eLife

Latest preprint reviews

1. Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

   This article has 18 authors:

   1. Hong Yang
   2. Cheng Zhang
   3. Woonghee Kim
   4. Mengnan Shi
   5. Metin Kiliclioglu
   6. Cemil Bayram
   7. Ismail Bolar
   8. Özlem Özdemir Tozlu
   9. Cem Baba
   10. Nursena Yuksel
   11. Serkan Yildirim
   12. Shazia Iqbal
   13. Jihad Sebhaoui
   14. Ahmet Hacımuftuoglu
   15. Matthias Uhlen
   16. Jan Boren
   17. Hasan Turkez
   18. Adil Mardinoglu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors implement a valuable multi-tissue approach to dissect the physiologic consequences of JNK inhibition in parallel with dietary perturbation via sucrose. The conclusions of disrupted liver, muscle and adipose metabolism being central to these effects are solid, as they are supported by a combination of experimental dissection and network modeling approaches.

   Reviewed by eLife

2. Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

   This article has 2 authors:

   1. Jie Luo
   2. Jeff Ranish

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents a valuable new quantitative crosslinking mass spectrometry approach using novel isobaric crosslinkers. The data are solid and the method has potential for a broad application in structural biology if more isobaric crosslinking channels are available and the quantitative information of the approach is exploited in more depth.

   Reviewed by eLife

3. Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

   This article has 6 authors:

   1. Odessa R Yabut
   2. Jessica Arela
   3. Hector G Gomez
   4. Jesse Garcia Castillo
   5. Thomas Ngo
   6. Samuel J Pleasure

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable new insight into the role of Fgf signalling in SUFU mutation-linked cerebellar tumors and indicates novel therapeutic interventions via inhibition of Fgf signalling. The potential impact of this work is therefore very high and it is supported by solid evidence. However, due to current limitations in the full identification of the cell types secreting FGF5, and issues with robustness of evaluation of genetically engineered animals, the validation of some interpretations awaits future experiments.

   Reviewed by eLife

4. Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal–fetal interface

   This article has 13 authors:

   1. Haiyi Fei
   2. Xiaowen Lu
   3. Zhan Shi
   4. Xiu Liu
   5. Cuiyu Yang
   6. Xiaohong Zhu
   7. Yuhan Lin
   8. Ziqun Jiang
   9. Jianmin Wang
   10. Dong Huang
   11. Liu Liu
   12. Songying Zhang
   13. Lingling Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the immune system's role in pre-eclampsia. The authors map the immune cell landscape of the human placenta and find an increase in macrophages and Th17 cells in patients with pre-eclampsia. Following mouse studies, the authors suggest that the IGF1-IGF1R pathway might play a role in how macrophages influence T cells, potentially driving the pathology of pre-eclampsia. There is convincing evidence in this study that will be of interest to immunologists and developmental biologists.

   Reviewed by eLife

5. Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

   This article has 13 authors:

   1. Shuo Chen
   2. Jinxiu Liang
   3. Jie Yin
   4. Weijia Zhang
   5. Peijun Jiang
   6. Wenyuan Wang
   7. Xiaoying Chen
   8. Yuanhong Zhou
   9. Peng Xia
   10. Fan Yang
   11. Ying Gu
   12. Ruilin Zhang
   13. Peidong Han

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding that the biomechanical force of heart contractility is required for robust endocardial id2b expression, which in return promotes valve development and myocardial function through upregulation of Neuregulin 1. The data were collected and analyzed using solid methodology and can be used as a starting point for deeper mechanistic insights into the genetic programs regulating endocardial-myocardial crosstalk during heart development.

   Reviewed by eLife

6. Effective population size does not explain long-term variation in genome size and transposable element content in animals

   This article has 5 authors:

   1. Alba Marino
   2. Gautier Debaecker
   3. Anna-Sophie Fiston-Lavier
   4. Annabelle Haudry
   5. Benoit Nabholz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study offers a powerful empirical test of a highly influential hypothesis in population genetics. It incorporates a large number of animal genomes spanning a broad phylogenetic spectrum and treats them in a rigorous unified pipeline, providing the convincing negative result that effective population size scales neither with the content of transposable elements nor with overall genome size. These observations demonstrate that there is still no simple, global hypothesis that can explain the observed variation in transposable element content and genome size in animals.

   Reviewed by eLife

7. Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

   This article has 13 authors:

   1. Hang Li
   2. Shengwei Ji
   3. Nanang R Ariefta
   4. Eloiza May S Galon
   5. Shimaa AES El-Sayed
   6. Thom Do
   7. Lijun Jia
   8. Miako Sakaguchi
   9. Masahito Asada
   10. Yoshifumi Nishikawa
   11. Xin Qin
   12. Mingming Liu
   13. Xuenan Xuan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings with practical and theoretical implications for drug discovery, particularly in the context of repurposing cipargamin CIP for the treatment of Babesia spp. The evidence is solid with the methods, data, and analyses broadly supporting the claims. The paper will be of great interest to scientists in drug discovery, computational biology, and microbiology.

   Reviewed by eLife

8. A unifying account of replay as context-driven memory reactivation

   This article has 3 authors:

   1. Zhenglong Zhou
   2. Michael J Kahana
   3. Anna C Schapiro

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important account of replay as recency-weighted context-guided memory reactivation that explains a number of empirical findings across human and rodent memory literatures. The evidence is compelling and the work is likely to inspire further adaptions to incorporate additional biological and cognitive features.

   Reviewed by eLife

9. Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis

   This article has 3 authors:

   1. Helge Feddersen
   2. Charlotte Dyckmans
   3. Marc Bramkamp

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides convincing data suggesting that subcellular localization of the spatial regulator of cell division, MinD, is an intrinsic feature of the protein's ability to associate with the membrane as both a dimer and a monomer. These findings distinguish the behavior of MinD in B. subtilis from its counterpart in E. coli and suggest that there is not a need to invoke additional localization factors. The reviewers felt that the revisions, particularly the additional experiments and changes to the text to make the experimental design and conclusions clearer, improve the quality of the manuscript.

   Reviewed by eLife

10. Membrane affinity difference between MinD monomer and dimer is not crucial for MinD gradient formation in Bacillus subtilis

    This article has 6 authors:

    1. Laura C Bohorquez
    2. Henrik Strahl
    3. Davide Marenduzzo
    4. Martin J Thiele
    5. Frank Bürmann
    6. Leendert W Hamoen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In the gram-positive model organism Bacillus subtilis, the membrane associated ParA family member MinD, concentrates the division inhibitor MinC at cell poles where it prevents aberrant division events. This important study presents compelling data suggesting that polar localization of MinCD is largely due to differences in diffusion rates between monomeric and dimeric MinD. This finding is exciting as it negates the necessity for a third, localization determinant, in this system as has been proposed by previous investigations.

    Reviewed by eLife