eLife

Latest preprint reviews

1. Single-cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes

   This article has 3 authors:

   1. GVS Devakinandan
   2. Mark Terasaki
   3. Adish Dani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable manuscript analyzing single-cell RNA-sequencing data from the mouse vomeronasal organ. Convincing evidence in this manuscript allows the authors to identify and verify the differential expression of genes that distinguish apical and basal vomeronasal neurons. The authors also show that Gnao1 neurons exhibit enriched expression of ER-related genes, which they verify with in situ hybridizations and immunostaining and also explore via electron microscopy.

   Reviewed by eLife

2. Perturbation-response analysis of in silico metabolic dynamics revealed hard-coded responsiveness in the cofactors and network sparsity

   This article has 2 authors:

   1. Yusuke Himeoka
   2. Chikara Furusawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study uses dynamic metabolic models to compare perturbation responses in a bacterial system, analyzing whether they return to their steady state or amplify beyond the initial perturbation. The evidence supporting the emergent properties of perturbed metabolic systems to network topology and sensitivity to specific metabolites is solid.

   Reviewed by eLife

3. Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

   This article has 10 authors:

   1. Aya Matsui
   2. Cathy Spangler
   3. Johannes Elferich
   4. Momoko Shiozaki
   5. Nikki Jean
   6. Xiaowei Zhao
   7. Maozhen Qin
   8. Haining Zhong
   9. Zhiheng Yu
   10. Eric Gouaux

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study demonstrates a novel method for imaging glutamate receptors in situ via cryo-ET. The use of cutting-edge methods is well-described and is compelling. This paper is broadly relevant to biophysicists and neuroscientists.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2404.07102v2

5. Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

   This article has 14 authors:

   1. Li Sun
   2. Xuejin Chen
   3. Chunlin Song
   4. Wenjing Shi
   5. Libo Liu
   6. Shuang Bai
   7. Xi Wang
   8. Jiali Chen
   9. Chengyu Jiang
   10. Shuang-min Wang
   11. Zhou-qing Luo
   12. Ruiwen Wang
   13. Yamei Wang
   14. Quan-wen Jin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The regulation of mitosis and the dynamics of the mitotic spindle in it are central to cell division with high fidelity and crucial for normal division and development and defects therein can lead to disease. A key component of ensuring the fidelity is the "spindle assembly checkpoint". This valuable study using convincing experimental approaches in fission yeast has revealed novel links between the MAP-kinase signalling pathway modulating the spindle assembly checkpoint.

   Reviewed by eLife

6. Dimeric R25CPTH(1–34) activates the parathyroid hormone-1 receptor in vitro and stimulates bone formation in osteoporotic female mice

   This article has 11 authors:

   1. Minsoo Noh
   2. Xiangguo Che
   3. Xian Jin
   4. Dong-Kyo Lee
   5. Hyun-Ju Kim
   6. Doo Ri Park
   7. Soo Young Lee
   8. Hunsang Lee
   9. Thomas J Gardella
   10. Je-Yong Choi
   11. Sihoon Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work investigates the functional difference between the most commonly expressed form of PTH, and a mutant form of PTH, identified in a patient with chronic hypocalcemia and hyperphosphatemia which characterizes hypoparathyroidism. The authors investigate the hypothesis that this mutant PTH assumes a dimeric form in vivo and serves anabolic functions in the bone. The data are compelling and the translational aspects are fundamental in understanding PTH-1 Receptor activation.

   Reviewed by eLife

7. Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning

   This article has 9 authors:

   1. Gitanjali Roy
   2. Rameesha Syed
   3. Olivia Lazaro
   4. Sylvia Robertson
   5. Sean D McCabe
   6. Daniela Rodriguez
   7. Alex M Mawla
   8. Travis S Johnson
   9. Michael A Kalwat

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a useful study that applies deep transfer learning to assign patient-level disease attributes to single cells of T2D and non-diabetic patients, including obese patients. This analysis identified a single cluster of T2D-associated β-cells; and two subpopulations of obese- β-cells derived from either non-diabetic or T2D donors. The findings were validated at the protein level using immunohistochemistry on islets derived from non-diabetic and T2D organ donors, contributing solid experimental evidence for the computational analyses.

   Reviewed by eLife

8. Semantical and geometrical protein encoding toward enhanced bioactivity and thermostability

   This article has 5 authors:

   1. Yang Tan
   2. Bingxin Zhou
   3. Lirong Zheng
   4. Guisheng Fan
   5. Liang Hong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     ProtSSN is a valuable approach that generates protein embeddings by integrating sequence and structural information, demonstrating improved prediction of mutation effects on thermostability compared to competing models. The evidence supporting the authors' claims is compelling, with well-executed comparisons. This work will be of particular interest to researchers in bioinformatics and structural biology, especially those focused on protein function and stability.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2401.07227v1

10. T-follicular helper cell profiles differ by malaria antigen and for children compared to adults

    This article has 8 authors:

    1. Catherine Suzanne Forconi
    2. Christina Nixon
    3. Hannah W Wu
    4. Boaz Odwar
    5. Sunthorn Pond-Tor
    6. John M Ong'echa
    7. Jonathan D Kurtis
    8. Ann M Moormann

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This descriptive study used multiparameter spectral flow cytometry and clustering analysis of a subset of CD4 T cells, termed circulating T follicular helper (cTfh), responding to Plasmodium falciparum antigens, PfSEA -1A and PfGARP. The results from this comprehensive study provide valuable information regarding differences in cTfh response profiles between children and adults living in malaria-endemic Kenya and thus offer a potential usefulness towards improving choices of antigen candidates for malaria vaccines. However, the analysis and interpretation of antigen-specific CD4 cTfh responses remain incomplete.

    Reviewed by eLife