eLife

Latest preprint reviews

1. Re-focusing visual working memory during expected and unexpected memory tests

   This article has 2 authors:

   1. Sisi Wang
   2. Freek van Ede

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides significant insights into the dynamics of attentional re-orienting within visual working memory, demonstrating how expected and unexpected memory tests influence attention focus and re-focus. The evidence supporting these conclusions is convincing, with the use of state-of-the-art methodologies. This work will be of interest to cognitive neuroscientists studying attention and memory.

   Reviewed by eLife

2. Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina

   This article has 9 authors:

   1. Sidney P Kuo
   2. Wan-Qing Yu
   3. Prerna Srivastava
   4. Haruhisa Okawa
   5. Luca Della Santina
   6. David M Berson
   7. Gautam B Awatramani
   8. Rachel OL Wong
   9. Fred Rieke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that retinal bipolar cell subtype-specific differences in the size of synaptic ribbon-associated vesicle pools contribute to the transient versus sustained kinetics of the responses of retinal ganglion cells. The data are extensive and compelling. This work will be of broad interest to researchers working on synaptic transmission, retinal signal processing, and sensory neurobiology.

   Reviewed by eLife

3. Brain-wide arousal signals are segregated from movement planning in the superior colliculus

   This article has 2 authors:

   1. Richard Johnston
   2. Matthew A Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding relating to how the state of arousal is represented within the superior colliculus, a principal visuo-oculomotor structure. The main conclusion that the representation of arousal is segregated, and thus influences visual activity but not motor output, is incompletely supported by the evidence, but could be stronger if a specific concern relating to an alternative explanation for the dichotomy was addressed. The work will be of interest to sensory, motor, and cognitive neuroscientists.

   Reviewed by eLife

4. Bridging verbal coordination and neural dynamics

   This article has 6 authors:

   1. Isaïh Schwab-Mohamed
   2. Manuel R Mercier
   3. Agnès Trebuchon
   4. Benjamin Morillon
   5. Leonardo Lancia
   6. Daniele Schön

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper reports on an important study that aims to move beyond current experimental approaches in speech production by (1) investigating speech in the context of a fully interactive task and (2) employing advanced methodology to record intracranial brain activity. Together these allow for examination of the unfolding temporal dynamics of brain-behaviour relationships during interactive speech. This approach and the analyses presented in support of the authors' claims pose convincing evidence.

   Reviewed by eLife

5. Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina

   This article has 10 authors:

   1. Sören J Zapp
   2. Mohammad H Khani
   3. Helene M Schreyer
   4. Shashwat Sridhar
   5. Varsha Ramakrishna
   6. Steffen Krüppel
   7. Matthias Mietsch
   8. Dario A Protti
   9. Dimokratis Karamanlis
   10. Tim Gollisch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper introduces an efficient approach to identify subunits in the receptive fields of retinal ganglion cells. The general approach has been used in this application previously and this limits the conceptual advance of the paper. The improved speed is valuable, as it allows a more thorough exploration of the control parameters in this analysis and facilitates application to larger populations of cells. Validation of the approach is convincing. The paper would benefit from a more thorough exploration of the method and its limitations, or an extension of the new results about subunit populations.

   Reviewed by eLife

6. Near infrared radiation-driven oxygenic photosynthesis contributes substantially to primary production in biofilms harboring chlorophyll f-containing cyanobacteria

   This article has 4 authors:

   1. Maria Mosshammer
   2. Erik CL Trampe
   3. Niels-Ulrik Frigaard
   4. Michael Kühl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study investigates the contribution of far-red light photo-acclimated cyanobacteria to primary production in intertidal beachrock habitats. Though the study presents solid evidence, the text would benefit from an improved discussion section and some additional methodological details.

   Reviewed by eLife

7. Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

   This article has 14 authors:

   1. Yue Yang
   2. Bin Huang
   3. Yimeng Qin
   4. Danwei Wang
   5. Yinuo Jin
   6. Linmin Su
   7. Qingxin Wang
   8. Yi Pan
   9. Yanfeng Zhang
   10. Yumeng Shen
   11. Wenjun Hu
   12. Zhengyu Cao
   13. Liang Jin
   14. Fangfang Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study utilizes a comprehensive array of animal and cellular models, alongside various techniques, to elucidate the mechanism by which adipose tissue miR-802 contributes to inflammation and metabolic dysfunction in obesity. The data is solid, with clear, reproducible changes showing low variability among biological replicates and consistency across different models. However, some conclusions should be further substantiated with additional data to enhance the scope and strength of the manuscript.

   Reviewed by eLife

8. Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

   This article has 4 authors:

   1. Eleanor Martin
   2. Rossana Girardello
   3. Gunnar Dittmar
   4. Alexander Ludwig

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses convincing time-resolved proximity proteomics, validated with proximity ligation assays, to provide new insight into mechanical regulation of caveolin-1 complexes that form in migrating cells. Solid follow up experiments reveal a reciprocal relationship between mechanosensitive caveolae and RhoGTPase signalling in migrating cells, but evidence supporting a direct link between the newly identified factors with a specific caveolae subpopulation remains incomplete at this stage.

   Reviewed by eLife

9. Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity

   This article has 2 authors:

   1. Alexa Tompary
   2. Lila Davachi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study investigates how memory representations are transformed over time (24h period). The work advances our understanding of the neural processes supporting the behavioral integration of memories for distinct events that are never experienced together in time but are linked by shared predictive cues. Evidence supporting the claims is solid, and reporting of additional comparisons would have strengthened the study.

   Reviewed by eLife

10. Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

    This article has 7 authors:

    1. Mehul Vora
    2. Jonathan Dietz
    3. Zachary Wing
    4. Karen George
    5. Jun Kelly Liu
    6. Christopher Rongo
    7. Cathy Savage-Dunn

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Modulation of BMP signalling affects body size in the nematode Caenorhabditis elegans, and this paper examines the effects on C. elegans body size brought about by the modulation of BMP signalling. Thw study provides valuable analyses of ChIP-seq and RNA-Seq data to understand the function of SMA-3 (Smad) and SMA-9 (Schnurri) in this model. The authors provide compelling evidence that the BMP-dependent body size effect could be due to defects in cuticle collagen secretion, a finding of interest to those studying organismal growth and epidermal function.

    Reviewed by eLife