eLife

Latest preprint reviews

1. Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

   This article has 15 authors:

   1. Jiro Yoshino
   2. Sonali S Mali
   3. Claire R Williams
   4. Takeshi Morita
   5. Chloe E Emerson
   6. Christopher J Arp
   7. Sophie E Miller
   8. Chang Yin
   9. Lydia Thé
   10. Chikayo Hemmi
   11. Mana Motoyoshi
   12. Kenichi Ishii
   13. Kazuo Emoto
   14. Diana M Bautista
   15. Jay Z Parrish

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is important work and provides a significant advance in our understanding of mechanosensation in the epidermis. The evidence presented is convincing and, barring a few minor weaknesses, strongly implicates activation of epidermal cells and store-operated calcium entry in the activation of nociceptive neurons innervating that tissue. This work will be of broad interest to neurobiologists, epithelial cell biologists, and mechanobiologists.

   Reviewed by eLife, Arcadia Science

2. Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

   This article has 15 authors:

   1. Alessandra Machado Araujo
   2. Joseph D Dekker
   3. Kendra Garrison
   4. Zhe Su
   5. Catherine Rhee
   6. Zicheng Hu
   7. Bum-Kyu Lee
   8. Daniel Osorio
   9. Jiwon Lee
   10. Vishwanath R Iyer
   11. Lauren IR Ehrlich
   12. George Georgiou
   13. Gregory Ippolito
   14. Stephen Yi
   15. Haley O Tucker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study reports that while most plasmacytoid dendritic cells (pDCs) originate from common dendritic cell precursors, approximately 20% are derived from lymphoid progenitors shared with B cells. The methodology used and the evidence are solid, and further demonstrate the distinct transcription factor requirements and activities of this subset of pDCs, although the functional significance of this dendritic cell subset will require further elucidation. The findings will be of great interest for those interested in the developmental and functional biology of the immune system.

   Reviewed by eLife

3. Fine-scale tracking reveals visual field use for predator detection and escape in collective foraging of pigeon flocks

   This article has 2 authors:

   1. Mathilde Delacoux
   2. Fumihiro Kano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this fundamental study, the authors use innovative fine-scale motion capture technologies to study visual vigilance with high-acuity vision, to estimate the visual fixation of free-feeding pigeons. The authors present compelling evidence for use of the fovea to inspect predator cues, the behavioral state influencing the latency for fovea use, and the use of the fovea decreasing the latency to escape of both the focal individual and other flock members. The work will be of broad interest to behavioral ecologists.

   Reviewed by eLife

4. SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

   This article has 12 authors:

   1. Somen K Mistri
   2. Brianna M Hilton
   3. Katherine J Horrigan
   4. Emma S Andretta
   5. Remi Savard
   6. Oliver Dienz
   7. Kenneth J Hampel
   8. Diana L Gerrard
   9. Joshua T Rose
   10. Nikoletta Sidiropoulos
   11. Dev Majumdar
   12. Jonathan E Boyson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study highlights the importance of SLAM-SAP signaling in determining innate gamma-delta T cell sublineages and their T cell receptor repertoires. It uncovers the complex role of the SLAM-SAP pathway in developing specific gamma-delta T cell subsets. The evidence presented is compelling, backed by high-quality data obtained through advanced single cell proteogenomics techniques.This work will be of broad interest to immunologists.

   Reviewed by eLife

5. Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

   This article has 3 authors:

   1. Suman Kundu
   2. Advait Shetty
   3. Maria Gomes-Solecki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study contributes to our understanding on how prior exposure to a non-pathogenic Leptospira strain could prime the host to prevent severe leptospirosis following infection with a pathogenic strain. The work described is solid and broadly supports the claims, with minor weaknesses that could be addressed in future studies. The work will be of interest to scientists interested in host-pathogen interactions and leptospirosis.

   Reviewed by eLife

6. Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

   This article has 9 authors:

   1. Jarno Mäkelä
   2. Alexandros Papagiannakis
   3. Wei-Hsiang Lin
   4. Michael Charles Lanz
   5. Skye Glenn
   6. Matthew Swaffer
   7. Georgi K Marinov
   8. Jan M Skotheim
   9. Christine Jacobs-Wagner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work by Mäkelä et al. presents compelling experimental evidence supported by a theoretical model that the amount of chromosomal DNA can become limiting for the total rate of mRNA transcription and consequently protein production in the model bacterium Escherichia coli. The work is based on a mutant that allows inhibition of DNA replication while following growth at the single-cell level due to cell filamentation. The work significantly advances our understanding of growth and of the central dogma, and will be of considerable interest within both systems biology and microbial physiology.

   Reviewed by eLife

7. The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

   This article has 10 authors:

   1. Nasim Saadat
   2. Rhys N. Colson
   3. Acadia L. Grimme
   4. Uri Seroussi
   5. Joshua W. Anderson
   6. Julie M. Claycomb
   7. Matthew C. J. Wilce
   8. Katherine McJunkin
   9. Jacqueline A. Wilce
   10. Peter R. Boag

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study identifies amino acid residues in the C. elegans RNA-binding protein NHL-2 that are required for RNA binding in vitro and NHL-2 function in vivo. The evidence in support of the authors' mechanistic model is currently incomplete, as data implicating specific NHL-2 amino acids in RNA binding per se in vivo are not presented. This manuscript will be of interest to scientists working in the area of gene regulation.

   Reviewed by eLife

8. Light-driven synchronization of optogenetic clocks

   This article has 5 authors:

   1. Maria Cristina Cannarsa
   2. Filippo Liguori
   3. Nicola Pellicciotta
   4. Giacomo Frangipane
   5. Roberto Di Leonardo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a light-entrainable synthetic oscillator in bacteria, the optorepressilator. The authors develop a toolbox using optogenetics that makes the cellular oscillator easily controllable. This toolbox is valuable, contributing both to bioengineering and to the understanding of biological dynamical systems. The comparison with a mathematical model, population, and single-cell measurements demonstrate convincingly that the planned system was achieved and is suitable to control and study biological oscillators.

   Reviewed by eLife

9. PPI-hotspotID for detecting protein–protein interaction hot spots from the free protein structure

   This article has 6 authors:

   1. Yao Chi Chen
   2. Karen Sargsyan
   3. Jon D Wright
   4. Yu-Hsien Chen
   5. Yi-Shuian Huang
   6. Carmay Lim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript presents a machine-learning method to predict protein hotspot residues. The validation is incomplete, along with the misinterpretation of the results with other current methods like FTMap.

   Reviewed by eLife

10. Dynamic reinforcement learning reveals time-dependent shifts in strategy during reward learning

    This article has 4 authors:

    1. Sarah Jo C Venditto
    2. Kevin J Miller
    3. Carlos D Brody
    4. Nathaniel D Daw

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important work by Veneditto and colleagues developed a new modeling approach, called a mixture-of-agent hidden Markov model (MoA-HMM), in which choice behaviors are modeled as transitions between discrete states defined by different weighting of several reinforcement learning and decision strategies. The authors apply this approach to their previous data collected from rats performing the two-step task, and show that this method predicts fluctuations in neural and other behavioral data and provides better fits to the data than previous methods. The revision has greatly improved the manuscript, the evidence supporting the conclusions is convincing, and the method is of general interest to the field.

    Reviewed by eLife