eLife

Latest preprint reviews

1. Overnight fasting facilitates safety learning by changing the neurophysiological response to relief from threat omission

   This article has 4 authors:

   1. Silvia Papalini
   2. Tom Beckers
   3. Lukas Van Oudenhove
   4. Bram Vervliet

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study on the effects of fasting on safety learning rests on basic premises and concepts that both reviewers found difficult to follow. If these can be clarified, the findings may well be useful and of some utility for the field of emotional learning as well as experimental clinical psychology. However, the main claims of the study are only partially supported and are therefore incomplete.

   Reviewed by eLife

2. Novel risk loci for COVID-19 hospitalization among admixed American populations

   This article has 122 authors:

   1. Silvia Diz-de Almeida
   2. Raquel Cruz
   3. Andre D Luchessi
   4. José M Lorenzo-Salazar
   5. Miguel López de Heredia
   6. Inés Quintela
   7. Rafaela González-Montelongo
   8. Vivian Nogueira Silbiger
   9. Marta Sevilla Porras
   10. Jair Antonio Tenorio Castaño
   11. Julian Nevado
   12. Jose María Aguado
   13. Carlos Aguilar
   14. Sergio Aguilera-Albesa
   15. Virginia Almadana
   16. Berta Almoguera
   17. Nuria Alvarez
   18. Álvaro Andreu-Bernabeu
   19. Eunate Arana-Arri
   20. Celso Arango
   21. María J Arranz
   22. Maria-Jesus Artiga
   23. Raúl C Baptista-Rosas
   24. María Barreda- Sánchez
   25. Moncef Belhassen-Garcia
   26. Joao F Bezerra
   27. Marcos AC Bezerra
   28. Lucía Boix-Palop
   29. María Brion
   30. Ramón Brugada
   31. Matilde Bustos
   32. Enrique J Calderón
   33. Cristina Carbonell
   34. Luis Castano
   35. Jose E Castelao
   36. Rosa Conde-Vicente
   37. M Lourdes Cordero-Lorenzana
   38. Jose L Cortes-Sanchez
   39. Marta Corton
   40. M Teresa Darnaude
   41. Alba De Martino-Rodríguez
   42. Victor del Campo-Pérez
   43. Aranzazu Diaz de Bustamante
   44. Elena Domínguez-Garrido
   45. Rocío Eirós
   46. María Carmen Fariñas
   47. María J Fernandez-Nestosa
   48. Uxía Fernández-Robelo
   49. Amanda Fernández-Rodríguez
   50. Tania Fernández-Villa
   51. Manuela Gago-Dominguez
   52. Belén Gil-Fournier
   53. Javier Gómez-Arrue
   54. Beatriz González Álvarez
   55. Fernan Gonzalez Bernaldo de Quirós
   56. Anna González-Neira
   57. Javier González-Peñas
   58. Juan F Gutiérrez-Bautista
   59. María José Herrero
   60. Antonio Herrero-Gonzalez
   61. María A Jimenez-Sousa
   62. María Claudia Lattig
   63. Anabel Liger Borja
   64. Rosario Lopez-Rodriguez
   65. Esther Mancebo
   66. Caridad Martín-López
   67. Vicente Martín
   68. Oscar Martinez-Nieto
   69. Iciar Martinez-Lopez
   70. Michel F Martinez-Resendez
   71. Angel Martinez-Perez
   72. Juliana F Mazzeu
   73. Eleuterio Merayo Macías
   74. Pablo Minguez
   75. Victor Moreno Cuerda
   76. Silviene F Oliveira
   77. Eva Ortega-Paino
   78. Mara Parellada
   79. Estela Paz-Artal
   80. Ney PC Santos
   81. Patricia Pérez-Matute
   82. Patricia Perez
   83. M Elena Pérez-Tomás
   84. Teresa Perucho
   85. Mellina Pinsach-Abuin
   86. Guillermo Pita
   87. Ericka N Pompa-Mera
   88. Gloria L Porras-Hurtado
   89. Aurora Pujol
   90. Soraya Ramiro León
   91. Salvador Resino
   92. Marianne R Fernandes
   93. Emilio Rodríguez-Ruiz
   94. Fernando Rodriguez-Artalejo
   95. José A Rodriguez-Garcia
   96. Francisco Ruiz-Cabello
   97. Javier Ruiz-Hornillos
   98. Pablo Ryan
   99. José Manuel Soria
   100. Juan Carlos Souto
   101. Eduardo Tamayo
   102. Alvaro Tamayo-Velasco
   103. Juan Carlos Taracido-Fernandez
   104. Alejandro Teper
   105. Lilian Torres-Tobar
   106. Miguel Urioste
   107. Juan Valencia-Ramos
   108. Zuleima Yáñez
   109. Ruth Zarate
   110. Itziar de Rojas
   111. Agustín Ruiz
   112. Pascual Sánchez
   113. Luis Miguel Real
   114. SCOURGE Cohort Group
   115. Encarna Guillen-Navarro
   116. Carmen Ayuso
   117. Esteban Parra
   118. José A Riancho
   119. Augusto Rojas-Martinez
   120. Carlos Flores
   121. Pablo Lapunzina
   122. Ángel Carracedo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors conduct a valuable GWAS meta-analysis for COVID-19 hospitalization in admixed American populations and prioritized risk variants and genes. The evidence supporting the claims of the authors is solid. The work will be of interest to scientists studying the genetic basis of COVID pathogenesis.

   Reviewed by eLife

3. Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics

   This article has 24 authors:

   1. William Stribling
   2. Lindsey R Hall
   3. Aubrey Powell
   4. Casey Harless
   5. Melissa J Martin
   6. Brendan W Corey
   7. Erik Snesrud
   8. Ana Ong
   9. Rosslyn Maybank
   10. Jason Stam
   11. Katie Bartlett
   12. Brendan T Jones
   13. Lan N Preston
   14. Katherine F Lane
   15. Bernadette Thompson
   16. Lynn M Young
   17. Yoon I Kwak
   18. Alice E Barsoumian
   19. Ana-Elizabeth Markelz
   20. John L Kiley
   21. Robert J Cybulski
   22. Jason W Bennett
   23. Patrick T Mc Gann
   24. Francois Lebreton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work presents an example of how genomic data can be used to improve understanding of an ongoing, long-term bacterial outbreak in a hospital with an application to multi-drug resistant Pseudomonas aeruginosa, and will be of interest to researchers concerned with the spread of drug-resistant bacteria in hospital settings. The convincing genomic analyses highlight the value of routine surveillance of patients and environmental sampling and show how such data can help in dating the origin of the outbreak and in characterising the epidemic lineages. These findings highlight the importance of understanding environmental factors contributing to the transmission of P. aeruginosa for guiding and tailoring infection control efforts.

   Reviewed by eLife

4. Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

   This article has 5 authors:

   1. Dipasree Hajra
   2. Raju S Rajmani
   3. Ayushi Devendrasingh Chaudhary
   4. Shashi Kumar Gupta
   5. Dipshikha Chakravortty

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This auhors present findings on the role of the sirtuins SIRT1 and SIRT3 during Salmonella Typhimurium infection. This valuable study increases our understanding of the mechanisms used by this pathogen to interact with its host and may have implications for other intracellular pathogens. The reviewers disagreed on the strength of the evidence to support the claims. Although one reviewer found the strength of the evidence convincing, the other found that it was incomplete, and that the main claims are only partially supported, as can be seen from the public reviews.

   Reviewed by eLife

5. Accelerated signal propagation speed in human neocortical dendrites

   This article has 10 authors:

   1. Gáspár Oláh
   2. Rajmund Lákovics
   3. Sapir Shapira
   4. Yonatan Leibner
   5. Attila Szücs
   6. Éva Adrienn Csajbók
   7. Pál Barzó
   8. Gábor Molnár
   9. Idan Segev
   10. Gábor Tamás

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable observations indicating that human pyramidal neurons propagate information as fast as rat pyramidal neurons despite their larger size. Convincing evidence demonstrates that this property is due to several biophysical properties of human neurons. This study will be of interest to neurophysiologists.

   Reviewed by eLife

6. Cell-autonomous timing drives the vertebrate segmentation clock’s wave pattern

   This article has 8 authors:

   1. Laurel A Rohde
   2. Arianne Bercowsky-Rama
   3. Guillaume Valentin
   4. Sundar Ram Naganathan
   5. Ravi A Desai
   6. Petr Strnad
   7. Daniele Soroldoni
   8. Andrew C Oates

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study demonstrates that the behavior of the cells in the presomitic mesoderm in zebrafish embryos depend on both an intrinsic program and external information, providing new insight into the biology underlying embryo axis segmentation. There is convincing support for the findings with a thorough and quantitative single-cell real-time imaging approach, both in vitro and in vivo, developed by the authors.

   Reviewed by eLife

7. Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study

   This article has 19 authors:

   1. Marco Bergamini
   2. Alberto Dalla Volta
   3. Carlotta Palumbo
   4. Stefania Zamboni
   5. Luca Triggiani
   6. Manuel Zamparini
   7. Marta Laganà
   8. Luca Rinaudo
   9. Nunzia Di Meo
   10. Irene Caramella
   11. Roberto Bresciani
   12. Francesca Valcamonico
   13. Paolo Borghetti
   14. Andrea Guerini
   15. Davide Farina
   16. Alessandro Antonelli
   17. Claudio Simeone
   18. Gherardo Mazziotti
   19. Alfredo Berruti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors observed a positive correlation between FSH and fat mass, as well as a negative association with the appendicular lean mass/fat mass ratio. These valuable findings in male subjects within a hypogonadal setting following Degarelix treatment imply that FSH might function as a predictor, similar to observations in women. However, it's important to note that the analysis is incomplete, as other major confounding factors such as testosterone were not included.

   Reviewed by eLife

8. Predicting metabolic modules in incomplete bacterial genomes with MetaPathPredict

   This article has 7 authors:

   1. David Geller-McGrath
   2. Kishori M Konwar
   3. Virginia P Edgcomb
   4. Maria Pachiadaki
   5. Jack W Roddy
   6. Travis J Wheeler
   7. Jason E McDermott

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This landmark study presents MetaPathPredict, a method that uses a stacked ensemble of neural networks to predict the presence or absence of KEGG modules based on annotated features in the genome. The evidence supporting the conclusions is compelling, with a tool that allows for prediction of KEGG modules in sparse gene sequence datasets.

   Reviewed by eLife

9. Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

   This article has 18 authors:

   1. Amir Hossein Kayvanjoo
   2. Iva Splichalova
   3. David Alejandro Bejarano
   4. Hao Huang
   5. Katharina Mauel
   6. Nikola Makdissi
   7. David Heider
   8. Hui Ming Tew
   9. Nora Reka Balzer
   10. Eric Greto
   11. Collins Osei-Sarpong
   12. Kevin Baßler
   13. Joachim L Schultze
   14. Stefan Uderhardt
   15. Eva Kiermaier
   16. Marc Beyer
   17. Andreas Schlitzer
   18. Elvira Mass

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using single-cell sequencing, high-resolution imaging, and inducible genetic deletion of yolk-sac (YS) derived macrophages, the authors present a useful map of fetal liver macrophage subpopulations and provide important data demonstrating that heterogeneous fetal liver macrophages regulate erythrocyte enucleation, interact physically with fetal HSCs, and may regulate neutrophil accumulation in the fetal liver. These novel findings, although yet incomplete, might provide a solid foundation for further investigating the effects of macrophages on HSC function during fetal hematopoiesis and into adulthood and will be useful for the field of macrophage biology and developmental hematopoiesis.

   Reviewed by eLife

10. A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis

    This article has 12 authors:

    1. Jaaved Mohammed
    2. Neha Arora
    3. Harold S Matthews
    4. Karissa Hansen
    5. Maram Bader
    6. Susan Walsh
    7. John R Shaffer
    8. Seth M Weinberg
    9. Tomek Swigut
    10. Peter Claes
    11. Licia Selleri
    12. Joanna Wysocka

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The findings are important and would potentially have theoretical and practical implications outside the field. However the strength of evidence presented was assessed as being incomplete in several respects. Major strengths are (1) genetic factors in facial appearance are of broad interest, and the potential influence of possibly identical factors in a serious congenital disorder (cleft lip/palate) heightens that interest further; (2) proving which single nucleotide variants influence phenotypes, and by what mechanisms, is a major challenge for the field as a whole. The weakness, as assessed, was that in its present form the experimental approach was not sufficiently rigorous to support the conclusions unambiguously.

    Reviewed by eLife