eLife

Latest preprint reviews

1. Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella

   This article has 3 authors:

   1. Liam P. Hallada
   2. Abbas Shirinifard
   3. David J Solecki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents a valuable finding in advancing our understanding of the cellular and molecular mechanisms that regulate the switching of the migration mode from parallel to radial in cerebellar granule cell development. The evidence supporting the claims of the authors is solid and supports the main conclusion; the highlight was the imaging system's visualization of the cell-recognition event associated with neuronal migration, which established a new standard for the field. This study would be of interest to cell biologists and neurodevelopmental biologists working on cell-cell interaction and neuronal migration.

   Reviewed by eLife

2. The neural dynamics of positive and negative expectations of pain

   This article has 3 authors:

   1. Christoph Arne Wittkamp
   2. Maren-Isabel Wolf
   3. Michael Rose

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Wittkamp et al. investigated the spatiotemporal dynamics of expectation of pain using an original fMRI-EEG approach. The methods are solid and the evidence for a substantially different neural representation between the anticipatory and the actual pain period is convincing. These important findings are discussed within a general framework that encompasses their research questions, hypotheses, and analysis of results. Although the choice of conditions and their influence on the results might accept different interpretations, the manuscript is strong and contributes beneficial insights to the field.

   Reviewed by eLife

3. Systematic evaluation of multifactorial causal associations for Alzheimer’s disease and an interactive platform MRAD developed based on Mendelian randomization analysis

   This article has 6 authors:

   1. Tianyu Zhao
   2. Hui Li
   3. Meishuang Zhang
   4. Yang Xu
   5. Ming Zhang
   6. Li Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study introduces the MRAD database, an advancement in Alzheimer's disease research that provides a powerful tool for evaluating risk and protective factors through Mendelian randomization analysis. The evidence supporting the database's utility is solid, with findings backed by robust data, though addressing methodological concerns and ensuring more rigorous validation of associations would further strengthen its impact. This resource represents a significant leap forward in the field, offering unprecedented opportunities for researchers and clinicians to uncover key insights into Alzheimer's etiology, potentially revolutionizing how Alzheimer's research is approached and accelerating the discovery of new prevention strategies and treatments.

   Reviewed by eLife

4. First evidence for the evolution of host manipulation by tumors during the long-term vertical transmission of tumor cells in Hydra oligactis

   This article has 12 authors:

   1. Justine Boutry
   2. Océane Rieu
   3. Lena Guimard
   4. Jordan Meliani
   5. Aurora M Nedelcu
   6. Sophie Tissot
   7. Nikita Stepanskyy
   8. Beata Ujvari
   9. Rodrigo Hamede
   10. Antoine M Dujon
   11. Jácint Tökölyi
   12. Fréderic Thomas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This interesting study explores whether tumor cells can manipulate their Hydra hosts, and includes important findings on the consequences for the fitness of the host Hydra. The evidence supporting these findings is convincing. The work will be of broad interest to many fields including development biology, evolutionary biology and tumor biology.

   Reviewed by eLife

5. Neural Trajectories of Conceptually Related Events

   This article has 5 authors:

   1. Matthew Schafer
   2. Philip Kamilar-Britt
   3. Vyoma Sahani
   4. Keren Bachi
   5. Daniela Schiller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Schafer et al. investigate the extremely interesting and important claim that the human hippocampus represents the interactions with multiple social interaction partners on two relatively abstract social dimensions – and that this ability correlates with the social network size of the participant. This research potentially demonstrates the intricate role of the hippocampus in navigating our social world. While some results are tantalizing, the empirical evidence for the main claims is currently incomplete and requires clarifications and substantial revisions.

   Reviewed by eLife

6. Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

   This article has 11 authors:

   1. Ole Bæk
   2. Tik Muk
   3. Ziyuan Wu
   4. Yongxin Ye
   5. Bekzod Khakimov
   6. Alessandra Maria Casano
   7. Bagirath Gangadharan
   8. Ivan Bilic
   9. Anders Brunse
   10. Per Torp Sangild
   11. Duc Ninh Nguyen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study follows up on previous work suggesting that lower glucose concentrations are protective from sepsis but put the patient at risk for hypoglycemia. In this paper, the authors identify that a slightly higher dose of glucose is still protective but no longer puts the patients at risk for hypoglycemia. The study is important, supported by convincing data, and will be of interest to a broad audience.

   Reviewed by eLife

7. Developmental stage shapes the realized energy landscape for a flight specialist

   This article has 14 authors:

   1. Elham Nourani
   2. Louise Faure
   3. Hester Brønnvik
   4. Martina Scacco
   5. Enrico Bassi
   6. Wolfgang Fiedler
   7. Martin U Grüebler
   8. Julia S Hatzl
   9. David Jenny
   10. Andrea Roverselli
   11. Petra Sumasgutner
   12. Matthias Tschumi
   13. Martin Wikelski
   14. Kamran Safi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study substantially advances our understanding of energy landscapes and their link to animal ontogeny. The evidence supporting the conclusions is compelling, with high-throughput telemetry data and advanced track segmentation methods used to develop and map energy landscapes. The work will be of broad interest to animal ecologists.

   Reviewed by eLife

8. Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking

   This article has 19 authors:

   1. Caitlin S. Mitchell
   2. Aida Mohammadkhani
   3. Elizabeth E. Manning
   4. Erin J. Campbell
   5. Simon D Fisher
   6. Jiann W. Yeoh
   7. Amy J. Pearl
   8. Nicholas J. Burton
   9. Min Qiao
   10. Jacqueline A. Iredale
   11. Jaideep S. Bains
   12. Gavan P. McNally
   13. Zane A. Andrews
   14. Brett A. Graham
   15. Thomas E. Scammell
   16. Bradford B. Lowell
   17. Dong Kong
   18. Stephanie L. Borgland
   19. Christopher V. Dayas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important and timely study that advances our understanding of the role of lateral hypothalamic orexin/hypocretin neurons in appetitive approach and consummatory behaviors. Specifically, using fiber photometry, the authors provide solid and convincing evidence that orexin neurons are primarily active during approach and not consummatory behavior, in a manner that is dependent on metabolic state. Further, using optogenetics and cell type-specific electrophysiology, they show that inputs from the ventral pallidum and lateral nucleus accumbens shell to orexin/hypocretin neurons in the lateral hypothalamus are predominantly inhibitory.

   Reviewed by eLife

9. Long non-coding RNA Malat1 fine-tunes bone homeostasis and repair by orchestrating cellular crosstalk and β-catenin-OPG/Jagged1 pathway

   This article has 14 authors:

   1. Yongli Qin
   2. Jumpei Shirakawa
   3. Cheng Xu
   4. Ruge Chen
   5. Xu Yang
   6. Courtney Ng
   7. Shinichi Nakano
   8. Mahmoud Elguindy
   9. Zhonghao Deng
   10. Kannanganattu V Prasanth
   11. Moritz F Eissmann
   12. Shinichi Nakagawa
   13. William M Ricci
   14. Baohong Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important and convincing dataset shedding new light on a role for Malat1 in osteoblast physiology. The work is of value to areas other than the bone field because it supports a role and mechanism for beta-catenin that is novel and unusual. The findings are significant in that they support the presence of another anabolic pathway in bone that can be productively targeted for therapeutic goals. Revisions further improved the paper and addressed the reviewers' concerns.

   Reviewed by eLife

10. Dynamic basis of lipopolysaccharide export by LptB2FGC

    This article has 4 authors:

    1. Marina Dajka
    2. Tobias Rath
    3. Nina Morgner
    4. Benesh Joseph

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study provides an important advance in the molecular understanding of the lipopolysaccharide export mechanism and machinery in bacteria. By using advanced spectroscopy approaches, the experiments provide convincing biophysical support for the dynamic behavior of the multisubunit Lpt transport system. This work has implications for understanding bacterial cell envelope biogenesis and developing drugs that target Gram negative pathogens.

    Reviewed by eLife