eLife

Latest preprint reviews

1. Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response

   This article has 8 authors:

   1. Harshavardhan Lingegowda
   2. Katherine B Zutautas
   3. Yuhong Wei
   4. Priyanka Yolmo
   5. Danielle J Sisnett
   6. Alison McCallion
   7. Madhuri Koti
   8. Chandrakant Tayade

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on how the endocannabinoid system is involved in endometriosis progression using CNR1 and CNR2 knockout (KO) mouse models. The evidence supporting the authors' claims is incomplete; including bulk RNA-seq, flow cytometry, and imaging mass cytometry would have strengthened the study. This work might be of interest to medical scientists working on endometriosis.

   Reviewed by eLife

2. FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells

   This article has 19 authors:

   1. Karin Uliczka
   2. Judith Bossen
   3. Ulrich M. Zissler
   4. Christine Fink
   5. Xiao Niu
   6. Mario Pieper
   7. Ruben D. Prange
   8. Christina Vock
   9. Christina Wagner
   10. Mirjam Knop
   11. Ahmed Abdelsadik
   12. Sören Franzenburg
   13. Iris Bruchhaus
   14. Michael Wegmann
   15. Carsten B. Schmidt-Weber
   16. Peter König
   17. Petra Pfefferle
   18. Holger Heine
   19. Thomas Roeder

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study investigates, from Drosophila to mammals, the role of the Forkhead box O (FoxO) transcription factors in airway epithelial cells' response to stressors including hypoxia, temperature variations, and oxidative stress. The findings suggest a conserved role of FoxO in maintaining airway homeostasis across species. However, limitations in the specificity and concerns with the loss-of-function experiments render the evidence presented incomplete. Nonetheless, this study highlights FoxO's potential relevance in respiratory diseases like asthma and offers insights into potential therapeutic targets for conditions affecting airway health.

   Reviewed by eLife

3. Heterozygous variants in PLCG1 affect hearing, vision, cardiac, and immune function

   This article has 30 authors:

   1. Mengqi Ma
   2. Yiming Zheng
   3. Mingxi Deng
   4. Shenzhao Lu
   5. Xueyang Pan
   6. Xi Luo
   7. Michelle Etoundi
   8. David Li-Kroeger
   9. Kim C Worley
   10. Lindsay C Burrage
   11. Lauren S Blieden
   12. Aimee Allworth
   13. Wei-Liang Chen
   14. Giuseppe Merla
   15. Barbara Mandriani
   16. Catherine E Otten
   17. Pierre Blanc
   18. Jill A Rosenfeld
   19. Debdeep Dutta
   20. Shinya Yamamoto
   21. Michael F Wangler
   22. Ian A Glass
   23. Jingheng Chen
   24. Elizabeth Blue
   25. Paolo Prontera
   26. Jeremie Rosain
   27. Sandrine Marlin
   28. Seema R Lalani
   29. Hugo J Bellen
   30. Undiagnosed Diseases Network

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reveals how Drosophila may be used to investigate the role of missense variants in the PLCG1 phospholipase gene in human diseases. The experimental evidence is compelling and brings together rigorous analysis of clinical and model organism phenotypes with a structural analysis of the PLCG1 protein.

   Reviewed by eLife

4. Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

   This article has 9 authors:

   1. Ritwik Maity
   2. Xuepei Zhang
   3. Francesca Romana Liberati
   4. Chiara Scribani Rossi
   5. Francesca Cutruzzolá
   6. Serena Rinaldo
   7. Massimiliano Gaetani
   8. José Antonio Aínsa
   9. Javier Sancho

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides insights into how pathogens respond, on a systemic level including several gene targets and clusters, to selected antimicrobial molecules. Compelling evidence is provided, through multi-omics and functional approaches, that very similar molecules originally designed to target the same bacterial protein act differently within the context of the whole set of cellular transcripts, expressed proteins, and pre-lethal metabolic changes. Given the rapid accumulation of omics data and the much slower capacity of extracting biologically relevant insights from big data, this work exemplifies how the development of sensitive data analysis is still a major necessity in modern research.

   Reviewed by eLife

5. Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

   This article has 3 authors:

   1. Sergio Casas-Tinto
   2. Nuria Garcia-Guillen
   3. María Losada-Perez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this work, the authors use a Drosophila melanogaster adult ventral nerve cord injury model extending and confirming previous observations. This important study reveals key aspects of adult neural plasticity. Taking advantage of several genetic reporter and fate tracing tools, the authors provide solid evidence for different forms of glial plasticity, that are increased upon injury. The significance of the generated cell types under homeostatic conditions and in response to injury remains to be further explored and open up new avenues of research.

   Reviewed by eLife

6. PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles

   This article has 12 authors:

   1. Lu Li
   2. Yin Li
   3. Caihong Huang
   4. Wenjuan Hou
   5. Zijian Lv
   6. Lizi Zhang
   7. Yishan Qu
   8. Yahan Sun
   9. Kaizhe Huang
   10. Xiao Han
   11. Zhixiong He
   12. Fadao Tai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work provides insights into the neural mechanisms regulating specific parental behaviors. By identifying a key role for oxytocin synthesizing cells in the paraventricular nucleus of the hypothalamus and their projections to the medial prefrontal cortex in promoting pup care and inhibiting infanticide, this study advances our understanding of the neurobiological basis of these contrasting behaviors in male and female mandarin voles. The evidence supporting the authors' conclusions is solid, and this work should be of interest to researchers studying neuropeptide control of social behaviors in the brain.

   Reviewed by eLife

7. Chronic activation of a negative engram induces behavioral and cellular abnormalities

   This article has 9 authors:

   1. Alexandra L Jellinger
   2. Rebecca L Suthard
   3. Bingbing Yuan
   4. Michelle Surets
   5. Evan A Ruesch
   6. Albit J Caban
   7. Shawn Liu
   8. Monika Shpokayte
   9. Steve Ramirez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study reports the behavioural and physiological effects of the longitudinal activation of neurons associated with negative experiences. The main claims of the paper are supported by solid experimental evidence, although the specificity of the long-term manipulation could have benefitted from additional validation. This study will be of interest to neuroscientists working on memory.

   Reviewed by eLife

8. A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings

   This article has 3 authors:

   1. Proloy Das
   2. Mingjian He
   3. Patrick L Purdon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This method paper proposes a valuable Oscillation Component Analysis (OCA) approach, in analogy to Independent Component Analysis (ICA), in which source separation is achieved through biophysically inspired generative modeling of neural oscillations. The empirical evidence justifying the approach's advantage is solid. This work will be of interest to researchers in the fields of cognitive neuroscience, neural oscillation, and MEG/EEG.

   Reviewed by eLife

9. Regulated mRNA recruitment in dinoflagellates is reflected in hyper-variable mRNA spliced leaders and novel eIF4Es

   This article has 7 authors:

   1. Grant D. Jones
   2. Ernest P. Williams
   3. Saddef Haq
   4. Tsvetan R. Bachvaroff
   5. M. Basanta Sanchez
   6. Allen R. Place
   7. Rosemary Jagus

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides previously unappreciated insights into the functions of protist eIF4E 5'mRNA cap-binding protein family members, thereby contributing to a better understanding of translation regulation in these organisms. The authors provide solid evidence to support the major conclusions of the article. However, the study may further benefit from establishing whether all of the eIF4E family members are indeed involved in translation and more direct evidence for the selectivity of their binding.

   Reviewed by eLife

10. The sperm hook as a functional adaptation for migration and self-organized behavior

    This article has 9 authors:

    1. Heungjin Ryu
    2. Kibum Nam
    3. Byeong Eun Lee
    4. Yundon Jeong
    5. Seunghun Lee
    6. Jeongmo Kim
    7. Young-Min Hyun
    8. Jae-Ick Kim
    9. Jung-Hoon Park

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study uses ex vivo live imaging of uteri post-mating to test the role of the sperm hook in the house mouse sperm in sperm movement that would be interesting to evolutionary biologists. The significance of the work is useful as live imaging can reveal information not seen in fixed images. The strength of evidence is incomplete as they cannot directly test the role of the sperm hook in facilitating movement along the uterine wall.

    Reviewed by eLife