Latest preprint reviews

  1. MLCK/MLCP regulates mammalian axon regeneration and redistributes the growth cone F-actin

    This article has 5 authors:
    1. Saijilafu
    2. Wei-Hua Wang
    3. Jin-Jin Ma
    4. Yin Yin
    5. Yan-Xia Ma
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Saijilafu et al. describe valuable findings suggesting that MLCK and MLCP bidirectionally regulate NMII phosphorylation ultimately impinging on axonal growth during regeneration in the central and peripheral nervous systems. Solid evidence is collected from culture and in vivo models, and through pharmacologic and genetic loss-of-function approaches. However, how MLCK and MLCP regulates NMII activity is not fully addressed or discussed. In sum, this knowledge is of potential interest for the field due to the relevance of identifying mechanistic details that regulate axonal regeneration

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  2. Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

    This article has 4 authors:
    1. Kleio Petratou
    2. Martin Stehling
    3. Ferenc Müller
    4. Stefan Schulte-Merker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental work describes for the first time the combined gene expression and chromatin structure at the genome level in isolated chondrocytes and classical (cranial) and non-classical (notochordal) osteoblasts. In a compelling analysis of RNA-Seq and ATAC data, the authors characterize the two osteoblast populations relative to their associated chondrocyte cells and further proceed with a convincing analysis of the crucial entpd5a gene regulatory elements by investigating their respective transcriptional activity and specificity in developing zebrafish.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
Newer Page 243 of 869 Older