eLife

Latest preprint reviews

1. Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

   This article has 6 authors:

   1. Kiwon Park
   2. Dohoon Lee
   3. Jiseok Jeong
   4. Sungwon Lee
   5. Sun Kim
   6. Kwangseog Ahn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents two main findings regarding HIV-1 genomic integration. The first, based on convincing evidence in primary cell models, is that HIV-1 induces R loop formation, though the viral driver of this process remains undefined. The second, based on model cell systems with limited physiological relevance to HIV-1, is that a portion of HIV-1 genomes integrates in the vicinity of where R loops form. This finding has the potential to offer fundamental insight into HIV-1 integration, but the strength of the presented evidence was viewed as incomplete and needing additional validation by more direct experimental methods in order to understand what the mechanistic relationship between the formation of R loops and HIV-1 integration is.

   Reviewed by eLife

2. Chromatin accessibility variation provides insights into missing regulation underlying immune-mediated diseases

   This article has 2 authors:

   1. Raehoon Jeong
   2. Martha L Bulyk

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper addresses a significant question regarding the low overlap between genetic discoveries for human complex diseases and those for gene expression by emphasizing the contribution of cell-type-specific chromatin accessibility QTLs. The analyses supporting the main claims are convincing, and the key conclusions are valuable and of interest to readers in the fields of human genetics and functional genomics.

   Reviewed by eLife

3. Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form of Cacopsylla chinensis

   This article has 6 authors:

   1. Zhixian Zhang
   2. Jianying Li
   3. Yilin Wang
   4. Zhen Li
   5. Xiaoxia Liu
   6. Songdou Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports that the neurohormone, bursicon, and its receptor, play a role in the seasonal polyphenism of the bug Cacopsylla chinensis. Low temperature activates the bursicon signaling pathway during the transition from the summer to the winter form, affecting cuticle pigment and thickness as well as chitin content. The solid experiments reveal how bursicon signaling, which is modulated by the microRNA miR-6012, regulates features of polyphenism related to the exoskeleton, although it is less clear what the upstream regulatory events are.

   Reviewed by eLife

4. Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

   This article has 14 authors:

   1. Shih-Wen Huang
   2. Yein-Gei Lai
   3. Hao-Ting Liao
   4. Chin-Ling Chang
   5. Ruo-Yu Ma
   6. Yung-Hsiang Chen
   7. Yae-Huei Liou
   8. Zhen-Qi Wu
   9. Yu-Chen Wu
   10. Ko-Jiunn Liu
   11. Yen-Tsung Huang
   12. Jen-Lung Yang
   13. Ming-Shen Dai
   14. Nan-Shih Liao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study the authors develop an elegant lung metastasis mouse model that closely mimics the events in human patients. They provide convincing evidence for the effectiveness of IL-15/12-conditioned NK cells in this design, which was also critical for the authors being able to conclusively reveal the T cell-dependency of NK-cell-mediated long-term control of experimental metastasis. Of note, an investigator-initiated clinical trial demonstrated that similar NK cell infusions in cancer patients after resections were safe and showed signs of efficacy, which is of promising clinical application value.

   Reviewed by eLife

5. Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

   This article has 8 authors:

   1. San Pin Steve Wu
   2. Elvis Quiroz
   3. Tianyuan Wang
   4. Skylar G Montague Redecke
   5. Xin Xu
   6. Lin Lin
   7. Matthew L Anderson
   8. Francesco J DeMayo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study employed a multi-omics approach to elucidate the regulatory mechanism underlying parturition and myometrial quiescence. The data presented to support the main conclusion are solid. This work will be of interest to both basic researchers who work on reproductive biology and clinicians who practice reproductive medicine.

   Reviewed by eLife

6. Associations of age at diagnosis of breast cancer with incident myocardial infarction and heart failure: A prospective cohort study

   This article has 7 authors:

   1. Jie Liang
   2. Yang Pan
   3. Wenya Zhang
   4. Darui Gao
   5. Yongqian Wang
   6. Wuxiang Xie
   7. Fanfan Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, the authors sought to investigate the associations of age at breast cancer onset with the incidence of myocardial infarction and heart failure. Based on results from a series of compelling statistical analyses, the authors conclude that a younger onset age of breast cancer is associated with myocardial infarction and heart failure, highlighting the need to carefully monitor the cardiovascular status of women who have been diagnosed with breast cancer.

   Reviewed by eLife

7. Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

   This article has 15 authors:

   1. Aleksandra Prochera
   2. Anoohya N Muppirala
   3. Gavin A Kuziel
   4. Salima Soualhi
   5. Amy Shepherd
   6. Liang Sun
   7. Biju Issac
   8. Harry J Rosenberg
   9. Farah Karim
   10. Kristina Perez
   11. Kyle H Smith
   12. Tonora H Archibald
   13. Seth Rakoff-Nahoum
   14. Susan J Hagen
   15. Meenakshi Rao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important findings on the function of enteric glia expressing proteolipid protein 1 (PLP1+ glia). The evidence supporting the claims of the authors is solid, although the inclusion of additional data showing the mechanisms by which PLP1+ enteric glia acts on Paneth cells would have strengthened the study. The work will be of interest to colleagues studying intestinal biology.

   Reviewed by eLife

8. Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

   This article has 15 authors:

   1. Yanling Huang
   2. Haocong Mo
   3. Jie Yang
   4. Luyang Gao
   5. Tian Tao
   6. Qing Shu
   7. Wenying Guo
   8. Yawen Zhao
   9. Jingya Lyu
   10. Qimeng Wang
   11. Jinghui Guo
   12. Hening Zhai
   13. Linyan Zhu
   14. Hui Chen
   15. Geyang Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study focuses on the regulation of GLP-1 in enteroendocrine L cells and how this may be stimulated by the mechanogated ion channel Piezo1 and the CaMKKbeta-CaMKIV-mTORC1 signaling pathway. The work is innovative and is considered valuable, as the hypothesis that is being tested may have significant mechanistic and translational implications. Data to support the proposed mechanism were considered incomplete, yet data to support the overall physiological characterization were considered solid.

   Reviewed by eLife

9. Frequent intertrophic transmission of Wolbachia by parasitism but not predation

   This article has 6 authors:

   1. Zhi-Chao Yan
   2. Lan-Da Qi
   3. Han-Le Ji
   4. Xiao-Xiang Wang
   5. Xiao-Yue Hong
   6. Yuan-Xi Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using experiments in the white fly, this manuscript provides evidence that the bacterial symbiont Wolbachia can be transmitted from parasitoid wasps to their insect hosts. Characterizing the transfer of Wolbachia between insect species is a valuable attempt to explain the widespread of this intracellular bacterium. This paper is incomplete as it does not furnish sufficient data to support several of its claims for which additional methods and data are necessary.

   Reviewed by eLife

10. Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

    This article has 11 authors:

    1. Marilina Raices
    2. Fabiola Balmir
    3. Nicola Silva
    4. Wei Li
    5. McKenzie K Grundy
    6. Dane K Hoffman
    7. Elisabeth Altendorfer
    8. Carlos Jaime Camacho
    9. Kara A Bernstein
    10. Monica P Colaiácovo
    11. Judith L Yanowitz

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study combines genetic, cell biological, and interaction data to propose a model of meiotic double-strand break regulation in C. elegans. Solid evidence supports the main conclusions, while by nature of a screening-type study, more may be needed to solidify speculations in future studies. Yet, comprehensive cataloging of the physical and genetic interactions of factors required for meiotic double-strand break is useful information for the field.

    Reviewed by eLife