eLife

Latest preprint reviews

1. History-dependent spiking facilitates efficient encoding of polarization angles in neurons of the central complex

   This article has 3 authors:

   1. Lisa Rother
   2. Anna Stöckl
   3. Keram Pfeiffer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines electrophysiology experiments and modeling to investigate the encoding of dynamic patterns of polarized light by identified neurons of the bumblebee central complex. The scientific question and methodology are compelling. However, the evidence supporting the authors' conclusions is incomplete without more comprehensive statistical analyses.

   Reviewed by eLife

2. Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

   This article has 6 authors:

   1. Masaya Muramoto
   2. Nozomi Hanawa
   3. Misako Okumura
   4. Takahiro Chihara
   5. Masayuki Miura
   6. Natsuki Shinoda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies a mechanism by which caspases are activated in a non-lethal context to induce functional modulation in Drosophila olfactory receptor neurons. To deliver, the authors generated a new reporter of caspases, used TurboID to identify proteins proximal of the Drosophila executioner caspases Drice, and then focused on Fasciclin 3 as a mediator. The experimental results and the main conclusions are convincing. This substantial body of work will be of interest to researchers across fields, from neuroscience of olfaction to development and cell biology.

   Reviewed by eLife

3. Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

   This article has 7 authors:

   1. Sihui Cai
   2. Jie Zhou
   3. Xiaotong Luo
   4. Chenqiu Zhang
   5. Shouheng Jin
   6. Jian Ren
   7. Jun Cui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that interferon beta stimulation induces WTAP transition from aggregates to liquid droplets, coordinating m6A modification of a subset of mRNAs that encode interferon-stimulated genes and restricting their expression. The evidence presented is solid, supported by microscopy, immunoprecipitations, m6A sequencing, and ChIP, to show that WTAP phosphorylation controls phase transition and its interaction with STAT1 and the methyltransferase complex.

   Reviewed by eLife

4. Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease

   This article has 9 authors:

   1. Edwin A Homan
   2. Ankit Gilani
   3. Alfonso Rubio-Navarro
   4. Maya A Johnson
   5. Odin M Schaepkens
   6. Eric Cortada
   7. Renan Pereira de Lima
   8. Lisa Stoll
   9. James C Lo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the role of Complement 3a Receptor 1 (C3aR) in the pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) using mouse models with specific target deletions in various cell types. While the general relevance of C3aR in inflammatory contexts has been established before, the authors provide solid evidence here that C3aR does not contribute significantly to MASLD pathogenesis in their models. The work will be of interest to colleagues studying diseases of the liver and the intersection with inflammation.

   Reviewed by eLife

5. Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

   This article has 22 authors:

   1. Priya Sharma
   2. Raman Deep Sharma
   3. Binayak Sarkar
   4. Varnika Panwar
   5. Mrinmoy Das
   6. Lakshya Veer Singh
   7. Neharika Jain
   8. Shivam Chaturvedi
   9. Lalita Mehra
   10. Aditya Rathee
   11. Shilpa Sharma
   12. Shihui Foo
   13. Andrea Lee
   14. Pavan Kumar N
   15. Prasenjit Das
   16. Vijay Viswanathan
   17. Hardy Kornfeld
   18. Shanshan W Howland
   19. Subash Babu
   20. Vinay Kumar Nandicoori
   21. Amit Singhal
   22. Dhiraj Kumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors provide solid data reporting that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. The specific contribution of neutrophil-derived IL-17 to disease pathogenesis remains to be definitively established through direct demonstration of IL-17 production by neutrophils and targeted depletion studies.

   Reviewed by eLife

6. Cellular coordination underpins rapid reversals in gliding filamentous cyanobacteria and its loss results in plectonemes

   This article has 11 authors:

   1. Jerko Rosko
   2. Rebecca N Poon
   3. Kelsey Cremin
   4. Emanuele Locatelli
   5. Mary Coates
   6. Sarah JN Duxbury
   7. Kieran Randall
   8. Katie Croft
   9. Chantal Valeriani
   10. Marco Polin
   11. Orkun S Soyer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using microscopy experiments and theoretical modelling, the authors present convincing evidence of cellular coordination in the gliding filamentous cyanobacterium Fluctiforma draycotensis. The results are fundamental for the understanding of cyanobacterial motility and the underlying molecular and mechanical pathways of cellular coordination.

   Reviewed by eLife

7. Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

   This article has 9 authors:

   1. Lulu Qin
   2. Chongbin Hu
   3. Qiong Zhao
   4. Yong Wang
   5. Dongdong Fan
   6. Aifu Lin
   7. Lixin Xiang
   8. Ye Chen
   9. Jianzhong Shao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study focuses on the role of a T-cell-specific receptor, ctla-4, in a new zebrafish model of IBD-like phenotype. Although implicated in IBD diseases, the function of ctla-4 has been hard to study in mice as the KO is lethal. Ctla-4 mutant zebrafish exhibited significant intestinal inflammation and dysbiosis, mirroring the pathology of inflammatory bowel disease (IBD) in mammals, providing a new valuable model to the field of IBD research. This is an key study with convincing evidence, comprehensive transcriptomic analysis, histological examinations, and functional assays all supporting the findings.

   Reviewed by eLife

8. Brochosomes as an antireflective camouflage coating for leafhoppers

   This article has 8 authors:

   1. Wei Wu
   2. Qianzhuo Mao
   3. Zhuang-Xin Ye
   4. Zhenfeng Liao
   5. Hong-Wei Shan
   6. Jun-Min Li
   7. Chuan-Xi Zhang
   8. Jian-Ping Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors provide important insights into a system of insect camouflage where a coating of self-made nano-particles (brochosomes) reduces the reflection of UV-light leading to lower predation by spiders. Compelling evidence is provided by micro-UV-Vis spectroscopy, electron microscopy, transcriptome and proteome analysis, histology, in-vivo predation assays and gene knock-downs. The phylogenetic analyses provide evidence that the genes coding for the brochosome proteins are clade-specific and have diversified by gene duplication.

   Reviewed by eLife

9. Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

   This article has 9 authors:

   1. Sytse J Piersma
   2. Shasha Li
   3. Pamela Wong
   4. Michael D Bern
   5. Jennifer Poursine-Laurent
   6. Liping Yang
   7. Diana L Beckman
   8. Bijal A Parikh
   9. Wayne M Yokoyama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study on mouse Ly49 receptors expressed on natural killer (NK) cells shows that Ly49A, in the presence of the corresponding MHC Class I allele, can lead to NK cell licensing, thereby providing valuable insights into the mechanisms of NK cell modulation by Ly49 receptors. The work may have significant implications for studies of human Killer-cell immunoglobulin-like receptors (KIR) expressing and other NK cells. Overall, the study was well-developed with convincing evidence.

   Reviewed by eLife

10. Short heat shock factor A2 regulates heat resistance and growth balance in Arabidopsis

    This article has 7 authors:

    1. Wanxia Chen
    2. Jiaqi Zhao
    3. Zhanxia Tao
    4. Shan Zhang
    5. Xiujuan Bei
    6. Wen Lu
    7. Xiaoting Qi

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The paper reports valuable findings about the mechanism of regulation of the heat shock response in plants that acts as a brake to prevent hyperactivation of the stress response, which have theoretical or practical implications for a subfield. The study presented by the authors provides solid methods, data, and analysis that broadly support the claims. This report presents helpful information regarding new spliced HSFs forms in Arabidopsis that highlights key information in the understanding of heat stress and plant growth.

    Reviewed by eLife