eLife

Latest preprint reviews

1. A modular platform to display multiple hemagglutinin subtypes on a single immunogen

   This article has 7 authors:

   1. Dana Thornlow Lamson
   2. Faez Amokrane Nait Mohamed
   3. Mya Vu
   4. Daniel P Maurer
   5. Larance Ronsard
   6. Daniel Lingwood
   7. Aaron G Schmidt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript describes the immunogenicity of a bead-on-a-string immunogen that allows the inclusion of multiple HA subtypes. The evidence to support the claims is convincing, and more importantly, this approach could be adapted to other vaccine platforms.

   Reviewed by eLife

2. Pectin methylesterase activity is required for RALF1 peptide signalling output

   This article has 8 authors:

   1. Ann-Kathrin Rößling
   2. Kai Dünser
   3. Chenlu Liu
   4. Susan Lauw
   5. Marta Rodriguez-Franco
   6. Lothar Kalmbach
   7. Elke Barbez
   8. Jürgen Kleine-Vehn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides convincing evidence for pectin modification as a requirement for RALF peptide signalling altering the apoplastic pH, adding further support for a key role of RALF peptides in linking the assembly and dynamics of the extracellular matrix with cellular activity and function. Data that have been added in comparison to a previous version have enhanced the study. The study should be of interest to anyone studying signaling and specifically to plant cell biologists.

   Reviewed by eLife

3. Modeling collective behavior in groups of mice housed under semi-naturalistic conditions

   This article has 6 authors:

   1. Xiaowen Chen
   2. Maciej Winiarksi
   3. Alicja Puścian
   4. Ewelina Knapska
   5. Thierry Mora
   6. Aleksandra M Walczak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work investigates the social interactions of mice living together in a system of multiple connected cages. It provides solid evidence for a statistical approach capturing changes in social interactions after manipulating prefrontal cortical plasticity. This research will be of broad interest to researchers studying animal social behavior.

   Reviewed by eLife

4. Unraveling the role of urea hydrolysis in salt stress response during seed germination and seedling growth in Arabidopsis thaliana

   This article has 8 authors:

   1. Yuanyuan Bu
   2. Xingye Dong
   3. Rongrong Zhang
   4. Xianglian Shen
   5. Yan Liu
   6. Shu Wang
   7. Tetsuo Takano
   8. Shenkui Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of the molecular mechanism underlying salt stress-induced inhibition of seed germination and seedling growth. The evidence supporting the conclusions is convincing, with rigorous genetic, physiological, and metabolic analyses. This paper will be of interest to plant stress biologists and crop breeders.

   Reviewed by eLife

5. Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity

   This article has 5 authors:

   1. Filip Knop
   2. Apolena Zounarová
   3. Vojtěch Šabata
   4. Teije Corneel Middelkoop
   5. Marie Macůrková

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study defines developmental roles for a protein kinase involved in endocytosis and reports a surprising finding that the kinase catalytic activity is unnecessary. However, several claims of the authors are only partially supported by the data. Although in its current form, this work is incomplete, it will be of broad interest to cell biologists and biochemists because this kinase was previously suggested to be a target of drug design efforts.

   Reviewed by eLife

6. Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

   This article has 25 authors:

   1. Maiko Kawasaki
   2. Katsushige Kawasaki
   3. Finsa Tisna Sari
   4. Takehisa Kudo
   5. Jun Nihara
   6. Madoka Kitamura
   7. Takahiro Nagai
   8. Vanessa Utama
   9. Yoko Ishida
   10. Fumiya Meguro
   11. Alex Kesuma
   12. Akira Fujita
   13. Takayuki Nishimura
   14. Yuan Kogure
   15. Satoshi Maruyama
   16. Jun-ichi Tanuma
   17. Yoshito Kakihara
   18. Takeyasu Maeda
   19. Sarah Ghafoor
   20. Roman H Khonsari
   21. Pierre Corre
   22. Paul T Sharpe
   23. Martyn Cobourne
   24. Brunella Franco
   25. Atsushi Ohazama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The investigation of the functional significance of the X-linked ciliary protein OFD1 gene in regulating the fate of cranial neural crest-derived cells (CNCCs) and its potential effect on myogenic progenitors during tongue development is interesting because the Ofd1 conditional knockout mouse model has a very striking phenotype and nicely mimics the phenotype in humans. It is a valuable model to understand human disease. This study will require additional experiments to support their conclusions.

   Reviewed by eLife

7. Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

   This article has 20 authors:

   1. Carolin Gerke
   2. Liane Bauersfeld
   3. Ivo Schirmeister
   4. Chiara Noemi-Marie Mireisz
   5. Valerie Oberhardt
   6. Lea Mery
   7. Di Wu
   8. Christopher Sebastian Jürges
   9. Robbert M Spaapen
   10. Claudio Mussolino
   11. Vu Thuy Khanh Le-Trilling
   12. Mirko Trilling
   13. Lars Dölken
   14. Wolfgang Paster
   15. Florian Erhard
   16. Maike Hofmann
   17. Andreas Schlosser
   18. Hartmut Hengel
   19. Frank Momburg
   20. Anne Halenius

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful finding on a virally encoded immune-evasin which differentially inhibits antigen presentation by cellular protein complexes called Major histocompatibility complex (MHC) class I, thereby diminishing the activation of cytotoxic T cells. The evidence supporting the claims of the authors is solid, although the addition of more mechanistic insights would strengthen the study. The work will be of interest to virologists and immunologists working on the adaptive immune response to herpesviral infection. Some conclusions would require additional experimental support.

   Reviewed by eLife

8. Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

   This article has 15 authors:

   1. Lan Pang
   2. Gangqi Fang
   3. Zhiguo Liu
   4. Zhi Dong
   5. Jiani Chen
   6. Ting Feng
   7. Qichao Zhang
   8. Yifeng Sheng
   9. Yueqi Lu
   10. Ying Wang
   11. Yixiang Zhang
   12. Guiyun Li
   13. Xuexin Chen
   14. Shuai Zhan
   15. Jianhua Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper presents valuable insights into the success of the parasitoid Trichopria drosophilae on Drosophila suzukii, elucidating the importance of both molecular adaptations, such as specialized venom proteins and unique cell types, ecological strategies, including tolerance of intraspecific competition and avoidance of interspecific competition. Through convincing methodological approaches, the authors demonstrate how these adaptations optimize nutrient uptake and enhance parasitic success, highlighting the intricate coordination between molecular and ecological factors in driving parasitization success.

   Reviewed by eLife

9. Regional response to light illuminance across the human hypothalamus

   This article has 16 authors:

   1. Islay Campbell
   2. Roya Sharifpour
   3. Jose Fermin Balda Aizpurua
   4. Elise Beckers
   5. Ilenia Paparella
   6. Alexandre Berger
   7. Ekaterina Koshmanova
   8. Nasrin Mortazavi
   9. John Read
   10. Mikhail Zubkov
   11. Puneet Talwar
   12. Fabienne Collette
   13. Siya Sherif
   14. Christophe Phillips
   15. Laurent Lamalle
   16. Gilles Vandewalle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work describes the complex interplay between light exposure, hypothalamic activity, and cognitive function. The evidence supporting the conclusion is compelling with potential therapeutic applications of light modulation. The work will be of broad interest to basic and clinical neuroscientists.

   Reviewed by eLife

10. SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress

    This article has 4 authors:

    1. Rezwana Karim
    2. Wendi Teng
    3. Cameron D Behram
    4. Hening Lin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This useful study describes a role for acetylation in controlling the stability of acetyl-CoA synthetase 2, which converts acetate to acetyl-CoA for de novo lipid synthesis. While many aspects of the study are solid, some evidence supporting these findings is incomplete. Including direct demonstration of target deacetylation by sirtuin 2, revisiting statistical analyses, and confirming generalizability to adipocyte cell lines would further strengthen the study. This work will be of interest to researchers studying lipid metabolism and related diseases.

    Reviewed by eLife