eLife

Latest preprint reviews

1. Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction

   This article has 11 authors:

   1. Laura Fargeot
   2. Camille Poesy
   3. Maxim Lefort
   4. Jerome G Prunier
   5. Madoka Krick
   6. Rik Verdonck
   7. Charlotte Veyssiere
   8. Murielle Richard
   9. Delphine Legrand
   10. Geraldine Loot
   11. Blanchet Simon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses a comprehensive observational dataset to provide solid evidence on how genetic diversity and species diversity differentially affect multiple ecosystem functions within and across multi-trophic levels in an aquatic ecosystem. The work will be of interest to ecologists working on multi-trophic relationships and biodiversity.

   Reviewed by eLife

2. Linalool combats Saprolegnia parasitica infections through direct killing of microbes and modulation of host immune system

   This article has 6 authors:

   1. Tao Tang
   2. Weiming Zhong
   3. Puyu Tang
   4. Rongsi Dai
   5. Jiajing Guo
   6. Zhipeng Gao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents findings on the efficacy and mechanisms of linalool protection against Saprolegnia parasitica oomycetes in the grass carp model. The evidence presented is solid since the methods, data and analyses broadly support the claims with only minor weaknesses. This work will be of great interest to scientists within the fields of aquaculture, ichthyology, microbiology, and drug discovery.

   Reviewed by eLife

3. Decreased Astrocytic CCL5 by MiR-324-5p Ameliorates Ischemic Stroke Injury via CCR5/ERK/CREB Pathway

   This article has 8 authors:

   1. Jingxiu Li
   2. Keyuan Gao
   3. Lili Wang
   4. Xinrui Wang
   5. Yubing Wang
   6. Chao Li
   7. Zhiqin Gao
   8. Chenxi Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful finding on the interplay of CCL5 and miR-324-5p during ischemic stroke injury. Despite its importance, the evidence supporting the claims of the authors is incomplete. In particular, the lack of methodological information, inappropriate statistical testing, a flawed culture system, and the temporal mismatch in the expression of CCL5 and miR-324-5p following stroke have hindered further evaluation of the claims. The work will be of interest to neuroscientists working on brain injury such as stroke.

   Reviewed by eLife

4. Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

   This article has 6 authors:

   1. Astrid Rollenhagen
   2. Akram Sadeghi
   3. Bernd Walkenfort
   4. Claus C Hilgetag
   5. Kurt Sätzler
   6. Joachim HR Lübke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important information on the ultrastructural organization of layer 1 of the human neocortex. The quantitative assessment of various synaptic parameters, astrocytic coverage and mitochondrial morphology is based on convincing experimental approaches. These data provide new information on the detailed morphology of human neocortical tissue that will be of interest to neuroscientists working on different network functions.

   Reviewed by eLife

5. The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

   This article has 11 authors:

   1. Wenqin Fang
   2. Xiaoyu Zai
   3. Jia Chen
   4. Yakubu Saddeeq Abubakar
   5. Qiuqiu Wu
   6. Zhenyu Fang
   7. Xiuwei Huang
   8. Xiang Gan
   9. Daniel J Ebbole
   10. Zonghua Wang
   11. Wenhui Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides strong evidence for the development of a penetration ring during Magnaporthe oryzae infection and, supported by knockout and expression studies, shows that Ppe1 is involved in the virulence of the fungus. Although the authors demonstrated the close association of Ppe1 with the host plasma membrane, the work fell short in providing direct evidence for its role at the host-pathogen interface and the precise molecular function of the penetration ring. Therefore, the study presented strong structural and phenotypic characterization but remains incomplete regarding mechanistic insights of Ppe1.

   Reviewed by eLife

6. Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking

   This article has 6 authors:

   1. Claire Cooper
   2. Daniel Parthier
   3. Jeremie Sibille
   4. John J Tukker
   5. Nicolas Tritsch
   6. Dietmar Schmitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that slow fluctuations in serotonin release during wakefulness and non-REM sleep correspond to periods of heightened arousal or enhanced offline information processing. The evidence supporting this claim is convincing, and the methodology is robust and broadly applicable, likely to benefit many researchers in the field. This work will be of significant interest to neuroscientists studying sleep, memory, and neuromodulation.

   Reviewed by eLife

7. Prosapip1 (encoded by the Lzts3 gene) in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

   This article has 10 authors:

   1. Zachary W Hoisington
   2. Himanshu Gangal
   3. Khanhky Phamluong
   4. Chhavi Shukla
   5. Jeffrey J Moffat
   6. Alexandra Salvi
   7. Gregg Homanics
   8. Jun Wang
   9. Yann Ehinger
   10. Dorit Ron

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study aims to understand the function of ProSAP-interacting protein 1 (Prosapip1) in the brain. Using a conditional Prosapip1 KO mouse (floxed prosapip1 crossed with Syn1-Cre line), the authors performed analysis including protein biochemistry, synaptic physiology, and behavioral learning. Convincing evidence from this study supports a role of Prosapip 1 in synaptic protein composition, synaptic NMDA responses, LTP, and spatial memory.

   Reviewed by eLife

8. Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory

   This article has 5 authors:

   1. Daniel Reznik
   2. Piotr Majka
   3. Marcello GP Rosa
   4. Menno P Witter
   5. Christian F Doeller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work discusses the phylogenetic conservation of the hippocampal region and primary sensory cortical regions in mammalian species. The authors propose that species-specific differences in behavior and mnemonic functions may be due to differences in cortico-hippocampal connectivity patterns. However, the manuscript, in its present form, is speculative, and the strength of evidence for this proposition is incomplete.

   Reviewed by eLife

9. Endogenous precision of the number sense

   This article has 2 authors:

   1. Arthur Prat-Carrabin
   2. Michael Woodford

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important research investigates the precision of numerosity perception in two types of tasks and concludes that human performance aligns with an efficient coding model optimized for current environmental statistics and task goals. The proposed model receives compelling evidence from two numerosity perception experiments and a reanalysis of an existing dataset of risky decision-making. These findings have theoretical implications for our understanding of numerosity perception and decision-making as well as the ongoing debate on different efficient coding models.

   Reviewed by eLife

10. Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

    This article has 25 authors:

    1. Kevin C Lister
    2. Calvin Wong
    3. Sonali Uttam
    4. Marc Parisien
    5. Patricia Stecum
    6. Nicole Brown
    7. Weihua Cai
    8. David Ho-Tieng
    9. Mehdi Hooshmandi
    10. Ning Gu
    11. Mehdi Amiri
    12. Francis Beaudry
    13. Seyed Mehdi Jafarnejad
    14. Diana Tavares-Ferreira
    15. Nikhil Nageshwar Inturi
    16. Khadijah Mazhar
    17. Hien T Zhao
    18. Bethany Fitzsimmons
    19. Christos G Gkogkas
    20. Nahum Sonenberg
    21. Theodore J Price
    22. Luda Diatchenko
    23. Yaser Atlasi
    24. Jeffrey S Mogil
    25. Arkady Khoutorsky

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Using a combination of innovative and robust techniques, this study outlines cell-type-specific translational landscape changes that occur in the spinal cord neurons in the early and late phases of nerve injury. The authors provided compelling evidence suggesting an essential role of protein synthesis regulation in the chronic phase of neuropathic pain. Although additional mechanisms contributing to late-phase neuropathic pain beyond altered PV+ neuron excitability remain to be elucidated, this is a fundamental and significant study toward a comprehensive understanding of the molecular pathways involved in neuropathic pain.

    Reviewed by eLife