eLife

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1. Multiomics reveals gut dysbiosis contributes to fatty acid dysmetabolism in early phase of acute myocardial infarction

   This article has 30 authors:

   1. Yong Fan
   2. Jiajun Ying
   3. Ning Huangfu
   4. Kewan He
   5. Teng Hu
   6. Pengpeng Su
   7. Xintao Hu
   8. Hequn He
   9. Wei Liang
   10. Junsong Liu
   11. Jinsong Cheng
   12. Shiqi Wang
   13. Ruochi Zhao
   14. Hengyi Mao
   15. Fuwei He
   16. Jia Su
   17. Honglin Zhou
   18. Zhenwei Li
   19. Xiaohong Fei
   20. Xiafei Sun
   21. Peipei Wang
   22. Minfang Guan
   23. Weiping Du
   24. Shaoyi Lin
   25. Yong Wang
   26. Fangkun Yang
   27. Renyuan Fang
   28. Ziqing Kong
   29. Xiaomin Chen
   30. Hanbin Cui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable information about the microbiome and metabolome, and their correlation with acute myocardial infarction. However, the relationship established between these variables is limited to a correlation, and therefore the strength of the evidence is incomplete.

   Reviewed by eLife

2. Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

   This article has 9 authors:

   1. Yajun Zhai
   2. Peiyi Liu
   3. Xueqin Hu
   4. Changjian Fan
   5. Xiaodie Cui
   6. Qibiao He
   7. Dandan He
   8. Xiaoyuan Ma
   9. Gongzheng Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study addresses the growing threat of multi-drug-resistant (MDR) pathogens by focusing on the enhanced efficacy of colistin when combined with artesunate and EDTA against colistin-resistant Salmonella strains. The evidence is solid, supported by comprehensive microbiological assays, molecular analyses, and in vivo experiments demonstrating the effectiveness of this synergic combination.

   Reviewed by eLife

3. Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

   This article has 20 authors:

   1. Ka Kiu Lee
   2. Urszula Łapińska
   3. Giulia Tolle
   4. Maureen Micaletto
   5. Bing Zhang
   6. Wanida Phetsang
   7. Anthony D Verderosa
   8. Brandon M Invergo
   9. Joseph Westley
   10. Attila Bebes
   11. Raif Yuecel
   12. Paul A O'Neill
   13. Audrey Farbos
   14. Aaron R Jeffries
   15. Stineke van Houte
   16. Pierluigi Caboni
   17. Mark AT Blaskovich
   18. Benjamin E Housden
   19. Krasimira Tsaneva-Atanasova
   20. Stefano Pagliara

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study by Lee et al. explores the heterogeneous response of non-growing bacteria to the antimicrobial peptide (AMP) tachyplesin. The authors identify a subpopulation of cells that evade lethal damage by limiting the intracellular accumulation of a fluorescently labeled tachyplesin analog. The study provides compelling evidence that reduced drug accumulation underlies the decreased susceptibility of this subpopulation to the AMP. The molecular basis of this phenotype is well supported by the data.

   Reviewed by eLife

4. Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

   This article has 6 authors:

   1. Yujie Fang
   2. Zihan Guan
   3. Xiangtao Zhu
   4. Zhenqiong Guan
   5. Shufen Li
   6. Ke Peng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes an unexpected role of cellular caspases in cleaving Drp1, a protein involved in mitochondrial fission, in virus-infected cells. Drp1 cleavage augments mitochondrial fission, reinforcing MAVS-dependent type-1 IFN response against multiple viruses. The findings presented in this manuscript are important and the strength of evidence is solid. Additional studies may allow for more robust mechanistic substantiation of the proposed model.

   Reviewed by eLife

5. Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

   This article has 8 authors:

   1. Zhen Wang
   2. Jie Zhu
   3. Mengda Xu
   4. Xuyuan Ma
   5. Maozheng Shen
   6. Jingyu Yan
   7. Guosheng Gan
   8. Xiang Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable report, the authors investigated the effect of mitochondrial transplantation on post-cardiac arrest myocardial dysfunction (PAMD), which is associated with mitochondrial dysfunction. They convincingly demonstrated that mitochondrial transplantation enhanced cardiac function and increased survival rates after the return of spontaneous circulation (ROSC). They have also shown that myocardial tissues with transplanted mitochondria exhibited increased mitochondrial complex activity, higher ATP levels, reduced cardiomyocyte apoptosis, and lower myocardial oxidative stress post-ROSC.

   Reviewed by eLife

6. Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

   This article has 9 authors:

   1. Giorgia Greter
   2. Claudia Moresi
   3. Stefanie Oswald
   4. Alice de Wouters d’Oplinter
   5. Daria Künzli
   6. Elisa Cappio Barazzone
   7. Jiayi Lan
   8. Emma Slack
   9. Markus Arnoldini

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Feeding, the circadian rhythm, and the gut microbiota are all intimately linked, motivating new approaches to identify causal relationships while minimizing confounding factors. The authors employ an innovative combination of the stool softener lactulose and a defined 3-member gut microbiota to acutely induce gut bacterial metabolism in mice during the daytime, resulting in changes in the ileal expression of clock genes and altered feeding behavior. Together, this study utilizes solid methods to provide important new insights into the role of gut microbiota in the circadian rhythm, setting the stage for follow-on studies aimed at better understanding the mechanisms responsible.

   Reviewed by eLife

7. Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

   This article has 37 authors:

   1. Patrick KA Kearns
   2. Charles Dixon
   3. Mihaly Badonyi
   4. Kim Lee
   5. Rafal Czapiewski
   6. Olivia Fleming
   7. Prajitha Nadukkandy
   8. Lukas Gerasimivicius
   9. Rinal Sahputra
   10. Bethany Potts
   11. Sam Benton
   12. Jacky Guy
   13. Scott Neilson
   14. Helen Wise
   15. Sara Jenks
   16. Kate Templeton
   17. CIRCO
   18. Christina Dold
   19. Teresa Lambe
   20. Andrew Pollard
   21. Alexander J Mentzer
   22. Julian C Knight
   23. COMBAT
   24. Susanna Dunachie
   25. Paul Klenerman
   26. Eleanor Barnes
   27. Alan Carson
   28. Laura McWhirter
   29. Tracy Hussell
   30. Rennos Fragkoudis
   31. Susan Rosser
   32. David Cavanagh
   33. Graeme Cowan
   34. Madhvi Menon
   35. Joseph A Marsh
   36. Dirk A Kleinjan
   37. Nick Gilbert

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides novel insights into COVID-19 immune responses by using the delta of the normalised accessible surface area (DASA) to map IgM responses to the SARS-CoV-2 Membrane protein M1-subtype across multiple European cohorts. The evidence supporting the findings is solid, with thorough validation and comprehensive analysis, although additional clarity on T-independent B cell reactions and the impact of comorbidities would further strengthen the conclusions. The methods and data presented are valuable for advancing diagnostic and prognostic tools for COVID-19, particularly in the context of long COVID.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2401.04873v2

9. Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

   This article has 12 authors:

   1. Masroor Ahmad Paddar
   2. Fulong Wang
   3. Einar S Trosdal
   4. Emily Hendrix
   5. Yi He
   6. Michelle R Salemi
   7. Michal Mudd
   8. Jingyue Jia
   9. Thabata Duque
   10. Ruheena Javed
   11. Brett S Phinney
   12. Vojo Deretic

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Masroor Ahmad Paddar and colleagues reveal noncanonical roles of ATG5 and membrane ATG8ylation in regulating retromer assembly and function. They identify ATG5's unique non-autophagic role and show that CASM partially contributes to these phenotypes. Although the mechanism by which ATG8ylation regulates the retromer remains unclear, the findings provide important insights with solid supporting evidence.

   Reviewed by eLife

10. Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

    This article has 10 authors:

    1. Akiko Hozumi
    2. Nozomu M Totsuka
    3. Arata Onodera
    4. Yanbin Wang
    5. Mayuko Hamada
    6. Akira Shiraishi
    7. Honoo Satake
    8. Takeo Horie
    9. Kohji Hotta
    10. Yasunori Sasakura

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important work substantially advances our understanding of the molecular mechanisms underlying the timing of the initiation of metamorphosis of the Ciona ascidian tadpole larva. Through the combination of gene knockdown experiments and fluorescent molecular reporters the authors provide compelling evidence about a crosstalk between different G protein mediated signalling pathways and are able to place different signalling molecules within a signalling network. The work will be of interest to molecular, developmental and marine biologists and to scientists working on animal metamorphosis.

    Reviewed by eLife