Latest preprint reviews

  1. ZNHIT1-dependent H2A.Z deposition at meiotic prophase I underlies pachytene gene expression and meiotic progression during male meiosis

    This article has 18 authors:
    1. Shenfei Sun
    2. Yamei Jiang
    3. Ning Jiang
    4. Qiaoli Zhang
    5. Hongjie Pan
    6. Fujing Huang
    7. Xinna Zhang
    8. Yuxuan Guo
    9. Xiaoyu You
    10. Kai Gong
    11. Wei Wei
    12. Hanmin Liu
    13. Zhenju Song
    14. Yuanlin Song
    15. Xiaofang Tang
    16. Miao Yu
    17. Runsheng Li
    18. Xinhua Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study shows that Znhit1, a regulator of chromatin and of the histone variant H2A.Z, is required for progression through meiotic prophase. It is an important observation that describes the role of epigenetics and gene expression during meiosis. The analysis is based on complementary approaches at the cytological, single-cell, and genomic levels that provide solid evidence for the role of Znhit1 in the control of gene expression and in the loading of H2A.Z in mouse spermatocytes.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

    This article has 11 authors:
    1. Xiaopei Wang
    2. Yongsen Ruan
    3. Lingjie Zhang
    4. Xiangnyu Chen
    5. Zongkun Shi
    6. Haiyu Wang
    7. Bingjie Chen
    8. Miles Tracy
    9. Liying Huang
    10. Chung-I Wu
    11. Haijun Wen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a useful theoretical model of molecular evolution of multi-copy gene systems by extending the classic Haldane model and applies the model to explain the surprisingly rapid evolution of rRNA genes. Although the conceptual model is intuitive and provides a new perspective for contextualizing this problem, the model presented does not adequately consider plausible biological constraints on the molecular and genetic processes. The lack of such constraints in the model, along with technical issues in the data analysis, provide incomplete support for the conclusion that the genetic variation patterns of rRNA genes in mouse is compatible with neutral evolution.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
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