eLife

Latest preprint reviews

1. The impact of surgery and oncological treatment on risk of type 2 diabetes onset in patients with colorectal cancer: nationwide cohort study in Denmark

   This article has 8 authors:

   1. Caroline Krag
   2. Maria Saur Svane
   3. Sten Madsbad
   4. Susanne Boel Graversen
   5. Jesper Frank Christensen
   6. Thorkild IA Sørensen
   7. Louise Lang Lehrskov
   8. Tinne Laurberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study presents findings that suggest the need for postoperative type 2 diabetes screening and that this should be prioritized in colorectal cancer survivors with overweight/obesity regardless of the type of colorectal cancer treatment applied. The evidence supporting the claims of the authors is solid and the authors use a population-based cohort study including all Danish colorectal patients who had undergone colorectal cancer surgery between 2001-2018. The work will be of interest to medical biologists, endocrinologists and oncologists working on colorectal cancer.

   Reviewed by eLife

2. Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

   This article has 10 authors:

   1. Tengteng Huang
   2. Xiaoling Chen
   3. Jun He
   4. Ping Zheng
   5. Yuheng Luo
   6. Aimin Wu
   7. Hui Yan
   8. Bing Yu
   9. Daiwen Chen
   10. Zhiqing Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful paper addresses a novel exercise mimetic agent on muscle exercise and performance. While the data provided are interesting, the evidence is incomplete, as much of it is correlative.

   Reviewed by eLife

3. Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

   This article has 9 authors:

   1. Angela Papalamprou
   2. Victoria Yu
   3. Wensen Jiang
   4. Julia Sheyn
   5. Tina Stefanovic
   6. Angel Chen
   7. Chloe Castaneda
   8. Melissa Chavez
   9. Dmitriy Sheyn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors established a useful syndetome differentiation protocol from human induced pluripotent stem cells, guided by single-cell transcriptomic analysis. Their findings could significantly impact the field, particularly for patients needing tendon cell therapy. However, the evidence presented is currently incomplete, as the authors did not yet test the applicability of their protocol across multiple human induced pluripotent stem cell lines.

   Reviewed by eLife

4. PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

   This article has 17 authors:

   1. Teruhiko Yoshida
   2. Khun Zaw Latt
   3. Avi Z Rosenberg
   4. Briana A Santo
   5. Komuraiah Myakala
   6. Yu Ishimoto
   7. Yongmei Zhao
   8. Shashi Shrivastav
   9. Bryce A Jones
   10. Xiaoping Yang
   11. Xiaoxin X Wang
   12. Vincent M Tutino
   13. Pinaki Sarder
   14. Moshe Levi
   15. Koji Okamoto
   16. Cheryl A Winkler
   17. Jeffrey B Kopp

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable new insights into a HIV-associated nephropathy (HIVAN) kidney phenotype in the Tg26 transgenic mouse model, and delineates the kidney cell types that express HIV genes and are injured in these HIV-transgenic mice. A series of compelling experiments demonstrated that PKR inhibition can ameliorate HIVAN with reversal of mitochondrial dysfunction (mainly confined to endothelial cells), a prominent feature shared in other kidney diseases. The data support that inhibition of PKR and mitochondrial dysfunction has potential clinical significance for HIVAN.

   Reviewed by eLife

5. Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype

   This article has 5 authors:

   1. Qinyu Zhang
   2. Rasmus Olofzon
   3. Anna Konturek-Ciesla
   4. Ouyang Yuan
   5. David Bryder

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable dissection on how functional HSCs are expanded in PVA cultures. The functional and multi-omic analyses provided are convincing, although the additional data and their analysis provided during revision could have been included in the test to assist readers and to strengthen the published manuscript. Nevertheless, the present work will be of value for stem cell biologists interested in HSC regulation.

   Reviewed by eLife

6. Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

   This article has 6 authors:

   1. Gabriel Birzu
   2. Harihara Subrahmaniam Muralidharan
   3. Danielle Goudeau
   4. Rex R. Malmstrom
   5. Daniel S. Fisher
   6. Devaki Bhaya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study demonstrates widespread introgression between species of cyanobacteria in hot springs in Yellowstone National Park. Using single cell sequencing of hundreds of genomes, the authors provide one of the most convincing demonstrations to date of the importance of selection and hybridization in shaping polymorphism within a natural community. The strong enthusiasm for the paper is only dampened slightly by the methods not being described in the clearest possible manner.

   Reviewed by eLife

7. Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

   This article has 10 authors:

   1. Kentarou Waki
   2. Hideki Tani
   3. Eigo Kawahara
   4. Yumiko Saga
   5. Takahisa Shimada
   6. Emiko Yamazaki
   7. Seiichi Koike
   8. Yoshitomo Morinaga
   9. Masaharu Isobe
   10. Nobuyuki Kurosawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides important insights into mucosal antibody responses against SARS-CoV-2 following intranasal immunization by characterizing a large number of monoclonal antibodies at both mucosal and non-mucosal sites. The evidence supporting the claims is solid. The demonstrated in vitro antiviral activity of antibodies characterized provides a rationale for developing mucosal vaccines, especially if confirmed in vivo and benchmarked against antibodies generated following intramuscular vaccination.

   Reviewed by eLife

8. Action does not enhance but attenuates predicted touch

   This article has 2 authors:

   1. Xavier Job
   2. Konstantina Kilteni

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     While decades of research findings have supported the idea that action attenuates predicted touch, recent work has countered this, proposing that action actually enhances predicted touch and the previously observed attenuation is due to tactile contact. This present study resolves these contradictory claims regarding the role of prediction in perception of self-action. This important work provides compelling evidence that self-generated touch is attenuated compared to the same touch externally-generated, and a clear explanation for recent high-profile results that appeared to support the opposite view.

   Reviewed by eLife

9. Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans

   This article has 11 authors:

   1. Shashwat Mishra
   2. Mohamed Dabaja
   3. Asra Akhlaq
   4. Bianca Pereira
   5. Kelsey Marbach
   6. Mediha Rovcanin
   7. Rashmi Chandra
   8. Antonio Caballero
   9. Diana Fernandes de Abreu
   10. QueeLim Ch'ng
   11. Joy Alcedo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents useful and potentially valuable findings on how food signals may influence reproduction in the nematode C. elegans. In the current manuscript, the evidence in support of the authors' model is incomplete, and additional experimental data is needed to buttress the authors' conclusions.

   Reviewed by eLife

10. A unified approach to dissecting biphasic responses in cell signaling

    This article has 2 authors:

    1. Vaidhiswaran Ramesh
    2. J Krishnan

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents a useful mathematical analysis of different signaling networks in an attempt to provide general rules that give rise to biphasic responses, a widely observed behavior in biology in which the outputs of the network depend non-monotonically on the inputs. Determining general conditions that underlie this behavior would be useful in engineering synthetic biological systems and for mechanistically understanding biphasic responses in biological systems. However, whereas the mathematical approach and methods are solid, as they stand, the analyses are inadequate to assess how these findings are applicable in nature and which are general.

    Reviewed by eLife