eLife

Latest preprint reviews

1. Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

   This article has 46 authors:

   1. Hengqi Betty Zheng
   2. Benjamin A. Doran
   3. Kyle Kimler
   4. Alison Yu
   5. Victor Tkachev
   6. Veronika Niederlova
   7. Kayla Cribbin
   8. Ryan Fleming
   9. Brandi Bratrude
   10. Kayla Betz
   11. Lorenzo Cagnin
   12. Connor McGuckin
   13. Paula Keskula
   14. Alexandre Albanese
   15. Maria Sacta
   16. Joshua de Sousa Casal
   17. Ruben van Esch
   18. Andrew C. Kwong
   19. Conner Kummerlowe
   20. Faith Taliaferro
   21. Nathalie Fiaschi
   22. Baijun Kou
   23. Sandra Coetzee
   24. Sumreen Jalal
   25. Yoko Yabe
   26. Michael Dobosz
   27. Matthew F. Wipperman
   28. Sara Hamon
   29. George D. Kalliolias
   30. Andrea Hooper
   31. Wei Keat Lim
   32. Sokol Haxhinasto
   33. Yi Wei
   34. Madeline Ford
   35. Lusine Ambartsumyan
   36. David L. Suskind
   37. Dale Lee
   38. Gail Deutsch
   39. Xuemei Deng
   40. Lauren V. Collen
   41. Vanessa Mitsialis
   42. Scott B. Snapper
   43. Ghassan Wahbeh
   44. Alex K. Shalek
   45. Jose Ordovas-Montanes
   46. Leslie S. Kean

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study substantially advances our understanding of pediatric Crohn's disease, mapping the cellular make-up of this disease and how patients respond to treatment. The evidence supporting the conclusions is compelling, with thorough bioinformatic analyses, underpinned by rigorous methodology and data integration. The work will be of broad interest to pediatric clinicians, immunologists and bioinformaticians.

   Reviewed by eLife

2. Pesticide-induced resurgence in brown planthopper is mediated by action on a suite of genes that promote juvenile hormone biosynthesis and female fecundity

   This article has 8 authors:

   1. Yang Gao
   2. Shao-Cong Su
   3. Ji-Yang Xing
   4. Zhao-Yu Liu
   5. Dick R Nässel
   6. Chris Bass
   7. Cong-Fen Gao
   8. Shun-Fan Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful manuscript reports mechanisms behind the increase in fecundity in response to sub-lethal doses of pesticides in the crop pest, the brown plant hopper. The authors hypothesize that the pesticide works by inducing the JH titer, which through the JH signaling pathway induces egg development. Evidence for this is, however, incomplete.

   Reviewed by eLife

3. Mapping the architecture of the initiating phosphoglycosyl transferase from S. enterica O-antigen biosynthesis in a liponanoparticle

   This article has 6 authors:

   1. Greg J Dodge
   2. Alyssa J Anderson
   3. Yi He
   4. Weijing Liu
   5. Rosa Viner
   6. Barbara Imperiali

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This valuable manuscript provides solid methodologies for utilizing SMALP nanodisks for oligomer characterization. The authors present a platform for capturing and studying native membrane protein oligomerization and subsequent cryoEM analysis. The specific application of the method to WbaP, a membrane-bound phosphoglycosyl transferase, adds to our understanding of glycoconjugate production in bacteria. This manuscript would be of interest to those focusing on native membrane protein studies and antimicrobial resistance.

   Reviewed by eLife

4. Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

   This article has 5 authors:

   1. Rajdeep Banerjee
   2. Thomas J Meyer
   3. Margaret C Cam
   4. Sukhbir Kaur
   5. David D Roberts

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the cell composition in mouse spleen depleted for the CD47 receptor and its signaling ligand Thrombospondin in hematopoietic differentiation. The supporting evidence is convincing with analytical improvements on the individual contributions of the signaling components and with functional studies. This work has implications for the role of CD47/Thsp in extramedullary erythropoiesis in mouse spleen and will be of interest to medical biologists working on cell signaling, transfusion medicine, and cell therapy.

   Reviewed by eLife

5. Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

   This article has 10 authors:

   1. Xiuling Cao
   2. Xiang Wu
   3. Lei Zhao
   4. Ju Zheng
   5. Xuejiao Jin
   6. Xinxin Hao
   7. Joris Winderickx
   8. Shenkui Liu
   9. Lihua Chen
   10. Beidong Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     By combining Synthetic Genetic Array (SGA) analysis with state-of-the-art imaging techniques, this study provides strong evidence that sphingolipid metabolism controls the maturation of Parkinson's disease-associated Synphilin-1 inclusion bodies (SY1 IBs) on the mitochondrial surface in a yeast model. The authors present compelling proof that perturbing the sphingolipid metabolic pathway leads to delayed SY1 IB maturation and enhanced SY1-triggered toxicity. Altogether, the authors show the important role of sphingolipid metabolism in the detoxification process of misfolded proteins by facilitating large IB formation on the mitochondrial outer membrane.

   Reviewed by eLife

6. Catalytic growth in a shared enzyme pool ensures robust control of centrosome size

   This article has 2 authors:

   1. Deb Sankar Banerjee
   2. Shiladitya Banerjee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work suggests a new physical model of centrosome maturation: a catalytic growth model with a shared enzyme pool. The authors provide compelling evidence to show that the model is able to reproduce various experimental results such as centrosome size scaling with cell size and centrosome growth curves in C. elegans, and that the final centrosome size is more robust to differences in initial centrosome size. While direct experimental support for this theory is currently lacking, the authors propose concrete experiments that could distinguish their shared-enzyme model from previously proposed alternatives.

   Reviewed by eLife

7. Selective consolidation of learning and memory via recall-gated plasticity

   This article has 2 authors:

   1. Jack W Lindsey
   2. Ashok Litwin-Kumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work proposes a novel mechanism for memory consolidation where short-term memory provides a gating signal for memories to be consolidated into long-term storage. The work combines extensive analytical and numerical work applied to three different scenarios and provides a convincing analysis of the benefits of the proposed model, although some of the analyses are limited to the type of memory consolidation the authors consider (and don't consider), which limits the impact. The work will be of interest to neuroscientists and many other researchers interested in the mechanistic underpinnings of memory.

   Reviewed by eLife

8. Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

   This article has 11 authors:

   1. Yongfeng Luo
   2. Ke Cao
   3. Joanne Chiu
   4. Hui Chen
   5. Hong-Jun Wang
   6. Matthew E Thornton
   7. Brendan H Grubbs
   8. Martin Kolb
   9. Michael S Parmacek
   10. Yuji Mishina
   11. Wei Shi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper characterizes a murine model for congenital cystic airway abnormalities (CPAM). In contrast to previous assumptions that only epithelial cells are involved in the formation of pulmonary cysts, the authors provide compelling new evidence that defective BMP signaling in lung mesenchymal cells can disrupt airway development. Knowing that proper BMP signaling in mesenchymal cells is required for normal cyst-free lungs could potentially pave the way to understanding and preventing CPAM in infants at risk for this common disorder, which can be fatal if untreated. The relevance of the murine model could be enhanced by further molecular and histological comparison with human cysts.

   Reviewed by eLife

9. Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

   This article has 10 authors:

   1. Mohammad Alfatah
   2. Jolyn Jia Jia Lim
   3. Yizhong Zhang
   4. Arshia Naaz
   5. Trishia Yi Ning Cheng
   6. Sonia Yogasundaram
   7. Nashrul Afiq Faidzinn
   8. Jovian Jing Lin
   9. Birgit Eisenhaber
   10. Frank Eisenhaber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study identifies an uncharacterized yeast gene regulating chronological lifespan in a mitochondrial-dependent pathway. The approach to identify and characterise this new gene is appealing, but the evidence in support of some of the major conclusions is incomplete. The paper focuses on chronological lifespan and mitochondrial function, and it will be of interest to yeast biologists working in metabolism and aging.

   Reviewed by eLife

10. Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes

    This article has 3 authors:

    1. Linda S Rubio
    2. Suman Mohajan
    3. David S Gross

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is a valuable contribution to our understanding of how different cell stressors (ethanol or heat-shock) elicit unique responses at the genomic and topographical level under the regulation of yeast transcription factor Hsf1, providing solid evidence documenting the temporal coupling (or lack thereof) between Hsf1 aggregation and long-range communication among co-regulated heat-shock loci versus chromatin remodeling and transcriptional activation. A particular strength is the combination of genomic and imaging-based experimental approaches applied to genetically engineered in vivo systems.

    Reviewed by eLife