eLife

Latest preprint reviews

1. Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

   This article has 18 authors:

   1. Camille Morel
   2. Eline Lemerle
   3. Feng-Ching Tsai
   4. Thomas Obadia
   5. Nishit Srivastava
   6. Maud Marechal
   7. Audrey Salles
   8. Marvin Albert
   9. Caroline Stefani
   10. Yvonne Benito
   11. François Vandenesch
   12. Christophe Lamaze
   13. Stéphane Vassilopoulos
   14. Matthieu Piel
   15. Patricia Bassereau
   16. David Gonzalez-Rodriguez
   17. Cecile Leduc
   18. Emmanuel Lemichez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies the role of Caveolin1 and Cavin1 as regulators of TransEndothelial Macroaperture (TEM). The methodology used is rigorous and compelling, and further research can point to more mechanistic understanding of the process.

   Reviewed by eLife

2. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/preprints/psyarxiv/r49sy

3. Identification of CFAP52 as a novel diagnostic target of male infertility with defects of sperm head-tail connection and flagella development

   This article has 7 authors:

   1. Hui-Juan Jin
   2. Tiechao Ruan
   3. Siyu Dai
   4. Xin-Yan Geng
   5. Yihong Yang
   6. Ying Shen
   7. Su-Ren Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful information on the function of a ciliary and flagellar-associated protein, CFAP52, in the assembly of sperm head-tail connecting apparatus (HTCA) and tail formation in humans and mice. The significance is to identify CFAP52 as a genetic factor for asthenoteratozoospermia with a mixed acephalic spermatozoa syndrome (ASS) and multiple morphological abnormalities of the sperm flagella (MMAF) phenotype. The strength of the study is that the experimental evidence using CFAP52 loss-of-function in mice is solid to support that CFAP52 is essential for sperm motility and male fertility by contributing to HTCA and 9+2 axoneme, corroborating the sperm phenotypes of human patients with compound heterozygous mutations in CFAP52.

   Reviewed by eLife

4. The embryonic role of juvenile hormone in the firebrat, Thermobia domestica, reveals its function before its involvement in metamorphosis

   This article has 6 authors:

   1. James W Truman
   2. Lynn M Riddiford
   3. Barbora Konopova
   4. Marcela Nouzova
   5. Fernando G Noriega
   6. Michelle Herko

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents findings regarding the role of Juvenile Hormone in development and cell differentiation in the ametabolous insect Thermobia domestica, providing an in-depth analysis of JH's roles in a member of this basally branching group. The evidence supporting the claims of the authors is convincing, drawing on a broad range of approaches and variety of experimental techniques. While the interpretation of this work in the wider context - its relevance for the evolution of metamorphosis - is in some places somewhat speculative, the work will be of interest to evolutionary developmental biologists studying the evolution of metamorphosis, and the evolution of insects in general.

   Reviewed by eLife, Arcadia Science

5. Species -shared and -unique gyral peaks on human and macaque brains

   This article has 12 authors:

   1. Songyao Zhang
   2. Tuo Zhang
   3. Guannan Cao
   4. Jingchao Zhou
   5. Zhibin He
   6. Xiao Li
   7. Yudan Ren
   8. Tao Liu
   9. Xi Jiang
   10. Lei Guo
   11. Junwei Han
   12. Tianming Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper compares cross-species cortical folding patterns in human and non-human primates, showing that most gyral peaks shared across species are in lower-order cortical regions. The supporting evidence is solid and multi-faceted, encompassing anatomy, connectivity and gene expression. This paper will be of interest to a broad readership within the neuroscience community, especially for those interested in cross-species correspondences in brain organisation.

   Reviewed by eLife

6. Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

   This article has 7 authors:

   1. Jongkyun Kang
   2. Guodong Huang
   3. Long Ma
   4. Youren Tong
   5. Anu Shahapal
   6. Phoenix Chen
   7. Jie Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This current revision builds on observations in validated conditional double KO (cDKO) mice for LRRK1 and LRRK2 that will be useful for the field, given that LRRK2 is widely expressed in the brain and periphery, and many divergent phenotypes have been attributed previously to LRRK2 expression. The manuscript presents solid data demonstrating that it is the loss of LRRK1 and LRRK2 expression within the SNpc DA cells that is not well tolerated, as it was previously unclear from past work whether neurodegeneration in the LRRK double Knock Out (DKO) was cell autonomous or the result of loss of LRRK1/LRRK2 expression in other types of cells. Future studies may pursue the biochemical mechanisms underlying the reason for the apoptotic cells noted in this study, as here, the LRRK1/LRRK2 KO mice did not replicate the dramatic increase in autophagic vacuole numbers previously noted in the germline global LRRK1/LRRK2 KO mice.

   Reviewed by eLife

7. A neurocomputational account of the link between social perception and social action

   This article has 4 authors:

   1. Lisa M Bas
   2. Ian D Roberts
   3. Cendri A Hutcherson
   4. Anita Tusche

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     These important findings stand out from other similar studies via some convincing demonstration of behavioural and neural relationships between two helping tasks – one focusing more on social perception, one more on its influence on social behaviour – that were performed more than 300 days apart. The claims however would be stronger with a larger sample size.

   Reviewed by eLife

8. Caspase-1 activates gasdermin A in non-mammals

   This article has 6 authors:

   1. Zachary Paul Billman
   2. Stephen Bela Kovacs
   3. Bo Wei
   4. Kidong Kang
   5. Ousmane H Cissé
   6. Edward A Miao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable insights into the evolution of the gasdermin family, making a strong case that a GSDMA-like gasdermin activated by caspase-1 cleavage was already present in early land vertebrates. Convincing biochemical evidence is provided that extant avian, reptilian, and amphibian GSDMA proteins can still be activated by caspase-1 and upon cleavage induce pyroptosis-like cell death -- at least that they do so in the context of human cell lines. The caspase-1 cleavage site has only been lost in mammals, which use the more recently evolved GSDMD as a caspase-1 cleavable pyroptosis inducer. The presented work will be of considerable interest to scientists working on the evolution of cell death pathways, or on cell death regulation in non-mammalian vertebrates.

   Reviewed by eLife

9. TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

   This article has 7 authors:

   1. Jessica Y Chotiner
   2. N Adrian Leu
   3. Fang Yang
   4. Isabella G Cossu
   5. Yongjuan Guan
   6. Huijuan Lin
   7. P Jeremy Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study defined the physiological function of a conserved meiosis factor during murine spermatogenesis. The genetic and cellular biological evidence supporting the conclusion is convincing. This work will be of broad interest to cell biologists, geneticists, and reproductive biologists.

   Reviewed by eLife

10. Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

    This article has 7 authors:

    1. Zian Liao
    2. Suni Tang
    3. Kaori Nozawa
    4. Keisuke Shimada
    5. Masahito Ikawa
    6. Diana Monsivais
    7. Martin Matzuk

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents two valuable new mouse models that individually tag proteins from the SMAD family to identify distinct roles during early pregnancy. Convincing evidence is provided that SMAD1 and SMAD5 target many of the same genomic regions as each other and the progesterone receptor. Given the broad effect of these signaling pathways in multiple systems, these new tools will most likely interest readers across biological disciplines.

    Reviewed by eLife