eLife

Latest preprint reviews

1. LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-β Signaling Suppression

   This article has 12 authors:

   1. Kai Xu
   2. Xiaoyue Pan
   3. Hui Lian
   4. Yaxuan Wang
   5. Ruyan Wan
   6. Zhongzheng Li
   7. Xin Pan
   8. Yajun Li
   9. Juntang Yang
   10. Ivan Rosas
   11. Lan Wang
   12. Guoying Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable manuscript, the authors propose that the lysosomal protein LAPTM4B plays a role in suppressing the TGF-β/SMAD signaling pathway and suggest that enhancing LAPTM4B function could be a potential therapeutic strategy for alleviating bleomycin-induced lung fibrosis. The findings will be of interest to the lung disease field, and the data presented to support the authors' conclusions is solid. However, it remains unclear whether the suppressive effect of LAPTM4b on idiopathic pulmonary fibrosis is mediated by Nedd4l.

   Reviewed by eLife

2. Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

   This article has 11 authors:

   1. Chong Zhang
   2. Zuoyan Zhang
   3. Yueyi Wu
   4. Yuchen Wu
   5. Jing Cheng
   6. Kaizhi Luo
   7. Zhidi Li
   8. Manman Zhang
   9. Jian Wang
   10. Xuesen Zhang
   11. Yangling Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides valuable mechanistic insight into NSCLC progression, both in terms of tumour metastasis and the development of chemoresistance. The authors draw upon a range of techniques and assays and the evidence shown is solid and has been strengthened by incorporation of suggestions by the two reviewers. The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies.

   Reviewed by eLife

3. HIV integrase compacts viral DNA into biphasic condensates

   This article has 14 authors:

   1. Pauline J Kolbeck
   2. Marjolein de Jager
   3. Margherita Gallano
   4. Tine Brouns
   5. Ben Bekaert
   6. Wout Frederickx
   7. Sebastian F Konrad
   8. Siska Van Belle
   9. Frauke Christ
   10. Steven De Feyter
   11. Zeger Debyser
   12. Laura Filion
   13. Jan Lipfert
   14. Willem Vanderlinden

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript by Kolbeck and co-workers is an important contribution to understanding the physical mechanism that controls a key step in the retroviral infectious cycle. The authors employ a wide range of experimental techniques, complemented with Montecarlo simulations, that result in convincing evidence of compaction of HIV DNA by the viral integrase. This manuscript would benefit from in-depth discussion and analysis of the biophysical implications of the results.

   Reviewed by eLife

4. Image-based identification and isolation of micronucleated cells to dissect cellular consequences

   This article has 5 authors:

   1. Lucian DiPeso
   2. Sriram Pendyala
   3. Heather Z Huang
   4. Douglas M Fowler
   5. Emily M Hatch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable paper reports machine learning-based image analysis pipelines for the automated segmentation of micronuclei and the detection and sorting of micronuclei-containing cells. These are powerful new tools for researchers who study micronuclei and their physiologic consequences. The analysis of the new tools and their benchmarking is rigorous and convincing; applications and remaining limitations are well explained in the paper.

   Reviewed by eLife

5. Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

   This article has 31 authors:

   1. Zuzana Outla
   2. Gizem Oyman-Eyrilmez
   3. Katerina Korelova
   4. Magdalena Prechova
   5. Lukas Frick
   6. Lenka Sarnova
   7. Piyush Bisht
   8. Petra Novotna
   9. Jan Kosla
   10. Patricia Bortel
   11. Yasmin Borutzki
   12. Andrea Bileck
   13. Christopher Gerner
   14. Mohammad Rahbari
   15. Nuh Rahbari
   16. Emrullah Birgin
   17. Bibiana Kvasnicova
   18. Andrea Galisova
   19. Katerina Sulkova
   20. Andreas Bauer
   21. Njainday Jobe
   22. Ondrej Tolde
   23. Eva Sticova
   24. Daniel Rösel
   25. Tracy O'Connor
   26. Martin Otahal
   27. Daniel Jirak
   28. Mathias Heikenwälder
   29. Gerhard Wiche
   30. Samuel M Meier-Menches
   31. Martin Gregor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigated the role of PLECTIN, a cytoskeletal crosslinker protein, in hepatocellular carcinoma development and progression. Using a liver-specific Plectin knockout mouse model, the authors showed solid evidence that PLECTIN is critical for hepatocarcinogenesis, since inhibition of PLECTIN suppressed tumor formation in multiple models. They also show that PLECTIN is key for HCC invasion and metastasis. They show a correlation between PLECTIN inhibition and attenuated FAK, MAPK/ERK, and PI3K/AKT signaling.

   Reviewed by eLife

6. Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

   This article has 16 authors:

   1. Weijie Wu
   2. Miao Yu
   3. Qianchen Li
   4. Yiqian Zhao
   5. Lei Zhang
   6. Yi Sun
   7. Zhenbin Wang
   8. Yuqing Gong
   9. Wenjing Wang
   10. Chenying Liu
   11. Jing Zhang
   12. Yan Tang
   13. Xiaojie Xu
   14. Xiaojing Guo
   15. Jun Zhan
   16. Hongquan Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The research presents valuable findings on the impact of FRMD8 loss on tumor progression and resistance to tamoxifen therapy. Through a series of convincing and systematic experiments, the author thoroughly investigates the role of FRMD8 in breast cancer and its underlying regulatory mechanisms. The study confirms that FRMD8 holds potential as a therapeutic target for reversing tamoxifen resistance, offering helpful insights for future treatment strategies.

   Reviewed by eLife

7. Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system

   This article has 8 authors:

   1. Zeng-Hang Wang
   2. Ying An
   3. Ting Zhao
   4. Tong-Tong Pei
   5. Dora Yuping Wang
   6. Xiaoye Liang
   7. Wenming Qin
   8. Tao Dong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes how a single effector of the Type Six Secretion System (T6SS) has two distinct functions, which may contribute to bacterial survival and the development of novel antibacterials. The authors utilized various methods in biochemistry, microbiology, and microscopy to produce convincing data supporting their claims about the protein's function; however, they could clarify the implications for non-experts to enhance the accessibility of this work. This manuscript is of interest to those studying T6SS, particularly those interested in effectors and bacterial enzymes.

   Reviewed by eLife, Arcadia Science

8. Range geography and temperature variability explain cross-continental convergence in range and phenology shifts in a model insect taxon

   This article has 3 authors:

   1. Catherine Sirois-Delisle
   2. Susan CC Gordon
   3. Jeremy Kerr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The article presents important findings on the impact of climate change on odonates, integrating phenological and range shifts to broaden our understanding of biodiversity change. The study leverages extensive natural history data, offering a convincing analysis of temporal trends in phenology and range limit and their potential drivers.

   Reviewed by eLife

9. Protein-induced membrane strain drives supercomplex formation

   This article has 4 authors:

   1. Maximilian C Pöverlein
   2. Alexander Jussupow
   3. Hyunho Kim
   4. Ville RI Kaila

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors conducted extensive atomistic and coarse-grained simulations as well as a lattice Monte Carlo analysis to probe the driving force and functional impact of supercomplex formation in the inner mitochondrial membrane. The study highlighted the major contribution from membrane mechanics to the supercomplex formation and revealed interesting differences in structural and dynamical features of the protein components upon complex formation. Upon revision, the analysis is considered solid, although the magnitude of estimated membrane deformation energies seem somewhat large. Overall, the study is thorough, creative and the impact on the field of bioenergetics is expected to be significant.

   Reviewed by eLife

10. Discovering root causal genes with high-throughput perturbations

    This article has 2 authors:

    1. Eric V Strobl
    2. Eric Gamazon

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This work provides an important framework for understanding the primary causes of disease. While the theoretical results rely on strong assumptions about the underlying causal mechanisms, the authors provide solid empirical evidence that the framework is robust to modest violations of these assumptions.

    Reviewed by eLife