and store-operated calcium entry in the activation of nociceptive neurons innervating that tissue. This work will be of broad interest to neurobiologists, epithelial cell biologists, and mechanobiologists.

   Reviewed by eLife, Arcadia Science

8. Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

   This article has 15 authors:

   1. Alessandra Machado Araujo
   2. Joseph D Dekker
   3. Kendra Garrison
   4. Zhe Su
   5. Catherine Rhee
   6. Zicheng Hu
   7. Bum-Kyu Lee
   8. Daniel Osorio
   9. Jiwon Lee
   10. Vishwanath R Iyer
   11. Lauren IR Ehrlich
   12. George Georgiou
   13. Gregory Ippolito
   14. Stephen Yi
   15. Haley O Tucker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study reports that while most plasmacytoid dendritic cells (pDCs) originate from common dendritic cell precursors, approximately 20% are derived from lymphoid progenitors shared with B cells. The methodology used and the evidence are solid, and further demonstrate the distinct transcription factor requirements and activities of this subset of pDCs, although the functional significance of this dendritic cell subset will require further elucidation. The findings will be of great interest for those interested in the developmental and functional biology of the immune system.

   Reviewed by eLife

9. Fine-scale tracking reveals visual field use for predator detection and escape in collective foraging of pigeon flocks

   This article has 2 authors:

   1. Mathilde Delacoux
   2. Fumihiro Kano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this fundamental study, the authors use innovative fine-scale motion capture technologies to study visual vigilance with high-acuity vision, to estimate the visual fixation of free-feeding pigeons. The authors present compelling evidence for use of the fovea to inspect predator cues, the behavioral state influencing the latency for fovea use, and the use of the fovea decreasing the latency to escape of both the focal individual and other flock members. The work will be of broad interest to behavioral ecologists.

   Reviewed by eLife

10. SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

    This article has 12 authors:

    1. Somen K Mistri
    2. Brianna M Hilton
    3. Katherine J Horrigan
    4. Emma S Andretta
    5. Remi Savard
    6. Oliver Dienz
    7. Kenneth J Hampel
    8. Diana L Gerrard
    9. Joshua T Rose
    10. Nikoletta Sidiropoulos
    11. Dev Majumdar
    12. Jonathan E Boyson

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study highlights the importance of SLAM-SAP signaling in determining innate gamma-delta T cell sublineages and their T cell receptor repertoires. It uncovers the complex role of the SLAM-SAP pathway in developing specific gamma-delta T cell subsets. The evidence presented is compelling, backed by high-quality data obtained through advanced single cell proteogenomics techniques.This work will be of broad interest to immunologists.

    Reviewed by eLife