eLife

Latest preprint reviews

1. Multi-day neuron tracking in high-density electrophysiology recordings using earth mover’s distance

   This article has 6 authors:

   1. Augustine Xiaoran Yuan
   2. Jennifer Colonell
   3. Anna Lebedeva
   4. Michael Okun
   5. Adam S Charles
   6. Timothy D Harris

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study proposes a new method for tracking neurons recorded with Neuropixel electrodes across days. The methods and the strength of the evidence are convincing, but the authors do not address whether their approach can be generalized to other brain areas, species, behaviors, or tools. Overall, this method will be potentially of interest to many neuroscientists who want to study long-term activity changes of individual neurons in the brain.

   Reviewed by eLife

2. Whole-brain in situ mapping of neuronal activation in Drosophila during social behaviors and optogenetic stimulation

   This article has 3 authors:

   1. Kiichi Watanabe
   2. Hui Chiu
   3. David J Anderson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work reports an important new method for activity-dependent neuronal labeling in Drosophila using in situ hybridization, with the potential to establish a new standard in the field. The authors demonstrate the method's applicability by generating compelling evidence of the function of male-specific neurons in both aggression and courtship behaviors. These results and the new method will be of great interest to the neuroscience community.

   Reviewed by eLife

3. mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming

   This article has 23 authors:

   1. Helmut Bischof
   2. Selina Maier
   3. Piotr Koprowski
   4. Bogusz Kulawiak
   5. Sandra Burgstaller
   6. Joanna Jasińska
   7. Kristian Serafimov
   8. Monika Zochowska
   9. Dominic Gross
   10. Werner Schroth
   11. Lucas Matt
   12. David Arturo Juarez Lopez
   13. Ying Zhang
   14. Irina Bonzheim
   15. Florian A Büttner
   16. Falko Fend
   17. Matthias Schwab
   18. Andreas L Birkenfeld
   19. Roland Malli
   20. Michael Lämmerhofer
   21. Piotr Bednarczyk
   22. Adam Szewczyk
   23. Robert Lukowski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The large-conductance Ca2+ activated K+ channel BKCa has been reported to promote breast cancer progression. The present study presents convincing evidence that an intracellular subpopulation of this channel reprograms breast cancer cells towards the Warburg phenotype, one of the metabolic hallmarks of cancer. This important finding advances the field of cancer cell metabolism and has potential therapeutic implications.

   Reviewed by eLife

4. A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

   This article has 12 authors:

   1. Jyotsna
   2. Binayak Sarkar
   3. Mohit Yadav
   4. Alvina Deka
   5. Manasvini Markandey
   6. Priyadarshini Sanyal
   7. Perumal Nagarajan
   8. Nilesh Gaikward
   9. Vineet Ahuja
   10. Debasisa Mohanty
   11. Soumen Basak
   12. Rajesh S Gokhale

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The current version of the study presents important findings on how the RelA/Stat3-dependent gene program in the liver influences intestinal homeostasis. The evidence supporting the conclusions is solid, with new data added compared to an earlier version of the study. The work will be of interest to scientists in gastrointestinal research fields.

   Reviewed by eLife

5. Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection

   This article has 5 authors:

   1. Sathyabaarathi Ravichandran
   2. Bharat Bhatt
   3. Awantika Shah
   4. Kithiganahalli Narayanaswamy Balaji
   5. Nagasuma Chandra

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors of this manuscript address the following question in the immunology field: what are the transcriptional regulators that allow macrophages to assume different functional phenotypes in response to immune stimuli? They generate a computational map of the gene regulatory networks involved in determining macrophage phenotypes and experimentally validate the role of putative regulatory factors in a myeloid cell line. This study represents a valuable approach to understanding how gene regulation impacts macrophage polarization but the analyses remain incomplete without further validation in primary cells or by examining the identified genes in the in vivo setting.

   Reviewed by eLife

6. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/preprints/psyarxiv

7. Synaptic interactions between stellate cells and parvalbumin interneurons in layer 2 of the medial entorhinal cortex are organized at the scale of grid cell clusters

   This article has 4 authors:

   1. Li-Wen Huang
   2. Derek LF Garden
   3. Christina McClure
   4. Matthew F Nolan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this compelling study, the authors examine the interactions between stellate cells and PV+ interneurons in the medial entorhinal cortex. Huang et al. focus on the spatial distribution of synaptic inputs and demonstrate that closely located neuron pairs receive common inputs, suggesting a structured functional organization in the entorhinal cortex. Advanced dual whole-cell patch recordings further reveal patterns of postsynaptic activation, indicating intensive interactions within clusters of these neurons, with weaker interactions between clusters. These findings offer significant insights into the functional dynamics of the entorhinal cortex and the circuit mechanisms that shape grid cell activity. This study is important not only for the field of MEC and grid cells, but also for broader fields of continuous attractor networks and neural circuits.

   Reviewed by eLife

8. Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

   This article has 6 authors:

   1. Baher A Ibrahim
   2. Yoshitaka Shinagawa
   3. Austin Douglas
   4. Gang Xiao
   5. Alexander R Asilador
   6. Daniel A Llano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable new insights into how multisensory information is processed in the lateral cortex of the inferior colliculus, a poorly understood part of the auditory midbrain. By developing new imaging techniques that provide the first optical access to the lateral cortex in a living animal, the authors provide convincing in vivo evidence that this region contains separate subregions that can be distinguished by their sensory inputs and neurochemical profiles, as suggested by previous anatomical and in vitro studies. This work provides a foundation for future research exploring how this part of the auditory midbrain contributes to multisensory-based behavior.

   Reviewed by eLife

9. Brain state and cortical layer-specific mechanisms underlying perception at threshold

   This article has 6 authors:

   1. Mitchell P Morton
   2. Sachira Denagamage
   3. Isabel J Blume
   4. John H Reynolds
   5. Monika P Jadi
   6. Anirvan S Nandy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study by Nandy and colleagues examined relationships between behavioral state, neural activity in cortical area V4, and trial-by-trial variability in the ability to detect weak visual stimuli. They present solid evidence indicating that certain changes in arousal and eye-position stability, along with patterns of synchrony in the activity of neurons in different layers of V4, can show modest correspondences to changes in the ability to correctly detect a stimulus. These findings are likely to be of interest to those who seek a deeper understanding of circuit mechanisms that underlie perception.

   Reviewed by eLife

10. Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

    This article has 11 authors:

    1. Bohan Zhu
    2. Richard I Ainsworth
    3. Zengmiao Wang
    4. Zhengzhi Liu
    5. Salvador Sierra
    6. Chengyu Deng
    7. Luis F Callado
    8. J Javier Meana
    9. Wei Wang
    10. Chang Lu
    11. Javier González-Maeso

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The study by Zhu et al. provides important insights into cell-specific genome-wide histone modifications in the frontal cortex of individuals with schizophrenia, as well as shedding light on the role of age and antipsychotic treatment in these associations. The evidence supporting the conclusions is solid.

    Reviewed by eLife