eLife

Latest preprint reviews

1. Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin

   This article has 18 authors:

   1. Kei Wada
   2. Kenji Kobayashi
   3. Iori Era
   4. Yusuke Isobe
   5. Taigo Kamimura
   6. Masaki Marukawa
   7. Takayuki Nagae
   8. Kazuki Honjo
   9. Noriko Kaseda
   10. Yumiko Motoyama
   11. Kengo Inoue
   12. Masakazu Sugishima
   13. Katsuhiro Kusaka
   14. Naomine Yano
   15. Keiichi Fukuyama
   16. Masaki Mishima
   17. Yasutaka Kitagawa
   18. Masaki Unno

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Ferredoxins are ubiquitous electron transfer proteins that drive essential metabolic processes across all domains of life. This fundamental contribution to the field provides the first description of how specific amino acids, though a series of hydrogen bonds, control the ability of iron-sulfur clusters in ferrodoxins to accept and donate electrons. The evidence supporting the conclusions is compelling as is the combined use of neutron crystallography with X-ray crystallography and classical spectral/redox studies.

   Reviewed by eLife

2. Basal Cambrian soft-bodied segmented bilaterians preserved as microbial pseudomorphs

   This article has 10 authors:

   1. Xiaoguang Yang
   2. Deng Wang
   3. Zhiliang Zhang
   4. Xing Wang
   5. Jie Sun
   6. Wenjing Hao
   7. Yiqun Liu
   8. Kentaro Uesugi
   9. Tsuyoshi Komiya
   10. Jian Han

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes valuable new material of small, unusually preserved fossils from deep in the Cambrian of China and argues they represent very early bilaterian animals such as annelids or panarthropods. The authors present convincing evidence of the fossilisation of specimens as microbial pseudomorphs, however, the fossils show few details and it is difficult to assess their affinity. The broader claims made about the timing and nature of the Cambrian explosion are inadequately supported by the material, given that bilaterians were already known to exist during that period.

   Reviewed by eLife

3. Osterix Facilitates Osteocytic Communication by Targeting Connexin43

   This article has 14 authors:

   1. Zuping Wu
   2. Qian Chen
   3. Qian Gao
   4. Muchun Liang
   5. Yumeng Zhou
   6. Li Zhu
   7. Jiahe Wang
   8. Yang Shen
   9. Junjun Jing
   10. Jing Xie
   11. Xiaoheng Liu
   12. Shujuan Zou
   13. Demao Zhang
   14. Chenchen Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers valuable insights into the molecular mechanisms by which Osx influences osteocyte function, particularly through its regulation of Cx43. However, the evidence supporting the authors' claims is incomplete, necessitating additional experimental data and further investigation to fully substantiate these findings. While this study presents a new perspective on the complex role of Osx in bone biology, it also raises significant questions about the intricacies of its regulatory network.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2024.09.03.610837

5. We couldn't get details of this article at this time:
   10.1101/2024.08.25.609458

6. Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters

   This article has 7 authors:

   1. Jennifer Madrigal
   2. Heidi L Schubert
   3. Matthew A Sdano
   4. Laura McCullough
   5. Zaily Connell
   6. Tim Formosa
   7. Christopher P Hill

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful manuscript presents findings on Tom1p's interaction with Spt6p and its role in chromatin dynamics, supported by structural analysis through CryoEM. The evidence for the conclusions is currently incomplete, lacking key experiments including continuation in vivo interaction and orthogonal binding assays (e.g., SPR, MST, ITC) to fully support the proposed mechanism. While the results are promising, further validation is needed to strengthen the evidence and improve the manuscript's overall cohesion.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2021.03.02.433644

8. We couldn't get details of this article at this time:
   10.1101/2024.10.17.618873

9. We couldn't get details of this article at this time:
   10.1101/2024.07.25.605170

10. Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

    This article has 13 authors:

    1. Breanna Lam
    2. Kathrin M Kajderowicz
    3. Heather R Keys
    4. Julian M Roessler
    5. Evgeni M Frenkel
    6. Adina Kirkland
    7. Punam Bisht
    8. Mohamed A El-Brolosy
    9. Rudolf Jaenisch
    10. George W Bell
    11. Jonathan S Weissman
    12. Eric C Griffith
    13. Sinisa Hrvatin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The evidence supporting these conclusions is compelling, combining multi-species CRISPR screening with rigorous pharmacological assays. This work will be of significant interest to biologists studying hibernation physiology and medical researchers interested in cold tolerance.

    Reviewed by eLife