Latest preprint reviews

  1. CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

    This article has 8 authors:
    1. Longxin Xie
    2. Jessica Merjane
    3. Cristian A Bergmann
    4. Jiazhen Xu
    5. Shruthi Balasubramaniyan
    6. Bryan Hurtle
    7. Charleen T Chu
    8. Christopher J Donnelly
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study developed a new sensor for TDP-43 activity that is sensitive and robust that should strongly impact the field's ability to monitor whether TDP-43 is functional or not. The evidence, though limited to cell culture, is compelling and is the first demonstration that a GFP on/off system can be used to assess genetic TDP-43 mutants as well as loss of soluble TDP-43.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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