Latest preprint reviews

  1. A humoral immune response to parasitoid wasps in Drosophila is regulated by JAK/STAT, NF-κB and GATA

    This article has 5 authors:
    1. Shuyu Olivia Zhou
    2. Jonathan P Day
    3. Bart Deplancke
    4. Alexandre B Leitão
    5. Francis M Jiggins
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reports an extensive analysis of the way a humoral immune response to parasitoid wasp is expressed and regulated, building on previous work from the authors on an anti-parasitoid effector lectin. The solid evidence uses two complementary approaches to show which innate immune pathways are involved in the regulation of the anti-parasitoid response. The evidence would be stronger if some analytical and related concerns can be addressed. The work will be of relevance to the community of investigators studying insect immune cells as well as researchers interested in host defense against parasitism.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    This article has 8 authors:
    1. Siying Zeng
    2. Yuqi Wang
    3. Minfeng Ying
    4. Chengmeng Jin
    5. Chang Ying
    6. Di Wang
    7. Hao Wu
    8. Xun Hu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents an assessment of the effect of lactate dehydrogenase (LDH) inhibition on the activity of glycolysis and tricarboxylic acid cycle. The data were collected and analyzed using solid and validated methodology. This paper makes a useful contribution to the field as it considers a control analysis of LDH flux. The findings differ from other published findings likely due to the time course of the incubations used to assess metabolism. While such comparative studies were not presented in the manuscript, the manuscript should be interpreted in light of this critical distinction.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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