eLife

Latest preprint reviews

1. Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components

   This article has 26 authors:

   1. Mattias Horan
   2. Daniel Regester
   3. Cristina Mazuski
   4. Thomas Jahans-Price
   5. Shanice Bailey
   6. Emmett Thompson
   7. Zuzanna Slonina
   8. Viktor Plattner
   9. Elena Menichini
   10. Irmak Toksöz
   11. Sandra Romero Pinto
   12. Mark Burrell
   13. Isabella Varsavsky
   14. Henry WP Dalgleish
   15. Célian Bimbard
   16. Anna Lebedeva
   17. Marius Bauza
   18. Francesca Cacucci
   19. Thomas Wills
   20. Athena Akrami
   21. Julija Krupic
   22. Marcus Stephenson-Jones
   23. Caswell Barry
   24. Neil Burgess
   25. John O’Keefe
   26. Yoh Isogai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This report details the creation and wide-scale utilization of "Repix", a new technique for chronic neurophysiological recordings using and re-using Neuropixels probes in freely behaving mice and rats. The authors include data and feedback from a variety of labs and researchers who have used this technique, setting an example for open science and reproducibility, and providing convincing evidence that this approach can be employed for chronic Neuropixels recordings. However, evidence is currently incomplete for claims about the advantages of this design over previous approaches and for cell yield and stability claims. This important work will have an impact on a broad range of neuroscientists seeking a straightforward methodology for chronic Neuropixels recordings and will facilitate ethologically relevant experimental designs.

   Reviewed by eLife

2. Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

   This article has 6 authors:

   1. Fayang Zhou
   2. Yuanyuan Zhang
   3. Yuyao Zhu
   4. Qiang Zhou
   5. Yigong Shi
   6. Qi Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents the cryo-EM structures of two human biotin-dependent mitochondria carboxylases involved in various biological pathways, including the metabolism of certain amino acids, cholesterol, and odd chain fatty acids. The cryo-EM structures offer a valuable addition to the structural description of biotin-dependent carboxylases and provide solid evidence to support the major conclusions of this study. This paper would be of interest to biochemists and structural biologists working on biotin-dependent carboxylases.

   Reviewed by eLife

3. Nutritional state-dependent modulation of insulin-producing cells in Drosophila

   This article has 5 authors:

   1. Rituja S Bisen
   2. Fathima Mukthar Iqbal
   3. Federico Cascino-Milani
   4. Till Bockemühl
   5. Jan M Ache

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     With compelling electrophysiological and behavioural evidence, this work establishes that the activity of insulin-producing cells (IPCs) depends on the nutritional state in Drosophila and that, like in mammals, there is also an incretin-like effect with IPCs responding to glucose feeding but not to glucose perfusion. Moreover, the authors demonstrate that DH44 neurons respond to glucose perfusion and, together with IPCs, modulate locomotor activity. This important study on the neuronal regulation of metabolic homeostasis will be of interest to both neuroscience and to medical research in diabetes.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2402.07252v2

5. Binding of LncRNA-DACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility

   This article has 18 authors:

   1. Zhenwei Pan
   2. Gen-Long Xue
   3. Jiming Yang
   4. Yang Zhang
   5. Ying Yang
   6. Ruixin Zhang
   7. Desheng Li
   8. Tao Tian
   9. Xiaofang Zhang
   10. Changzhu Li
   11. Xingda Li
   12. Jiqin Yang
   13. Kewei Shen
   14. Yang Guo
   15. Xuening Liu
   16. Guohui Yang
   17. Yanjie Lu
   18. Baofeng Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important contribution to cardiac arrhythmia research by demonstrating long noncoding RNA Dachshund homolog 1 (lncDACH1) tunes sodium channel functional expression and affects cardiac action potential conduction and rhythms. The evidence supporting the major claims are convincing. The work will be of broad interest to cell biologists and cardiac electrophysiologists.

   Reviewed by eLife

6. Feeding rates in sessile versus motile ciliates are hydrodynamically equivalent

   This article has 4 authors:

   1. Jingyi Liu
   2. Yi Man
   3. John H Costello
   4. Eva Kanso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper addresses the role of fluid flows in nutrient uptake by microorganisms propelled by the action of cilia or flagella. Using a range of mathematical models for the flows created by such appendages, the authors provide convincing evidence that the two strategies of swimming and sessile motion can be competitive. These results will have significant implications for our understanding of the evolution of multicellularity in its various forms.

   Reviewed by eLife

7. Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

   This article has 8 authors:

   1. Ning Song
   2. Hang Gao
   3. Jianhao Li
   4. Yi Liu
   5. Mingze Wang
   6. Zhiming Ma
   7. Naisheng Zhang
   8. Wenlong Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study showing that age-related gut microbiota modulate uric acid metabolism through the NLRP3 inflammasome pathway and thereby regulate susceptibility to age-related gout. Several experimental approaches (mechanistic insights) and methods (data quality) remain incomplete. This paper should be of interest to researchers working on gout and microbiota.

   Reviewed by eLife

8. SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

   This article has 19 authors:

   1. Kira Breunig
   2. Xuifen Lei
   3. Mauro Montalbano
   4. Gabriela DA Guardia
   5. Shiva Ostadrahimi
   6. Victoria Alers
   7. Adam Kosti
   8. Jennifer Chiou
   9. Nicole Klein
   10. Corina Vinarov
   11. Lily Wang
   12. Mujia Li
   13. Weidan Song
   14. W Lee Kraus
   15. David S Libich
   16. Stefano Tiziani
   17. Susan T Weintraub
   18. Pedro AF Galante
   19. Luiz O Penalva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports valuable insights into the interactome of the RNA-binding protein SERBP1 and possible links through PARylation to diverse processes, including splicing, cell division, and ribosome biogenesis. The diversity of processes SERBP1 may regulate means this work would be of very broad interest to the cell biology community. The proteomics data are solid, but the functional connection to downstream processes and the link to Alzheimer's disease, while compelling, still require further examination. These latter data currently rely on a very limited set of experiments and patient samples with questionable quality of preservation and methodology.

   Reviewed by eLife

9. Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions

   This article has 7 authors:

   1. Katarzyna Tutak
   2. Izabela Broniarek
   3. Andrzej Zielezinski
   4. Daria Niewiadomska
   5. Tomasz Skrzypczak
   6. Anna Baud
   7. Krzysztof Sobczak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, Tutak and colleagues set out to identify factors that mediate Repeat Associated Non-AUG (RAN) translation of CGG repeats in the FMR1 mRNA which are implicated in toxic protein accumulation that underpins ensuing neurological pathologies. The authors provide solid evidence that RPS26 may be implicated in mediating the RAN translation of FMR1 mRNA. This article should be of broad interest to researchers in the variety of disciplines including post-transcriptional regulation of gene expression and neurobiology.

   Reviewed by eLife

10. Observing one-divalent-metal-ion-dependent and histidine-promoted His-Me family I-PpoI nuclease catalysis in crystallo

    This article has 3 authors:

    1. Caleb Chang
    2. Grace Zhou
    3. Yang Gao

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Chang et al. have investigated the catalytic mechanism of I-PpoI nuclease, a one-metal-ion dependent nuclease, by time-resolved X-ray crystallography using soaking of crystals with metal ions under different pH conditions. This convincing study revealed that I-PpoI catalyzes the reaction process through a single divalent cation. The study uncovers important details of the roles of the metal ion and the active site histidine in catalysis.

    Reviewed by eLife