eLife

Latest preprint reviews

1. Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

   This article has 16 authors:

   1. Sophie Leclercq
   2. Hany Ahmed
   3. Camille Amadieu
   4. Géraldine Petit
   5. Ville Koistinen
   6. Quentin Leyrolle
   7. Marie Poncin
   8. Peter Stärkel
   9. Eloise Kok
   10. Pekka J Karhunen
   11. Philippe de Timary
   12. Sophie Laye
   13. Audrey M Neyrinck
   14. Olli K Kärkkäinen
   15. Kati Hanhineva
   16. Nathalie Delzenne

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable insights and allows for hypothesis generation around diet-microbe-host interactions in alcohol use disorder. The strength of the evidence is convincing: the work is done in a rigorous manner in a well-described cohort of patients with AUD before and after withdrawal. There are several weaknesses, including validating the metabolites identified by metabolomics, the cross-sectional study design, the lack of a healthy control group, and the descriptive nature of such clinical cohort studies. Nevertheless, the study provides a wealth of new data that may be the basis for future studies that test causality and elucidate the role of single metabolites in the psychiatric sequela of AUD.

   Reviewed by eLife

2. Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex

   This article has 3 authors:

   1. Claire Meissner-Bernard
   2. Friedemann Zenke
   3. Rainer W Friedrich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study introduces a biologically constrained model of telencephalic area of adult zebrafish to highlight the significance of precisely balanced memory networks in olfactory processing. The authors provide compelling evidence that their model performs better in multiple situations (for e.g. in terms of network stability and shaping the geometry of representations), compared to traditional attractor networks and persistent activity. The work supports recent studies reporting functional E/I subnetworks in several sensory cortexes, and will be of interest to both theoretical and experimental neuroscientists studying network dynamics based on structured excitatory and inhibitory interactions.

   Reviewed by eLife

3. Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

   This article has 14 authors:

   1. Jan Stuchly
   2. David Novak
   3. Nadezda Brdickova
   4. Petra Hadlova
   5. Vojen Sadilek
   6. Ahmad Iksi
   7. Daniela Kuzilkova
   8. Michael Svaton
   9. George Alehandro Saad
   10. Pablo Engel
   11. Herve Luche
   12. Ana E Sousa
   13. Afonso RM Almeida
   14. Tomas Kalina

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors present an algorithm and workflow for the inference of developmental trajectories from single-cell data, including a mathematical approach to increase computational efficiency. In this latest version, the authors addressed the benchmarking of the novel method, but the absence of quantitative comparisons to state-of-the-art methods still make this study incomplete. Based on the shown validation approaches, one can neither ultimately judge if the shown method will be an advance over previous work nor whether the approach will be of general useful applicability.

   Reviewed by eLife

4. Shortcutting from self-motion signals reveals a cognitive map in mice

   This article has 5 authors:

   1. Jiayun Xu
   2. Mauricio Girardi-Schappo
   3. Jean-Claude Beique
   4. André Longtin
   5. Leonard Maler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work provides creative and thoughtful analysis of rodent foraging behavior and its dependence on body reference frame-based vs world reference frame-based cues. Compelling evidence demonstrates that a robust map, capable of supporting taking novel shortcuts, can be learned primarily if not exclusively based on self-motion cues, which has rarely if ever been reported outside of the human literature. The work, which will be of interest to a broad audience of neuroscientists, provides a rich discussion about the role of the hippocampus in supporting the behavior that should guide future neurophysiological investigations.

   Reviewed by eLife

5. Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

   This article has 11 authors:

   1. Ziyu Wen
   2. Pingchao Li
   3. Yue Yuan
   4. Congcong Wang
   5. Minchao Li
   6. Haohang Wang
   7. Minjuan Shi
   8. Yizi He
   9. Mingting Cui
   10. Ling Chen
   11. Caijun Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this useful study, the authors tested a novel approach to eradicate the HIV reservoir by constructing a herpes simplex virus (HSV)-based therapeutic vaccine designed to reactivate HIV from latently infected cells and induce an immune response to kill such infected cells. Testing this approach with SIV in a primate model, the authors report that the SIV reservoir was reduced. However, the evidence presented appears to be incomplete because the animal group size was small and the SIV reservoir size highly variable.

   Reviewed by eLife

6. Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

   This article has 16 authors:

   1. Yiwei Huang
   2. Gujie Wu
   3. Guoshu Bi
   4. Lin Cheng
   5. Jiaqi Liang
   6. Ming Li
   7. Huan Zhang
   8. Guangyao Shan
   9. Zhengyang Hu
   10. Zhencong Chen
   11. Zongwu Lin
   12. Wei Jiang
   13. Qun Wang
   14. Junjie Xi
   15. Shanye Yin
   16. Cheng Zhan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports single-cell RNA sequencing results of lung adenocarcinoma, comparing 4 treatment-naive and 5 post-neoadjuvant chemotherapy tumor samples. Of interest is the delineation of two macrophage subtypes: Anti-mac cells (CD45+CD11b+CD86+) and Pro-mac cells (CD45+CD11b+ARG+), with the proportion of Pro-mac/pro-tumorigenic cells significantly increasing in LUAD tissues after neoadjuvant chemotherapy. In terms of significance, the findings might be useful. However issues remain after the revision with lengthy descriptive clustering type analysis, insufficient statistical support, and inefficient figure presentation. As it stands, the level of supportive evidence is inadequate.

   Reviewed by eLife

7. Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

   This article has 13 authors:

   1. Balázs István Tóth
   2. Bahar Bazeli
   3. Annelies Janssens
   4. Erika Lisztes
   5. Márk Racskó
   6. Balázs Kelemen
   7. Mihály Herczeg
   8. Tamás Milán Nagy
   9. Katalin E Kövér
   10. Argha Mitra
   11. Attila Borics
   12. Tamás Bíró
   13. Thomas Voets

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents valuable findings showing that rapamycin directly activates the cool-sensing ion channel, TRPM8, acting through a different binding site than other small-molecule cooling agents such as menthol. The use of Ca2+-imaging, electrophysiology, and computational biology provides solid evidence to support the finding. The authors also present a novel NMR-based method to help identify details of the binding site interactions. In this revised version, some analysis and the presentation have been corrected and improved. Their findings provide insights into TRP channel pharmacology and may indicate previously unknown physiological effects or therapeutic mechanisms of the immunosuppressant, rapamycin.

   Reviewed by eLife

8. The identification of extensive samples of motor units in human muscles reveals diverse effects of neuromodulatory inputs on the rate coding

   This article has 5 authors:

   1. Simon Avrillon
   2. François Hug
   3. Roger M Enoka
   4. Arnault HD Caillet
   5. Dario Farina

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Leveraging state-of-the-art experimental and analytical approaches, this important study characterizes the recruitment and activation of large populations of human motor units during slow isometric contractions in two lower limb muscles. Evidence for the main claims is solid and advances our understanding of how humans generate and control voluntary force.

   Reviewed by eLife

9. Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states

   This article has 15 authors:

   1. Revathi Balasubramanian
   2. Krishnakumar Kizhatil
   3. Taibo Li
   4. Nicholas Tolman
   5. Aakriti Bhandari
   6. Graham Clark
   7. Violet Bupp-Chickering
   8. Ruth A Kelly
   9. Sally Zhou
   10. John Peregrin
   11. Marina Simón
   12. Christa Montgomery
   13. W Daniel Stamer
   14. Jiang Qian
   15. Simon WM John

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study has characterized the unique expression of Schlemm's canal endothelial cells (SECs) using FACS-sorted specific cell bulk RNA-Seq and scRNA-/snRNA-Seq of mouse SECs. The compelling study identified novel biomarkers for SECs and molecular markers for two inner wall SEC states and outwall SECs in mouse eyes. Significant gene networks and pathways were elucidated for their potential contribution to glaucoma pathogenesis, providing targets for further research in relation to glaucoma.

   Reviewed by eLife

10. Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan

    This article has 12 authors:

    1. Kristin Nordin
    2. Robin Pedersen
    3. Farshad Falahati
    4. Jarkko Johansson
    5. Filip Grill
    6. Micael Andersson
    7. Saana M Korkki
    8. Lars Bäckman
    9. Andrew Zalesky
    10. Anna Rieckmann
    11. Lars Nyberg
    12. Alireza Salami

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This fundamental work demonstrates the importance of considering overlapping modes of functional organization (i.e. gradients) in the hippocampus, showing associations with aging, dopaminergic receptor distribution and episodic memory. The evidence supporting the conclusions is convincing, although not all analyses were performed in a replication sample. The work will be of broad interest to basic and clinical neuroscientists.

    Reviewed by eLife