eLife

Latest preprint reviews

1. ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

   This article has 6 authors:

   1. Jing Sun
   2. Desmond Choy
   3. Nicolas Sompairac
   4. Shirin Jamshidi
   5. Michele Mishto
   6. Shahram Kordasti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     ImmCellTyper presents a useful toolkit for CyTOF data analysis, integrating BinaryClust for semi-supervised clustering and cell type annotation. The evidence supporting the findings is convincing, with appropriate and validated methodology. This tool will be helpful to researchers in immunology and cytometry, offering a robust solution for cell type identification and differential analysis.

   Reviewed by eLife

2. Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum

   This article has 3 authors:

   1. Pyae Hein Htet
   2. Edward Avezov
   3. Eric Lauga

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work explores the physical principles underlying fluid flow and luminal transport within the endoplasmic reticulum. Its important contribution is to highlight the strong physical constraints imposed by viscous dissipation in nanoscopic tubular networks. In particular, the work presents convincing evidence based on theoretical analysis that commonly discussed mechanisms such as tubular contraction are unlikely to be at the origin of the observed transport velocities. As such, it will be of relevance to cell biologists and physicists interested in organelle dynamics. As this study is solely theoretical and deals with order of magnitude estimates, its main conclusions await experimental validation.

   Reviewed by eLife

3. Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

   This article has 6 authors:

   1. MinHyuk Lee
   2. Se Hoon Park
   3. Kyeung Min Joo
   4. Jae Young Kwon
   5. Kyung-Hoon Lee
   6. KyeongJin Kang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important new insight into how non-synaptic interactions affect the activity of adjacent gustatory neurons housed within the same sensillum. The conclusions are supported by convincing electrophysiological, behavioral, and genetic data. This work will be of interest to neuroscientists studying chemosensory processing or regulation of neuronal excitability.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2209.08066v4

5. Sensory-memory interactions via modular structure explain errors in visual working memory

   This article has 3 authors:

   1. Jun Yang
   2. Hanqi Zhang
   3. Sukbin Lim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important computational study provides new insights into how neural dynamics may lead to time-evolving behavioral errors as observed in certain working-memory tasks. By combining ideas from efficient coding and attractor neural networks, the authors construct a two-module network model to capture the sensory-memory interactions and the distributed nature of working memory representations. They provide convincing evidence supporting that their two-module network, although none of the alternative circuit structures they considered can account for error patterns reported in orientation-estimation tasks with delays.

   Reviewed by eLife

6. Dynamic organization of visual cortical networks inferred from massive spiking datasets

   This article has 3 authors:

   1. Colin Graber
   2. Yurii Vlasov
   3. Alexander Schwing

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors describe a model for tracking time-varying functional connectivity between neurons from multi-electrode spike recordings. This is an interesting and potentially useful approach to an open problem in neural data analysis, and could be an essential tool for investigating the neural code from large-scale in-vivo recordings of spiking activity. However, the evidence is incomplete: systematic comparisons with existing methods and/or demonstration of its utility relative to conventional methods are essential to demonstrate the usefulness of the method.

   Reviewed by eLife

7. Subcortical correlates of consciousness with human single neuron recordings

   This article has 11 authors:

   1. Michael Pereira
   2. Nathan Faivre
   3. Fosco Bernasconi
   4. Nicholas Brandmeir
   5. Jacob E Suffridge
   6. Kaylee Tran
   7. Shuo Wang
   8. Victor Finomore
   9. Peter Konrad
   10. Ali Rezai
   11. Olaf Blanke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports human single-neuron recordings in subcortical structures while participants performed a tactile detection task around the perceptual threshold. The study and the analyses are well conducted and provide convincing evidence that the thalamus and the subthalamic nucleus contain neurons whose activity correlates with the task, with stimulus presentation, and even with whether the stimulation is consciously detected or not. The study will be relevant for researchers interested in the role of subcortical structures in tactile perception and the neural correlates of consciousness.

   Reviewed by eLife

8. Identification of novel human microcephaly-linked protein Mtss2 that mediates cortical progenitor cell division and corticogenesis through Nedd9-RhoA

   This article has 11 authors:

   1. Aurelie Carabalona
   2. Henna Kallo
   3. Maryanne Gonzalez
   4. Liliia Andriichuk
   5. Ellinoora Elomaa
   6. Florence Molinari
   7. Christiana Fragkou
   8. Pekka Lappalainen
   9. Marja W Wessels
   10. Juha Saarikangas
   11. Claudio Rivera

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important contribution to the field evaluated the function of the cytoskeletal protein ABBA in mediating key aspects of mitosis of neuronal precursor cells. The authors provide compelling evidence that ABBA interactions with its signaling partners is related to the development of at least some cases of microcephaly-a developmental anomaly associated with intellectual disability and other neurological findings.

   Reviewed by eLife

9. Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes

   This article has 6 authors:

   1. Ji Eun Ryu
   2. Kyu-Won Shim
   3. Hyun Woong Roh
   4. Minsung Park
   5. Jae-Hyung Lee
   6. Eun Young Kim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work describes a circadian regulation in the expression of HERP, a regulator of endoplasmic reticulum calcium, in primary astrocytic cultures. This work is important because it highlights the potential importance of circadian rhythms in astrocytes, even though making a direct comparison between these rhythms in vitro and in vivo remains challenging. The technical approaches used in this work (RNA-seq, siRNA, Ca2+ imaging) are a solid support for data interpretation.

   Reviewed by eLife

10. Optogenetic silencing of hippocampal inputs to the retrosplenial cortex causes a prolonged disruption of spatial working memory

    This article has 3 authors:

    1. Bárbara Pinto-Correia
    2. Patrícia Caldeira-Bernardo
    3. Miguel Remondes

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The authors report that optogenetic inhibition of hippocampal axon terminals in retrosplenial cortex impairs the performance of a delayed non-match to place task. Elucidating the role of hippocampal projections to the retrosplenial cortex in memory and decision-making behaviors is important. However, the strength of evidence for the paper's claims is incomplete.

    Reviewed by eLife