eLife

Latest preprint reviews

1. The epididymis contributes to sperm DNA integrity and early embryo development through Cysteine-Rich Secretory Proteins

   This article has 6 authors:

   1. Valeria Sulzyk
   2. Ludmila Curci
   3. Lucas N González
   4. Abril Rebagliati Cid
   5. Mariana Weigel Muñoz
   6. Patricia S Cuasnicu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reports that epididymal proteins are required for embryogenesis after fertilization. The data presented are generally supportive of the conclusion and considered solid. This work will be of interest to reproductive biologists and andrologists.

   Reviewed by eLife

2. Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary

   This article has 5 authors:

   1. Dilara N Anbarci
   2. Jennifer McKey
   3. Daniel S Levic
   4. Michel Bagnat
   5. Blanche Capel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports the developmental dynamics and molecular markers of the rete ovarii during ovarian development. The data supporting the main conclusions are convincing. This study will be of interest to developmental and reproductive biologists.

   Reviewed by eLife

3. The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

   This article has 22 authors:

   1. Rion Brattig-Correia
   2. Joana M Almeida
   3. Margot Julia Wyrwoll
   4. Irene Julca
   5. Daniel Sobral
   6. Chandra Shekhar Misra
   7. Sara Di Persio
   8. Leonardo Gastón Guilgur
   9. Hans-Christian Schuppe
   10. Neide Silva
   11. Pedro Prudêncio
   12. Ana Nóvoa
   13. Ana S Leocádio
   14. Joana Bom
   15. Sandra Laurentino
   16. Moises Mallo
   17. Sabine Kliesch
   18. Marek Mutwil
   19. Luis M Rocha
   20. Frank Tüttelmann
   21. Jörg D Becker
   22. Paulo Navarro-Costa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study reports the deep evolutionary conservation of a core genetic program regulating spermatogenesis in flies, mice, and humans. Convincing data were presented and supported the main conclusion. This work will be of interest to evolutionary and reproductive biologists.

   Reviewed by eLife

4. Benchmarking reveals superiority of deep learning variant callers on bacterial nanopore sequence data

   This article has 10 authors:

   1. Michael B Hall
   2. Ryan R Wick
   3. Louise M Judd
   4. An N Nguyen
   5. Eike J Steinig
   6. Ouli Xie
   7. Mark Davies
   8. Torsten Seemann
   9. Timothy P Stinear
   10. Lachlan Coin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows how a combination of the latest generation of Oxford Nanopore Technology long reads with state-of-the art variant callers enables bacterial variant discovery at an accuracy that matches or exceeds the current "gold standard" with short reads. The work thus heralds a new era, in which Illumina short-read sequencing no longer rules supreme. While the inclusion of a larger number of reference genomes would have enabled an even more fine-grained analysis, the evidence as it is supports the claims of the authors convincingly. The work will be of interest to anyone performing sequencing for outbreak investigations, bacterial epidemiology, or similar studies.

   Reviewed by eLife

5. EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

   This article has 39 authors:

   1. Lianlei Wang
   2. Xinyu Yang
   3. Sen Zhao
   4. Pengfei Zheng
   5. Wen Wen
   6. Kexin Xu
   7. Xi Cheng
   8. Qing Li
   9. Anas M Khanshour
   10. Yoshinao Koike
   11. Junjun Liu
   12. Xin Fan
   13. Nao Otomo
   14. Zefu Chen
   15. Yaqi Li
   16. Lulu Li
   17. Haibo Xie
   18. Panpan Zhu
   19. Xiaoxin Li
   20. Yuchen Niu
   21. Shengru Wang
   22. Sen Liu
   23. Suomao Yuan
   24. Chikashi Terao
   25. Ziquan Li
   26. Shaoke Chen
   27. Xiuli Zhao
   28. Pengfei Liu
   29. Jennifer E Posey
   30. Zhihong Wu
   31. Guixing Qiu
   32. DISCO study group (Deciphering Disorders Involving Scoliosis & COmorbidities)
   33. Shiro Ikegawa
   34. James R Lupski
   35. Jonathan J Rios
   36. Carol A Wise
   37. Jianguo T Zhang
   38. Chengtian Zhao
   39. Nan Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Genetic variants have been strongly implicated in idiopathic scoliosis (IS), however, the list of variants that are causative of IS is not complete and the cellular and molecular mechanisms that underlie IS are poorly understood. These authors combined human genetic analysis with zebrafish experiments to produce valuable evidence that alleles that impair function of EPHA4 cause IS, thereby extending our understanding of the basis of IS. The human genetic data are quite convincing but the zebrafish work lacks some validations and details.

   Reviewed by eLife

6. Mapping spatial patterns to energetic benefits in groups of flow-coupled swimmers

   This article has 3 authors:

   1. Sina Heydari
   2. Haotian Hang
   3. Eva Kanso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides a modeling regime that provides new insight into the energy-preservation parameters among schooling fish. The strength of the evidence supporting observations such as distilled dynamics between leading and lagging schooling fish which are derived from emergent properties is compelling. Overall, the study provides exciting insights into energetic coupling with respect to group swimming dynamics.

   Reviewed by eLife

7. Alasemenia, the earliest ovule with three wings and without cupule

   This article has 7 authors:

   1. Deming Wang
   2. Jiangnan Yang
   3. Le Liu
   4. Yi Zhou
   5. Peng Xu
   6. Min Qin
   7. Pu Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study describes the second earliest known winged ovule without a capule in the Famennian of Late Devonian. Using solid mathematical analysis, the authors demonstrate that three-winged seeds are more adapted to wind dispersal than one-, two- and four-winged seeds. The manuscript will help the scientific community to understand the origin and early evolutionary history of wind dispersal strategy of early land plants.

   Reviewed by eLife

8. UFMTrack, an Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

   This article has 9 authors:

   1. Mykhailo Vladymyrov
   2. Luca Marchetti
   3. Sidar Aydin
   4. Sasha GN Soldati
   5. Adrien Mossu
   6. Arindam Pal
   7. Laurent Gueissaz
   8. Akitaka Ariga
   9. Britta Engelhardt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work is important because it elucidates how immune cells migrate across the blood brain barrier. In the revised version of this study, the authors present a convincing framework to visualize, recognize and track the movement of different immune cells across primary human and mouse brain microvascular endothelial cells without the need for fluorescence-based imaging using microfluidic devices. This work will be of broad interest to the cancer biology, immunology and medical therapeutics fields.

   Reviewed by eLife

9. Coupling of saccade plans to endogenous attention during urgent choices

   This article has 3 authors:

   1. Allison T Goldstein
   2. Terrence R Stanford
   3. Emilio Salinas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of the temporal dynamics and cortical mechanisms of eye movements and the cognitive process of attention. The evidence supporting the conclusions is convincing and based on measuring the time course of the eye movement-attention interaction in a novel, carefully-controlled experimental task. This study will be of broad interest to psychologists and neuroscientists interested in the dynamics of cognitive processes.

   Reviewed by eLife

10. A double dissociation between semantic and spatial cognition in visual to default network pathways

    This article has 12 authors:

    1. Tirso RJ Gonzalez Alam
    2. Katya Krieger-Redwood
    3. Dominika Varga
    4. Zhiyao Gao
    5. Aidan J Horner
    6. Tom Hartley
    7. Michel Thiebaut de Schotten
    8. Magdalena Sliwinska
    9. David Pitcher
    10. Daniel S Margulies
    11. Jonathan Smallwood
    12. Elizabeth Jefferies

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This useful experiment seeks to better understand how memory interacts with incoming visual information to effectively guide human behavior. Using several methods, the authors identify two distinct pathways relating visual processing to the default mode network: one that emphasizes semantic cognition, and the other, spatial cognition. The evidence presented is solid and will be of interest to cognitive and systems neuroscientists.

    Reviewed by eLife