eLife

Latest preprint reviews

1. Mast cells promote pathology and susceptibility in tuberculosis

   This article has 15 authors:

   1. Ananya Gupta
   2. Vibha Taneja
   3. Javier Rangel-Moreno
   4. Nilofer Naqvi
   5. Abhimanyu
   6. Yun Tao
   7. Mushtaq Ahmed
   8. Kuldeep Singh Chauhan
   9. Daniela Trejo-Ponce de Leon
   10. Gustavo Ramírez-Martínez
   11. Luis Jiménez-Alvarez
   12. Cesar Luna-Rivero
   13. Joaquin Zuniga
   14. Deepak Kaushal
   15. Shabaana A Khader

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this useful study, the authors utilize published scRNA-seq data to highlight the potential importance of mast cells (MCs) in TB granulomas, presenting a solid comparative assessment of chymase- and tryptase-expressing MCs in the lungs of Mycobacterium tuberculosis-infected individuals and non-human primates. While the authors appropriately discussed the inconsistencies across models, adoptive transfer experiments in MC-deficient mice would substantially strengthen the causal link between MCs and TB outcomes, providing more direct functional validation of the proposed role of MCs in TB pathogenesis.

   Reviewed by eLife, Arcadia Science

2. C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

   This article has 10 authors:

   1. Toru Tanaka
   2. Naoto Sasaki
   3. Aga Krisnanda
   4. Hilman Zulkifli Amin
   5. Ken Ito
   6. Sayo Horibe
   7. Kazuhiko Matsuo
   8. Ken-ichi Hirata
   9. Takashi Nakayama
   10. Yoshiyuki Rikitake

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides in-vivo evidence that CCR4 regulates the early inflammatory response during atherosclerotic plaque formation. The authors propose that altered T-cell response plays a role in this process, shedding light on mechanisms that may be of interest to medical biologists, biochemists, cell biologists, and immunologists. The work is currently considered incomplete pending textual changes and the inclusion of proper controls.

   Reviewed by eLife

3. A novel method (RIM-Deep) for enhancing imaging depth and resolution stability of deep cleared tissue in inverted confocal microscopy

   This article has 4 authors:

   1. Yisi Liu
   2. Pu Wang
   3. Junjie Zou
   4. Hongwei Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study describes a useful technique to improve imaging depth using confocal microscopy for imaging large, cleared samples. The work is supported by solid findings and will be of broad interest to many microscopical researchers in different fields who want a cost effective way to image deep into samples.

   Reviewed by eLife

4. Group identification drives brain integration for collective performance

   This article has 4 authors:

   1. Enhui Xie
   2. Shuyi Zha
   3. Yiyang Xu
   4. Xianchun Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This timely and important study used functional near-infrared spectroscopy hyperscanning to examine the neural correlates of how group identification influences collective behavior. The work provides solid evidence to indicate that the synchronization of brain activity between different people underlies collective performance and that changes in brain activity patterns within individuals may, in turn, underlie this between-person synchrony, although the order in which different task stages were completed could not be counter-balanced. This study will be of interest to researchers investigating the neuroscience of social behaviour.

   Reviewed by eLife

5. Self-association enhances early attentional selection through automatic prioritization of socially salient signals

   This article has 5 authors:

   1. Meike Scheller
   2. Jan Tünnermann
   3. Katja Fredriksson
   4. Huilin Fang
   5. Jie Sui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the mechanism of self-prioritization by revealing the influence of self-associations on early attentional selection. The evidence supporting the claims of the authors is solid, although inclusion of a discussion about the generalization and limitation would have strengthened the study. The work will be of interest to researchers in psychology, cognitive science, and neuroscience.

   Reviewed by eLife

6. Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles

   This article has 19 authors:

   1. Lizi Zhang
   2. Yishan Qu
   3. Larry J Young
   4. Wenjuan Hou
   5. Limin Liu
   6. Jing Liu
   7. Yuqian Wang
   8. Lu Li
   9. Xing Guo
   10. Yin Li
   11. Caihong Huang
   12. Zijian Lv
   13. Yi-Tong Li
   14. Rui Jia
   15. Ting Lian
   16. Hao Feng
   17. Hui Qiao
   18. Zhixiong He
   19. Fa-Dao Tai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of the role of dopamine in modulating pair bonding in mandarin voles by examining dopamine signaling within the nucleus accumbens across various social stimuli using state-of-the-art causal perturbations. The evidence supporting the findings is compelling, particularly cutting-edge approaches for measuring dopamine release as well as the activity of dopamine receptor populations during social bonding. Some concerns remain about the statistical analyses.

   Reviewed by eLife

7. Non-feature-specific elevated responses and feature-specific backward replay in human brain induced by visual sequence exposure

   This article has 6 authors:

   1. Tao He
   2. Xizi Gong
   3. Qian Wang
   4. Xinyi Zhu
   5. Yunzhe Liu
   6. Fang Fang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates both online responses to, and offline replay of, visual motion sequences. Sophisticated MEG analyses provide convincing evidence for both feature-specific and non-specific sequence representations. These intriguing findings will be of interest to perception and learning researchers alike.

   Reviewed by eLife

8. Ribosome demand links transcriptional bursts to protein expression noise

   This article has 3 authors:

   1. Sampriti Pal
   2. Upasana Ray
   3. Riddhiman Dhar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study focuses on a previously reported positive correlation between translational efficiency and protein noise. Using mathematical modeling and analysis of experimental data the authors reach the valuable conclusion that this phenomenon arises due to ribosomal demand. While some aspects of the work appear to be incomplete, the results have the potential to be of value and interest to the field of gene expression.

   Reviewed by eLife

9. Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos

   This article has 9 authors:

   1. Yanlin Hou
   2. Zhengwen Nie
   3. Qi Jiang
   4. Sergiy Velychko
   5. Sandra Heising
   6. Ivan Bedzhov
   7. Guangming Wu
   8. Kenjiro Adachi
   9. Hans R Scholer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. The evidence supporting the claims of the authors is solid, although inclusion of additional omics data would further strengthen the study. The work will be of interest to biologists working on embryonic development and gene regulation.

   Reviewed by eLife

10. Morphology and synapse topography optimize linear encoding of synapse numbers in Drosophila looming responsive descending neurons

    This article has 6 authors:

    1. Anthony Moreno-Sanchez
    2. Alexander N Vasserman
    3. HyoJong Jang
    4. Bryce W Hina
    5. Catherine R von Reyn
    6. Jessica Ausborn

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study provides a detailed picture of the synapse distributions for a set of visual projection neurons and their downstream partners, in combination with multi-compartmental modelling fitted to electrophysiological data. The model reveals interesting consequences of synapse topography for neuronal computation. The analysis, however, seems incomplete as the authors only analyze passive models of these spiking neurons, and do not attempt to connect their analysis to the bigger picture at the behavioral level.

    Reviewed by eLife