eLife

Latest preprint reviews

1. Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

   This article has 21 authors:

   1. Ananda Kishore Mukherjee
   2. Subhajit Dutta
   3. Ankita Singh
   4. Shalu Sharma
   5. Shuvra Shekhar Roy
   6. Antara Sengupta
   7. Megha Chatterjee
   8. Soujanya Vinayagamurthy
   9. Sulochana Bagri
   10. Divya Khanna
   11. Meenakshi Verma
   12. Dristhi Soni
   13. Anshul Budharaja
   14. Sagar Kailasrao Bhisade
   15. Vivek Anand
   16. Ahmad Perwez
   17. Nija George
   18. Mohammed Faruq
   19. Ishaan Gupta
   20. Radhakrishnan Sabarinathan
   21. Shantanu Chowdhury

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important finding on the role of telomeres in modulating interleukin-1 signaling and tumor immunity in TNBC. The evidence supporting these findings is solid, presented through comprehensive analyses including TNBC clinical samples, tumor-derived organoids, cancer cells, and xenografts. The work will be of broad interest to cell and medical biologists focusing on TNBC.

   Reviewed by eLife

2. Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model

   This article has 4 authors:

   1. Jeong-Oh Shin
   2. Jong-Bin Lee
   3. Sihoon Lee
   4. Jin-Woo Kim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using a large animal model, this study demonstrated valuable findings that R25CPTH(1-34), based on a mutation associated with isolated familial hypoparathyroidism, generated an anabolic osteointegration effect comparable to that of native PTH1-34. The translational aspect of this human-to-animal work, aimed at animal-to-human translation for therapeutic purposes, should be highlighted. The study design is simple and straightforward, and the methods used are solid. The authors have addressed all the questions in their revision.

   Reviewed by eLife

3. Disentangling the relationship between cancer mortality and COVID-19 in the US

   This article has 3 authors:

   1. Chelsea L Hansen
   2. Cécile Viboud
   3. Lone Simonsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work explores death coding data to understand the impact of COVID-19 on cancer mortality. The work provides solid evidence that deaths with cancer as a contributing cause were not above what would be expected during pandemic waves, suggesting that cancer did not strongly increase the risk of dying of COVID-19. These results are an interesting exploration into the coding of causes of death that can be used to make sense of how deaths are coded during a pandemic in the presence of other underlying diseases, such as cancer.

   Reviewed by eLife

4. Rapid bacterial evaluation beyond the colony forming unit in osteomyelitis

   This article has 8 authors:

   1. Qi Sun
   2. Kimberley Huynh
   3. Dzenita Muratovic
   4. Nicholas J Gunn
   5. Anja R Zelmer
   6. Lucian Bogdan Solomon
   7. Gerald J Atkins
   8. Dongqing Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study addresses discrepancies in determining bacterial burden in osteomyelitis as determined by culture and enumeration using DNA. The authors present compelling data demonstrating the emergence of discrepancies between CFU counts and genome copy numbers detected by PCR in Staphylococcus aureus strains infecting osteocyte-like cells. The observations represent a substantial addition to the field of musculoskeletal infection, with possible broad applicability and clinical benefit to other infectious diseases.

   Reviewed by eLife

5. Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

   This article has 25 authors:

   1. Charline Vilpreux
   2. Guillaume Martinez
   3. Paul Fourquin
   4. Magali Court
   5. Florence Appaix
   6. Jean-Luc Duteyrat
   7. Maxime Henry
   8. Julien Vollaire
   9. Camille Ayad
   10. Altan Yavuz
   11. Lisa De Macedo
   12. Geneviève Chevalier
   13. Edgar Del Llano
   14. Emeline Lambert
   15. Sekou Ahmed Conte
   16. Zeina Wehbe
   17. Elsa Giordani
   18. Véronique Josserand
   19. Jacques Brocard
   20. Coutton Charles
   21. Bernard Verrier
   22. Pierre F Ray
   23. Corinne Loeuillet
   24. Christophe Arnoult
   25. Jessica Escoffier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports an approach for restoring sperm motility in mice. The strength lies in in the novelty of the methodology being developed, but the evidence for the success of the method or its mechanism is inadequate. Additional experimental support would be required to support the conclusions of the authors.

   Reviewed by eLife

6. Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

   This article has 10 authors:

   1. Tackhoon Kim
   2. Byung-Sun Park
   3. Soobeen Heo
   4. Heeju Jeon
   5. Jaeyeal Kim
   6. Donghwa Kim
   7. Sang Kook Lee
   8. So-Youn Jung
   9. Sun-Young Kong
   10. Timothy Lu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding that synthetically lethal kinase genes FYN and KDM4 may play a role in drug resistance to kinase inhibitors in TNBC. The evidence supporting the claims of the authors is solid, although the exploration of the upstream mechanisms regulating KDM4A or the downstream pathways through which FYN upregulation confers drug resistance would have strengthened the study. The work will be of interest to medical biologists working in the field of breast cancer.

   Reviewed by eLife

7. Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice

   This article has 5 authors:

   1. Cristina Sáenz de Miera
   2. Nicole Bellefontaine
   3. Susan J Allen
   4. Martin G Myers
   5. Carol F Elias

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports that glutamate signaling in LepRb PMv neurons is necessary for leptin-dependent fertility. The data supporting the conclusion is solid. This work will be of interest to researchers in the fields of both reproductive and metabolic biology.

   Reviewed by eLife

8. RNA polymerase III is involved in regulating Plasmodium falciparum virulence

   This article has 9 authors:

   1. Gretchen Diffendall
   2. Aurelie Claes
   3. Anna Barcons-Simon
   4. Prince Nyarko
   5. Florent Dingli
   6. Miguel M Santos
   7. Damarys Loew
   8. Antoine Claessens
   9. Artur Scherf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study links the activity of polymerase III to the regulation of virulence gene expression in the deadliest malaria parasite, Plasmodium falciparum. It identifies Maf1 as a Pol III inhibitor that enables the parasite to respond to external stimuli such as magnesium chloride plasma levels by downregulating Pol III-transcribed ruf6 genes and subsequently regulated var genes. While the evidence presented is generally convincing, some of the results are incomplete, and the mechanistic link between external signals and Maf1 activation remains unknown.

   Reviewed by eLife

9. Recent evolutionary origin and localized diversity hotspots of mammalian coronaviruses

   This article has 4 authors:

   1. Renan Maestri
   2. Benoît Perez-Lamarque
   3. Anna Zhukova
   4. Hélène Morlon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Maestri et al report the absence of phylogenetic evidence supporting codiversification of mammalian coronaviruses and their hosts, leading to the important conclusion that the evolutionary history of the virus and its hosts are decoupled through frequent host switches. The evidence for frequent host switching, derived from state-of-the-art probabilistic modeling of co-evolution, is convincing. The study adds a new perspective to the ongoing debate over the timescale of coronavirus evolution.

   Reviewed by eLife

10. Population clustering of structural brain aging and its association with brain development

    This article has 29 authors:

    1. Haojing Duan
    2. Runye Shi
    3. Jujiao Kang
    4. Tobias Banaschewski
    5. Arun LW Bokde
    6. Christian Büchel
    7. Sylvane Desrivières
    8. Herta Flor
    9. Antoine Grigis
    10. Hugh Garavan
    11. Penny A Gowland
    12. Andreas Heinz
    13. Rüdiger Brühl
    14. Jean-Luc Martinot
    15. Marie-Laure Paillère Martinot
    16. Eric Artiges
    17. Frauke Nees
    18. Dimitri Papadopoulos Orfanos
    19. Luise Poustka
    20. Sarah Hohmann
    21. Nathalie Nathalie Holz
    22. Juliane Fröhner
    23. Michael N Smolka
    24. Nilakshi Vaidya
    25. Henrik Walter
    26. Robert Whelan
    27. Gunter Schumann
    28. Xiaolei Lin
    29. Jianfeng Feng

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Duan et al analyzed brain imaging data in UKBK and divided structural brain aging into two groups, revealing that one group is more vulnerable to aging and brain-related diseases compared to the other group. Such subtyping could be valuable and utilized in predicting and diagnosing cognitive decline and neurodegenerative brain disorders in the future. This discovery, supported by solid evidence, harbors a substantial impacts in aging and brain structure and function.

    Reviewed by eLife