eLife

Latest preprint reviews

1. ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis

   This article has 25 authors:

   1. Stephanie Guillet
   2. Tomi Lazarov
   3. Natasha Jordan
   4. Bertrand Boisson
   5. Maria Tello
   6. Barbara Craddock
   7. Ting Zhou
   8. Chihiro Nishi
   9. Rohan Bareja
   10. Hairu Yang
   11. Frederic Rieux-Laucat
   12. Rosa Irene Fregel Lorenzo
   13. Sabrina D Dyall
   14. David Isenberg
   15. David D'Cruz
   16. Nico Lachmann
   17. Olivier Elemento
   18. Agnes Viale
   19. Nicholas D Socci
   20. Laurent Abel
   21. Shigekazu Nagata
   22. Morgan Huse
   23. W Todd Miller
   24. Jean-Laurent Casanova
   25. Frédéric Geissmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors found, with the use of statistical methods, that compound heterozygous rare deletion variants affecting the kinase-domain of non-receptor tyrosine kinase TNK2/ACK1 and PTK6/BRK are associated with human systemic lupus erythematosus (SLE). The authors use a convincing mouse experimental model and human-induced pluripotent stem cell (hiPSC)-derived macrophages to clarify cause-effect relationships and the cellular basis of nephritis. With the identification of new SLE-related genes, this manuscript improves our understanding of human SLE pathogenesis.

   Reviewed by eLife

2. OsNF-YB7 inactivates OsGLK1 to inhibit chlorophyll biosynthesis in rice embryo

   This article has 5 authors:

   1. Zongju Yang
   2. Tianqi Bai
   3. Zhiguo E
   4. Baixiao Niu
   5. Chen Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides important insights into the role of rice OsNF-YB7, an ortholog of Arabidopsis LEC1, in chlorophyll biosynthesis, uncovering the genetic and molecular basis for negative regulation of chlorophyll production in the rice embryo. Mutational analysis, gene expression profiles and protein interaction combine for convincing evidence that OsNF-YB7 represses chlorophyll biosynthesis.

   Reviewed by eLife

3. Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

   This article has 14 authors:

   1. Youxi Liu
   2. Meimei Yin
   3. Xiaoting Mao
   4. Shuai Wu
   5. Shuangping Wei
   6. Shujun Heng
   7. Yichun Yang
   8. Jinwen Huang
   9. Zhuolin Guo
   10. Chuan Li
   11. Chao Ji
   12. Liu Hu
   13. Wenjie Liu
   14. Ling-juan Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses single-cell RNA-seq to obtain a more granular understanding of cell subsets within allergic contact dermatitis in a model system with DNFB. The convincing data revela unique subpopulations of dermal fibroblasts as key responders to interferon gamma and likely as mediators of dermatitis. This study has many novel aspects and provides a unique resource as well.

   Reviewed by eLife

4. Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

   This article has 10 authors:

   1. Showkat Ahmad Dar
   2. Sulochan Malla
   3. Vlastimil Martinek
   4. Matthew John Payea
   5. Christopher Tai-Yi Lee
   6. Jessica Martin
   7. Aditya Jignesh Khandeshi
   8. Jennifer L Martindale
   9. Cedric Belair
   10. Manolis Maragkakis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes mRNA shortening during cellular stress and interestingly observes that this shortening is dependent on localization in stress granules. Surprisingly, this mRNA shortening does not appear to require the shortening of poly A tails. These are novel, paradigm-shifting findings, using cutting-edge technologies and convincing data, that should be of broad interest to the RNA community and beyond.

   Reviewed by eLife, PREreview

5. Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals

   This article has 3 authors:

   1. Wenyu Tu
   2. Samuel R Cramer
   3. Nanyin Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines fMRI and electrophysiology in sedated and awake rats to show that LFPs strongly explain spatial correlations in resting-state fMRI but only weakly explain temporal variability. The authors propose that other, electrophysiology-invisible mechanisms contribute to the fMRI signal. The evidence supporting the separation of spatial and temporal correlations is convincing, and the authors consider alternative potential factors that could account for the differences in spatial and temporal correlation that were observed. This work will be of interest to researchers who study the mechanisms behind resting-state fMRI.

   Reviewed by eLife

6. Mechanism of dimer selectivity and binding cooperativity of BRAF inhibitors

   This article has 6 authors:

   1. Joseph Clayton
   2. Aarion Romany
   3. Evangelia Matenoglou
   4. Evripidis Gavathiotis
   5. Poulikos I Poulikakos
   6. Jana Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study illuminates the dynamics of BRAF in its monomeric and dimeric forms, both in the absence and presence of inhibitors, through a convincing combination of traditional experiments and sophisticated computational analyses. By revealing novel insights into the selectivity and cooperative processes of BRAF inhibitors, it holds significant promise for the development of future therapeutics, particularly against mutant isoforms in cancer. Overall, these findings will be of great interest to structural biologists, medicinal chemists, and pharmacologists.

   Reviewed by eLife

7. Context dependent contributions of the direct and indirect pathways in the associative and sensorimotor striatum

   This article has 6 authors:

   1. Nisa Cuevas
   2. Argelia Llanos-Moreno
   3. Kathia I. Ramírez-Armenta
   4. Hector Alatriste-León
   5. Josué O. Ramírez Jarquin
   6. Fatuel Tecuapetla

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript shows that the optogenetic stimulation of direct and indirect pathway spiny projection neurons (SPNs) in the dorsomedial versus the dorsolateral striatum has different consequences for locomotor activity, real-time place preference, and action selection, in a contextually mediated manner. The evidence in support of this conclusion is solid but would be further strengthened through deeper analysis of the effect and specificity of optogenetic manipulations on SPN activity. These findings will be of interest to neuroscientists, particularly behavioral neuroscientists.

   Reviewed by eLife

8. Multimodal mismatch responses in mouse auditory cortex

   This article has 2 authors:

   1. Magdalena Solyga
   2. Georg B Keller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This well-designed study provides important findings concerning the way the brain encodes prediction about self-generated sensory inputs. The authors report that neurons in auditory cortex respond to mismatches in locomotion-driven auditory feedback and that those responses can be enhanced by concurrent mismatches in visual inputs. While there remain alternative explanations for some of the data, these findings provide convincing support for the role of predictive processing in cortical function by indicating that sensorimotor prediction errors in one modality influence the computation of prediction errors in another modality.

   Reviewed by eLife

9. Neural activity ramps in frontal cortex signal extended motivation during learning

   This article has 7 authors:

   1. Josue M Regalado
   2. Ariadna Corredera Asensio
   3. Theresa Haunold
   4. Andrew C Toader
   5. Yan Ran Li
   6. Lauren A Neal
   7. Priyamvada Rajasethupathy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript provides compelling experimental evidence of extended motivational signals encoded in the mouse anterior cingulate cortex (ACC) that are implemented by orbitofrontal cortex (OFC)-to-ACC signaling during learning. The experimental methods used were state-of-the-art. These results will be of interest to those interested in cortical function, learning, and/or motivation.

   Reviewed by eLife

10. Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

    This article has 3 authors:

    1. Selene Seoyun Lee
    2. Livia Civitelli
    3. Laura Parkkinen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important work compares the strain properties of a-synuclein fibrils isolated from LBD and MSA patient samples with the resulting amplified fibrils following SAA. Using orthogonal biochemical and structural approaches to strengthen their analyses, the authors provide solid evidence that the SAA-amplified fibrils do not recapitulate the disease-relevant strains present in the patient samples. CryoEM would further strengthen this data but it is outside the scope of the work. This work should be considered in the widespread applications of SAA in synucleopathies and its potential limitations.

    Reviewed by eLife