eLife

Latest preprint reviews

1. Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

   This article has 8 authors:

   1. Minsik Yun
   2. Do-Hyoung Kim
   3. Tal Soo Ha
   4. Kang-Min Lee
   5. Eungyu Park
   6. Markus Knaden
   7. Bill S Hansson
   8. Young-Joon Kim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work unravels how female Drosophila can assess their social context via chemosensory cues and modulate the sperm storage process after copulation accordingly. A compelling set of rigorous experiments uncovers specific pheromones that influence the excitability of the female brain receptivity circuit and their propensity to discard inseminate from a mating. This insight into neuronal mechanisms of sexual behavior plasticity is of general interest to scientists working in the fields of animal behavior, neuroscience, evolution, and sexual selection, as well as insect chemosensation and reproduction.

   Reviewed by eLife

2. Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis

   This article has 11 authors:

   1. Cuong Pham
   2. Yuji Komaki
   3. Anna Deàs-Just
   4. Benjamin Le Gac
   5. Christine Mouffle
   6. Clara Franco
   7. Agnès Chaperon
   8. Vincent Vialou
   9. Tomokazu Tsurugizawa
   10. Bruno Cauli
   11. Dongdong Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this work, the authors propose that astrocytic aquaporin 4 (AQP4) is the main pathway for tonic water efflux, without which astrocytes undergo cell swelling. These findings are important, because they shed light on key molecular mechanisms implicated with the regulation of brain water homeostasis. The authors use a broad set of experimental tools (e.g., acute brain slices, in vivo recording, and diffusion-weighted MRI) but the evidence remains incomplete without ruling out non-specific effects of TGN-020, and without evidence that changes in sulforhodamine B fluorescence can be used as reliable readouts of cell volume dynamics.

   Reviewed by eLife

3. DNA methylome regulates virulence and metabolism in Pseudomonas syringae

   This article has 7 authors:

   1. Jiadai Huang
   2. Fang Chen
   3. Beifang Lu
   4. Yue Sun
   5. Youyue Li
   6. Canfeng Hua
   7. Xin Deng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents findings on DNA methylation as an efficient epigenetic transcriptional regulating strategy in bacteria. The authors utilized single-molecule real-time sequencing to profile the DNA methylation landscape across three model pathovars of Pseudomonas syringae, identifying significant epigenetic mechanisms through the Type-I restriction-modification system, which includes a conserved sequence motif associated with N6-methyladenine. The evidence presented is solid and the study provides novel insights into the epigenetic mechanisms of P. syringae, expanding the understanding of bacterial pathogenicity and adaptation.

   Reviewed by eLife

4. Stratification of viral shedding patterns in saliva of COVID-19 patients

   This article has 16 authors:

   1. Hyeongki Park
   2. Raiki Yoshimura
   3. Shoya Iwanami
   4. Kwang Su Kim
   5. Keisuke Ejima
   6. Naotoshi Nakamura
   7. Kazuyuki Aihara
   8. Yoshitsugu Miyazaki
   9. Takashi Umeyama
   10. Ken Miyazawa
   11. Takeshi Morita
   12. Koichi Watashi
   13. Christopher B. Brooke
   14. Ruian Ke
   15. Shingo Iwami
   16. Taiga Miyazaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful work by Park attempts to use machine learning algorithms to identify correlates of different observed shedding patterns in two COVID-19 cohorts. The evidence supporting the study conclusions is incomplete due to the lack of uniformity in assays between the 2 cohorts, relevant metadata (previous infection/vaccination status, viral variant), early viral load data in the cohorts, and incomplete statistical analyses. With a strengthened analysis, the work may be of interest to virologists, clinicians, and public health scientists.

   Reviewed by eLife

5. Explaining the counter-intuitive effectiveness of trophectoderm biopsy for PGT-A using computational modelling

   This article has 5 authors:

   1. Benjamin M Skinner
   2. Manuel Viotti
   3. International Registry of Mosaic Embryo Transfers (IRMET)
   4. Darren K Griffin
   5. Peter JI Ellis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable computational model for elaborating on the interpretation of chromosomal mosaicism in preimplantation embryos. The evidence supporting the claims of the authors is incomplete due to the assumption that is possible to quantify the cells in the embryo, oversimplification of mitotic errors, and the inclusion of the self-correction premise. The work will be of interest to embryologists, and geneticists working on reproductive medicine.

   Reviewed by eLife

6. A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides

   This article has 15 authors:

   1. Malik Zohaib Ali
   2. Taru S Dutt
   3. Amy MacNeill
   4. Amanda Walz
   5. Camron Pearce
   6. Ha Lam
   7. Jamie S Philp
   8. Johnathan Patterson
   9. Marcela Henao-Tamayo
   10. Richard Lee
   11. Jiuyu Liu
   12. Gregory T Robertson
   13. Anthony J Hickey
   14. Bernd Meibohm
   15. Mercedes Gonzalez Juarrero

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this useful study, the authors report the efficacy, hematological effects, and inflammatory response of the BPaL regimen (containing bedaquiline, pretomanid, and linezolid) compared to a variation in which Linezolid is replaced with the preclinical development candidate spectinamide 1599, administered by inhalation in tuberculosis-infected mice. The authors provide convincing evidence that supports the replacement of Linezolid in the current standard of care for drug-resistant tuberculosis. The work will be of interest to those studying tuberculosis treatment regimens.

   Reviewed by eLife

7. Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

   This article has 11 authors:

   1. Wenjing Liu
   2. Shujin Li
   3. Mu Yang
   4. Jie Ma
   5. Lu Liu
   6. Ping Fei
   7. Qianchun Xiang
   8. Lulin Huang
   9. Peiquan Zhao
   10. Zhenglin Yang
   11. Xianjun Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study explores the role of calcyphosine-like (CAPSL) in Familial Exudative Vitreoretinopathy (FEVR) via the MYC pathway, offering valuable insights into disease mechanisms that are supported by a solid, multi-pronged approach. The manuscript, which presents the phenotype of an interesting new mouse model, provides convincing evidence that CAPSL variants cause disease.

   Reviewed by eLife

8. Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoids

   This article has 13 authors:

   1. Wei Jie Wong
   2. Yi Wen Zhu
   3. Hai Ting Wang
   4. Jia Wen Qian
   5. Ziyi Li
   6. Song Li
   7. Zhao Yuan Liu
   8. Wei Guo
   9. Shuang Yan Zhang
   10. Bing Su
   11. Fang Ping He
   12. Kang Wang
   13. Florent Ginhoux

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on the mechanisms underlying a rare brain disease using an organoid system. In this revised version, there are remaining reviewers' comments that are not yet addressed and as such, while the data presented are solid, the evidence supporting some of the claims is deemed incomplete. The work will be of interest to neuroscientists and clinicians aiming to understand and combat similar neurodegenerative disorders.

   Reviewed by eLife

9. Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

   This article has 6 authors:

   1. Yuqi Cai
   2. Zhirong Zhao
   3. Mingyue Shi
   4. Mingfang Zheng
   5. Ling Gong
   6. Miao He

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study the authors revisited the question of the embryonic origin of telencephalic oligodendrocytes using some new and powerful genetic tools. There is convincing evidence to support previous suggestions of a predominantly cortical origin of oligodendrocytes in the cerebral cortex, however the new studies suggest that LGE/CGE-derived oligodendrocytes make a modest contribution in some areas, while MGE/POA-derived oligodendrocytes make a small but enduring contribution. The findings are valuable and should be of interest to developmental and myelin biologists.

   Reviewed by eLife

10. Chemokine expression profile of an innate granuloma

    This article has 5 authors:

    1. Megan E Amason
    2. Cole J Beatty
    3. Carissa K Harvest
    4. Daniel R Saban
    5. Edward A Miao

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable study advances the understanding of granuloma formation by identifying a key chemokine receptors in containing infection by a specific species of bacteria. The evidence supporting this is solid, providing a spatial transcriptomic dataset spanning granuloma formation and resolution by a specific species of bacteria. The work should be of interest to microbiologists and immunologists.

    Reviewed by eLife