eLife

Latest preprint reviews

1. Different treatment durations of loperamide in preventing pyrotinib-induced diarrhea: A randomized, parallel-group sub-study of the phase II PHAEDRA trial

   This article has 22 authors:

   1. Changjun Wang
   2. Yan Lin
   3. Ying Xu
   4. Feng Mao
   5. Jinghong Guan
   6. Xuejing Wang
   7. Yanna Zhang
   8. Xiaohui Zhang
   9. Songjie Shen
   10. Ying Zhong
   11. Bo Pan
   12. Li Peng
   13. Xin Huang
   14. Xi Cao
   15. Ru Yao
   16. Xintong Zhou
   17. Zecheng He
   18. Yuhan Liu
   19. Jie Lang
   20. Chenggang Li
   21. Yidong Zhou
   22. Qiang Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful finding for the prevention of diarrhea with loperamide in patients with early HER2-positive breast cancer treated with nab-paclitaxel in combination with pyrotinib. The evidence supporting the claims of the authors is somewhat incomplete. The enrollment of patients as a control group who have not received prophylactic treatment for diarrhea would have strengthened the study, and the addition of double-blinding for the assessment of treatment may be necessary. The work will be of interest to scientists working in the field of clinical breast cancer treatment.

   Reviewed by eLife

2. Spatial localization of hippocampal replay requires dopamine signaling

   This article has 2 authors:

   1. Matthew R Kleinman
   2. David J Foster

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides a valuable contribution to our understanding of the neurobiological mechanisms underlying spatial memory and learning, suggesting that dopamine plays a pivotal role in linking reward context and novelty to memory consolidation processes. The evidence presented to support the main conclusions is solid, although reviewers felt that the strength of evidence could have been further strengthened by more rigorous histological verification of the experimental conditions and the complexity of the experimental manipulations, increased sample sizes, and a more consistent approach to experimental dosing and timing, which will be crucial for confirming the reproducibility and reliability of the observed effects.

   Reviewed by eLife

3. fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

   This article has 9 authors:

   1. Angela M Tuckowski
   2. Safa Beydoun
   3. Elizabeth S Kitto
   4. Ajay Bhat
   5. Marshall B Howington
   6. Aditya Sridhar
   7. Mira Bhandari
   8. Kelly Chambers
   9. Scott F Leiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study offers convincing evidence that fmo-4 plays essential roles in established lifespan interventions and downstream of its paralog fmo-2. The work is of substantial benefit for our understanding of this enzyme family, underscoring their importance in longevity and stress resistance. The study also suggests a connection between fmo-4 and dysregulation of calcium signalling, with conclusions and interpretations based on solid genetic methodology and evidence.

   Reviewed by eLife

4. Heparan sulphate binding controls in vivo half-life of the HpARI protein family

   This article has 9 authors:

   1. Florent Colomb
   2. Abhishek Jamwal
   3. Adefunke Ogunkanbi
   4. Tania Frangova
   5. Alice R Savage
   6. Sarah Kelly
   7. Gavin J Wright
   8. Matthew K Higgins
   9. Henry J McSorley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses in vitro and in vivo methods to identify HpARI proteins from H. polygyrus as modulators of the host immune system. The data from comprehensive approaches for investigating differential roles of HpARI proteins are convincing. This paper is relevant to those who investigate host-pathogen interactions at the systems and molecular levels.

   Reviewed by eLife

5. Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

   This article has 7 authors:

   1. Lili Karashchuk
   2. Jing Shuang Li
   3. Grant M Chou
   4. Sarah Walling-Bell
   5. Steven L Brunton
   6. John C Tuthill
   7. Bingni W Brunton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a computational model that simulates walking motions in Drosophila and suggests that, if sensorimotor delays in the neural circuitry were any longer, the system would be easily destabilized by external perturbations. The hierarchical control model is sensible and the evidence supporting the conclusions convincing. The modular model, which has many interacting components with varying degrees of biological realism, will serve as a well-grounded starting point for future studies that incorporate richer or more complete empirical data.

   Reviewed by eLife

6. Neural dynamics of visual working memory representation during sensory distraction

   This article has 4 authors:

   1. Jonas Karolis Degutis
   2. Simon Weber
   3. Joram Soch
   4. John-Dylan Haynes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports a reanalysis of one experiment of a previously-published report to characterize the dynamics of neural population codes during visual working memory in the presence of distracting information. This paper presents solid evidence that working memory representations are dynamic and distinct from sensory representations of intervening distractions. This research will be of interest to cognitive neuroscientists working on the neural bases of visual perception and memory.

   Reviewed by eLife

7. The inevitability and superfluousness of cell types in spatial cognition

   This article has 3 authors:

   1. Xiaoliang Luo
   2. Robert M Mok
   3. Bradley C Love

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that some degree of spatial tuning (e.g., place cells) and ability to decode spatial location emerges in sufficiently complex systems trained to process visual information. This intriguing observation challenges existing approaches and findings used in the study of spatial navigation. However, the strength of evidence regarding the nature and quality of spatial tuning, its compatibility with experimental data, and the overall interpretation of the study remains incomplete. This work will be of interest to the research community of spatial navigation.

   Reviewed by eLife

8. Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9

   This article has 10 authors:

   1. Hey-Kyeong Jeong
   2. Estibaliz Gonzalez-Fernandez
   3. Ilan Crawley
   4. Julia M Coakley
   5. Jinha Hwang
   6. Dale DO Martin
   7. Shernaz X Bamji
   8. Jong-Il Kim
   9. Shin H Kang
   10. Gareth M Thomas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an in-depth exploration of the impact of X-linked ZDHHC9 gene mutations on cognitive deficits and epilepsy, with a particular focus on the expression and function of ZDHHC9 in myelin-forming oligodendrocytes (OLs). These valuable findings offer insights into ZDHHC9-related X-linked intellectual disability (XLID) and shed light on the regulatory mechanisms of palmitoylation in myelination. The experimental design and analysis of results are solid, providing a reference for further research in this field.

   Reviewed by eLife

9. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

   This article has 8 authors:

   1. Abdulkadir Ozkan
   2. Hari K Padmanabhan
   3. Seth L Shipman
   4. Eiman Azim
   5. Priyanka Kumar
   6. Cameron Sadegh
   7. A Nazli Basak
   8. Jeffrey D Macklis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents fundamental new findings introducing a new approach for the reprogramming of brain glial cells to corticospinal neurons. The data is highly compelling, with multiple lines of evidence demonstrating the success of this new assay. These exciting findings set the stage for future studies of the potential of these reprogrammed cells to form functional connections in vivo and their utility in clinical conditions where corticospinal neurons are compromised.

   Reviewed by eLife

10. The emergence of visual category representations in infants’ brains

    This article has 6 authors:

    1. Xiaoqian Yan
    2. Sarah Shi Tung
    3. Bella Fascendini
    4. Yulan Diana Chen
    5. Anthony M Norcia
    6. Kalanit Grill-Spector

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study investigates the development of high-level visual responses in infants, finding that neural responses specific to faces are present by 4-6 months but not earlier. The study is methodologically convincing, using state-of-the-art experimental design and analysis approaches. The findings would be of broad interest to the cognitive neuroscience and developmental psychology research communities.

    Reviewed by eLife