eLife

Latest preprint reviews

1. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2211.16879v3

2. Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages

   This article has 6 authors:

   1. Ainhoa Arbués
   2. Sarah Schmidiger
   3. Miriam Reinhard
   4. Sonia Borrell
   5. Sebastien Gagneux
   6. Damien Portevin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study describes the impact of mycobacterial genetic diversity on host-infection phenotypes by assessing the effect of different M. tuberculosis lineages on granulomatous inflammation using a 3D in vitro granuloma model. Despite being descriptive and showing mostly correlative relationships, the findings are useful and provide some solid support regarding the functional impact of M. tuberculosis's natural diversity on host-pathogen interactions. The study will interest researchers working on mycobacteria and motivate future studies to understand how genetic diversity influences virulence and immunity outcomes.

   Reviewed by eLife

3. Differences in size and number of embryonic type II neuroblast lineages correlate with divergent timing of central complex development between beetle and fly

   This article has 5 authors:

   1. Simon Rethemeier
   2. Sonja Fritzsche
   3. Dominik Mühlen
   4. Gregor Bucher
   5. Vera S Hunnekuhl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study is a valuable contribution to the question of evolutionary shifts in neuronal proliferation patterns and the timing of developmental progressions. The authors present convincing data which confirm the presence of type-II NB lineages in beetle with the same molecular characteristics as the Drosophila counterparts but differing in lineage size and number. The data lay the foundation for future analysis of the role and molecular characteristics of individual lineages and of whether differences in the identity, proliferation pattern and timing of developmental progression can be linked to differences in the development of functionality of the central complex.

   Reviewed by eLife

4. A molecular proximity sensor based on an engineered, dual-component guide RNA

   This article has 5 authors:

   1. Junhong Choi
   2. Wei Chen
   3. Hanna Liao
   4. Xiaoyi Li
   5. Jay Shendure

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important manuscript describes a creative approach using dual-component gRNAs to create a new class of molecular proximity sensors for genome editing. The authors demonstrate that this tool can be coupled with several different gene editing effectors, showing convincingly that the tool functions as intended. This study not only introduces a first-of-its kind approach, but through careful measurements also enables future further development of the technology.

   Reviewed by eLife

5. Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

   This article has 14 authors:

   1. Kira A Cozzolino
   2. Lynn Sanford
   3. Samuel Hunter
   4. Kayla Molison
   5. Benjamin Erickson
   6. Meaghan CS Courvan
   7. Taylor Jones
   8. Deepa Ajit
   9. Matthew D Galbraith
   10. Joaquín M Espinosa
   11. David Bentley
   12. Mary Ann Allen
   13. Robin D Dowell
   14. Dylan J Taatjes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study providing compelling evidence that the Mediator kinase module mediates an elevated inflammatory response, manifested by heightened cytokine levels, associated with Downs syndrome (DS) via transcriptional changes impacting cell signaling and metabolism that involve mobilization of nuclear receptors by altered lipid metabolites, which has significance for the treatment of DS and other chronic inflammatory conditions. Particular strengths of the study include the combined experimental approaches of transcriptomics, untargeted metabolomics and cytokine screens and the use of sibling matched cell lines (trisomy 21 vs disomy 21) from various donors. Evidence is also provided implicating the Mediator kinase module in controlling mRNA splicing and mitochondrial function that should stimulate new research to elucidate the mechanistic bases for these novel functions.

   Reviewed by eLife

6. Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration

   This article has 8 authors:

   1. Hyunggu Hahn
   2. Carole Daly
   3. John Little
   4. Nicole A Perry-Hauser
   5. Emmanuel Flores-Espinoza
   6. Asuka Inoue
   7. Bianca Plouffe
   8. Alex RB Thomsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that provides CCR7-APEX2 proximity labelling mass spectrometry data that is expected to provide new insights into CCR7 signaling partners and pathways. The study is technically easy to follow and the data is convincing. It will be interesting in the future to have complementary studies in lymphocytes/dendritic cells that endogenously express CCR7. This is of value to the community, and there are likely multiple opportunities to use the APEX2 data set to extend these findings, strengthen some claims, and even explore a new pathway identified in the APEX2 data set.

   Reviewed by eLife

7. GnRH pulse generator activity in mouse models of polycystic ovary syndrome

   This article has 8 authors:

   1. Ziyue Zhou
   2. Su Young Han
   3. Maria Pardo-Navarro
   4. Ellen G Wall
   5. Reena Desai
   6. Szilvia Vas
   7. David J Handelsman
   8. Allan E Herbison

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports findings on the GnRH pulse generator's role in androgen-exposed mouse models, providing further insights into PCOS pathophysiology and advancing the field of reproductive endocrinology. The experimental data were collected using cutting-edge methodologies and are solid. The findings, while interesting, are primarily applicable to mouse models, and their translation to human physiology requires cautious interpretation and further validation. This work will be of interest to endocrinologists and reproductive biologists.

   Reviewed by eLife

8. A Scene with an Invisible Wall—Navigational Experience Shapes Visual Scene Representation

   This article has 5 authors:

   1. Shi Pui Donald Li
   2. Jiayu Shao
   3. Zhengang Lu
   4. Michael McCloskey
   5. Soojin Park

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides novel evidence that navigational experiences can shape perceptual scene representations. The evidence presented is incomplete and would benefit from clearer explanations of the experiment design and careful discussion of alternative interpretations such as contextual associations or familiarity. The work will be of interest to cognitive psychologists and neuroscientists working on perception and navigation.

     [Editors’ note: A revised version of this work has been published in the Journal of Cognitive Neuroscience (DOI: https://doi.org/10.1162/JOCN.a.2409).]

   Reviewed by eLife

9. UNC-6/Netrin promotes both adhesion and directed growth within a single axon

   This article has 3 authors:

   1. Ev L Nichols
   2. Joo Lee
   3. Kang Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     These studies make a fundamental contribution to our understanding of axon-guidance mechanisms, focusing on the role of UNC-6/Netrin in the long-range growth and targeting of axons. Using state-of-the-art genetics and in vivo imaging, the authors provide compelling support for the finding that UNC-6/Netrin can act via both chemotaxis and haptotaxis. This work will be of interest to a wide variety of cell and developmental biologists and neuroscientists.

   Reviewed by eLife

10. An anatomical and physiological basis for flexible coincidence detection in the auditory system

    This article has 6 authors:

    1. Lauren J Kreeger
    2. Suraj Honnuraiah
    3. Sydney Maeker
    4. Siobhan Shea
    5. Gordon Fishell
    6. Lisa Goodrich

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Kreeger et al. convincingly demonstrate that octopus cells in the mouse cochlear nucleus, previously thought to rely primarily on excitatory inputs for coincidence detection, also receive glycinergic inhibitory synaptic inputs that influence their synaptic integration. Using advanced techniques, including genetic mouse models, optogenetics, microscopy, slice physiology, and computational modeling, this important study reveals that inhibition can shunt synaptic currents and alter the timing of dendritic EPSPs, both of which are significant for auditory processing. This research broadens the understanding of octopus cells' roles in sensory processing, highlighting the importance of inhibitory inputs in shaping fast, high-frequency neural response capabilities.

    Reviewed by eLife