eLife

Latest preprint reviews

1. Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

   This article has 13 authors:

   1. Clément Mazeaud
   2. Stefan Pfister
   3. Jonathan E Owen
   4. Higor Sette Pereira
   5. Flavie Charbonneau
   6. Zachary E Robinson
   7. Anaïs Anton
   8. Cheyanne L Bemis
   9. Aïssatou Aïcha Sow
   10. Trushar R Patel
   11. Christopher J Neufeldt
   12. Pietro Scaturro
   13. Laurent Chatel-Chaix

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines multidisciplinary approaches to examine the role of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) as a potential novel host dependency factor for Zika virus. The main claims are supported by the data but remain incomplete. The evidence would be strengthened by improving the western blot analyses and adjusting the toning of their claims in relation to the role of IGF2BP2 for viral replication. With the experimental evidence strengthened, this work will be of interest to virologists working on flaviviruses.

   Reviewed by eLife

2. How did UGA codon translation as tryptophan evolve in certain ciliates? A critique of Kachale et al. 2023 Nature

   This article has 6 authors:

   1. Estienne Carl Swart
   2. Christiane Emmerich
   3. Kwee Boon Brandon Seah
   4. Minakshi Singh
   5. Yekaterina Shulgina
   6. Aditi Singh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript explores the ways in which the genetic code evolves, specifically how stop codons are reassigned to become sense codons. The authors present phylogenetic data showing that mutations at position 67 of the termination factor are present in organisms that nevertheless use the UGA codon as a stop codon, thereby questioning the importance of this position in the reassignment of stop codons. Alternative models on the role of eRF1 would reflect a more balanced view of the data. Overall, the data are solid and these findings will be valuable to the genomic/evolution fields.

   Reviewed by eLife

3. Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection

   This article has 21 authors:

   1. Gregory Lane
   2. Guangyu Zhou
   3. Judd F. Hultquist
   4. Lacy M. Simons
   5. Ramon Lorenzo- Redondo
   6. Egon A. Ozer
   7. Danielle M. McCarthy
   8. Michael G. Ison
   9. Chad J. Achenbach
   10. Xinkun Wang
   11. Ching Man Wai
   12. Eugene Wyatt
   13. Alan Aalsburg
   14. Qiaohan Yang
   15. Torben Noto
   16. Arghavan Alisoltani
   17. Daniel Ysselstein
   18. Rajeshwar Awatramani
   19. Robert Murphy
   20. Grant Theron
   21. Christina Zelano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript by Lane introduces an exciting way to measure SARS-CoV-2 aerosolized shedding using a disposable exhaled breath condensate collection device (EBCD). The paper draws the conclusion that the contagious shedding of the virus via the aerosol route persists at a high level until 8 days after symptoms. While the methodology is potentially of high importance and the paper is clearly written, the conclusions are incomplete and only partially supported by the data.

   Reviewed by eLife

4. Analysis of fast calcium dynamics of honey bee olfactory coding

   This article has 4 authors:

   1. Marco Paoli
   2. Antoine Wystrach
   3. Brice Ronsin
   4. Martin Giurfa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How neural circuits represent sensory signals during and after stimulus presentation is a central question in neuroscience. Here, a model of the insect mushroom body, constructed from simple, known synaptic connectivity rules, is shown to convincingly explain stimulus discrimination and associative memory, even in the presence of variability in the input signals as experimentally measured from the antennal lobe of the honeybee. This important study makes testable predictions for the role of specific neurons in a neural circuit for associative memory, of relevance to any study of neural network design and operation.

   Reviewed by eLife

5. Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography

   This article has 13 authors:

   1. Lukas Rier
   2. Natalie Rhodes
   3. Daisie O Pakenham
   4. Elena Boto
   5. Niall Holmes
   6. Ryan M Hill
   7. Gonzalo Reina Rivero
   8. Vishal Shah
   9. Cody Doyle
   10. James Osborne
   11. Richard W Bowtell
   12. Margot Taylor
   13. Matthew J Brookes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important evidence supporting the ability of a new type of neuroimaging, OPM-MEG system, to measure beta-band oscillation in sensorimotor tasks in 2-14 years old children and to demonstrate the corresponding development changes, since neuroimaging methods with high spatiotemporal resolution that could be used on small children are quite limited. The evidence supporting the conclusion is compelling. This work will be of interest to the neuroimaging and developmental science communities.

   Reviewed by eLife

6. Neurexins control the strength and precise timing of glycinergic inhibition in the auditory brainstem

   This article has 8 authors:

   1. He-Hai Jiang
   2. Ruoxuan Xu
   3. Xiupeng Nie
   4. Zhenghui Su
   5. Xiaoshan Xu
   6. Ruiqi Pang
   7. Yi Zhou
   8. Fujun Luo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important insights into the role of neurexins as regulators of synaptic strength and timing at the glycinergic synapse between neurons of the medial nucleus of the trapezoid body and the lateral superior olive, key components of the auditory brainstem circuit involved in computing sound source location from differences in the intensity of sounds arriving at the two ears. Through an elegant combination of genetic manipulation, fluorescence in-situ hybridization, ex vivo slice electrophysiology, pharmacology and optogenetics, the authors provide compelling and rigorous evidence to support their claims. While further work is needed to reveal the mechanistic basis by which neurexins influence glycinergic neurotransmission, this work will be of interest to both auditory and synaptic neuroscientists.

   Reviewed by eLife

7. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2305.04587

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2305.04587v3

9. Fast evolution of SOS-independent multi-drug resistance in bacteria

   This article has 10 authors:

   1. Le Zhang
   2. Yunpeng Guan
   3. YuenYee Cheng
   4. Nural N Cokcetin
   5. Amy L Bottomley
   6. Andrew Robinson
   7. Elizabeth J Harry
   8. Antoine M van Oijen
   9. Qian Peter Su
   10. Dayong Jin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable observation of how deletion of a major repair protein in bacteria can facilitate the rise of mutations that confer resistance against a range of different antibiotics. The data presented are convincing, and the authors addressed the concerns raised by the reviewers in their resubmission, improving the strength of their findings.

   Reviewed by eLife

10. Metabolic disruption impairs ribosomal protein levels, resulting in enhanced aminoglycoside tolerance

    This article has 2 authors:

    1. Rauf Shiraliyev
    2. Mehmet A Orman

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The findings of this study are valuable as they challenge the dogma regarding the link between lowered bacterial metabolism and tolerance to aminoglycosides. The authors propose that the well-known tolerance to AG of mutants such as those of complexes I and II is not due to a decrease in the proton motive force and thus antibiotic uptake. The results presented here are convincing.

    Reviewed by eLife