eLife

Latest preprint reviews

1. PUFA stabilizes a conductive state of the selectivity filter in IKs channels

   This article has 11 authors:

   1. Alessia Golluscio
   2. Jodene Eldstrom
   3. Jessica J Jowais
   4. Marta Elena Perez
   5. Kevin Peter Cunningham
   6. Alicia De La Cruz
   7. Xiaoan Wu
   8. Valentina Corradi
   9. D Peter Tieleman
   10. David Fedida
   11. H Peter Larsson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reveals an important mechanism of KCNQ1/IKs channel gating and PUFA modulation of this mechanism. This mechanism is supported by convincing single channel recordings, macroscopic current recordings and mutational analyses. These findings are of importance to the ion channel field and possibly future therapeutic applications.

   Reviewed by eLife

2. Senescent cells inhibit mouse myoblast differentiation via the SASP-lipid 15d-PGJ2 mediated modification and control of HRas

   This article has 9 authors:

   1. Swarang Sachin Pundlik
   2. Alok Barik
   3. Ashwin Venkateshvaran
   4. Snehasudha Subhadarshini Sahoo
   5. Mahapatra Anshuman Jaysingh
   6. Raviswamy GH Math
   7. Heera Lal
   8. Maroof Athar Hashmi
   9. Arvind Ramanathan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript outlines an interaction between senescence-related 15d-PGJ2 and the proliferation and differentiation of myoblasts, with potential implications for muscle health. This manuscript is useful in understanding the role of lipid metabolite 15d-PGJ2 in myoblast proliferation and differentiation. However, in its current form, the manuscript is incomplete as there are several concerns in the statistical analysis, lack of clarity on the mechanistic details, and concerns about the use of an immortalized C2C12 myoblasts cell line to draw major conclusions related to senescence-associated secreted phenotype.

   Reviewed by eLife

3. Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

   This article has 7 authors:

   1. Shristi Pawnikar
   2. Brenda S Magenheimer
   3. Keya Joshi
   4. Ericka Nevarez-Munoz
   5. Allan Haldane
   6. Robin L Maser
   7. Yinglong Miao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This joint computational/experimental study demonstrates the ability of synthetic peptides derived from the stalk-tethered agonist in Polycystin-1 (PC1) to re-activate signaling by a stalkless C-terminal fragment of PC1. The study is valuable as it discovered peptide agonists for PC1 and the integrated in vitro and in silico approach is potentially applicable to the analysis of related systems. Following the revision, the line of evidence presented in the current manuscript is considered convincing.

   Reviewed by eLife

4. SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

   This article has 12 authors:

   1. Dandan Wu
   2. Chi Yang
   3. Yanfang Yao
   4. Dongmei Ma
   5. Hong Lin
   6. Ling Hao
   7. Wenwen Xin
   8. Kangfu Ye
   9. Minghui Sun
   10. Yule Hu
   11. Yanling Yang
   12. Zhenhong Zhuang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this useful study, the authors investigate the regulatory mechanisms related to toxin production and pathogenicity in Aspergillus flavus. Their observations indicate that the SntB protein regulates morphogenesis, aflatoxin biosynthesis, and the oxidative stress response. The data supporting the conclusions are compelling and contribute significantly the advancing the understanding of SntB function.

   Reviewed by eLife

5. Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

   This article has 14 authors:

   1. Jianwen Chen
   2. Bao Zhao
   3. Hong Dong
   4. Tianliang Li
   5. Xiang Cheng
   6. Wang Gong
   7. Jing Wang
   8. Junran Zhang
   9. Gang Xin
   10. Yanbao Yu
   11. Yu L Lei
   12. Jennifer D Black
   13. Zihai Li
   14. Haitao Wen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The author demonstrates that deficiency or pharmacological inhibition of O-glcNac transferase (OGT) enhances tumor immunity in colorectal cancer models. This useful study unveils that OGT deficiency triggers a DNA damage response that can affect immune status in colorectal cancers. It provides convincing evidence showing that OGT-mediated processing of HSF1 is crucial in maintaining genomic integrity.

   Reviewed by eLife

6. Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022

   This article has 16 authors:

   1. Lucia Inchauste
   2. Elif Nurtop
   3. Lissete Bautista Machicado
   4. Yanine Leigue Roth
   5. Shirley Lenz Gonzales
   6. Maria Luisa Herrera
   7. Katty Mina Villafan
   8. Pedro Mamani Mamani
   9. Marcelo Ramos Espinoza
   10. Juan Carlos Pavel Suarez
   11. Juan Cansio Garcia Copa
   12. Yitzhak Leigue Zabala
   13. Etzel Arancibia Cardozo
   14. Pierre Gallian
   15. Xavier de Lamballerie
   16. Stéphane Priet

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This serostudy of blood donors in Bolivia (a country with very high COVID death rates in 2020-21) provides useful insights on the successive viral variants of SARS-CoV-2 over 2021 and 2022. Using compelling antibody and neutralization assays, the authors describe variant specific distributions in the different parts of Bolivia. The main methodological advance is to use serology to understand variant diversity, which in turn helps deepen understanding of "hybrid" immunity from widespread infection (and vaccination).

   Reviewed by eLife

7. Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity

   This article has 13 authors:

   1. Xiaolin Yu
   2. Guangfei Duan
   3. Pengfei Pei
   4. Long Chen
   5. Renji Gu
   6. Wenrui Hu
   7. Hongli Zhang
   8. Yan-Dong Wang
   9. Lili Gong
   10. Lihong Liu
   11. Ting-Ting Chu
   12. Jin-Ping Li
   13. Shi-Zhong Luo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How the triplicate interaction between chemokines with both GAGs and G protein-coupled receptors (GPCR) works and how gradients are created and potentially maintained in vivo are poorly understood. The authors provide solid evidence to show phase separation can drive chemotactic gradient formation. The paper is a useful advance in the field of chemokine biology.

   Reviewed by eLife

8. Predicting the causal relationship between polyunsaturated fatty acids and cerebral aneurysm risk from a Mendelian randomization study

   This article has 12 authors:

   1. Weijie Yu
   2. Liwei Zhou
   3. Chongfei Li
   4. Zhenwei Lu
   5. Xiaoyu Chen
   6. Hao Yu
   7. Xiaoyan Chen
   8. Qionghui Huang
   9. Zhangyu Li
   10. Deyong Xiao
   11. Yunyun Mei
   12. Zhanxiang Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Yu and colleagues used two-sample MR to test the effect of PUFA on cerebral aneurysms. They found that genetically predicted omega-3 and DHA decreased the risk for Intracranial Aneurysm and Subarachnoid Haemorrhage. This work is useful and the revised version provides solid evidence to support the claims.

   Reviewed by eLife

9. Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration

   This article has 4 authors:

   1. Yu-Ming Lu
   2. Shan Yan
   3. Shih-Chieh Ti
   4. Chaogu Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study analyzes the roles of post-translational modifications of tubulin by generating a large panel of tubulin mutants and describing their effects on morphogenesis and function of sensory neurons in C. elegans. The work, which is of interest to all cell biologists, in particular researchers with an interest in the microtubule cytoskeleton and neurobiology, presents conclusions that are supported by solid evidence. Demonstrating that all introduced mutations have the intended consequences and exploring their direct effect on microtubules would further increase the impact of the work.

   Reviewed by eLife

10. The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

    This article has 4 authors:

    1. Karolina Honzejkova
    2. Dalibor Kosek
    3. Veronika Obsilova
    4. Tomas Obsil

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important manuscript reports the cryo-EM structure of the ASK1 protein, which is a critical regulator of the MAPKs, JNKs, and p38 MAPKs in diverse cellular stress responses. The evidence of ASK1 interaction with TRX1 is compelling and will eventually allow the discovery of small molecule inhibitors of ASK1 activity.

    Reviewed by eLife