eLife

Latest preprint reviews

1. Expression of most retrotransposons in human blood correlates with biological aging

   This article has 8 authors:

   1. Yi-Ting Tsai
   2. Nogayhan Seymen
   3. I Richard Thompson
   4. Xinchen Zou
   5. Warisha Mumtaz
   6. Sila Gerlevik
   7. Ghulam J Mufti
   8. Mohammad M Karimi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study by Tsai et al. employed multi-omics approaches, including transcriptomic, methylomic, and single-cell RNA-seq, and provided a solid and comprehensive analysis of the correlation between retrotransposable element (RTE) expression and biological aging in human blood. Their findings highlight the differential roles of RTE families, providing valuable insights for understanding the mechanisms of human aging.

   Reviewed by eLife

2. Deciphering the actin structure-dependent preferential cooperative binding of cofilin

   This article has 6 authors:

   1. Kien Xuan Ngo
   2. Huong T Vu
   3. Kenichi Umeda
   4. Minh-Nhat Trinh
   5. Noriyuki Kodera
   6. Taro Uyeda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this manuscript the authors present high-speed atomic force microscopy (HSAFM) to analyze real-time structural changes in actin filaments induced by cofilin binding. This important study enhances our understanding of actin dynamics which plays a crucial role in a broad spectrum of cellular activities based on solid experimental evidence. Some technical questions, however, remain, making the data interpretation incomplete.

   Reviewed by eLife

3. Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

   This article has 14 authors:

   1. Shaohua Gu
   2. Yuanzhe Shao
   3. Karoline Rehm
   4. Laurent Bigler
   5. Di Zhang
   6. Ruolin He
   7. Ruichen Xu
   8. Jiqi Shao
   9. Alexandre Jousset
   10. Ville-Petri Friman
   11. Xiaoying Bian
   12. Zhong Wei
   13. Rolf Kümmerli
   14. Zhiyuan Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents a novel pipeline for the large-scale genomic prediction of members of the non-ribosomal peptide group of pyoverdines based on a dataset from nearly 2000 Pseudomonas genomes. The advance presented in this study is based on convincing evidence. This study of bacterial siderophores has broad theoretical and practical implications beyond a singular subfield.

   Reviewed by eLife

4. Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

   This article has 7 authors:

   1. Ruggiero Francavilla
   2. Bidisha Chattopadhyaya
   3. Jorelle Linda Damo Kamda
   4. Vidya Jadhav
   5. Saïd Kourrich
   6. Jacques L Michaud
   7. Graziella Di Cristo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable evidence indicating that SynGap1 regulates the synaptic drive and membrane excitability of parvalbumin- and somatostatin-positive interneurons in the auditory cortex. Since haplo-insufficiency of SynGap1 has been linked to intellectual disabilities without a well-defined underlying cause, the central question of this study is timely. The experimental data is solid, as in their revisions the authors successfully addressed questions related to changes in thalamocortical presynaptic excitability, the contradiction between spontaneous and mini EPSCs data, and the anatomical analysis of excitatory synapses.

   Reviewed by eLife

5. CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

   This article has 11 authors:

   1. Liangliang Fu
   2. Chenghu Yin
   3. Qin Zhao
   4. Shuling Guo
   5. Wenjun Shao
   6. Ting Xia
   7. Quan Sun
   8. Liangwen Chen
   9. Jinghan Li
   10. Min Wang
   11. Haibin Xia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies a population of CD81-positive fibroblasts showing senescence signatures that can activate neutrophils through the C3/C3aR1 axis, hence contributing to the inflammatory response in periodontitis. Solid evidence, combining in vitro and in vivo analyses and mouse and human data, supports these findings. The revised manuscript has addressed many concerns significantly. The work would be of interest to researchers working in the senescence and oral medicine fields.

   Reviewed by eLife

6. Insights into metabolic heterogeneity of colorectal cancer gained from fluorescence lifetime imaging

   This article has 14 authors:

   1. Anastasia D Komarova
   2. Snezhana D Sinyushkina
   3. Ilia D Shchechkin
   4. Irina N Druzhkova
   5. Sofia A Smirnova
   6. Vitaliy M Terekhov
   7. Artem M Mozherov
   8. Nadezhda I Ignatova
   9. Elena E Nikonova
   10. Evgeny A Shirshin
   11. Liubov E Shimolina
   12. Sergey V Gamayunov
   13. Vladislav I Shcheslavskiy
   14. Marina V Shirmanova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the heterogeneity of tumour metabolism using fluorescence lifetime imaging, measured across 4 cell lines, 4 tumour types of in vivo mouse models, and 29 patient samples. The indication is that the level of heterogeneity of cellular metabolism increases with model complexity and demonstrates high heterogeneity at a clinical level. The evidence supporting the claims of the authors is solid, and at the revision stage, the authors have included additional samples from 8 patients in the data pool, which is helpful for the conclusions that the authors are trying to draw. The work will be of interest to medical biologists developing methods for quantifying metabolic heterogeneity.

   Reviewed by eLife

7. Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity

   This article has 9 authors:

   1. Andrew E Worthy
   2. Joanna T Anderson
   3. Alicia R Lane
   4. Laura J Gomez-Perez
   5. Anthony A Wang
   6. Ronald W Griffith
   7. Andre F Rivard
   8. Jay B Bikoff
   9. Francisco J Alvarez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable description of subtypes of V1 neurons, including birthdates and connections to motor neurons. V1 neurons are one of the main groups of inhibitory neurons in the spinal cord. The methods of data collection and analysis are convincing. This work will interest developmental biologists and neuroscientists working on spinal circuits.

   Reviewed by eLife

8. An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks

   This article has 3 authors:

   1. Gaetan De Waele
   2. Gerben Menschaert
   3. Willem Waegeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a machine learning model to recommend effective antimicrobial drugs from patients' samples analysed with mass spectrometry. The evidence supporting the claims of the authors is convincing. This work will be of interest to computational biologists, microbiologists, and clinicians.

   Reviewed by eLife

9. Implicit motor adaptation patterns in a redundant motor task manipulating a stick with both hands

   This article has 2 authors:

   1. Toshiki Kobayashi
   2. Daichi Nozaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on how the sensorimotor control system deals with redundancy within our body, based on a novel bimanual task. The evidence supporting the authors' claims is convincing, as demonstrated over four different experiments. The work will be of interest to researchers from the motor control community and related fields, and further investigation into the interpretation of the findings could increase the generalisation of the study to a broader audience.

   Reviewed by eLife

10. Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

    This article has 5 authors:

    1. Daniel Chen
    2. Polyxeni Philippidou
    3. Bianca de Freitas Brenha
    4. Ashleigh E. Schaffer
    5. Helen C. Miranda

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is an important study describing a neuromuscular junction co-culture system using human cells that the authors use to study the synaptic consequences of ALS mutations. The data supporting the system are solid and show the value of using myotubes and motor neurons from the same donor. The study will be of interest to researchers who model neuromuscular junction disorders, however, the authors could more comprehensively compare and contrast their system with previous literature describing other similar models. There are also technical weaknesses that limit the interpretation of specific findings.

    Reviewed by eLife