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  1. Insect metamorphosis is regulated differently between sexes by members of a microRNA cluster

    This article has 13 authors:
    1. Chade Li
    2. Ki Kei Chan
    3. Wenyan Nong
    4. ShanShan Chen
    5. Wai Lok So
    6. Zhe Qu
    7. Heidi YC Wu
    8. Ho Yin Yip
    9. Chi Bun Chan
    10. Stephen S Tobe
    11. William G Bendena
    12. Zhen Peng Kai
    13. Jerome HL Hui
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides a useful inventory of genes that are up- or down-regulated during the early metamorphic development of male and female larvae and proposes that the microRNA cluster miR-277/34 is involved in the development of sexual differences during early metamorphosis of Drosophila melanogaster, although its precise role remains unclear. The strength of evidence, based on a combination of diverse methods including mRNA and small RNA sequencing, in silico analyses, in vitro assays, and loss-of-function experiments, is incomplete as it lacks a general model and an examination of the potential effects of the miR-277/34 mutations on phenotypes such as morphology or developmental time. This work will be of interest to developmental biologists interested in sexual dimorphism and in the interplay between hormones and microRNAs during development.

    Reviewed by eLife

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