eLife

Latest preprint reviews

1. Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells

   This article has 13 authors:

   1. Amélie-Rose Boudjema
   2. Rémi Balagué
   3. Cayla E Jewett
   4. Gina M LoMastro
   5. Olivier Mercey
   6. Adel Al Jord
   7. Marion Faucourt
   8. Alexandre Schaeffer
   9. Camille Noûs
   10. Nathalie Delgehyr
   11. Andrew J Holland
   12. Nathalie Spassky
   13. Alice Meunier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, Boudjema et al. use cell culture models and advanced microscopic imaging to provide detailed analyses of the cellular events underlying centriole amplification, apical migration, and assembly of hundreds of motile cilia in multi-ciliated cells. This largely descriptive work provides a better understanding of this process that is of interest to cell biologists studying centrioles and cilia. Most of the claims are supported by the data, but the study would benefit from additional analyses regarding the roles of microtubules, which are currently incomplete, and from text editing to improve accessibility and readability, especially for a wider audience.

   Reviewed by eLife

2. Superoxide Dismutases maintain niche homeostasis in stem cell populations

   This article has 4 authors:

   1. Olivia Majhi
   2. Aishwarya Chhatre
   3. Tanvi Chaudhary
   4. Devanjan Sinha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this work, the authors intend to assess the existence of a redox potential across germline stem cells and neighboring somatic stem cells in the Drosophila testis. Some aspects of the manuscript are solid, like the clear effect of SOD KD on cyst cell differentiation state. Other conclusions of the work, such as the non-autonomous effect of this KD in germ cells are not sufficiently supported by the data. The work is potentially useful if the critiques of the reviewers are fully addressed; the strength of the evidence of the manuscript as it stands is incomplete.

   Reviewed by eLife

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2307.05304v2

4. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination

   This article has 19 authors:

   1. Hideo Fukuhara
   2. Kohei Yumoto
   3. Miyuki Sako
   4. Mizuho Kajikawa
   5. Toyoyuki Ose
   6. Mihiro Kawamura
   7. Mei Yoda
   8. Surui Chen
   9. Yuri Ito
   10. Shin Takeda
   11. Mwila Mwaba
   12. Jiaqi Wang
   13. Takao Hashiguchi
   14. Jun Kamishikiryo
   15. Nobuo Maita
   16. Chihiro Kitatsuji
   17. Makoto Takeda
   18. Kimiko Kuroki
   19. Katsumi Maenaka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript presents valuable findings, using solid techniques and approaches, that shed additional light into how the canine distemper virus (CDV) hemagglutinin might engage cellular receptors and how that engagement impacts host tropism. The structural data and their analysis were thorough and well-presented. The HS-AFM data, which indicate that homodimers may dissociate into monomers - and thus have significant implications for the model of fusion triggering - are very exciting, but require further validation, perhaps by alternate approaches, to bolster the current molecular model of the CDV fusion triggering.

   Reviewed by eLife

5. Time to Eat - A Personalized Circadian Eating Schedule Leads to Weight Loss Without Imposing Calorie Restriction: A Randomized Controlled Pilot Study

   This article has 6 authors:

   1. Isabell Wilming
   2. Jana Tuschewski
   3. Jessie M Osterhaus
   4. Theresa JG Bringmann
   5. Anisja Hühne-Landgraf
   6. Dominic Landgraf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigates a dietary intervention that employs a smartphone app to promote meal regularity, findings that have theoretical or practical implications for a subfield and may be clinically useful. The intervention to entice participants to adhere to specific meal times represents a restrictive diet (even though it does not ask to limit caloric intake) similar to a time-restricted feeding diet, while the control subjects are not experiencing or adhering to dietary restrictions. The authors report significant weight loss but did not rigorously assess caloric intake which remains a weakness of this study as food diaries are notoriously unreliable. While the concept is very interesting, the study is considered incomplete, and the rigor of the results should be strengthened in follow-up studies to add more stringent methods to assess caloric intake. Additionally, the study hypothesizes that the intervention resets the circadian clock. However, the study needs an objective method for assessing circadian rhythms, such as actigraphy, in addition to a subjective questionnaire.

   Reviewed by eLife

6. Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

   This article has 13 authors:

   1. Sujeethkumar Prithiviraj
   2. Alejandro Garcia Garcia
   3. Karin Linderfalk
   4. Bai Yiguang
   5. Sonia Ferveur
   6. Ludvig Nilsén Falck
   7. Agatheeswaran Subramaniam
   8. Sofie Mohlin
   9. David Hidalgo Gil
   10. Steven J Dupard
   11. Dimitra Zacharaki
   12. Deepak Bushan Raina
   13. Paul E Bourgine

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents a potentially valuable approach to genetically modify cells to produce extracellular matrices with altered compositions, termed cell-laid, engineered extracellular matrices (eECM). The evidence supporting the authors' conclusions regarding the utility of eECM for endogenous repair is solid, although there are some disagreements on the chondrogenicity of lyophilized constructs which was viewed as lacking robust evidence for endochondral ossification.

   Reviewed by eLife

7. A single-cell atlas of the miracidium larva of Schistosoma mansoni reveals cell types, developmental pathways, and tissue architecture

   This article has 10 authors:

   1. Teresa Attenborough
   2. Kate A Rawlinson
   3. Carmen L Diaz Soria
   4. Kirsty Ambridge
   5. Geetha Sankaranarayanan
   6. Jennie Graham
   7. James A Cotton
   8. Stephen R Doyle
   9. Gabriel Rinaldi
   10. Matthew Berriman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study in which the authors provide an expression profile of the human blood fluke, Schistosoma mansoni. A strength of this solid study is in its inclusion of in situ hybridisation to validate the predictions of the transcript analysis.

   Reviewed by eLife

8. Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

   This article has 13 authors:

   1. Phaedra C Ghazi
   2. Kayla T O'Toole
   3. Sanjana Srinivas Boggaram
   4. Michael T Scherzer
   5. Mark R Silvis
   6. Yun Zhang
   7. Madhumita Bogdan
   8. Bryan D Smith
   9. Guillermina Lozano
   10. Daniel L Flynn
   11. Eric L Snyder
   12. Conan G Kinsey
   13. Martin McMahon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a mechanistic study showing the effect of combining inhibition of autophagy (through ULK1/2) and KRAS (using sotorasib) on KRAS mutant NSCLC making the study valuable to cancer biologists and more broadly in a clinical setting. The evidence generated by GEM mouse models and cell lines is solid but could be further strengthened by increasing the mouse cohort size. This study holds translational relevance beyond NSCLC to other indications that carry KRAS mutations.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.1101/2024.01.24.577030

10. Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

    This article has 7 authors:

    1. Kyle Spinler
    2. Michael Hamilton
    3. Jeevisha Bajaj
    4. Yutaka Shima
    5. Emily Diaz
    6. Marcie Kritzik
    7. Tannishtha Reya

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The study presents important findings on the role of MSI2-HOXA9 translocation in chronic myeloid leukemia. The authors provide convincing evidence supporting the role of this translocation in leukemogenesis by using elegant mouse modeling and in vitro mechanistic studies. Consistent with the reviews, the studies can be strengthened with further murine and cell line experiments.

    Reviewed by eLife