eLife

Latest preprint reviews

1. Poseidon – A framework for archaeogenetic human genotype data management

   This article has 6 authors:

   1. Clemens Schmid
   2. Ayshin Ghalichi
   3. Thiseas C. Lamnidis
   4. Dhananjaya B. A. Mudiyanselage
   5. Wolfgang Haak
   6. Stephan Schiffels

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper describes an important software framework for the curation, retrieval, and analysis of ancient human genomic data and their associated metadata, overcoming long-standing coordination and harmonization issues in ancient human genomics. The resource is built on compelling and sometimes exceptional principles of software engineering and reproducibility, and the authors make an excellent case that their resource will be of practical use to many researchers studying human history using DNA. The main issues include natural uncertainties regarding future funding and maintenance of this resource, as well as deviation from established standards in other areas of genomics.

   Reviewed by eLife

2. Adaptations in wing morphology rather than wingbeat kinematics enable flight in small hoverfly species

   This article has 4 authors:

   1. Camille Le Roy
   2. Nina Tervelde
   3. Thomas Engels
   4. Florian T Muijres

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study addresses how wing morphology and kinematics change across hoverflies of different body sizes. The authors provide convincing evidence that there is no significant correlation between body size and wing kinematics across 28 species and instead argue that non-trivial changes in wing size and shape evolved to support flight across the size range. Overall, this paper illustrates the power and beauty of an integrative approach to animal biomechanics and will be of broad interest to biologists, physicists and engineers.

   Reviewed by eLife

3. Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

   This article has 16 authors:

   1. Weigao Zhang
   2. Hu Liu
   3. Danyang Zhang
   4. Yuguo Yi
   5. Liang Tao
   6. Yunfeng Zhu
   7. Shuxian Huang
   8. Xunan Zhao
   9. Qianchao Shao
   10. Peiqi Li
   11. Yiwen Weng
   12. Wei Lu
   13. Jianfa Zhang
   14. Haibing Zhang
   15. Yuxin Chen
   16. Dan Weng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides insights into the physiological role of RIPK1 in liver physiology, particularly during short-term fasting. The discovery that RIPK1 deficiency sensitizes the liver to acute injury and hepatocyte apoptosis is based on convincing evidence, highlighting the importance of RIPK1 in maintaining liver homeostasis under metabolic stress. The work will be of relevance to anyone studying liver pathologies.

   Reviewed by eLife

4. Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

   This article has 16 authors:

   1. Matteo Napoli
   2. Roland Immler
   3. Ina Rohwedder
   4. Valerio Lupperger
   5. Johannes Pfabe
   6. Mariano Gonzalez Pisfil
   7. Anna Yevtushenko
   8. Thomas Vogl
   9. Johannes Roth
   10. Melanie Salvermoser
   11. Steffen Dietzel
   12. Marjan Slak Rupnik
   13. Carsten Marr
   14. Barbara Walzog
   15. Markus Sperandio
   16. Monika Pruenster

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates the contribution of cytosolic S100A/8 to neutrophil migration to inflamed tissues. The authors provide convincing evidence for how the loss of cytosolic S100A/8 specifically affects the ability of neutrophils to crawl and subsequently adhere under shear stress. This study will be of interest in fields where inflammation is implicated, such as autoimmunity or sepsis.

   Reviewed by eLife

5. Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability

   This article has 8 authors:

   1. Jia-Ying Su
   2. Yun-Lin Wang
   3. Yu-Tung Hsieh
   4. Yu-Chi Chang
   5. Cheng-Han Yang
   6. YoonSoon Kang
   7. Yen-Tsung Huang
   8. Chien-Ling Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study combines massively parallel reporter assays and regression analysis to identify sequence features in untranslated regions contributing to the stability of in vitro transcribed mRNA delivered to cells. The strength of evidence presented is solid, although some points about half-life measurements and the relevance of identified sequence features to native transcript stability will inform future discussion surrounding the present study. Taken together, the work will be of interest to a broad swath of colleagues studying post-transcriptional gene regulation and especially to those using massively parallel reporter assays.

   Reviewed by eLife

6. Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

   This article has 10 authors:

   1. Kazuya Ono
   2. Amandine Jarysta
   3. Natasha C Hughes
   4. Alma Jukic
   5. Hui Ho Vanessa Chang
   6. Michael R Deans
   7. Ruth Anne Eatock
   8. Kathleen E Cullen
   9. Katie S Kindt
   10. Basile Tarchini

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides convincing evidence that mutant hair cells with abnormal, reversed polarity of their hair bundles in mouse otolith organs retain wild-type localization, mechanoelectrical transduction and firing properties of their afferent innervation, leading to mild behavioral dysfunction. It thus demonstrates that the bimodal pattern of afferent nerve projections in this organ is not causally related to the bimodal distribution of hair-bundle orientations, as also confirmed in the zebrafish lateral line. The work will be of interest to scientists interested in the development and function of the vestibular system as well as in planar-cell polarity.

   Reviewed by eLife

7. Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy

   This article has 11 authors:

   1. Carmina Lichauco
   2. Eric J Foss
   3. Tonibelle Gatbonton-Schwager
   4. Nelson F Athow
   5. Brandon Lofts
   6. Robin Acob
   7. Erin Taylor
   8. James J Marquez
   9. Uyen Lao
   10. Shawna Miles
   11. Antonio Bedalov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study is a detailed investigation of how chromatin structure influences replication origin function in yeast ribosomal DNA, with a focus on the role of the histone deacetylase Sir2 and the chromatin remodeler Fun30. The paper shows that Sir2 does not affect origin licensing but rather affects local transcription and nucleosome positioning which correlates with increased origin firing. Overall, the evidence is convincing and the model is plausible.

   Reviewed by eLife

8. An adaptable, reusable, and light implant for chronic Neuropixels probes

   This article has 26 authors:

   1. Célian Bimbard
   2. Flóra Takács
   3. Joana A Catarino
   4. Julie MJ Fabre
   5. Sukriti Gupta
   6. Stephen C Lenzi
   7. Maxwell D Melin
   8. Nathanael O'Neill
   9. Ivana Orsolic
   10. Magdalena Robacha
   11. James S Street
   12. José M Gomes Teixeira
   13. Simon Townsend
   14. Enny H van Beest
   15. Arthur M Zhang
   16. Anne K Churchland
   17. Chunyu A Duan
   18. Kenneth D Harris
   19. Dimitri Michael Kullmann
   20. Gabriele Lignani
   21. Zachary F Mainen
   22. Troy W Margrie
   23. Nathalie L Rochefort
   24. Andrew Wikenheiser
   25. Matteo Carandini
   26. Philip Coen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents the design of a new device for using high-density electrophysiological probes ('Neuropixels') in freely moving rodents. The evidence demonstrating the system's versatility and ability to record high-quality extracellular data in both mice and rats is compelling. This study will be of significant interest to neuroscientists performing chronic electrophysiological recordings.

   Reviewed by eLife

9. Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

   This article has 8 authors:

   1. Fatima Tleiss
   2. Martina Montanari
   3. Romane Milleville
   4. Olivier Pierre
   5. Julien Royet
   6. Dani Osman
   7. Armel Gallet
   8. C Leopold Kurz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This article describes a novel mechanism allows Drosophila to combat enteric pathogens while also preserving the beneficial indigenous microbiota. The authors provide compelling evidence that oral infection of Drosophila larvae by pathogenic bacteria activate a valve that traps the intruders in the anterior midgut, allowing them to be killed by antimicrobial peptides. This is an important finding revealing a new mechanism of host defense in the gut of insects.

   Reviewed by eLife

10. Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves

    This article has 10 authors:

    1. Rosanna P Sammons
    2. Stefano Masserini
    3. Laura Moreno Velasquez
    4. Verjinia D Metodieva
    5. Gaspar Cano
    6. Andrea Sannio
    7. Marta Orlando
    8. Nikolaus Maier
    9. Richard Kempter
    10. Dietmar Schmitz

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study represents valuable findings on the asymmetric connectivity pattern of two different types of CA3 pyramidal cell types showing that while athorny cells receive strong inputs from all other cell types, thorny cells receive weaker inputs from athorny neurons. Computational modeling is used to evaluate the impact of this connectivity scheme on the sequential activation of different cell types during sharp wave ripples. The evidence combining experimental and computational modelling approaches convincingly supports the authors' claims regarding the network mechanisms underlying the temporal sequences of neuronal activity during sharp-waves.

    Reviewed by eLife