eLife

Latest preprint reviews

1. Restraint of melanoma progression by cells in the local skin environment

   This article has 10 authors:

   1. Yilun Ma
   2. Mohita Tagore
   3. Miranda V Hunter
   4. Ting-Hsiang Huang
   5. Emily Montal
   6. Joshua M Weiss
   7. Yingxiao Shi
   8. Tuulia Vallius
   9. Peter K Sorger
   10. Richard M White

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo Epithelial-Mesenchymal Transition (EMT). Surprisingly, when overexpressing Twist in keratinocytes, the resulting alteration in keratinocytes is inhibitory for melanoma invasion in both zebrafish and human cell culture models. The results are supported by convincing experimental data that provide new insights into the interactions between melanoma cells and their environment.

   Reviewed by eLife

2. The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

   This article has 5 authors:

   1. Yutaro Hama
   2. Yuko Fujioka
   3. Hayashi Yamamoto
   4. Noboru Mizushima
   5. Nobuo N Noda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Building on previous structural studies, this work provides valuable new insights into the architecture of the autophagy initiation complex, comprising ULK1, ATG13, and FIP200. The authors present their findings with solid supporting evidence, making this study a significant contribution to the autophagy field.

   Reviewed by eLife

3. PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

   This article has 12 authors:

   1. Jiongke Wang
   2. Yujie Shi
   3. Ying Wang
   4. Yingqiang Shen
   5. Huan Liu
   6. Silu Sun
   7. Yimei Wang
   8. Xikun Zhou
   9. Yu Zhou
   10. Xin Zeng
   11. Jing Li
   12. Qianming Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript determines how PA28g, a proteasome regulator that is overexpressed in tumors, and C1QBP, a mitochondrial protein for maintaining oxidative phosphorylation that plays a role in tumor progression, interact in tumor cells to promote their growth, migration and invasion. Additional experiments and analyses that supported the theoretical models for the interaction have been performed in response to the reviews. The overall findings and conceptual framework are important and the evidence is solid. A logical extrapolation of this work is to test the C1QBP mutants using functional assays to determine whether the mutations can decrease the protein stability mediated by the interaction with PA28g.

   Reviewed by eLife

4. The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

   This article has 7 authors:

   1. Jiayin Gao
   2. Jiawei Wang
   3. Shiyu Liu
   4. Jinzhu Song
   5. Chuanxin Zhang
   6. Boyang Liu
   7. Keliang Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study by Gao et al identifies Hspa2 as a heterogeneous transcript in the early embryo and proposes a plausible mechanism showing interactions with Carm1. The authors propose that variability in HSPA2 levels among blastomeres at the 4-cell stage skews their relative contribution to the embryonic lineage. Given only 4 other heterogeneous transcripts/non-coding RNA have been proposed to act similarly at or before the 4-cell stage, this would be a key addition to our understanding of how the first cell fate decision is made. While this is a solid study, further data are needed to fully support the conclusions.

   Reviewed by eLife

5. GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

   This article has 12 authors:

   1. Joseph A Bisson
   2. Miriam Gordillo
   3. Ritu Kumar
   4. Neranjan de Silva
   5. Ellen Yang
   6. Kelly M Banks
   7. Zhong-Dong Shi
   8. Kihyun Lee
   9. Dapeng Yang
   10. Wendy K Chung
   11. Danwei Huangfu
   12. Todd Evans

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates the function of a critical regulator of human early cardiac development. The convincing examination of GATA6 function is thorough and well-executed. The study will be of interest to scientists working on how the human heart acquires its identity.

   Reviewed by eLife

6. Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

   This article has 2 authors:

   1. Bhanu Priya Somashekar
   2. Upinder Singh Bhalla

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable quantitative insights into the prevalence of functionally clustered synaptic inputs on neuronal dendrites. The simple analytical calculations and computer simulations provide solid support for the main arguments. The findings can lead to a more detailed understanding of how dendrites contribute to the computation of neuronal networks.

   Reviewed by eLife

7. Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

   This article has 3 authors:

   1. Jacob W Klemm
   2. Chloe Van Hazel
   3. Robin E Harris

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports fundamental discoveries on how necrotic cells contribute to organ regeneration through apoptotic signalling to produce cells with non-lethal apoptotic caspase activity that contribute to the regenerated tissue. These findings will be of broad interest to those who study wound repair and tissue regeneration. The strength of the evidence is solid and has been improved in the revised version.

   Reviewed by eLife

8. Hierarchical cortical plasticity in congenital sight impairment

   This article has 9 authors:

   1. Roni O Maimon-Mor
   2. Mahtab Farahbakhsh
   3. Nicholas Hedger
   4. Andrew T Rider
   5. Elaine J Anderson
   6. Geraint Rees
   7. Tomas Knapen
   8. Michel Michaelides
   9. Tessa M Dekker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the stability and compensatory plasticity in the retinotopic mapping in patients with congenital achromatopsia. It provides convincing evidence for a stable mapping of the visual field in V1, alongside changes of the readout from V1 into V3, which shows revised receptive field location and size. This paper would be of interest to scientists studying the visual system, brain plasticity, and development.

   Reviewed by eLife

9. Full factorial construction of synthetic microbial communities

   This article has 5 authors:

   1. Juan Diaz-Colunga
   2. Pablo Catalan
   3. Magdalena San Roman
   4. Andrea Arrabal
   5. Alvaro Sanchez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript introduces a new low-cost and accessible method for assembling combinatorially complete microbial consortia using basic laboratory equipment, which is a valuable contribution to the field of microbial ecology and biotechnology. The evidence presented is compelling, demonstrating the method's effectiveness through empirical testing on both synthetic colorants and Pseudomonas aeruginosa strains.

   Reviewed by eLife, Arcadia Science

10. Odors drive feeding through gustatory receptor neurons in Drosophila

    This article has 3 authors:

    1. Hongping Wei
    2. Thomas Ka Chung Lam
    3. Hokto Kazama

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study convincingly demonstrates that odors evoke a feeding response in Drosophila, mediated by gustatory receptors and observed as a proboscis extension. The evidence is comprehensive, encompassing behavior, functional imaging and electrophysiology. This important results on the molecular and cellular basis of multimodal integration across olfaction and gustation will be of interest for the study of chemosensation, sensory biology, and animal behavior.

    Reviewed by eLife