eLife

Latest preprint reviews

1. The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling

   This article has 4 authors:

   1. Kara A Nelson
   2. Kari F Lenhart
   3. Lauren Anllo
   4. Stephen DiNardo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the role of a well-studied signal transduction pathway, the Slit/Robo system, in the context of the assembly of the hematopoietic niche in the Drosophila embryo. The evidence supporting the claims of the authors is solid. The work will interest developmental biologists working on molecular mechanisms of tissue morphogenesis.

   Reviewed by eLife

2. Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

   This article has 11 authors:

   1. Amanda Mixon Blackwell
   2. Yasaman Jami-Alahmadi
   3. Armiyaw S Nasamu
   4. Shota Kudo
   5. Akinobu Senoo
   6. Celine Slam
   7. Kouhei Tsumoto
   8. James A Wohlschlegel
   9. Jose Manuel Martinez Caaveiro
   10. Daniel E Goldberg
   11. Paul A Sigala

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reveals that the malaria parasite protein PfHO, although lacking typical heme oxygenase activity, is essential for the survival of Plasmodium falciparum. Structural and localization analyses demonstrated that PfHO plays a critical role in maintaining the apicoplast, specifically in gene expression and biogenesis, suggesting an adaptive function for this protein in parasite biology. While the findings convincingly support the authors' claims, further investigation into apicoplast gene expression and the specific function of PfHO remains a future challenge. The topic and results are important and will be of interest to researchers studying various aspects of malaria, Plasmodium physiology, host-pathogen interactions, and heme metabolism.

   Reviewed by eLife

3. Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

   This article has 13 authors:

   1. Wei-Ping Li
   2. Jia-Ying Su
   3. Yu-Chi Chang
   4. Hung-Lun Chiang
   5. Yun-Lin Wang
   6. Ang-Chu Huang
   7. Yu-Tung Hsieh
   8. Yi-Hsuan Chiang
   9. Yen-Ling Ko
   10. Bing-Jen Chiang
   11. Cheng-Han Yang
   12. Yen-Tsung Huang
   13. Chien-Ling Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The effort is timely and the paper carries valuable insights into the function of UTR mutations. There are still significant concerns about both the quality of the screen data, and its ability to detect significant changes in translation and their direction. Therefore, the ability of the screen to support the extensive downstream statistical analysis is limited and leaves the paper incomplete.

   Reviewed by eLife

4. Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation

   This article has 12 authors:

   1. Yicong Wang
   2. Masato Abe
   3. Yuka Kadoya
   4. Takeru Saiki
   5. Kanae Imai
   6. Xuejing Wang
   7. Taiko Kim To
   8. Soichi Inagaki
   9. Takamasa Suzuki
   10. Tetsuji Kakutani
   11. Toshiro Ito
   12. Nobutoshi Yamaguchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of the mechanisms underlying chromatin-mediated gene regulation by SET DOMAIN-CONTAINING PROTEIN 7 (SDG7). The evidence supporting the author's claims – centered on a combination of imaging approaches with molecular and genetic experiments – is convincing, although certain aspects can be improved. The work will be of broad interest to molecular biologists studying epigenetic regulation of gene expression.

   Reviewed by eLife

5. Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

   This article has 21 authors:

   1. Menglei Yang
   2. Hafiz Muhammad Jafar Hussain
   3. Manan Khan
   4. Zubair Muhammad
   5. Jianteng Zhou
   6. Ao Ma
   7. Xiongheng Huang
   8. Jingwei Ye
   9. Min Chen
   10. Aoran Zhi
   11. Tao Liu
   12. Ranjha Khan
   13. Ali Asim
   14. Wasim Shah
   15. Aurang Zeb
   16. Nisar Ahmad
   17. Huan Zhang
   18. Bo Xu
   19. Hui Ma
   20. Qinghua Shi
   21. Baolu Shi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study further validates DNAH12 as a causative gene for asthenoteratozoospermia and male infertility in both humans and mice. Compelling evidence supports the notion that DNAH12 is essential for proper axonemal development. This work will be of interest to reproductive biologists studying spermatogenesis and sperm biology, as well as andrologists focusing on male fertility.

   Reviewed by eLife

6. Structure transfer and consolidation in visual implicit learning

   This article has 2 authors:

   1. Dominik Garber
   2. József Fiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigates the conditions under which abstract knowledge transfers to new learning. It presents convincing evidence across a number of behavioral experiments that when explicit awareness of learned statistical structure is present, knowledge can transfer immediately, but that otherwise similar transfer requires sleep-dependent consolidation. The valuable results provide new constraints on theories of transfer learning and consolidation.

   Reviewed by eLife

7. A pair of dopaminergic neurons DAN-c1 mediate Drosophila larval aversive olfactory learning through D2-like receptors

   This article has 5 authors:

   1. Cheng Qi
   2. Cheng Qian
   3. Emma Steijvers
   4. Robert A Colvin
   5. Daewoo Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the role of dopamine receptor D2R in dopaminergic neurons DAN-c1 and mushroom body neurons (Y201-GAL4 pattern) on aversive and appetitive conditioning. The evidence supporting the claims of the authors is solid in the context of their behavioural paradigm. Controls using a reciprocal training protocol would have broadened the scope of their conclusions. The work will be of interest to researchers studying the role of dopamine during learning and memory.

   Reviewed by eLife

8. Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms

   This article has 8 authors:

   1. Martin Breyton
   2. Jan Fousek
   3. Giovanni Rabuffo
   4. Pierpaolo Sorrentino
   5. Lionel Kusch
   6. Marcello Massimini
   7. Spase Petkoski
   8. Viktor Jirsa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examined the complexity of emergent dynamics of large-scale neural network models after perturbation (perturbational complexity index, PCI) and used it as a measurement of consciousness to account for previous recordings of humans at various anesthetized levels. The evidence supporting the conclusion is convincing and constitutes a unified framework for different observations related to consciousness. There are many fields that would be interested in this study, including cognitive neuroscience, psychology, complex systems, neural networks, and neural dynamics.

   Reviewed by eLife

9. A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

   This article has 20 authors:

   1. Lotfi Ferhat
   2. Rabia Soussi
   3. Maxime Masse
   4. Grigorios Kyriatzis
   5. Stéphane Girard
   6. Fanny Gassiot
   7. Nicolas Gaudin
   8. Mathieu Laurencin
   9. Anne Bernard
   10. Angélique Bôle
   11. Géraldine Ferracci
   12. Maria Smirnova
   13. François Roman
   14. Vincent Dive
   15. Salvatore Cisternino
   16. Jamal Temsamani
   17. Marion David
   18. Pascaline Lécorché
   19. Guillaume Jacquot
   20. Michel Khrestchatisky

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors developed a method to allow a hypothermic agent, neurotensin, to cross the blood-brain barrier so it could potentially protect the brain from seizures and the adverse effects of seizures. The work is important because it is known that cooling the brain can protect it but developing a therapeutic approach based on that knowledge has not been done. The paper is well presented and the data are convincing.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.48550/arxiv.2310.02257v3