eLife

Latest preprint reviews

1. Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis

   This article has 6 authors:

   1. Davinder Singh
   2. Yajun Liu
   3. Yi-Hua Zhu
   4. Sha Zhang
   5. Shelby M Naegele
   6. Jian-Qiu Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     How secretion is regulated during cell division and how membrane trafficking factors cooperate with the cytoskeleton during cell division remain poorly understood. In this work the authors find protein-protein interactions and localization dependencies between the polymeric septin cytoskeleton and the exocyst complex, using fission yeast as a model organism and using alphafold 3 based structural predictions. The work provides a valuable body of new information that will be of great interest to the cell biology community. The evidence is solid and provides the authors and the community a framework to test if the identified interfaces reflect bona fide interaction sites in vivo and in vitro in future.

   Reviewed by eLife

2. Unraveling CRP/cAMP-mediated metabolic regulation in Escherichia coli persister cells

   This article has 4 authors:

   1. Han G Ngo
   2. Sayed Golam Mohiuddin
   3. Aina Ananda
   4. Mehmet Orman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study reports an important finding on the role of the global metabolic regulator Crp/cAMP in the formation of antibiotic persister Escherichia coli. The evidence supporting the claims is solid including metabolomic analysis and characterization of many mutant strains.

   Reviewed by eLife

3. Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study

   This article has 12 authors:

   1. Yuan Zhang
   2. Dan Tang
   3. Ning Zhang
   4. Yi Xiang
   5. Yifan Hu
   6. Wen Qian
   7. Yangji Baima
   8. Xianbin Ding
   9. Ziyun Wang
   10. Jianzhong Yin
   11. Xiong Xiao
   12. Xing Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study examined the associations of a healthy lifestyle with comprehensive and organ-specific biological ages defined using common blood biomarkers and body measures. Its large sample size, longitudinal design, and robust statistical analysis provide solid support for the findings, which will be of interest to epidemiologists and clinicians.

   Reviewed by eLife

4. NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors

   This article has 7 authors:

   1. Connor Hill
   2. Alexandra Indeglia
   3. Francis Picone
   4. Maureen E Murphy
   5. Cara Cipriano
   6. Robert G Maki
   7. Alessandro Gardini

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides compelling data regarding the molecular characterization of a rare tumor type with few treatment options. This fundamental work significantly advances our mechanistic understanding of solitary fibrous tumours, a critical first step towards targeted precision medicine approaches. The results of this study will be of broad interest to cancer biologists and experimental oncologists.

   Reviewed by eLife

5. DeePosit, an AI-based tool for detecting mouse urine and fecal depositions from thermal video clips of behavioral experiments

   This article has 5 authors:

   1. David Peles
   2. Shai Netser
   3. Natalie Ray
   4. Taghreed Suliman
   5. Shlomo Wagner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents an important machine-learning-based approach to the automated detection of urine and fecal deposits by rodents, key ethological behaviors that have traditionally been very poorly studied. The strength of evidence for the claim is solid, showing accuracy near 90% across several contexts. Training and testing for the specific contexts used by other experimenters, however, is probably warranted to make the model most relevant to the data that may be analyzed.

   Reviewed by eLife

6. The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)

   This article has 11 authors:

   1. Lingjie Zhang
   2. Tong Deng
   3. Zhongqi Liufu
   4. Xueyu Liu
   5. Bingjie Chen
   6. Zheng Hu
   7. Chenli Liu
   8. Miles E Tracy
   9. Xuemei Lu
   10. Hai-Jun Wen
   11. Chung-I Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper introduces a theoretical framework and methodology for identifying Cancer Driving Nucleotides (CDNs), primarily based on single nucleotide variant (SNV) frequencies. A variety of solid approaches indicate that a mutation recurring three or more times is more likely to reflect selection rather than being the consequence of a mutation hotspot. The method is rigorously quantitative, though the requirement for larger datasets to fully identify all CDNs remains a noted limitation. The work will be of broad interest to cancer geneticists and evolutionary biologists.

   Reviewed by eLife

7. Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function

   This article has 14 authors:

   1. Bei Zhang
   2. Ting Cai
   3. Esha Reddy
   4. Yuanna Wu
   5. Isha Mondal
   6. Yinglu Tang
   7. Adaeze Scholastical Gbufor
   8. Jerry Wang
   9. Yawei Shen
   10. Qing Liu
   11. Raymond Sun
   12. Winson S Ho
   13. Rongze Olivia Lu
   14. Zhihao Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Glioblastoma is among the most aggressive cancers without a cure, and its cells are characterized by high mitochondrial membrane potential. This manuscript provides convincing evidence that glioblastoma tumorigenesis is closely linked to mitochondrial stress. The study makes a valuable contribution to the field by advancing our understanding of the metabolic mechanisms driving glioblastoma and highlighting potential therapeutic targets.

   Reviewed by eLife

8. Multiomics reveals gut dysbiosis contributes to fatty acid dysmetabolism in early phase of acute myocardial infarction

   This article has 30 authors:

   1. Yong Fan
   2. Jiajun Ying
   3. Ning Huangfu
   4. Kewan He
   5. Teng Hu
   6. Pengpeng Su
   7. Xintao Hu
   8. Hequn He
   9. Wei Liang
   10. Junsong Liu
   11. Jinsong Cheng
   12. Shiqi Wang
   13. Ruochi Zhao
   14. Hengyi Mao
   15. Fuwei He
   16. Jia Su
   17. Honglin Zhou
   18. Zhenwei Li
   19. Xiaohong Fei
   20. Xiafei Sun
   21. Peipei Wang
   22. Minfang Guan
   23. Weiping Du
   24. Shaoyi Lin
   25. Yong Wang
   26. Fangkun Yang
   27. Renyuan Fang
   28. Ziqing Kong
   29. Xiaomin Chen
   30. Hanbin Cui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable information about the microbiome and metabolome, and their correlation with acute myocardial infarction. However, the relationship established between these variables is limited to a correlation, and therefore the strength of the evidence is incomplete.

   Reviewed by eLife

9. Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

   This article has 9 authors:

   1. Yajun Zhai
   2. Peiyi Liu
   3. Xueqin Hu
   4. Changjian Fan
   5. Xiaodie Cui
   6. Qibiao He
   7. Dandan He
   8. Xiaoyuan Ma
   9. Gongzheng Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study addresses the growing threat of multi-drug-resistant (MDR) pathogens by focusing on the enhanced efficacy of colistin when combined with artesunate and EDTA against colistin-resistant Salmonella strains. The evidence is solid, supported by comprehensive microbiological assays, molecular analyses, and in vivo experiments demonstrating the effectiveness of this synergic combination.

   Reviewed by eLife

10. Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

    This article has 20 authors:

    1. Ka Kiu Lee
    2. Urszula Łapińska
    3. Giulia Tolle
    4. Maureen Micaletto
    5. Bing Zhang
    6. Wanida Phetsang
    7. Anthony D Verderosa
    8. Brandon M Invergo
    9. Joseph Westley
    10. Attila Bebes
    11. Raif Yuecel
    12. Paul A O'Neill
    13. Audrey Farbos
    14. Aaron R Jeffries
    15. Stineke van Houte
    16. Pierluigi Caboni
    17. Mark AT Blaskovich
    18. Benjamin E Housden
    19. Krasimira Tsaneva-Atanasova
    20. Stefano Pagliara

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study by Lee et al. explores the heterogeneous response of non-growing bacteria to the antimicrobial peptide (AMP) tachyplesin. The authors identify a subpopulation of cells that evade lethal damage by limiting the intracellular accumulation of a fluorescently labeled tachyplesin analog. The study provides compelling evidence that reduced drug accumulation underlies the decreased susceptibility of this subpopulation to the AMP. The molecular basis of this phenotype is well supported by the data.

    Reviewed by eLife