eLife

Latest preprint reviews

1. A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

   This article has 11 authors:

   1. Paolo Petazzi
   2. Telma Ventura
   3. Francesca Paola Luongo
   4. Heather McClafferty
   5. Alisha May
   6. Helen Alice Taylor
   7. Michael J Shipston
   8. Nicola Romanò
   9. Lesley M Forrester
   10. Pablo Menendez
   11. Antonella Fidanza

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents useful findings to inform and improve the in vitro differentiation of hematopoietic progenitor cells from human induced pluripotent stem cells. Relying on a well-characterised technical approach, the data analysis is overall solid and reasonably supports the main conclusions.

   Reviewed by eLife

2. Neural representations of predicted events: Evidence from time-resolved EEG decoding

   This article has 3 authors:

   1. Ai-Su Li
   2. Jan Theeuwes
   3. Dirk van Moorselaar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study investigates how a predicted - but not presented - stimulus within a sequence is represented in the brain using time-resolved EEG decoding. The results demonstrate that when the predicted stimulus is omitted, it is still represented at the expected space and time, although at present they provide only incomplete support given some alternative explanations. The findings will have implications for researchers across domains who are interested in learning and perception.

   Reviewed by eLife

3. The NeuroML ecosystem for standardized multi-scale modeling in neuroscience

   This article has 11 authors:

   1. Ankur Sinha
   2. Padraig Gleeson
   3. Bóris Marin
   4. Salvador Dura-Bernal
   5. Sotirios Panagiotou
   6. Sharon Crook
   7. Matteo Cantarelli
   8. Robert C Cannon
   9. Andrew P Davison
   10. Harsha Gurnani
   11. Robin Angus Silver

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work presents a consolidated overview of the NeuroML2 open community standard and provides convincing evidence for its central role within a broader software ecosystem for the development of neuronal models that are open, shareable, reproducible, and interoperable. A major strength of the work is the continued development over more than two decades to establish, maintain, and adapt this standard to meet the evolving needs of the field. This work is of broad interest to the sub-cellular, cellular, computational, and systems neuroscience communities undertaking studies involving theory, modeling, and simulation.

   Reviewed by eLife

4. Energetic demands regulate sleep-wake rhythm circuit development

   This article has 5 authors:

   1. Amy R Poe
   2. Lucy Zhu
   3. Si Hao Tang
   4. Ella Valencia
   5. Matthew S Kayser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings as it shows that sleep rhythm formation and memory capabilities depend on a balanced and rich diet in fly larvae. The evidence supporting the claims of the authors is convincing with rigorous behavioral assays and state-of-the-art genetic manipulations. The work will be of interest to researchers working on sleep and memory.

   Reviewed by eLife

5. A septo-hypothalamic-medullary circuit directs stress-induced analgesia

   This article has 4 authors:

   1. Devanshi Piyush Shah
   2. Pallavi Raj Sharma
   3. Rachit Agarwal
   4. Arnab Barik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work explores the modulation of pain by intense stress. The authors employed a series of cutting-edge techniques and provided convincing evidence suggesting that the dorsal lateral septum-> lateral hypothalamus-> rostral ventromedial medulla circuit is responsible for mediating stress-induced analgesia. This work will be of interest to neuroscientists interested in the neural circuits of behavior, and scientists interested in stress or pain.

   Reviewed by eLife

6. Axon arrival times and physical occupancy establish visual projection neuron integration on developing dendrites in the Drosophila optic glomeruli

   This article has 11 authors:

   1. Brennan W. McFarland
   2. HyoJong Jang
   3. Natalie Smolin
   4. Bryce W. Hina
   5. Michael J. Parisi
   6. Kristen C. Davis
   7. Timothy J. Mosca
   8. Tanja A. Godenschwege
   9. Aljoscha Nern
   10. Yerbol Z. Kurmangaliyev
   11. Catherine R. von Reyn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study establishes a two distinct feature-encoding visual projection neurons in Drosophila as a model for the development of synaptic specificity. The comprehensive description of connectivity development in this system is valuable to a more general understanding of principles that underlie neural circuit development. The high-quality supporting evidence is convincing.

   Reviewed by eLife

7. Polysaccharides induce deep-sea Lentisphaerae strains to release chronic bacteriophages

   This article has 4 authors:

   1. Chong Wang
   2. Rikuan Zheng
   3. Tianhang Zhang
   4. Chaomin Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents valuable findings on two isolates of deep sea Lentisphaerae strains, which further our understanding of deep sea microbial life. The manuscript's primary claim is that phage isolates augment polysaccharide use in Pseudomonas bacteria, with preliminary evidence for the potential auxiliary metabolic genes in chronic phage infection and/or host proliferation. The strength of the evidence is overall solid and there are only minor weaknesses regarding the mechanism of polysaccharide use by the phages and the evidence for chronic infection. Overall, the data on Lentisphaerae strains will deepen our understanding of microbial life in the deep sea.

   Reviewed by eLife

8. Leveraging mobility data to analyze persistent SARS-CoV-2 mutations and inform targeted genomic surveillance

   This article has 14 authors:

   1. Riccardo Spott
   2. Mathias W Pletz
   3. Carolin Fleischmann-Struzek
   4. Aurelia Kimmig
   5. Christiane Hadlich
   6. Matthias Hauert
   7. Mara Lohde
   8. Mateusz Jundzill
   9. Mike Marquet
   10. Petra Dickmann
   11. Ruben Schüchner
   12. Martin Hölzer
   13. Denise Kühnert
   14. Christian Brandt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors analyze the relationship between human mobility and genomic data of SARS-CoV-2 using mobile phone mobility data and sequence data and present a solid proof of concept. This useful work was conducted on a fine spatial scale and provides suggestions on how mobility-derived surveillance could be conducted, although these results are mixed. The primary significance of this work is the strong use of large datasets that were highly granular. The authors provide a rigorous study, but with less clear predictive power of mobility to inform transmission patterns.

   Reviewed by eLife

9. Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

   This article has 16 authors:

   1. Mie Suzuki Okutani
   2. Shinya Okamura
   3. Tang Gis
   4. Hitomi Sasaki
   5. Suni Lee
   6. Akiho Kashiwabara
   7. Simon Goto
   8. Mai Matsumoto
   9. Mayuko Yamawaki
   10. Toshiaki Miyazaki
   11. Tatsuya Nakagawa
   12. Masahito Ikawa
   13. Wataru Kamitani
   14. Shiro Takekawa
   15. Koichi Yamanishi
   16. Hirotaka Ebina

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study on the efficacy of a live attenuated vaccine that was tested in different animal models and the evidence is convincing. The study has been strengthened after revisions.

   Reviewed by eLife

10. A direct experimental test of Ohno’s hypothesis

    This article has 8 authors:

    1. Ljiljana Mihajlovic
    2. Bharat Ravi Iyengar
    3. Florian Baier
    4. Içvara Barbier
    5. Justyna Iwaszkiewicz
    6. Vincent Zoete
    7. Andreas Wagner
    8. Yolanda Schaerli

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This fundamental study uses a creative experimental system to directly test Ohno's hypothesis, which describes how and why new genes might evolve by duplication of existing ones. In agreement with existing criticism of Ohno's original idea, the authors present compelling evidence that having two gene copies does not speed up the evolution of a new function as posited by Ohno, but instead leads to the rapid inactivation of one of the copies through the accumulation of mostly deleterious mutations. These findings will be of broad interest to evolutionary biologists and geneticists.

    Reviewed by eLife, preLights