eLife

Latest preprint reviews

1. Atomic-Level Free Energy Landscape Reveals Cooperative Symport Mechanism of Melibiose Transporter

   This article has 2 authors:

   1. Ruibin Liang
   2. Lan Guan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this potentially important study, the authors employed advanced computational techniques to explore a detailed atomistic description of the mechanism and energetics of substrate translocation in the MelB transporter. The overall approach is solid and reveals the coupling between sodium binding and melibiose transport through a series of conformational transitions, and the results for a mutant are also in qualitative agreement with the experiment, providing further support to the computational analyses. Nevertheless, the level of evidence is considered incomplete since there are concerns regarding the convergence and initial guess of the string calculations, leaving doubts that the computed pathway does not reflect the most energetically favorable mechanism.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2024.08.05.24311344

3. We couldn't get details of this article at this time:
   10.1101/2024.05.13.593917

4. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/kt7dm

5. Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening

   This article has 7 authors:

   1. Deb Sankar Banerjee
   2. Tafadzwa Chigumira
   3. Rachel M Lackner
   4. Josiah C Kratz
   5. David M Chenoweth
   6. Shiladitya Banerjee
   7. Huaiying Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this potentially valuable study, the authors employed in vivo experiments and theoretical modeling to study the growth dynamics of nuclear condensates. They observed that condensates can exhibit distinct growth modes, as dictated by the competition between condensate surface tension and local elasticity of chromatin. While the theoretical model appears to capture the experimental observations, the level of evidence supporting the proposed growth mechanism is incomplete due to, among other limitations, the multiple fitting parameters and poorly justified Neo-Hookean elasticity.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2024.04.12.588762

7. We couldn't get details of this article at this time:
   10.1101/2024.01.21.576499

8. We couldn't get details of this article at this time:
   10.1101/2023.07.26.550645

9. We couldn't get details of this article at this time:
   10.1101/2024.10.07.617051

10. We couldn't get details of this article at this time:
    10.1101/2024.10.04.616675