eLife

Latest preprint reviews

1. The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

   This article has 3 authors:

   1. Elise S Bruguera
   2. Jacob P Mahoney
   3. William I Weis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a fundamental study that addresses the key question of how the tetraspanin Tspan12 functions biochemically as a co-receptor for Norrin to initiate β-catenin signaling. The strength of the work lies in the rigorous and compelling binding analyses involving various purified receptors, co-receptors, and ligands, as well as molecular modeling by AlphaFold that was subsequently validated by an extensive series of mutagenesis experiments. The study advances the field by providing a novel mechanism of co-receptor function and shedding new light on how signaling specificity is achieved in the complex Wnt/Norrin signaling system.

   Reviewed by eLife

2. Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization

   This article has 10 authors:

   1. Dena Goldblatt
   2. Basak Rosti
   3. Kyla Rose Hamling
   4. Paige Leary
   5. Harsh Panchal
   6. Marlyn Li
   7. Hannah Gelnaw
   8. Stephanie Huang
   9. Cheryl Quainoo
   10. David Schoppik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study asks whether motor neurons within the vestibulo-ocular circuit of zebrafish are required to determine the identity, connectivity, and function of upstream premotor neurons. They provide compelling and comprehensive genetic, anatomical and behavioral evidence that the answer is, "No!". This work will be of general interest to developmental neurobiologists and will motivate future studies of whether motor neurons are dispensable for assembly of other sensorimotor neural circuits.

   Reviewed by eLife

3. Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

   This article has 10 authors:

   1. Han V Han
   2. Richard Efem
   3. Barbara Rosati
   4. Kevin Lu
   5. Sara Maimouni
   6. Ya-Ping Jiang
   7. Valeria Montoya
   8. Ando Van Der Velden
   9. Wei-Xing Zong
   10. Richard Z Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The significance of the findings is valuable, with implications for immunotherapy design in pancreatic ductal adenocarcinoma. The evidence was considered incomplete and partially supportive of the major claims.

   Reviewed by eLife

4. RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

   This article has 10 authors:

   1. Yang Liu
   2. Yi Jiang
   3. Peng Qiu
   4. Tie Ma
   5. Yang Bai
   6. Jiawen Bu
   7. Yueting Hu
   8. Ming Jin
   9. Tong Zhu
   10. Xi Gu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper first demonstrated that RGS10 was identified as a biomarker to evaluate the prognosis of breast cancer. To prevent the loss of RGS10 theoretically provide a new strategy for the treatment of breast cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples and an animal model would have strengthened the study. The work will be of interest to clinicians working on breast cancer.

   Reviewed by eLife

5. Dual targeting of histone deacetylases and MYC as potential treatment strategy for H3-K27M pediatric gliomas

   This article has 11 authors:

   1. Danielle Algranati
   2. Roni Oren
   3. Bareket Dassa
   4. Liat Fellus-Alyagor
   5. Alexander Plotnikov
   6. Haim Barr
   7. Alon Harmelin
   8. Nir London
   9. Guy Ron
   10. Noa Furth
   11. Efrat Shema

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work contributes to the study of H3-K27M mutated pediatric gliomas. It convincingly demonstrates that the concomitant targeting of histone deacetylases (HDACs) and the transcription factor MYC results in a notable reduction in cell viability and tumor growth. This reduction is linked to the suppression of critical oncogenic pathways, particularly mTOR signaling, emphasizing the role of these pathways in the disease's pathogenesis. The current version of the manuscript is important because it unveils a vulnerability from dual targeting HDACs and MYC in the context of pediatric gliomas. This work will be of interest to cancer epigenetics and therapeutics research, with a focus on the neuro-oncology field.

   Reviewed by eLife

6. Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis

   This article has 9 authors:

   1. Daniel Spari
   2. Annina Schmid
   3. Daniel Sanchez-Taltavull
   4. Shaira Murugan
   5. Keely Keller
   6. Nadia Ennaciri
   7. Lilian Salm
   8. Deborah Stroka
   9. Guido Beldi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study advances our understanding of the role of bacterial-derived extracellular ATP in the pathogenesis of sepsis. The evidence supporting the conclusions is compelling, although not all concerns from a previous round of reviews were adequately addressed. The work will be of broad interest to researchers on microbiology and infectious diseases.

   Reviewed by eLife

7. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

   This article has 12 authors:

   1. Chuchu Wang
   2. Chunyu Zhao
   3. Hu Xiao
   4. Jiali Qiang
   5. Zhenying Liu
   6. Jinge Gu
   7. Shengnan Zhang
   8. Dan Li
   9. Yaoyang Zhang
   10. Jacqueline Burré
   11. Jiajia Diao
   12. Cong Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this useful study, the authors show that N-acetylation of synuclein increases clustering of synaptic vesicles in vitro and that this effect is mediated by enhanced interaction with lysophosphatidylcholine. While the evidence for enhanced clustering is largely solid, the biological significance remains unclear.

   Reviewed by eLife

8. Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50’s ATPase activities and homologous recombination

   This article has 4 authors:

   1. Sugith Badugu
   2. Kshitiza Mohan Dhyani
   3. Manoj Thakur
   4. Kalappa Muniyappa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports important data providing evidence that a 42 amino acid region of Rev7 is necessary and sufficient for interaction with the Rad50-Mre11-Xrs2 complex in budding yeast. The authors conclude that Rev7 inhibits the Rad50 ATPase and the Mre11 nuclease with the exception of ssDNA exonuclease activity. The convincing data largely support the conclusions, although the effect of Rev7 on homologous recombination is less well documented and the observed effect on resection is moderate. Specifically, the result that the Rev7 C-terminal truncation lacking the 42 amino acid region still suppresses homologous recombination is unexpected and unexplained.

   Reviewed by eLife

9. De novo-designed minibinders expand the synthetic biology sensing repertoire

   This article has 8 authors:

   1. Zara Y Weinberg
   2. Sarah S Soliman
   3. Matthew S Kim
   4. Devan H Shah
   5. Irene P Chen
   6. Melanie Ott
   7. Wendell A Lim
   8. Hana El-Samad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a useful investigation of the use of small, de novo-designed protein binding domains (mini-binders) against the Spike protein of SARS-CoV-2 and EGFR, as ligand binding domains on two classes of synthetic receptors, second-generation synNotch (SNIPR) and CAR. The methods and evidence supporting the focused claims are solid. This work will be of interest to synthetic biologists and cell engineers as a starting point to map out the rules for receptor engineering based on mini-binders and ultimately to advance them in biomedical applications.

   Reviewed by eLife

10. Lack of evidence supporting transgenerational effects of non-transmitted paternal alleles on the murine transcriptome

    This article has 3 authors:

    1. Rodrigo Gularte-Mérida
    2. Carole Charlier
    3. Michel Georges

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important article presents the results of a large screen for non-genetic transgenerational effects that may influence gene expression and other phenotypes in mice. An extraordinary amount of mouse breeding, phenotyping, and RNA sequencing data provide compelling evidence that, for the phenotypes and genomic regions interrogated in these mouse strains, non-genetic transgenerational effects of appreciable magnitude are likely to be extremely rare. This paper will be of broad interest to geneticists and of particular interest to those studying epigenetic inheritance.

    Reviewed by eLife