eLife

Latest preprint reviews

1. The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

   This article has 4 authors:

   1. Sebastián Giunti
   2. María Gabriela Blanco
   3. María José De Rosa
   4. Diego Rayes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a conceptually appealing study in which the authors identify genes whose function is important for the development of inhibitory (GABA) neurons, and then demonstrate that a diet rich in ketone body β-hydroxybutyrate partially suppresses specific mutant phenotypes. The authors provide compelling evidence that features methods, data and analyses more rigorous than the current state-of-the-art. Conceptually, this is evidence of a rescue of a developmental defect with dietary metabolic intervention, linking, in an elegant way, the underpinning genetic mechanisms with novel metabolic pathways that could be used to circumvent the defects.

   Reviewed by eLife

2. Mining the neuroimaging literature

   This article has 5 authors:

   1. Jérome Dockès
   2. Kendra M Oudyk
   3. Mohammad Torabi
   4. Alejandro I de la Vega
   5. Jean-Baptiste Poline

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents an important ecosystem designed to support literature mining in biomedical research, showcasing a methodological framework that includes tools like Pubget for article collection and labelbuddy for text annotation. The solid evidence presented for these tools suggests they could streamline the analysis and annotation of scientific literature, potentially benefiting research across a range of biomedical disciplines. While the primary focus is on neuroimaging literature, the applicability of these methods and tools might extend further, offering an advance in the practices of meta-research and literature mining.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.03218

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.03218v3

5. Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

   This article has 17 authors:

   1. Sindre Lee-Ødegård
   2. Marit Hjorth
   3. Thomas Olsen
   4. Gunn-Helen Moen
   5. Emily Daubney
   6. David M Evans
   7. Andrea L Hevener
   8. Aldons J Lusis
   9. Mingqi Zhou
   10. Marcus M Seldin
   11. Hooman Allayee
   12. James Hilser
   13. Jonas Krag Viken
   14. Hanne Gulseth
   15. Frode Norheim
   16. Christian A Drevon
   17. Kåre Inge Birkeland

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful manuscript describes a proteomic analysis of plasma from subjects before and after an exercise regime consisting of endurance and resistance exercise. The work identifies a putative new exerkine, CD300LG, and finds associations of this protein with aspects of insulin sensitivity and angiogenesis. The characterization remains incomplete at present. Because CD300LG may have a transmembrane domain, one possibility is that exercise causes the release of extracellular vesicles containing this protein. As this study reports associations, additional studies will be needed to establish causality. The paper will hopefully prompt further studies to more fully elucidate the underlying biology.

   Reviewed by eLife

6. ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

   This article has 6 authors:

   1. Jing Sun
   2. Desmond Choy
   3. Nicolas Sompairac
   4. Shirin Jamshidi
   5. Michele Mishto
   6. Shahram Kordasti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     ImmCellTyper presents a useful toolkit for CyTOF data analysis, integrating BinaryClust for semi-supervised clustering and cell type annotation. The evidence supporting the findings is convincing, with appropriate and validated methodology. This tool will be helpful to researchers in immunology and cytometry, offering a robust solution for cell type identification and differential analysis.

   Reviewed by eLife

7. Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum

   This article has 3 authors:

   1. Pyae Hein Htet
   2. Edward Avezov
   3. Eric Lauga

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work explores the physical principles underlying fluid flow and luminal transport within the endoplasmic reticulum. Its important contribution is to highlight the strong physical constraints imposed by viscous dissipation in nanoscopic tubular networks. In particular, the work presents convincing evidence based on theoretical analysis that commonly discussed mechanisms such as tubular contraction are unlikely to be at the origin of the observed transport velocities. As such, it will be of relevance to cell biologists and physicists interested in organelle dynamics. As this study is solely theoretical and deals with order of magnitude estimates, its main conclusions await experimental validation.

   Reviewed by eLife

8. Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

   This article has 6 authors:

   1. MinHyuk Lee
   2. Se Hoon Park
   3. Kyeung Min Joo
   4. Jae Young Kwon
   5. Kyung-Hoon Lee
   6. KyeongJin Kang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important new insight into how non-synaptic interactions affect the activity of adjacent gustatory neurons housed within the same sensillum. The conclusions are supported by convincing electrophysiological, behavioral, and genetic data. This work will be of interest to neuroscientists studying chemosensory processing or regulation of neuronal excitability.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2209.08066v4

10. Sensory-memory interactions via modular structure explain errors in visual working memory

    This article has 3 authors:

    1. Jun Yang
    2. Hanqi Zhang
    3. Sukbin Lim

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important computational study provides new insights into how neural dynamics may lead to time-evolving behavioral errors as observed in certain working-memory tasks. By combining ideas from efficient coding and attractor neural networks, the authors construct a two-module network model to capture the sensory-memory interactions and the distributed nature of working memory representations. They provide convincing evidence supporting that their two-module network, although none of the alternative circuit structures they considered can account for error patterns reported in orientation-estimation tasks with delays.

    Reviewed by eLife