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10. Mitochondrial calcium modulates odor-mediated behavioral plasticity in Caenorhabditis elegans

    This article has 4 authors:

    1. Hee Kyung Lee
    2. Abe Gayle Santos
    3. Kyu-Sang Park
    4. Kyoung-hye Yoon

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents important findings that will allow for a better understanding of the role of mitochondria in behaviours of C. elegans. There is convincing evidence that mutants in a subunit of the mitochondrial calcium uniporter (MCU-1) show defects in olfactory adaptation and this gene regulates neuropeptide secretion and allows for behavioural modulation in C. elegans. However, the evidence that mitochondrial calcium modulates odour-based behaviour in C. elegans is incomplete. This claim would require support from calcium imaging in conditioned WT and mcu-1 animals. This work would be of interest to labs working on behaviours across phyla.

    Reviewed by eLife