eLife

Latest preprint reviews

1. LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

   This article has 22 authors:

   1. Giulia Tombesi
   2. Shiva Kompella
   3. Giulia Favetta
   4. Chuyu Chen
   5. Marta Ornaghi
   6. Yibo Zhao
   7. Ester Morosin
   8. Martina Sevegnani
   9. Adriano Lama
   10. Antonella Marte
   11. Ilaria Battisti
   12. Lucia Iannotta
   13. Nicoletta Plotegher
   14. Laura Civiero
   15. Franco Onofri
   16. Britta J Eickholt
   17. Giovanni Piccoli
   18. Giorgio Arrigoni
   19. Dayne Beccano-Kelly
   20. Claudia Manzoni
   21. Loukia Parisiadou
   22. Elisa Greggio

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work begins to understand how BDNF regulates the phosphorylation and activity of LRRK2. The overall strength of evidence has been assessed as compelling, though some claims are only partially supported. The work will be of interest for those that might pursue specific LRRK2 interactions and mutational effects on these pathways as the work continues to develop.

   Reviewed by eLife

2. Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

   This article has 8 authors:

   1. Katrina Bartas
   2. May Hui
   3. Pieter Derdeyn
   4. Guilian Tian
   5. Jose J. Vasquez
   6. Ghalia Azouz
   7. Cindy M. Yamamoto
   8. Kevin T. Beier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study by Bartas and colleagues examined how patterns of monosynaptic input to specific cell types in the ventral tegmental area are altered by drugs of abuse. The authors applied a dimensionality reduction approach (principal component analysis) and showed that various drugs of abuse, and somewhat surprisingly the anesthesia alone (ketamine/xylasin), caused changes in the distribution of inputs labeled by the transsynaptic rabies virus. While there are some issues to be addressed, the evidence supporting the conclusions is overall solid, and provides information that is of value to the field, as well as a cautionary note on the interpretation of rabies virus-based tracing experiments.

   Reviewed by eLife

3. Identification of an early subset of cerebellar nuclei neurons in mice

   This article has 8 authors:

   1. Maryam Rahimi-Balaei
   2. Shayan Amiri
   3. Thomas Lamonerie
   4. Sih-Rong Wu
   5. Huda Y Zoghbi
   6. G Giacomo Consalez
   7. Daniel Goldowitz
   8. Hassan Marzban

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors are interested in the developmental origin of the neurons of the cerebellar nuclei. In this study, they identify a population of neurons with a specific complement of markers that originate in a distinct location from where cerebellar nuclear precursor cells have been thought to originate that show distinct developmental properties. The discovery of a new germinal zone giving rise to a new population of neurons is an exciting finding, and it enriches our understanding of cerebellar development. The important claims, better explained in the current version, are well supported by solid evidence with the authors using a wide range of technical approaches, including transgenic mice that allow them to disentangle the influence of distinct developmental organizers

   Reviewed by eLife

4. Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

   This article has 7 authors:

   1. Felix Michaud
   2. Ruggiero Francavilla
   3. Dimitry Topolnik
   4. Parisa Iloun
   5. Suhel Tamboli
   6. Frederic Calon
   7. Lisa Topolnik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study describes fundamental findings related to early disruptions in disinhibitory modulation exerted by VIP+ interneurons, in CA1 in a transgenic model of Alzheimer's disease pathology. The authors provide a compelling analysis at the cellular, synaptic, network, and behavioral levels on how these changes correlate and might be related to behavioral impairments during these early stages of AD pathology.

   Reviewed by eLife

5. Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species

   This article has 16 authors:

   1. Hans Martin Kjer
   2. Mariam Andersson
   3. Yi He
   4. Alexandra Pacureanu
   5. Alessandro Daducci
   6. Marco Pizzolato
   7. Tim Salditt
   8. Anna-Lena Robisch
   9. Marina Eckermann
   10. Mareike Töpperwien
   11. Anders Bjorholm Dahl
   12. Maria Louise Elkjær
   13. Zsolt Illes
   14. Maurice Ptito
   15. Vedrana Andersen Dahl
   16. Tim B Dyrby

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents new observations on white matter organisation at the micron scale, using a combination of synchrotron imaging and diffusion MRI across two species. Notably, the authors provide solid evidence for the fasciculation of axons within major fibre bundles into laminar structures, though these structures are not consistently observed across modalities or species. The study will be of general interest to neuroanatomists and those interested in white matter imaging.

   Reviewed by eLife

6. The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants

   This article has 4 authors:

   1. Sebastián Giunti
   2. María Gabriela Blanco
   3. María José De Rosa
   4. Diego Rayes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a conceptually appealing study in which the authors identify genes whose function is important for the development of inhibitory (GABA) neurons, and then demonstrate that a diet rich in ketone body β-hydroxybutyrate partially suppresses specific mutant phenotypes. The authors provide compelling evidence that features methods, data and analyses more rigorous than the current state-of-the-art. Conceptually, this is evidence of a rescue of a developmental defect with dietary metabolic intervention, linking, in an elegant way, the underpinning genetic mechanisms with novel metabolic pathways that could be used to circumvent the defects.

   Reviewed by eLife

7. Mining the neuroimaging literature

   This article has 5 authors:

   1. Jérome Dockès
   2. Kendra M Oudyk
   3. Mohammad Torabi
   4. Alejandro I de la Vega
   5. Jean-Baptiste Poline

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents an important ecosystem designed to support literature mining in biomedical research, showcasing a methodological framework that includes tools like Pubget for article collection and labelbuddy for text annotation. The solid evidence presented for these tools suggests they could streamline the analysis and annotation of scientific literature, potentially benefiting research across a range of biomedical disciplines. While the primary focus is on neuroimaging literature, the applicability of these methods and tools might extend further, offering an advance in the practices of meta-research and literature mining.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.03218

9. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.03218v3

10. Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

    This article has 17 authors:

    1. Sindre Lee-Ødegård
    2. Marit Hjorth
    3. Thomas Olsen
    4. Gunn-Helen Moen
    5. Emily Daubney
    6. David M Evans
    7. Andrea L Hevener
    8. Aldons J Lusis
    9. Mingqi Zhou
    10. Marcus M Seldin
    11. Hooman Allayee
    12. James Hilser
    13. Jonas Krag Viken
    14. Hanne Gulseth
    15. Frode Norheim
    16. Christian A Drevon
    17. Kåre Inge Birkeland

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This useful manuscript describes a proteomic analysis of plasma from subjects before and after an exercise regime consisting of endurance and resistance exercise. The work identifies a putative new exerkine, CD300LG, and finds associations of this protein with aspects of insulin sensitivity and angiogenesis. The characterization remains incomplete at present. Because CD300LG may have a transmembrane domain, one possibility is that exercise causes the release of extracellular vesicles containing this protein. As this study reports associations, additional studies will be needed to establish causality. The paper will hopefully prompt further studies to more fully elucidate the underlying biology.

    Reviewed by eLife