eLife

Latest preprint reviews

1. RNA tertiary structure and conformational dynamics revealed by BASH MaP

   This article has 2 authors:

   1. Maxim Oleynikov
   2. Samie R Jaffrey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work substantially advances our understanding of RNA structure analysis by introducing an innovative method that extends DMS probing to include guanosine residues, thereby enhancing our ability to detect complex tertiary interactions. The evidence supporting the conclusions is compelling, with detailed analyses demonstrating the method's capacity to differentiate structural contexts and improve RNA structure predictions. This work will be of broad interest to RNA structural biology, biochemistry, and biophysics researchers.

   Reviewed by eLife

2. NK cell exhaustion in Wilson’s disease revealed by single-cell RNA sequencing predicts the prognosis of cholecystitis

   This article has 12 authors:

   1. Yong Jin
   2. Jiayu Xing
   3. Chenyu Dai
   4. Lei Jin
   5. Wanying Zhang
   6. Qianqian Tao
   7. Mei Hou
   8. Ziyi Li
   9. Wen Yang
   10. Qiyu Feng
   11. Hongyang Wang
   12. Qingsheng Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings, based on solid methods, to link metabolic dysfunction in Wilson's disease to immune cell dysregulation and poor cholecystitis outcomes. The integration of clinical data and single-cell analyses highlights NK cell exhaustion as a key factor, offering insights with potential therapeutic implications. The work will be of interest to colleagues in inflammatory and metabolic diseases.

   Reviewed by eLife

3. PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

   This article has 5 authors:

   1. Thomas E Forman
   2. Marcin P Sajek
   3. Eric D Larson
   4. Neelanjan Mukherjee
   5. Katherine A Fantauzzo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work provides new mechanistic insight in regulation of PDGF signaling through splicing controls. The evidence is compelling to demonstrate functional involvement of Srsf3, an RNA binding protein to this new and interesting mechanism. The work will be of broad interest to developmental biologists in general and molecular biologists/biochemists in the field of growth factor signaling and RNA processing.

   Reviewed by eLife

4. Elucidating ATP’s role as solubilizer of biomolecular aggregate

   This article has 5 authors:

   1. Susmita Sarkar
   2. Saurabh Gupta
   3. Chiranjit Mahato
   4. Dibyendu Das
   5. Jagannath Mondal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors combined molecular dynamics simulations and experiments to study the role of ATP as a hydrotrope of protein aggregates. The topic is of major current interest and thus the study potentially makes an important contribution to the community. With the revised version, the level of evidence is considered generally solid, although there remains concern regarding the unusually high ATP concentration used in the simulation.

   Reviewed by eLife

5. Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

   This article has 8 authors:

   1. Kai Sha
   2. Renyuan Zhang
   3. Aerken Maolake
   4. Shalini Singh
   5. Gurkamal Chatta
   6. Kevin H Eng
   7. Kent L Nastiuk
   8. John J Krolewski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This potentially valuable work aimed at a better understanding of the mechanisms of response and resistance to androgen deprivation therapy in prostate cancer using genetically engineered mouse models. A key observation relates to the timing of TNF blockage therapy and the concept of a "TNF switch." The solid data were collected using conventional approaches and the conclusions are mostly justified, particularly with the inclusion of more detailed statistics in the revision. The work will be of interest to the prostate cancer research community.

   Reviewed by eLife

6. Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

   This article has 15 authors:

   1. Megan E Patton
   2. Sherwin Kelekar
   3. Lauren J Taylor
   4. Angela E Dean
   5. Qianying Zuo
   6. Rhishikesh N Thakare
   7. Sung Hwan Lee
   8. Emily C Gentry
   9. Morgan Panitchpakdi
   10. Pieter Dorrestein
   11. Yazen Alnouti
   12. Zeynep Madak-Erdogan
   13. Ju-Seog Lee
   14. Milton J Finegold
   15. Sayeepriyadarshini Anakk

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the influence of sex on bile acid metabolism and the risk of hepatocellular carcinoma (HCC). The data to support that there are inter-relationships between sex, bile acids, and HCC in mice are convincing, although this is a largely descriptive study. Future studies are needed to understand the interaction of sex hormones, bile acids, and chronic liver diseases and cancer at a mechanistic level. Also, there is not enough evidence to determine the clinical significance of the findings given the differences in bile acid composition between mice and men.

   Reviewed by eLife

7. Dynamic readout of the Hh gradient in the Drosophila wing disc reveals pattern-specific tradeoffs between robustness and precision

   This article has 3 authors:

   1. Rosalío Reyes
   2. Arthur D Lander
   3. Marcos Nahmad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the precision conferred by dynamical interpretation of morphogen gradients. The evidence supporting the claims of the authors is convincing, with compelling theoretical analysis and solid yet incomplete experimental data. With the experimental part strengthened, the work could be of interest to the developmental biology and developmental systems biology communities.

   Reviewed by eLife

8. Plasticity of the proteasome-targeting signal Fat10 enhances substrate degradation

   This article has 5 authors:

   1. Hitendra Negi
   2. Aravind Ravichandran
   3. Pritha Dasgupta
   4. Shridivya Reddy
   5. Ranabir Das

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript probes the ways in which a protein tag might influence the structure, dynamics and stability of a covalently-attached substrate protein. Such findings are of important significance to several fields, particularly in understanding how these influences control the abundance of proteins within a cell. The evidence provided to support the authors' conclusions are, however, incomplete and further control experiments are necessary to fully support the proposed model.

   Reviewed by eLife

9. Basal ganglia output (entopeduncular nucleus) coding of contextual kinematics and reward in the freely moving mouse

   This article has 4 authors:

   1. Anil K Verma Rodriguez
   2. Josue O Ramírez-Jarquin
   3. Román Rossi-Pool
   4. Fatuel Tecuapetla

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reports on electrophysiological recording of the spiking activity of single neurons in the entopeduncular nucleus (EPN) in freely-moving mice performing an auditory discrimination task. The data show that the activity of single EPN neurons is modulated by reward and movement kinematics, with the latter further affected by task contexts (e.g. movement toward or away from a reward location). The results provide solid evidence for the conclusions. There is some ambiguity as to whether the data contain the population of EPN neurons characterized in previous studies that obtained different results. Investigations separating confounding factors would be of benefit. Nonetheless, the work is overall of interest to those who study how the basal ganglia, particularly the EPN, contribute to behavior.

   Reviewed by eLife

10. Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis

    This article has 22 authors:

    1. Paul Horn
    2. Jenny Norlin
    3. Kasper Almholt
    4. Birgitte M Viuff
    5. Elisabeth D Galsgaard
    6. Andreas Hald
    7. Franziska Zosel
    8. Helle Demuth
    9. Svend Poulsen
    10. Peder L Norby
    11. Morten G Rasch
    12. Mogens Vyberg
    13. Jan Fleckner
    14. Mikkel Parsberg Werge
    15. Lise Lotte Gluud
    16. Marco R Rink
    17. Emma Shepherd
    18. Ellie Northall
    19. Patricia F Lalor
    20. Chris J Weston
    21. Morten Fog-Tonnesen
    22. Philip N Newsome

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important paper shows that the anti-gremlin-1 (GREM1) antibody is not effective at treating liver inflammation or fibrosis. Critically, the evidence also challenges existing data on the detection of GREM1 by ELISA in serum or plasma by demonstrating that high-affinity binding of GREM1 to heparin would lead to localisation of GREM1 in the ECM or at the plasma membrane of cells. The conclusions are supported by a convincing, well-controlled set of experiments.

    Reviewed by eLife