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   10.1101/2024.06.07.597998

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9. RNase III in Salmonella Enteritidis enhances bacterial virulence by reducing host immune responses

   This article has 7 authors:

   1. Bill Kwan-wai Chan
   2. Yingxue Li
   3. Hongyuhang Ni
   4. Edward Wai-chi Chan
   5. Xin Deng
   6. Linfeng Huang
   7. Sheng Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study examines the function of the rnc gene, which encodes the RNase III ribonuclease, as it relates to virulence of Salmonella Enteritidis. The authors demonstrate that the rnc gene is markedly upregulated in strains proposed to exhibit high virulence and that the product of the rnc gene promotes the expression of SodA, which contributes to the survival of Salmonella Enteritidis in the face of oxidative stress. The study also suggests that elevated levels of rnc gene expression assist Salmonella Enteritidis in evading immune responses by diminishing the presence of accumulated double-stranded RNA (dsRNA), although the evidence substantiating this and the above assertions remains incomplete.

   Reviewed by eLife

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    10.1101/2024.01.07.574574