eLife

Latest preprint reviews

1. STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm

   This article has 10 authors:

   1. Sam Weeks
   2. Dubravka Pezic
   3. Martin Dodel
   4. Kunal Shah
   5. Amandeep Bhamra
   6. Stephen Henderson
   7. Silvia Surinova
   8. Tyson Sharp
   9. Faraz Mardakheh
   10. Suzana Hadjur

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This potentially valuable study reports new and unexpected roles of STAG3 in regulating exit from pluripotency in mouse embryonic stem cells (mESCs). However, the evidence for the proposed role of STAG3 in the post-transcriptional regulation of gene expression is viewed as yet incomplete. The work will be of interest to colleagues studying stem cells, early steps in differentiation, and gene regulation.

   Reviewed by eLife

2. Control of 3′ splice site selection by the yeast splicing factor Fyv6

   This article has 6 authors:

   1. Katherine A Senn
   2. Karli A Lipinski
   3. Natalie J Zeps
   4. Amory F Griffin
   5. Max E Wilkinson
   6. Aaron A Hoskins

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study addresses how 3' splice site choice is modulated by the conserved spliceosome-associated protein Fyv6. The authors provide compelling evidence that Fyv6 functions to enable selection of 3' splice sites distal to a branch point and in doing so antagonizes more proximal, suboptimal 3' splice sites.

   Reviewed by eLife

3. Sox9 marks limbal stem cells and is required for asymmetric cell fate switch in the corneal epithelium

   This article has 10 authors:

   1. Gabriella Rice
   2. Olivia Farrelly
   3. Sixia Huang
   4. Paola Kuri
   5. Ezra Curtis
   6. Lisa Ohman
   7. Ning Li
   8. Christopher Lengner
   9. Vivian Lee
   10. Panteleimon Rompolas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work advances our understanding of the regulation of corneal stem cell fate and differentiation, identifying Sox9 as a player in this process. The evidence supporting the conclusions is compelling, with rigorous genomic experiments and genetic mouse models that are state-of-the-art in the field. The work will be of broad interest to developmental, stem cell, and transcriptional biologists.

   Reviewed by eLife

4. Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

   This article has 18 authors:

   1. Tao Cheng
   2. Xiang Liu
   3. Yang Dong
   4. Yi-Meng Tian
   5. Yan-Yi Xing
   6. Chen-Yi Chen
   7. Cong Liu
   8. Yun-Fei Li
   9. Ying Huang
   10. Ding-Hao Zhuo
   11. Xiao Xu
   12. Jing-Yun Luan
   13. Xin-Xin Fu
   14. Zi-Xin Jin
   15. Jing Mo
   16. Xiang Xu
   17. Hong-Qing Liang
   18. Peng-Fei Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a useful analysis of the changes in chromatin organization and gene expression that occur during the differentiation of two cell types (anterior endoderm and prechordal plate) from a common progenitor in zebrafish, together with investigations into the molecular factors involved. Although the findings are consistent with previous work, the evidence presented appears to be incomplete and would benefit from more rigorous quantification of live imaging and Cre-Lox experiments, a stronger rationale and controls for experiments manipulating chromatin remodeling factors, and a strong justification for the explant model especially given differences between explant and whole embryo data. This work may be of interest to zebrafish developmental biologists investigating the mechanisms underlying specification.

   Reviewed by eLife, Review Commons

5. Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

   This article has 9 authors:

   1. Jixing Li
   2. Qixuan Wang
   3. Qian Zhou
   4. Lu Yang
   5. Yutong Shen
   6. Shujian Huang
   7. Shaonan Wang
   8. Liina Pylkkänen
   9. Zhiwu Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study a computational language model, i.e., HM-LSTM, to quantify the neural encoding of hierarchical linguistic information in speech, and addresses how hearing impairment affects neural encoding of speech. Overall the evidence for the findings is solid, although the evidence for different speech processing stages could be strengthened by a more rigorous temporal response function (TRF) analysis. The study is of potential interest to audiologists and researchers who are interested in the neural encoding of speech.

   Reviewed by eLife

6. T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

   This article has 5 authors:

   1. Yan Zhao
   2. Hanshuo Zhu
   3. Jinqian Li
   4. Hang Xu
   5. Li Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that Type 3 secretion translocons in Edwardsiella tarda and other bacteria activate the NAIP-NLRC4 inflammasome. The data from cellular and biochemical experiments showing that EseB is required for activation of the NLRC4 inflammasome are convincing. This paper is broadly relevant to those investigating host-pathogen interactions in diverse organisms.

   Reviewed by eLife

7. Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

   This article has 9 authors:

   1. Eyal Paz
   2. Sahil Jain
   3. Irit Gottfried
   4. Orna Staretz-Chacham
   5. Muhammad Mahajnah
   6. Pritha Bagchi
   7. Nicholas T Seyfried
   8. Uri Ashery
   9. Abdussalam Azem

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study presents interesting results aimed at explaining the effects of a human mutation on the mitochondrial import protein TIMM50 on mitochondrial function and neuronal excitability. While the evidence supporting the conclusions is convincing, the mechanisms driving changes in the levels of certain proteins within and outside the mitochondria (such as certain ion channels) remain unexplained. This paper will be of interest to scientists in the mitochondria field.

   Reviewed by eLife

8. Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study

   This article has 9 authors:

   1. Gillian AM Tarr
   2. Linda Chui
   3. Kim Stanford
   4. Emmanuel W Bumunang
   5. Rahat Zaheer
   6. Vincent Li
   7. Stephen B Freedman
   8. Chad R Laing
   9. Tim A McAllister

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study revealed numerous distinct lineages that evolved within a local human population in Alberta, Canada, leading to persistent cases of E. coli O157:H7 infections for over a decade and highlighting the ongoing involvement of local cattle in disease transmission, as well as the possibility of intermediate hosts and environmental reservoirs. This study also showed a shift towards more virulent stx2a-only strains becoming predominant in the local lineages. The evidence supporting the role played by cattle in the transmission system of human cases of E. coli O157:H7 in Alberta is solid.

   Reviewed by eLife

9. Glia control experience-dependent plasticity in an olfactory critical period

   This article has 9 authors:

   1. Hans C Leier
   2. Alexander J Foden
   3. Darren A Jindal
   4. Abigail J Wilkov
   5. Paola Van der Linden Costello
   6. Pamela J Vanderzalm
   7. Jaeda Coutinho-Budd
   8. Masashi Tabuchi
   9. Heather T Broihier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Periods in which experience regulates early plasticity in sensory circuits are well established, but the mechanisms that control these critical periods are poorly understood. In this important study, the authors examine early-life critical periods that regulate the Drosophila antennal lobe and show that constant odor exposure markedly reduces the volume, synapse number, and function of a specific glomerulus. The authors offer compelling evidence that these changes are mediated by the invasion of ensheathing glia into the glomerulus where they phagocytose connections via a mechanism involving the engulfment receptor Draper.

   Reviewed by eLife

10. Should I stay or should I go? Spatiotemporal dynamics of bacterial biofilms in confined flows

    This article has 6 authors:

    1. Massinissa Benbelkacem
    2. Gabriel Ramos
    3. Fatima El Garah
    4. Yara Abidine
    5. Christine Roques
    6. Yohan Davit

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study combines microfluidic experiments with mathematical modeling to elucidate the reciprocal interplay between flow dynamics and biofilm growth and detachment. Using Pseudomonas aeruginosa as a model organism, the authors identify several key regimes and stages of biofilm development. Overall, the comparison between experimental observations of biofilm behavior under varying flow conditions and corresponding theoretical predictions forms a compelling understanding of the processes involved in biofilm dynamics. The results will be of interest to researchers studying biofilms and their technological and biological applications.

    Reviewed by eLife