eLife reviews preprints in the life sciences and medicine.

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  1. Diurnal rhythmicity in metabolism and salivary effector expression shapes host colonization by aphids

    1. Jinlong Han
    2. Daniel Kunk
    3. Meihua Cui
    4. Yoshiahu Goldstein
    5. Vered Tzin
    6. Vamsi J. Nalam

    • Curated by eLife

      eLife assessment

      In this study, the authors found that a species of aphid that is a known agricultural pest salivated longer and produced more honeydew when feeding at night. The authors identified aphid genes with diurnal expression patterns, including potential saliva-related genes. Silencing these genes reduced aphid performance only on real plants, suggesting a specific role in plant feeding. While this study is valuable for understanding plant-insect interactions in agriculture, it is currently incomplete, as further research is needed to elucidate the function of the identified genes.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

    1. Jae Hun Shin
    2. Jooyoung Park
    3. Jaechul Lim
    4. Jaekwang Jeong
    5. Ravi K Dinesh
    6. Stephen E Maher
    7. Jeonghyun Kim
    8. Soyeon Park
    9. Jun Young Hong
    10. John Wysolmerski
    11. Jungmin Choi
    12. Alfred LM Bothwell

    • Curated by eLife

      eLife Assessment

      This valuable study proposes that protein secreted by colon cancer cells induces cells with Paneth-like properties that favor colon cancer metastasis. The evidence supporting the conclusions is strong but would benefit from more direct experiments to test the functional role of Paneth-like cells and to monitor metastasis from colon tumors. The work will be of interest to researchers studying colon cancer metastasis.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  3. Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes

    1. Hope M Healey
    2. Hayden B Penn
    3. Clayton M Small
    4. Susan Bassham
    5. Vithika Goyal
    6. Micah A Woods
    7. William A Cresko

    • Curated by eLife

      eLife Assessment

      This study provides a valuable new resource to investigate the molecular basis of the particular features characterizing the pipefish embryo. The authors found both unique and shared gene expression patterns in pipefish organs compared with other teleost fishes. The solid data collected in this unconventional model organism will give new insights into understanding the extraordinary adaptations of the Syngnathidae family and will be of interest in the domain of evolution of fish development.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  4. The autophagy protein ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

    1. Pooja Popli
    2. Arin K Oestreich
    3. Vineet K Maurya
    4. Marina N Rowen
    5. Yong Zhang
    6. Michael J Holtzman
    7. Ramya Masand
    8. John P Lydon
    9. Shizuo Akira
    10. Kelle Moley
    11. Ramakrishna Kommagani

    • Curated by eLife

      eLife Assessment

      This important study reports a novel function of ATG14 in preventing pyroptosis and inflammation in oviduct cells, thus allowing smooth transport of the early embryo to the uterus and implantation. The data supporting the main conclusion are convincing. This work will be of interest to reproductive biologists and physicians practicing reproductive medicine.

    Reviewed by eLife

    15 evaluationsAppears in 1 listLatest version Latest activity

  6. Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi

    1. Hieng Chiong Tie
    2. Haiyun Wang
    3. Divyanshu Mahajan
    4. Hilbert Yuen In Lam
    5. Xiuping Sun
    6. Bing Chen
    7. Yuguang Mu
    8. Lei Lu

    • Curated by eLife

      eLife Assessment

      This important study offers convincing evidence that intra-Golgi transport slows from cis to trans and varies between cargos even within the same cisternae, supporting a more stable compartment model. Using nocodazole-induced ministacks, the authors show cargo-specific transport kinetics with distinct velocities and residence times. These findings refine the cisternal progression model and prompt further investigation into alternative mechanisms, such as rapid partitioning or rim progression. This study will be of interest to cell biologists studying membrane trafficking, Golgi organization, and protein secretion, as well as researchers investigating the mechanisms of organelle dynamics and the molecular basis of intracellular transport.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  7. Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure

    1. Stefan Passlick
    2. Ghanim Ullah
    3. Christian Henneberger

    • Curated by eLife

      eLife assessment

      The authors show that short bouts of chemical ischemia lead to presynaptic changes in glutamate release and long-term potentiation, whereas longer bouts of chemical ischemia lead to synaptic failure and presumably cell death. This convincing work relies on rigorous electrophysiology/imaging experiments and data analysis. It is important as it provides new mechanistic details on chemical ischemia, which could offer potential insights into ischemic stroke in vivo.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  8. A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

    1. Yihe Weng
    2. Johann Kruschwitz
    3. Laura M Rueda-Delgado
    4. Kathy L Ruddy
    5. Rory Boyle
    6. Luisa Franzen
    7. Emin Serin
    8. Tochukwu Nweze
    9. Jamie Hanson
    10. Alannah Smyth
    11. Tom Farnan
    12. Tobias Banaschewski
    13. Arun LW Bokde
    14. Sylvane Desrivières
    15. Herta Flor
    16. Antoine Grigis
    17. Hugh Garavan
    18. Penny A Gowland
    19. Andreas Heinz
    20. Rüdiger Brühl
    21. Jean-Luc Martinot
    22. Marie-Laure Paillère Martinot
    23. Eric Artiges
    24. Jane McGrath
    25. Frauke Nees
    26. Dimitri Papadopoulos Orfanos
    27. Tomas Paus
    28. Luise Poustka
    29. Nathalie Holz
    30. Juliane Fröhner
    31. Michael N Smolka
    32. Nilakshi Vaidya
    33. Gunter Schumann
    34. Henrik Walter
    35. Robert Whelan
    36. IMAGEN Consortium

    • Curated by eLife

      eLife assessment

      This study presents an important finding on the relationship between brain activity related to sustained attention and substance use in adolescence/early adulthood with a large longitudinal dataset. The evidence supporting the claims of the authors is convincing. The work will be of interest to cognitive neuroscientists, psychologists, and clinicians working on substance use or addiction.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  9. A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

    1. Yihe Weng
    2. Johann Kruschwitz
    3. Laura M Rueda-Delgado
    4. Kathy L Ruddy
    5. Rory Boyle
    6. Luisa Franzen
    7. Emin Serin
    8. Tochukwu Nweze
    9. Jamie Hanson
    10. Alannah Smyth
    11. Tom Farnan
    12. Tobias Banaschewski
    13. Arun LW Bokde
    14. Sylvane Desrivières
    15. Herta Flor
    16. Antoine Grigis
    17. Hugh Garavan
    18. Penny A Gowland
    19. Andreas Heinz
    20. Rüdiger Brühl
    21. Jean-Luc Martinot
    22. Marie-Laure Paillère Martinot
    23. Eric Artiges
    24. Jane McGrath
    25. Frauke Nees
    26. Dimitri Papadopoulos Orfanos
    27. Tomas Paus
    28. Luise Poustka
    29. Nathalie Holz
    30. Juliane Fröhner
    31. Michael N Smolka
    32. Nilakshi Vaidya
    33. Gunter Schumann
    34. Henrik Walter
    35. Robert Whelan
    36. IMAGEN Consortium

    • Curated by eLife

      eLife assessment

      This study presents an important finding on the relationship between brain activity related to sustained attention and substance use in adolescence/early adulthood with a large longitudinal dataset. The evidence supporting the claims of the authors is convincing. The work will be of interest to cognitive neuroscientists, psychologists, and clinicians working on substance use or addiction.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  10. Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis

    1. Kyusang Yoo
    2. Young-Woo Jo
    3. Takwon Yoo
    4. Sang-Hyeon Hann
    5. Inkuk Park
    6. Yea-Eun Kim
    7. Ye Lynne Kim
    8. Joonwoo Rhee
    9. In-Wook Song
    10. Ji-Hoon Kim
    11. Daehyun Baek
    12. Young-Yun Kong

    • Curated by eLife

      eLife assessment

      The study has identified a cell type in muscle that is characterized as an adipogenic progenitor cell that is capable of promoting regeneration through the action of BDNF, a prominent growth factor regulated by GDNF in Schwann cells. These results represent an important cellular explanation for nerve regeneration. The revised analysis is solid but the work remains incomplete due to a lack of evidence that BDNF is produced during the process through the action of GDNF.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity
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