eLife

Latest preprint reviews

1. Flexible neural representations of abstract structural knowledge in the human entorhinal cortex

   This article has 6 authors:

   1. Shirley Mark
   2. Philipp Schwartenbeck
   3. Avital Hahamy
   4. Veronika Samborska
   5. Alon Boaz Baram
   6. Timothy E Behrens

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Mark and colleagues developed and validated a valuable method for examining subspace generalization in fMRI data and applied it to understand whether the entorhinal cortex uses abstract representations that generalize across different environments with the same structure. The manuscript presents convincing evidence for the conclusion that abstract entorhinal representations of hexagonal associative structures generalize across different stimulus sets.

   Reviewed by eLife

2. PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

   This article has 15 authors:

   1. Julia Raulino Lima
   2. Nicha Ungvijanpunya
   3. Qing Chen
   4. Hoang Quoc Hai Pham
   5. Tal Rosen
   6. Greg Park
   7. Mohammadreza Vatankhah
   8. Steven Yen
   9. Yang Chai
   10. Amy E Merrill
   11. Zhaoyang Liu
   12. Jian-Fu Chen
   13. Yanzhong Yang
   14. Weiqun Peng
   15. Jian Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work establishes a connection between PRMT1 and SFPQ by identifying common phenotypes downstream of their inactivation. In the resubmission, authors now include NMD as a contributor to aberrant gene expression underpinning craniofacial development. The complementary experiments help strengthen some solid conclusions. This paper describes an interesting mechanism for the regulation of RNA levels, which is of interest to the readers of eLife.

   Reviewed by eLife

3. Multi-dimensional oscillatory activity of mouse GnRH neurons in vivo

   This article has 5 authors:

   1. Su Young Han
   2. Shel-Hwa Yeo
   3. Jae-Chang Kim
   4. Ziyue Zhou
   5. Allan E Herbison

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the oscillatory activity of gonadotropin-releasing hormone (GnRH) neurones in mice using GCaMP fiber photometry. It demonstrates three distinct patterns of oscillatory activity that occur in GnRH neurons comprising low-level rapid baseline activity, abrupt short-duration oscillations that drive pulsatile gonadotropin secretion, and, in females, a gradual and prolonged oscillating increase in activity responsible for the relatively short-lived preovulatory LH surge. The evidence presented in the study is solid, offering theoretical implications for understanding the behaviour of GnRH neurones in the context of reproductive physiology, and will be of interest to researchers in neuroendocrinology and reproductive biology.

   Reviewed by eLife

4. Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration

   This article has 24 authors:

   1. Thomas M Hallam
   2. Emanuela Gardenal
   3. Fraser McBlane
   4. GaEun Cho
   5. Lucy Lee Ferraro
   6. Eva Pekle
   7. Darlene Lu
   8. Kate Carney
   9. Claire Wenden
   10. Hannah Beadsmoore
   11. Sergio Kaiser
   12. Lauren Drage
   13. Thomas Haye
   14. Iris Kassem
   15. Nalini Rangaswamy
   16. Ma’en Obeidat
   17. Cyndy Grosskreutz
   18. Magali Saint-Geniez
   19. David H Steel
   20. Robert E MacLaren
   21. Scott Ellis
   22. Claire L Harris
   23. Stephen Poor
   24. Amy V Jones

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of factors influencing efficacy assessments and biomarker viability for complement-directed gene therapy against age-related macular degeneration. The data presented is convincing and offers insights and teachings for the design of gene therapy and complement-targeted therapeutics in the eye and more broadly for future ocular biomarker studies.

   Reviewed by eLife

5. Reevaluating the neural noise in dyslexia using biomarkers from electroencephalography and high-resolution magnetic resonance spectroscopy

   This article has 6 authors:

   1. Agnieszka Glica
   2. Katarzyna Wasilewska
   3. Julia Jurkowska
   4. Jarosław Żygierewicz
   5. Bartosz Kossowski
   6. Katarzyna Jednoróg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study empirically investigates the neural noise hypothesis of developmental dyslexia using electroencephalography (EEG) during a spoken language task and 7T magnetic resonance spectroscopy (MRS). The convincing findings indicate no evidence of an imbalance between excitatory and inhibitory (E/I) brain activity in adolescents and young adults with dyslexia compared to controls, thereby challenging the neural noise hypothesis. This research is valuable for advancing our understanding of the neural mechanisms underlying dyslexia and offers broader insights into the neural processes involved in reading development.

   Reviewed by eLife

6. Mixed representations of choice direction and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus

   This article has 8 authors:

   1. Julianna Locantore
   2. Yijun Liu
   3. Jesse White
   4. Janet Berrios Wallace
   5. Celia Beron
   6. Emily Kraft
   7. Bernardo Sabatini
   8. Michael Wallace

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Somatostatin-expressing neurons of the entopeduncular nucleus (EPNSst+) provide a limbic output of the basal ganglia and co-release GABA and Glutamate in their projection to the lateral habenula, a structure that is key for reward-based learning. Combining fiber photometry and computational modeling, the authors provide compelling evidence that EPNSst+ neural activity represents movement, choice direction and reward outcomes in a probabilistic switching task but, surprisingly, neither chronic genetic silencing of these neurons nor selectively elimination glutamate release affected behavioral performance in well-trained animals. This valuable study shows that despite its representation of key task variables, EPNSst+ neurons are dispensable for ongoing performance in a task requiring outcome monitoring to optimize reward. This work will be of interest to those interested in neural circuits, learning, and/or decision making.

   Reviewed by eLife

7. Functional connectivity-based attractor dynamics of the human brain in rest, task, and disease

   This article has 11 authors:

   1. Robert Englert
   2. Balint Kincses
   3. Raviteja Kotikalapudi
   4. Giuseppe Gallitto
   5. Jialin Li
   6. Kevin Hoffschlag
   7. Choong-Wan Woo
   8. Tor D Wager
   9. Dagmar Timmann
   10. Ulrike Bingel
   11. Tamas Spisak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable approach for revealing large-scale brain attractor dynamics during resting states, task processing, and disease conditions using insights from Hopfield neural networks. The evidence supporting the findings is convincing across the many datasets analysed. The work will be of broad interest to neuroscientists using neuroimaging data with interest in computational modelling of brain activity.

   Reviewed by eLife

8. Characterization of cancer-driving nucleotides (CDNs) across genes, cancer types, and patients

   This article has 16 authors:

   1. Lingjie Zhang
   2. Tong Deng
   3. Zhongqi Liufu
   4. Xiangnyu Chen
   5. Shijie Wu
   6. Xueyu Liu
   7. Changhao Shi
   8. Bingjie Chen
   9. Zheng Hu
   10. Qichun Cai
   11. Chenli Liu
   12. Mengfeng Li
   13. Miles E Tracy
   14. Xuemei Lu
   15. Chung-I Wu
   16. Hai-Jun Wen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study is a companion to a paper introducing a theoretical framework and methodology for identifying Cancer Driving Nucleotides (CDNs). The evidence that recurrent SNVs or CDNs are common in true cancer driver genes is convincing, with more limited evidence that many more undiscovered cancer driver mutations will have CDNs, and that this approach could identify these undiscovered driver genes with about 100,000 samples.

   Reviewed by eLife

9. Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques

   This article has 7 authors:

   1. Nico A Flierman
   2. Sue Ann Koay
   3. Willem S van Hoogstraten
   4. Tom JH Ruigrok
   5. Pieter Roelfsema
   6. Aleksandra Badura
   7. Chris I De Zeeuw

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examined neuronal activity in the dentate nucleus of the cerebellum when monkeys performed a difficult perceptual decision-making task. The authors provide convincing evidence that the cerebellum represents sensory, motor, and behavioral outcome signals that are sent to the attentional system. This paper is of great general interest in that it shows the involvement of the cerebellum in cognitive processes at the neuronal level.

   Reviewed by eLife

10. A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

    This article has 2 authors:

    1. Gabriele Baniulyte
    2. Joseph T Wade

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      In this important study, Baniulyte and Wade provide convincing evidence that translation of a short ORF denoted toiL positioned upstream of the topAI-yjhQP operon is responsive to different ribosome-targeting antibiotics, consequently controlling translation of the TopAI toxin as well as Rho-dependent transcription termination. Strengths of the study include combining a genetic screen to identify 23S rRNA mutations that affect topA1 expression and a creative approach to map the different locations of ribosome stalling within toiL induced by different antibiotics, with ribosome profiling and RNA structure probing by SHAPE to examine consequences of different antibiotics on toiL-mediated regulation. The work leaves unanswered how bacteria benefit by activating expression of the genes using the proposed strategy and the mechanism underlying ToiL's sensing of structurally distinct antibiotics.

    Reviewed by eLife