eLife

Latest preprint reviews

1. Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

   This article has 18 authors:

   1. Tao Cheng
   2. Xiang Liu
   3. Yang Dong
   4. Yi-Meng Tian
   5. Yan-Yi Xing
   6. Chen-Yi Chen
   7. Cong Liu
   8. Yun-Fei Li
   9. Ying Huang
   10. Ding-Hao Zhuo
   11. Xiao Xu
   12. Jing-Yun Luan
   13. Xin-Xin Fu
   14. Zi-Xin Jin
   15. Jing Mo
   16. Xiang Xu
   17. Hong-Qing Liang
   18. Peng-Fei Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a useful analysis of the changes in chromatin organization and gene expression that occur during the differentiation of two cell types (anterior endoderm and prechordal plate) from a common progenitor in zebrafish, together with investigations into the molecular factors involved. Although the findings are consistent with previous work, the evidence presented appears to be incomplete and would benefit from more rigorous quantification of live imaging and Cre-Lox experiments, a stronger rationale and controls for experiments manipulating chromatin remodeling factors, and a strong justification for the explant model especially given differences between explant and whole embryo data. This work may be of interest to zebrafish developmental biologists investigating the mechanisms underlying specification.

   Reviewed by eLife, Review Commons

2. Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

   This article has 9 authors:

   1. Jixing Li
   2. Qixuan Wang
   3. Qian Zhou
   4. Lu Yang
   5. Yutong Shen
   6. Shujian Huang
   7. Shaonan Wang
   8. Liina Pylkkänen
   9. Zhiwu Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study a computational language model, i.e., HM-LSTM, to quantify the neural encoding of hierarchical linguistic information in speech, and addresses how hearing impairment affects neural encoding of speech. Overall the evidence for the findings is solid, although the evidence for different speech processing stages could be strengthened by a more rigorous temporal response function (TRF) analysis. The study is of potential interest to audiologists and researchers who are interested in the neural encoding of speech.

   Reviewed by eLife

3. T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

   This article has 5 authors:

   1. Yan Zhao
   2. Hanshuo Zhu
   3. Jinqian Li
   4. Hang Xu
   5. Li Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that Type 3 secretion translocons in Edwardsiella tarda and other bacteria activate the NAIP-NLRC4 inflammasome. The data from cellular and biochemical experiments showing that EseB is required for activation of the NLRC4 inflammasome are convincing. This paper is broadly relevant to those investigating host-pathogen interactions in diverse organisms.

   Reviewed by eLife

4. Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

   This article has 9 authors:

   1. Eyal Paz
   2. Sahil Jain
   3. Irit Gottfried
   4. Orna Staretz-Chacham
   5. Muhammad Mahajnah
   6. Pritha Bagchi
   7. Nicholas T Seyfried
   8. Uri Ashery
   9. Abdussalam Azem

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study presents interesting results aimed at explaining the effects of a human mutation on the mitochondrial import protein TIMM50 on mitochondrial function and neuronal excitability. While the evidence supporting the conclusions is convincing, the mechanisms driving changes in the levels of certain proteins within and outside the mitochondria (such as certain ion channels) remain unexplained. This paper will be of interest to scientists in the mitochondria field.

   Reviewed by eLife

5. Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study

   This article has 9 authors:

   1. Gillian AM Tarr
   2. Linda Chui
   3. Kim Stanford
   4. Emmanuel W Bumunang
   5. Rahat Zaheer
   6. Vincent Li
   7. Stephen B Freedman
   8. Chad R Laing
   9. Tim A McAllister

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study revealed numerous distinct lineages that evolved within a local human population in Alberta, Canada, leading to persistent cases of E. coli O157:H7 infections for over a decade and highlighting the ongoing involvement of local cattle in disease transmission, as well as the possibility of intermediate hosts and environmental reservoirs. This study also showed a shift towards more virulent stx2a-only strains becoming predominant in the local lineages. The evidence supporting the role played by cattle in the transmission system of human cases of E. coli O157:H7 in Alberta is solid.

   Reviewed by eLife

6. Glia control experience-dependent plasticity in an olfactory critical period

   This article has 9 authors:

   1. Hans C Leier
   2. Alexander J Foden
   3. Darren A Jindal
   4. Abigail J Wilkov
   5. Paola Van der Linden Costello
   6. Pamela J Vanderzalm
   7. Jaeda Coutinho-Budd
   8. Masashi Tabuchi
   9. Heather T Broihier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Periods in which experience regulates early plasticity in sensory circuits are well established, but the mechanisms that control these critical periods are poorly understood. In this important study, the authors examine early-life critical periods that regulate the Drosophila antennal lobe and show that constant odor exposure markedly reduces the volume, synapse number, and function of a specific glomerulus. The authors offer compelling evidence that these changes are mediated by the invasion of ensheathing glia into the glomerulus where they phagocytose connections via a mechanism involving the engulfment receptor Draper.

   Reviewed by eLife

7. Should I stay or should I go? Spatiotemporal dynamics of bacterial biofilms in confined flows

   This article has 6 authors:

   1. Massinissa Benbelkacem
   2. Gabriel Ramos
   3. Fatima El Garah
   4. Yara Abidine
   5. Christine Roques
   6. Yohan Davit

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study combines microfluidic experiments with mathematical modeling to elucidate the reciprocal interplay between flow dynamics and biofilm growth and detachment. Using Pseudomonas aeruginosa as a model organism, the authors identify several key regimes and stages of biofilm development. Overall, the comparison between experimental observations of biofilm behavior under varying flow conditions and corresponding theoretical predictions forms a compelling understanding of the processes involved in biofilm dynamics. The results will be of interest to researchers studying biofilms and their technological and biological applications.

   Reviewed by eLife

8. Physiological magnetic field strengths help magnetotactic bacteria navigate in simulated sediments

   This article has 10 authors:

   1. Agnese Codutti
   2. Mohammad A Charsooghi
   3. Konrad Marx
   4. Elisa Cerdá-Doñate
   5. Omar Muñoz
   6. Paul Zaslansky
   7. Vitali Telezki
   8. Tom Robinson
   9. Damien Faivre
   10. Stefan Klumpp

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable experimental and numerical results on the motility of a magnetotactic bacterium living in sedimentary environments, particularly in environments of varying magnetic field strengths. The evidence supporting the claims of the authors is compelling and the study will be of specific relevance to biophysicists interested in bacterial motility.

   Reviewed by eLife

9. Simultaneous cyclin D1 overexpression and p27kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina

   This article has 7 authors:

   1. Zhifei Wu
   2. Baoshan Liao
   3. Julia Ying
   4. Jan Keung
   5. Zongli Zheng
   6. Virpi Ahola
   7. Wenjun Xiong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents a potentially important strategy for stimulating mammalian Müller glia to proliferate in vivo by manipulating cell cycle components. The results are convincing that a large number of Müller glia can be induced to re-enter the cell cycle without a damage stimulus. These findings are likely to appeal to retinal biologists and neuroscientists in general.

   Reviewed by eLife

10. Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

    This article has 14 authors:

    1. Moloy T Goswami
    2. Eric Weh
    3. Shubha Subramanya
    4. Katherine M Weh
    5. Hima Bindu Durumutla
    6. Heather Hager
    7. Nicholas Miller
    8. Sraboni Chaudhury
    9. Anthony Andren
    10. Peter Sajjakulnukit
    11. Li Zhang
    12. Cagri Besirli
    13. Costas A Lyssiotis
    14. Thomas J Wubben

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Goswami and colleagues used rod-specific Gls1 (the gene encoding glutaminase 1) knockout mice to investigate the role of GLS1 in photoreceptor health when GLS1 was deleted from developing or adult photoreceptor cells. This study is fundamental as it shows the critical role of glutamine catabolism in photoreceptor cell health using in vivo model systems. The evidence supporting the authors' claims is compelling. The studies add new insight into how specific metabolites support vision.

    Reviewed by eLife