eLife

Latest preprint reviews

1. Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI

   This article has 10 authors:

   1. Joonas A Autio
   2. Ikko Kimura
   3. Takayuki Ose
   4. Yuki Matsumoto
   5. Masahiro Ohno
   6. Yuta Urushibata
   7. Takuro Ikeda
   8. Matthew F Glasser
   9. David C van Essen
   10. Takuya Hayashi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the relative cerebral blood volume of non-human primates that move us closer to uncovering the functional and architectonic principles that govern the interplay between neuronal and vascular networks. The evidence of areal variations and of vessel counting and laminar analysis is solid. The lack of a direct comparison of their approach against better-established MRI-based methods for measuring hemodynamics and vascular structure somewhat weakens the evidence provided in the current paper version, but the current work is an significant step forward. The work will be of interest to NHP imaging scientists.

   Reviewed by eLife

2. Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation

   This article has 4 authors:

   1. Hendrik Heinbockel
   2. Gregor Leicht
   3. Anthony D Wagner
   4. Lars Schwabe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents important findings of a modulatory effect of yohimbine, an alpha2-adrenergic antagonist that raises noradrenaline levels, on the reconsolidation of emotionally neutral word-picture pairs, depending on the hippocampal and cortical reactivation during retrieval. The evidence supporting the main conclusions is convincing, with an elegant design combining fMRI and psychopharmacology. The work will be of broad interest to researchers working on memory.

   Reviewed by eLife

3. Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice

   This article has 6 authors:

   1. Carlos A Sánchez-León
   2. Guillermo Sánchez-Garrido Campos
   3. Marta Fernández
   4. Álvaro Sánchez-López
   5. Javier F Medina
   6. Javier Márquez-Ruiz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important and compelling study, Sánchez-León et al. investigate the effects of tDCS on the firing of single cerebellar neurons in awake and anesthetized mice. They find heterogeneous responses depending on the orientation of the recorded Purkinje cell. The paper may well explain part of the controversial and ambiguous outcomes of various clinical trials.

   Reviewed by eLife

4. Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

   This article has 10 authors:

   1. Xiangning Bu
   2. Nathanael Ashby
   3. Teresa Vitali
   4. Sulgi Lee
   5. Ananya Gottumukkala
   6. Kangsun Yun
   7. Sana Tabbara
   8. Patricia Latham
   9. Christine Teal
   10. Inhee Chung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study provides compelling evidence that TRPV4 plays a crucial role in mechanical sensing during cancer cell transition from non-invasive to invasive states, and offers novel insights into metastasis. By employing multiple experimental approaches, including pharmacological and genetic manipulation, as well as advanced imaging techniques, the authors demonstrate a strong correlation between TRPV4 dynamics, calcium homeostasis, and cell volume plasticity. The findings significantly enhance our understanding of mechanotransduction in cancer and present TRPV4 as a promising therapeutic target for inhibiting metastasis.

   Reviewed by eLife

5. Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice

   This article has 5 authors:

   1. Alessandro Piccin
   2. Anne-Emilie Allain
   3. Jérôme M Baufreton
   4. Sandrine S Bertrand
   5. Angelo Contarino

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The revised report provides valuable findings for the field, suggesting a relationship between CRF1 receptors, sociability deficits in morphine-treated male mice yet not females, and a potential mechanism involving oxytocin neurons in the paraventricular nucleus of the hypothalamus. Generally, the strength of evidence is solid in terms of the methods, data, and analyses. This work will be of interest to those interested in social behavior and addiction.

   Reviewed by eLife

6. Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

   This article has 8 authors:

   1. Xiao Cong
   2. Huachen Liu
   3. Lihua Liu
   4. Nayeli Escudero Castelán
   5. Kite GE Jones
   6. Michaela Egertová
   7. Maurice R Elphick
   8. Muyan Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study characterises receptors for calcitonin-related peptides from a deuterostomian animal, the echinoderm Apostichopus japonicus, by a combination of heterologous expression, pharmacological experiments, and the quantification of gene-expression levels. The authors provide convincing evidence for a functional calcitonin-related peptide system in the sea cucumber, but further work will be needed to confirm the proposed physiological functions of PDF receptor system in this species. This work should be of interest to scientists studying the signaling pathways, functions, and evolution of neuropeptides, and could be of relevance to improving the culture conditions of this economically key species.

   Reviewed by eLife

7. Chromatin endogenous cleavage provides a global view of yeast RNA polymerase II transcription kinetics

   This article has 7 authors:

   1. Jake VanBelzen
   2. Bennet Sakelaris
   3. Donna G Brickner
   4. Nikita Marcou
   5. Hermann Riecke
   6. Niall M Mangan
   7. Jason H Brickner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study compares ChIP-seq and ChEC-seq2 techniques to investigate RNA polymerase II (RNAPII) binding patterns in yeast, revealing that ChEC-seq2 captures distinct regulatory events associated with active transcription missed by ChIP-seq. The authors use ChEC-seq2 data to build a stochastic model of RNAPII kinetics, providing convincing new insights into transcription regulation and the role of the nuclear pore complex. The paper highlights the importance of careful methodological comparisons in understanding RNAPII dynamics.

   Reviewed by eLife

8. Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis

   This article has 13 authors:

   1. Nelson García-Vázquez
   2. Tania J González-Robles
   3. Ethan Lane
   4. Daria Spasskaya
   5. Qingyue Zhang
   6. Marc A Kerzhnerman
   7. YeonTae Jeong
   8. Marta Collu
   9. Daniele Simoneschi
   10. Kelly V Ruggles
   11. Gergely Róna
   12. Sharon Kaisari
   13. Michele Pagano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this article, García-Vázquez et al. report valuable findings demonstrating that G2 and S phases expressed protein 1 (GTSE1), is a previously unappreciated non-pocket substrate of the cyclin D/cyclin-dependent kinase (CDK) 4/6 axis. The authors provide convincing evidence showing that this mechanism is triggered in pathological states in which cyclin D levels are elevated (e.g., cancer). Overall, this study holds a promise to improve understanding of the mechanisms underpinning cell cycle progression including its dysregulation in neoplasia and may thus be of broad interest to researchers belonging to diverse biomedical disciplines ranging from cancer research to cell biology.

   Reviewed by eLife

9. Changes in neural progenitor lineage composition during astrocytic differentiation of human iPSCs

   This article has 8 authors:

   1. Zongze Li
   2. Lucia Fernandez Cardo
   3. Michal Rokicki
   4. Jimena Monzón-Sandoval
   5. Viola Volpato
   6. Frank Wessely
   7. Caleb Webber
   8. Meng Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript by Li and coworkers analyzed astrocytic differentiation of midbrain floor plate-patterned neural cells originating from human iPS cells, with a LMX1A reporter. This valuable work identifies transcriptomic differences at the single-cell level, between astrocytes generated from LMX1A reporter positive or negative cells, as well as non-patterned astrocytes and neurons. The evidence is solid, but the paper can be strengthened by further analyses of the transcriptomic data, and astrocytic morphology; also, searching for some of the differentially expressed genes by immunohistochemistry in different regions of the mammalian brain, or in human specimens, would be very informative.

   Reviewed by eLife

10. 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking

    This article has 2 authors:

    1. Victoria B Hosack
    2. Fritzie Arce-McShane

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study characterises motor and somatosensory cortex neural activity during naturalistic eating and drinking tongue movement in nonhuman primates. The data, which include electrophysiology, three-dimensional tracking of tongue movements, and nerve block manipulations, are valuable to neuroscientists and neural engineers interested in tongue use. Although the current analyses provide a solid description of single neuron activity in these areas, both the population level analyses and the characterisation of activity changes following nerve block could be improved.

    Reviewed by eLife