eLife

Latest preprint reviews

1. Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity

   This article has 9 authors:

   1. Andrew E Worthy
   2. Joanna T Anderson
   3. Alicia R Lane
   4. Laura J Gomez-Perez
   5. Anthony A Wang
   6. Ronald W Griffith
   7. Andre F Rivard
   8. Jay B Bikoff
   9. Francisco J Alvarez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable description of subtypes of V1 neurons, including birthdates and connections to motor neurons. V1 neurons are one of the main groups of inhibitory neurons in the spinal cord. The methods of data collection and analysis are convincing. This work will interest developmental biologists and neuroscientists working on spinal circuits.

   Reviewed by eLife

2. An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks

   This article has 3 authors:

   1. Gaetan De Waele
   2. Gerben Menschaert
   3. Willem Waegeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a machine learning model to recommend effective antimicrobial drugs from patients' samples analysed with mass spectrometry. The evidence supporting the claims of the authors is convincing. This work will be of interest to computational biologists, microbiologists, and clinicians.

   Reviewed by eLife

3. Implicit motor adaptation patterns in a redundant motor task manipulating a stick with both hands

   This article has 2 authors:

   1. Toshiki Kobayashi
   2. Daichi Nozaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on how the sensorimotor control system deals with redundancy within our body, based on a novel bimanual task. The evidence supporting the authors' claims is convincing, as demonstrated over four different experiments. The work will be of interest to researchers from the motor control community and related fields, and further investigation into the interpretation of the findings could increase the generalisation of the study to a broader audience.

   Reviewed by eLife

4. Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

   This article has 5 authors:

   1. Daniel Chen
   2. Polyxeni Philippidou
   3. Bianca de Freitas Brenha
   4. Ashleigh E. Schaffer
   5. Helen C. Miranda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study describing a neuromuscular junction co-culture system using human cells that the authors use to study the synaptic consequences of ALS mutations. The data supporting the system are solid and show the value of using myotubes and motor neurons from the same donor. The study will be of interest to researchers who model neuromuscular junction disorders, however, the authors could more comprehensively compare and contrast their system with previous literature describing other similar models. There are also technical weaknesses that limit the interpretation of specific findings.

   Reviewed by eLife

5. Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection

   This article has 10 authors:

   1. Kavidha Reddy
   2. Guinevere Q Lee
   3. Nicole Reddy
   4. Tatenda JB Chikowore
   5. Kathy Baisley
   6. Krista L Dong
   7. Bruce D Walker
   8. Xu G Yu
   9. Mathias Lichterfeld
   10. Thumbi Ndung'u

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental, clearly written, and timely manuscript links the timing of ART with the kinetics of total and intact proviral HIV DNA. The conclusions are interesting and novel, and the importance of the work is high because the focus is on African women and clade C virus, both of which are understudied in the HIV reservoir field. The strength of the evidence is compelling. Overall, this work will be of very high interest to scientists and clinicians in the HIV cure/persistence fields.

   Reviewed by eLife, Rapid Reviews Infectious Diseases

6. The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

   This article has 5 authors:

   1. Yueliang Zhang
   2. Sara B Noya
   3. Yongjun Li
   4. Jichao Fang
   5. Amita Sehgal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings about daily rhythm changes of the Drosophila melanogaster adult gut metabolome, which is shown to be dependent on the circadian clock genotype, dietary regime and composition, and gut microbiota. The phenomena observed are supported by convincing experimental evidence. The general descriptive approach limits the power of the proposed conclusions. The work will be of interest to a broad range of physiology specialists

   Reviewed by eLife

7. The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms

   This article has 7 authors:

   1. Qian Wang
   2. Jinxin Liu
   3. Yuhang Luo
   4. Vicky Kliemke
   5. Giuliana Leonarda Matta
   6. Jingjing Wang
   7. Qian Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study advances our understanding of how Nipah virus fusion protein F (NiV-F) organizes into nanoclusters on cell and viral membranes using biochemical and super-resolution microscopy methods. The conclusions are supported by solid evidence and the revision has addressed most of the reviewers' concerns. The relationship between clustering and fusion is of high interest and an interesting hypothesis to continue investigating in future studies.

   Reviewed by eLife

8. Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

   This article has 19 authors:

   1. Xiaoning Gao
   2. WuYan Guo
   3. Peiyuan Liu
   4. Mingyue Yuwen
   5. Zixiang Liu
   6. Ruyang Tan
   7. Kairui Liu
   8. Zhiru Yang
   9. Junli Ba
   10. Xue Bai
   11. Shiti Shama
   12. Cong Tang
   13. Kai Miao
   14. Haozhi Pei
   15. Liren Liu
   16. Cheng Zhu
   17. Tao Wang
   18. Bo Zhang
   19. Jun Kang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study suggests that capsaicin nanoparticle administration in rats activates the transcription factor Nrf2 by directly binding to its repressor, KEAP1, leading to the induction of cytoprotective genes and preventing alcohol-induced gastric damage, offering a potential avenue for treating alcoholism-related gastric disorders. Although improvements were made following the first revision, the evidence supporting capsaicin as an Nrf2 activator remains incomplete, as some methodological aspects still require revision and the interpretation of key data needs further clarification.

   Reviewed by eLife

9. JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

   This article has 5 authors:

   1. Yunpo Zhao
   2. Jianli Duan
   3. Hannah Seah
   4. Joyce van de Leemput
   5. Zhe Han

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important new insights linking obesity to kidney disease using a Drosophila model. A series of compelling experiments demonstrate that a high-fat diet induces excretion of a leptin-like JAK-STAT ligand from fat body, driving the adipose-nephrocyte axis through activated JAK-STAT signaling and subsequently causing a functional defect in nephrocytes. The approach using combination of genetic tools and pharmacological intervention is solid and confirms the mechanistic link, together with phenotypic analysis that further supports the authors conclusions.

   Reviewed by eLife

10. TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

    This article has 7 authors:

    1. Augustus J Lowry
    2. Pengfei Liang
    3. Mo Song
    4. Yuichun Wan
    5. Zhen-Ming Pei
    6. Huanghe Yang
    7. Yang Zhang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study advances our understanding of the mechanisms controlling lipid flux and ion permeation in the TMEM16 and OSCA/TMEM63 family channels. The study provides compelling new evidence indicating that side chains along the TM4/6 interface play a key role in gating lipid and ion fluxes in these channels. The authors suggest that the transmembrane channel/scramblase family proteins may have originally functioned as scramblases but lost this capacity over evolution.

    Reviewed by eLife