eLife

Latest preprint reviews

1. Structural basis for molecular assembly of fucoxanthin chlorophyll a/c-binding proteins in a diatom photosystem I supercomplex

   This article has 8 authors:

   1. Koji Kato
   2. Yoshiki Nakajima
   3. Jian Xing
   4. Minoru Kumazawa
   5. Haruya Ogawa
   6. Jian-Ren Shen
   7. Kentaro Ifuku
   8. Ryo Nagao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study presents a high-resolution cryoEM structure of the supercomplex between photosystem I (PSI) and fucoxanthin chlorophyll a/c-binding proteins (FCPs) from the model diatom Thalassiosira pseudonana CCMP1335, revealing subunits, protein:protein interactions and pigments not previously seen in other diatoms or red/green photosynthetic lineages. Combining structural, sequence and phylogenetic analyses, the authors provide convincing evidence of conserved motifs crucial for the binding of FCPs, accompanied by interesting speculation about the mechanisms governing the assembly of PSI-FCP supercomplexes in diatoms and their implications for related PSI-LHC supercomplexes in plants. The findings set the stage for functional experiments that will further advance the fields of photosynthesis, bioenergy, ocean biogeochemistry and evolutionary relationships between photosynthetic organisms.

   Reviewed by eLife

2. Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

   This article has 6 authors:

   1. Zhengyu Wu
   2. Maojin Tian
   3. Sanyuan Fu
   4. Min Chen
   5. Rongjing Zhang
   6. Junhua Yuan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study by Wu et al presents convincing data on bacterial cell organization, demonstrating that the two structures that account for bacterial motility - the chemotaxis complex and the flagella - colocalize to the same pole in Pseudomonas aeruginosa cells, and expose the regulation underlying their spatial organization and functioning. This manuscript will be of interest to cell biologists, primarily those studying bacteria.

   Reviewed by eLife

3. An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish

   This article has 11 authors:

   1. Tian-Lun Chen
   2. Qiu-Sui Deng
   3. Kun-Zhang Lin
   4. Xiu-Dan Zheng
   5. Xin Wang
   6. Yong-Wei Zhong
   7. Xin-Yu Ning
   8. Ying Li
   9. Fu-Qiang Xu
   10. Jiu-Lin Du
   11. Xu-Fei Du

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important technical development for neural circuit tracing in larval zebrafish consists in an enhanced rabies virus for improved retrograde transneuronal tracing, supporting a new method for combined structural and functional brain mapping which is demonstrated with compelling evidence. The work will interest zebrafish neurobiologists for the identification of neuronal connectivity patterns while simultaneously monitoring circuit activity.

   Reviewed by eLife

4. sisterless A is required for activation of Sex lethal in the Drosophila germline

   This article has 3 authors:

   1. Raghav Goyal
   2. Ellen Baxter
   3. Mark Van Doren

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study reports that the Drosophila transcription factor sisterless A (sisA) regulates the expression of Sex-lethal (Sxl) in female germ cells. The data supporting claims regarding the genetic requirement of sisA are convincing, but the characterization of the cis-regulatory elements controlling Sxl expression in the female germline is viewed as incomplete. The work will be of significant interest to colleagues studying reproductive biology and sex determination.

   Reviewed by eLife

5. Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

   This article has 9 authors:

   1. Javier Ruiz-Navarro
   2. Sara Fernández-Hermira
   3. Irene Sanz-Fernández
   4. Pablo Barbeito
   5. Alfonso Navarro-Zapata
   6. Antonio Pérez-Martínez
   7. Francesc R Garcia-Gonzalo
   8. Víctor Calvo
   9. Manuel Izquierdo Pastor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses the Jurkat T cell model to study the role of Formin-like 1 β phosphorylation at S1086 on actin dynamics and exosome release at the immunological synapse. The evidence supporting these findings is compelling within the framework of the Jurkat model. As the Jurkat model is known to have a bias toward formin-mediated actin filament formation at the expense of Arp2/3-mediated branched F-actin foci observed in primary T cells, it will be beneficial in the future to confirm major findings in primary T cells.

   Reviewed by eLife

6. Re-focusing visual working memory during expected and unexpected memory tests

   This article has 2 authors:

   1. Sisi Wang
   2. Freek van Ede

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides significant insights into the dynamics of attentional re-orienting within visual working memory, demonstrating how expected and unexpected memory tests influence attention focus and re-focus. The evidence supporting these conclusions is convincing, with the use of state-of-the-art methodologies. This work will be of interest to cognitive neuroscientists studying attention and memory.

   Reviewed by eLife

7. Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina

   This article has 9 authors:

   1. Sidney P Kuo
   2. Wan-Qing Yu
   3. Prerna Srivastava
   4. Haruhisa Okawa
   5. Luca Della Santina
   6. David M Berson
   7. Gautam B Awatramani
   8. Rachel OL Wong
   9. Fred Rieke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that retinal bipolar cell subtype-specific differences in the size of synaptic ribbon-associated vesicle pools contribute to the transient versus sustained kinetics of the responses of retinal ganglion cells. The data are extensive and compelling. This work will be of broad interest to researchers working on synaptic transmission, retinal signal processing, and sensory neurobiology.

   Reviewed by eLife

8. Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque

   This article has 2 authors:

   1. Richard Johnston
   2. Matthew A Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding relating to how the state of arousal is represented within the superior colliculus (SC), a principal visuo-oculomotor structure. The main conclusion that the SC's neural representation of arousal is segregated from motor related output appears to have solid support by the data. The work will be of interest to sensory, motor and cognitive neuroscientists.

   Reviewed by eLife

9. Bridging verbal coordination and neural dynamics

   This article has 6 authors:

   1. Isaïh Schwab-Mohamed
   2. Manuel R Mercier
   3. Agnès Trebuchon
   4. Benjamin Morillon
   5. Leonardo Lancia
   6. Daniele Schön

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper reports on an important study that aims to move beyond current experimental approaches in speech production by (1) investigating speech in the context of a fully interactive task and (2) employing advanced methodology to record intracranial brain activity. Together these allow for examination of the unfolding temporal dynamics of brain-behaviour relationships during interactive speech. This approach and the analyses presented in support of the authors' claims pose convincing evidence.

   Reviewed by eLife

10. Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina

    This article has 10 authors:

    1. Sören J Zapp
    2. Mohammad H Khani
    3. Helene M Schreyer
    4. Shashwat Sridhar
    5. Varsha Ramakrishna
    6. Steffen Krüppel
    7. Matthias Mietsch
    8. Dario A Protti
    9. Dimokratis Karamanlis
    10. Tim Gollisch

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper introduces an efficient approach to identify subunits in the receptive fields of retinal ganglion cells. The general approach has been used in this application previously and this limits the conceptual advance of the paper. The improved speed is valuable, as it allows a more thorough exploration of the control parameters in this analysis and facilitates application to larger populations of cells. Validation of the approach is convincing. The paper would benefit from a more thorough exploration of the method and its limitations, or an extension of the new results about subunit populations.

    Reviewed by eLife