eLife

Latest preprint reviews

1. A causal role of the NMDA receptor in recurrent processing during perceptual integration

   This article has 5 authors:

   1. Samuel Noorman
   2. Timo Stein
   3. Jasper Zantvoord
   4. Johannes Fahrenfort
   5. Simon van Gaal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a new, fundamental finding to the field interested in recurrent processing and its neuromodulatory underpinnings, finding unexpectedly that memantine (blocking NMDA-receptors) enhances the decoding of features thought to rely on NMDA-receptors. This interesting, compelling result identifies new directions for researchers studying consciousness, sensory processing, attention, and neurotransmitters.

   Reviewed by eLife

2. A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

   This article has 3 authors:

   1. Sean A Ridout
   2. Priyathama Vellanki
   3. Ilya Nemenman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This theoretical study makes a useful contribution to our understanding of a subtype of type 2 diabetes - ketosis-prone diabetes mellitus (KPD) - with a potential impact on our broader understanding of diabetes and glucose regulation. The article presents an ordinary differential equation-based model for KPD that incorporates a number of distinct timescales - fast, slow, as well as intermediate, incorporating a key hypothesis of reversible beta cell deactivation. The presented evidence is solid and shows that observed clinical disease trajectories may be explained by a simple mathematical model in a particular parameter regime.

   Reviewed by eLife

3. The extra-islet pancreas supports autoimmunity in human type 1 diabetes

   This article has 15 authors:

   1. Graham L Barlow
   2. Christian M Schürch
   3. Salil S Bhate
   4. Darci J Phillips
   5. Arabella Young
   6. Shen Dong
   7. Hunter A Martinez
   8. Gernot Kaber
   9. Nadine Nagy
   10. Sasvath Ramachandran
   11. Janet Meng
   12. Eva Korpos
   13. Jeffrey A Bluestone
   14. Garry P Nolan
   15. Paul L Bollyky

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study leverages innovative high-dimensional imaging strategies to interrogate pancreatic immune cell profiles and distributions throughout stages of type 1 diabetes (T1D). Despite a notable limitation in the number of donor samples analyzed, the authors identify a series of intriguing "immune signatures" and histopathological features that collectively constitute a solid foundation for future investigations into immunological processes underpinning the pathogenesis of T1D. Accordingly, the work will be of considerable interest to the community of T1D researchers and clinicians.

   Reviewed by eLife

4. Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

   This article has 11 authors:

   1. Affiong Ika Oqua
   2. Kin Chao
   3. Liliane El Eid
   4. Lisa Casteller
   5. Billy P Baxter
   6. Alba Miguéns-Gómez
   7. Sebastian Barg
   8. Ben Jones
   9. Jorge Bernardino de la Serna
   10. Sarah L Rouse
   11. Alejandra Tomas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents a valuable finding on the role of cholesterol-binding sites on GLP-1 receptors although the clinical ramifications are unclear and not eminent at this point. Based on the detailed and persuasive responses provided by authors to the concerns raised by reviewers, the revised manuscript is improved substantially and is convincing enough in its scientific merit. The study is a good addition to the scientific community working on receptor biology and drug development for GLP-1 R.

   Reviewed by eLife

5. Disrupted hippocampal theta-gamma coupling and spike-field coherence following experimental traumatic brain injury

   This article has 8 authors:

   1. Christopher D Adam
   2. Ehsan Mirzakhalili
   3. Kimberly G Gagnon
   4. Carlo Cottone
   5. John D Arena
   6. Alexandra Ulyanova
   7. Victoria E Johnson
   8. John A Wolf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important paper that reports in vivo physiological abnormalities in the hippocampus of a rat model of traumatic brain injury (TBI). In this study, authors focused on changes in theta-gamma phase coupling and action potential entrainment to theta, phenomena hypothesized to be critical for cognition. The authors provide convincing evidence of deficits in both features post-TBI and contributes new understanding to how disruptions in oscillatory coordination and spike timing may relate to cognitive impairment.

   Reviewed by eLife

6. Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

   This article has 5 authors:

   1. Besma Brahmia
   2. Yahaira Naaldijk
   3. Pallabi Sarkar
   4. Loukia Parisiadou
   5. Sabine Hilfiker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable contribution follows past descriptions of ciliation defects, potentially linked to cholinergic neuronal dysfunction, associated with mutated G2019S Lrrk2 expression. The strength of evidence is considered solid and broadly supportive of the claims concerning well-characterized cilia changes in cholinergic neurons over time in the model; however, additional work may be required to define the specificity of the pRab12 antibody in the IHC technique, dependence on LRRK2, and clarification of the cilia phenotype in sporadic PD brains that exists (for the moment) only in a non-peer-reviewed pre-print, despite the prominence of these (preliminary) results highlighted in the abstract and text of the current manuscript. It is hoped that the authors will begin to address the feedback provided by the expert reviewers to help provide a more mechanistic basis for the audience interested in cholinergic defects associated with Parkinson's disease.

   Reviewed by eLife

7. Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress

   This article has 11 authors:

   1. Alina Malita
   2. Anne H Skakkebaek
   3. Olga Kubrak
   4. Xiaokang Chen
   5. Takashi Koyama
   6. Elizabeth C Connolly
   7. Nadja Ahrentloev
   8. Ditte S Andersen
   9. Michael J Texada
   10. Kenneth Halberg
   11. Kim Rewitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work by Malita et al. describes a mechanism by which an intestinal infection causes an increase in daytime sleep through signaling from the gut to the blood-brain barrier. Their findings suggest that cytokines upd3 and upd2 produced by the intestine following infection act on glia of the blood brain barrier to regulate sleep by modulating Allatostatin A signaling. The evidence is compelling and elegantly performed using the ample Drosophila genetic toolbox, making this work appealing for a broad group of neuroscience researchers interested in sleep and gut-brain interactions.

   Reviewed by eLife

8. Integration of sensory and fear memories in the rat medial temporal lobe

   This article has 6 authors:

   1. Francesca S Wong
   2. Alina B Thomas
   3. Simon Killcross
   4. Vincent Laurent
   5. R Fred Westbrook
   6. Nathan M Holmes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study by Wong et al. addresses a longstanding question in the field of associative learning regarding how a motivationally relevant event can be inferred from prior learning based on neutral stimulus-stimulus associations. The research provides convincing behavioral and neurophysiological evidence to address this question. The manuscript will be interesting for researchers in behavioral and cognitive neuroscience.

   Reviewed by eLife

9. Normative evidence weighing and accumulation in correlated environments

   This article has 3 authors:

   1. Nathan Tardiff
   2. Jiwon Kang
   3. Joshua I Gold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work combines theory and experiment to demonstrate convincingly how humans make decisions about sequences of pairs of correlated observations. The proposed model for evidence integration in correlated environments will be of use for the study of decision-making.

   Reviewed by eLife

10. Supralinear dendritic integration in murine dendrite-targeting interneurons

    This article has 3 authors:

    1. Simonas Griesius
    2. Amy Richardson
    3. Dimitri Michael Kullmann

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this manuscript, Griesius et al analyze the dendritic integration properties of NDNF and OLM interneurons, and suggest that the supralinear NMDA receptor-dependent synaptic integration may be associated with dendritic calcium transients only in NDNF interneurons. These findings are important because they suggest there might be functional heterogeneities in the mechanisms underlying synaptic integration in different classes of interneurons of the mouse neocortex and hippocampus. The revised work remains incomplete due to remaining concerns about experimental methodology, cell health, and lack of dendritic Na-spikes which have been recorded in previous works.

    Reviewed by eLife