Latest preprint reviews

  1. Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

    This article has 6 authors:
    1. Richard J Lindsay
    2. Abhilash Sahoo
    3. Rafael Giordano Viegas
    4. Vitor BP Leite
    5. Philip A Wigge
    6. Sonya M Hanson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this potentially valuable computational study, the authors conducted extensive atomistic and coarse-grained simulations to probe the temperature-dependent phase behaviors of ELF3, a disordered component of the evening complex in plant. The results aim to highlight the role of polyQ tracts in modulating temperature-responsive structural and condensation behavior. Despite considerable improvements in the revised manuscript, the level of evidence is considered incomplete, since several of the supplementary observables introduced to support the revised claim indicate that the variants studied are not statistically distinguishable within the reported replicate uncertainty.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage

    This article has 7 authors:
    1. Joanna Krwawicz
    2. Caroline J Sheeba
    3. Katie Hains
    4. Thomas McMahon
    5. Yimo Zhang
    6. Skirmantas Kriaucionis
    7. Peter Sarkies
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of DNA methylation and its consequences for susceptibility to DNA damage. This work presents evidence that DNA methylation can accentuate the genomic damage propagated by DNA damaging agents as well as potentially being an independent source of such damage. The experimental results reported are sound. The evidence presented to support the conclusions drawn is convincing and alternative interpretations are considered. The work will be of broad interest to biochemists, cell and genome biologists.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
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