eLife

Latest preprint reviews

1. Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM

   This article has 7 authors:

   1. Lina Antenucci
   2. Salla Virtanen
   3. Chandan Thapa
   4. Minne Jartti
   5. Ilona Pitkänen
   6. Helena Tossavainen
   7. Perttu Permi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes a valuable study aimed at identifying the substrate specificity of two cell wall hydrolases LSS and LytM in S. aureus. The authors show that LytM has a novel function of cleaving D-Ala-Gly instead of only Gly-Gly by using synthetic substrates and compelling NMR-based real-time kinetics measurements.

   Reviewed by eLife

2. Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

   This article has 7 authors:

   1. Felix Y Zhou
   2. David P Waterman
   3. Marissa Ashton
   4. Suhaily Caban-Penix
   5. Gonen Memisoglu
   6. Vinay V Eapen
   7. James E Haber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study on the damage-induced checkpoint maintenance and termination in budding yeast that provides novel and convincing evidence for a role of the spindle assembly checkpoint and mitotic exit network in halting the cell cycle after prolonged arrest in response to irreparable DNA double strand breaks (DSBs). The study identifies particular components from these checkpoints that are specifically required for the establishment and/or the maintenance of a cell cycle block triggered by such DSBs. The authors propose an interesting model for how these different checkpoints intersect and crosstalk for timely resumption of cell cycling even without repairing DNA damage that has been revised by addressing the bulk of the reviewers' comments to the first version of the manuscript.

   Reviewed by eLife

3. Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

   This article has 12 authors:

   1. Aleksandar Bartolome
   2. Julia C Heiby
   3. Domenico Di Fraia
   4. Ivonne Heinze
   5. Hannah Knaudt
   6. Ellen Spaeth
   7. Omid Omrani
   8. Alberto Minetti
   9. Maleen Hofmann
   10. Joanna M Kirkpatrick
   11. Therese Dau
   12. Alessandro Ori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important method and resource in cell lines and in mice for mass spectrometry-based identification of interactors of the proteasome, a multi-protein complex with a central role in protein turnover in almost all tissues and cell types. The method presented, including the experimental workflow and analysis pipeline, as well as the several lines of validation provided throughout, is convincing. Given the growing interest in protein aggregation and targeted protein degradation modalities, this work will be of interest to a broad spectrum of basic cell biologists and translational researchers.

   Reviewed by eLife, preLights

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2302.14157v2

5. Autoacetylation-mediated phase separation of TIP60 is critical for its functions

   This article has 3 authors:

   1. Shraddha Dubey
   2. Himanshu Gupta
   3. Ashish Gupta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study on K187 acetylation of the nuclear protein, TIP60, required for its phase separation and function. The evidence supporting the primary conclusion is incomplete and warrants more scrutiny.

   Reviewed by eLife

6. Multiple objects evoke fluctuating responses in several regions of the visual pathway

   This article has 12 authors:

   1. Meredith N Schmehl
   2. Valeria C Caruso
   3. Yunran Chen
   4. Na Young Jun
   5. Shawn M Willett
   6. Jeff T Mohl
   7. Douglas A Ruff
   8. Marlene Cohen
   9. Akinori F Ebihara
   10. Winrich A Freiwald
   11. Surya T Tokdar
   12. Jennifer M Groh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study adds to the growing body of evidence that neural responses fluctuate in time to alternatively represent one among multiple concurrent stimuli and that these fluctuations seize when objects fuse into one perceived object. The present study provides solid evidence from multiple brain areas and stimuli types to support this hypothesis. Overall, the study illustrates how the brain can use time dimension and synchrony to either parse or integrate stimuli into a coherent representation.

   Reviewed by eLife

7. A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis

   This article has 6 authors:

   1. Pengfei Guo
   2. Rebecca C Lim
   3. Keshari Rajawasam
   4. Tiffany Trinh
   5. Hong Sun
   6. Hui Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a fundamental study describing a novel methylation event on EZH2 that regulates EZH2 protein stability and hematopoiesis. The methodologies are sound and the conclusions are largely supported by solid data. The work will be of interest to biomedical researchers in the field of cancer epigenetics.

   Reviewed by eLife

8. Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls

   This article has 5 authors:

   1. Alyssa M. Pivirotto
   2. Alexander Platt
   3. Ravi Patel
   4. Sudhir Kumar
   5. Jody Hey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Drawing on a human population genomic data set, this valuable study seeks to show that potentially advantageous alleles are on average older than neutral alleles, invoking the action of balancing selection as the underlying explanation. Currently it is unfortunately unclear how robust the estimates of allele ages are, and the evidence for the authors' proposal is therefore at this stage incomplete. If confirmed, the conclusions would be of interest to population genomicists, especially those studying humans.

   Reviewed by eLife

9. Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord

   This article has 7 authors:

   1. Bridget M Curran
   2. Kelsey R Nickerson
   3. Andrea R Yung
   4. Lisa V Goodrich
   5. Alexander Jaworski
   6. Marc Tessier-Lavigne
   7. Le Ma

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study expands our understanding of the role of two axon guidance factors in a specific axon guidance decision. The strength of the study is the compelling axonal labeling and quantification, which allows the authors to establish precise consequences of the loss of each guidance factor or receptor.

   Reviewed by eLife

10. Perceptual error based on Bayesian cue combination drives implicit motor adaptation

    This article has 5 authors:

    1. Zhaoran Zhang
    2. Huijun Wang
    3. Tianyang Zhang
    4. Zixuan Nie
    5. Kunlin Wei

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents an important finding on the influence of visual uncertainty and Bayesian cue combination on implicit motor adaptation in young healthy participants, hereby linking perception and action during implicit adaptation. The evidence supporting the claims of the authors is convincing. The normative approach of the proposed PEA model, which combines ideas from separate lines of research, including vision research and motor learning, opens avenues for future developments. This work will be of interest to researchers in sensory cue integration and motor learning.

    Reviewed by eLife