eLife

Latest preprint reviews

1. Ocular dominance-dependent binocular combination of monocular neuronal responses in macaque V1

   This article has 5 authors:

   1. Sheng-Hui Zhang
   2. Xing-Nan Zhao
   3. Dan-Qing Jiang
   4. Shi-Ming Tang
   5. Cong Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Overall, the reviewers found the significance of the work valuable to the field of visual neuroscience, particularly given the large data set and strength of the method used that allowed for spatial analysis of neuronal responses in macaque V1. The evidence was deemed compelling, owing in part to the consistency of responses across animals and the fitness of modeling. The authors have addressed the major comments from reviewers and improved the manuscript through relation to prior literature and addressing specific limitations of the method used.

   Reviewed by eLife

2. Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

   This article has 18 authors:

   1. Apostolos Papandreou
   2. Nivedita Singh
   3. Lorita Gianfrancesco
   4. Dimitri Budinger
   5. Katy Barwick
   6. Alexander Agrotis
   7. Christin Luft
   8. Ying Shao
   9. An-Sofie Lenaerts
   10. Allison Gregory
   11. Suh Young Jeong
   12. Penelope Hogarth
   13. Susan Hayflick
   14. Serena Barral
   15. Janos Kriston-Vizi
   16. Paul Gissen
   17. Manju A Kurian
   18. Robin Ketteler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript reports alterations in autophagy present in dopaminergic neurons differentiated from iPSCs of patients with WDR45 mutations. The authors identified compounds that improved the defects present in mutant cells by generating isogenic iPSC without the mutation and performing an automated drug screening. The methodological approaches are solid, but the claims still need to be completed; showing the effects of the identified compounds on iron-related alterations is crucial. The effects of these drugs in vivo would be a great addition to the study.

   Reviewed by eLife

3. Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits

   This article has 13 authors:

   1. Samyogita Hardikar
   2. Bronte Mckeown
   3. H Lina Schaare
   4. Raven Star Wallace
   5. Ting Xu
   6. Mark Edgar Lauckener
   7. Sofie Louise Valk
   8. Daniel S Margulies
   9. Adam Turnbull
   10. Boris C Bernhardt
   11. Reinder Vos de Wael
   12. Arno Villringer
   13. Jonathan Smallwood

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     These are important findings that support a link between low-dimensional brain network organisation, patterns of ongoing thought, and trait-level personality factors, making it relevant for researchers in the field of spontaneous cognition, personality, and neuropsychiatry. While this link is not entirely new, the paper brings to bear a rich dataset and a well-conducted study, to approach this question in a novel way. The evidence in support of the findings is convincing.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2302.14157

5. Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

   This article has 41 authors:

   1. Trang H Pham
   2. Kanika Bajaj Pahuja
   3. Thijs J Hagenbeek
   4. Jason Zbieg
   5. Cameron L Noland
   6. Victoria C Pham
   7. Xiaosai Yao
   8. Christopher M Rose
   9. Kristen C Browder
   10. Ho-June Lee
   11. Mamie Yu
   12. May Liang-Chu
   13. Scott Martin
   14. Erik Verschueren
   15. Jason Li
   16. Marta H Kubala
   17. Rina Fong
   18. Maria Lorenzo
   19. Paul Beroza
   20. Peter Hsu
   21. Sayantanee Paul
   22. Elisia Villemure
   23. Wendy Lee
   24. Tommy K Cheung
   25. Saundra Clausen
   26. Jennifer Lacap
   27. Yuxin Liang
   28. Jason Cheng
   29. Steve Schmidt
   30. Zora Modrusan
   31. Michael Cohen
   32. James Crawford
   33. Heinrich Jasper
   34. Alan Ashworth
   35. Jennie R Lill
   36. Shiva Malek
   37. Joachim Rudolph
   38. Ingrid E Wertz
   39. Matthew T Chang
   40. Xin Ye
   41. Anwesha Dey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes two findings: first, that TEAD is subject to turnover by the ubiquitin-proteasome system involving RNF146 and Parylation, and second, the development of a pan-TEAD heterobifunctional degrader that is used to inhibit growth of a YAP-dependent cancer cell line and to characterize TEAD binding sites in the genome. Convincing evidence supports the development and specificity of the degrader. This article will be of relevance to cancer biologists and scientists interested in proteostasis, cellular signaling, and post-translation modification of proteins.

   Reviewed by eLife

6. Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease

   This article has 6 authors:

   1. Vibhavari Aysha Bansal
   2. Jia Min Tan
   3. Hui Rong Soon
   4. Norliyana Zainolabidin
   5. Takaomi Saido
   6. Toh Hean Ch'ng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study focuses on nuclear pore complex dysfunction in a mouse model of Alzheimer's disease related Aβ pathology. If future revisions can adequately respond to the reviewer comments, the findings may eventually be useful in supporting the idea that nuclear cytoplasmic transport defects occur prior to plaque deposition in this disease model and may be caused by Alzheimer's disease pathology. However, even after revision, the work suffers from overinterpretation of some of the data and remains incomplete in several respects.

   Reviewed by eLife

7. STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

   This article has 4 authors:

   1. Stephen D'Amico
   2. Varvara Kirillov
   3. Oleksi Petrenko
   4. Nancy C Reich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study delves into the complex role of STAT3 signaling and its interplay with TGF-beta and SMAD4 in KRAS mutant pancreatic cancer. The authors demonstrate that both the presence and absence of STAT3, relative to SMAD4, can lead to poor PDAC differentiation and that STAT3 mutations affect p53-null fibroblasts with KRASG12D and induce an EMT-like phenotype. By providing convincing evidence, the authors were able to derive important insights into KRAS mutant cancers.

   Reviewed by eLife

8. SCC3 is an axial element essential for homologous chromosome pairing and synapsis

   This article has 12 authors:

   1. Yangzi Zhao
   2. Lijun Ren
   3. Tingting Zhao
   4. Hanli You
   5. Yongjie Miao
   6. Huixin Liu
   7. Lei Cao
   8. Bingxin Wang
   9. Yi Shen
   10. Yafei Li
   11. Ding Tang
   12. Zhukuan Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study elucidates the function of the cohesin subunit SCC3 in maintaining homologous chromosome pairing and synapsis during meiosis. The observation of sterility in the SCC3 weak mutant prompted an investigation of abnormal chromosome behavior during anaphase I, and the discovery that SCC3's loading onto meiotic chromosomes is REC8-dependent. The convincing evidence presented in this study contributes to our understanding of meiosis in rice and attracts cell biologists, reproductive biologists, and plant geneticists.

   Reviewed by eLife

9. CEP44 is required for maintaining centriole duplication and spindle integrity

   This article has 9 authors:

   1. Donghui Zhang
   2. Wenlu Wei
   3. Xiaopeng Zou
   4. Hui Meng
   5. Fangyuan Li
   6. Minjun Yao
   7. Junling Teng
   8. Ning Huang
   9. Jianguo Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study investigates the role of the centrosomal protein CEP44 in centriole duplication and mitotic spindle formation. While the analysis of CEP44 mitotic phosphorylation and spindle recruitment is solid, the characterization of CEP44's role at centrioles is incomplete and would benefit from additional controls and analyses. Since the work links CEP44 reduced expression to poor survival in breast cancer patients, it is of interest not only to cell biologists but also to cancer researchers.

   Reviewed by eLife

10. Loss of CTRP10 results in female obesity with preserved metabolic health

    This article has 7 authors:

    1. Fangluo Chen
    2. Dylan C Sarver
    3. Muzna Saqib
    4. Leandro M Velez
    5. Susan Aja
    6. Marcus M Seldin
    7. G William Wong

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This manuscript presents a detailed characterization of male and female wildtype and Ctrp10 knockout mice, and reveals that knockout mice develop female-specific obesity that is largely uncoupled from metabolic dysfunction. The data are convincing, and the work will be an important contribution to understanding how obesity is coupled to metabolic dysfunction, and how this can occur in a sex-specific manner.

    Reviewed by eLife