eLife

Latest preprint reviews

1. Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates

   This article has 17 authors:

   1. Gianpaolo Antonio Basile
   2. Augusto Ielo
   3. Lilla Bonanno
   4. Antonio Cerasa
   5. Giuseppe Santoro
   6. Demetrio Milardi
   7. Giuseppe Pio Anastasi
   8. Ambra Torre
   9. Sergio Baldari
   10. Riccardo Laudicella
   11. Michele Gaeta
   12. Marina Quartu
   13. Maria Pina Serra
   14. Marcello Trucas
   15. Angelo Quartarone
   16. Manojkumar Saranathan
   17. Alberto Cacciola

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a useful characterisation of the topographical organisation of the human pulvinar, an associative thalamic subregion crucial for visual perception and attention. The evidence supporting the conclusions is solid given the multimodal validation and replication across datasets, although even higher-resolution imaging data would have strengthened the study. In their revised manuscript, the authors elaborated further on the motivation for their study and conducted several robustness checks. Nevertheless, there remains an opportunity for a more fully integrated interpretation of the findings. The work would be of interest to neuroscientists, neurologists, and neuropsychiatrists working on pulvinar functioning in health and disease.

   Reviewed by eLife

2. Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning

   This article has 6 authors:

   1. Zhe Zhang
   2. Xu Hong
   3. Peng Xiong
   4. Junfeng Wang
   5. Yaoqi Zhou
   6. Jian Zhan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uncovers a surprising link between two self-cleaving RNAs that belong to the same structural family. The evidence supporting the main conclusions is convincing and based on extensive biochemical and bioinformatic analysis. This research will be of broad interest to RNA molecular biologists and biochemists.

   Reviewed by eLife

3. FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis

   This article has 16 authors:

   1. Matthew Yorek
   2. Xingshan Jiang
   3. Shanshan Liu
   4. Jiaqing Hao
   5. Jianyu Yu
   6. Anthony Avellino
   7. Zhanxu Liu
   8. Melissa Curry
   9. Henry Keen
   10. Jianqiang Shao
   11. Anand Kanagasabapathy
   12. Maying Kong
   13. Yiqin Xiong
   14. Edward R Sauter
   15. Sonia L Sugg
   16. Bing Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper uses elegant models, including genetic knock outs, to demonstrate that FABP4 contributes to lipid accumulation in tumor-associated macrophages, which seems to increase breast cancer migration. While the work is of high interest, the strength of the evidence relating to some of the conclusions is incomplete and the paper would benefit from some refinement. The work will be of interest to those researchers trying to link metabolism, the immune system, and cancer.

   Reviewed by eLife

4. The membrane domains of mammalian adenylyl cyclases are lipid receptors

   This article has 6 authors:

   1. Marius Landau
   2. Sherif Elsabbagh
   3. Harald Gross
   4. Adrian CD Fuchs
   5. Anita CF Schultz
   6. Joachim E Schultz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes an important study of a new lipid-mediated regulation mechanism of adenylyl cyclases. The biochemical evidence provided is convincing and will trigger more research in this mechanism. This manuscript will be of interest to all scientists working on lipid regulation and adenylyl cyclases.

   Reviewed by eLife, Arcadia Science

5. Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos

   This article has 8 authors:

   1. Ryan M Finnerty
   2. Daniel J Carulli
   3. Akshata Hedge
   4. Yanli Wang
   5. Frimpong Boadu
   6. Sarayut Winuthayanon
   7. Jianlin Jack Cheng
   8. Wipawee Winuthayanon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports the transcriptomic and proteomic landscapes of the oviducts at four different preimplantation stages during natural fertilization, pseudopregnancy, and superovulation. The supporting data are convincing. This work will be of interest to reproductive biologists and clinicians practicing reproductive medicine.

   Reviewed by eLife

6. Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish

   This article has 5 authors:

   1. Wenqing Li
   2. Sara McCurdy
   3. Miguel A Lopez-Ramirez
   4. Ho-Sup Lee
   5. Mark H Ginsberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors test the model that a type of vascular lesion caused by the inactivation of one gene in the cells that line blood vessels requires the activity of a second gene for the lesions to form. The evidence supporting the conclusions is solid.

   Reviewed by eLife

7. Restraint of melanoma progression by cells in the local skin environment

   This article has 7 authors:

   1. Yilun Ma
   2. Mohita Tagore
   3. Miranda V Hunter
   4. Ting-Hsiang Huang
   5. Emily Montal
   6. Joshua M Weiss
   7. Richard M White

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo Epithelial-Mesenchymal Transition (EMT). Surprisingly, when overexpressing Twist in keratinocytes, the resulting alteration in keratinocytes is inhibitory for melanoma invasion in both zebrafish and human cell culture models. The results are supported by overall convincing experimental data that provide new insights into the interactions between melanoma cells and their environment.

   Reviewed by eLife

8. The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

   This article has 5 authors:

   1. Yutaro Hama
   2. Yuko Fujioka
   3. Hayashi Yamamoto
   4. Noboru Mizushima
   5. Nobuo N Noda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Building on previous structural studies, this work provides valuable new insights into the architecture of the autophagy initiation complex, comprising ULK1, ATG13, and FIP200. The authors present their findings with solid supporting evidence, making this study a significant contribution to the autophagy field.

   Reviewed by eLife

9. PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

   This article has 12 authors:

   1. Jiongke Wang
   2. Yujie Shi
   3. Ying Wang
   4. Yingqiang Shen
   5. Huan Liu
   6. Silu Sun
   7. Yimei Wang
   8. Xikun Zhou
   9. Yu Zhou
   10. Xin Zeng
   11. Jing Li
   12. Qianming Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript determines how PA28g, a proteasome regulator that is overexpressed in tumors, and C1QBP, a mitochondrial protein for maintaining oxidative phosphorylation that plays a role in tumor progression, interact in tumor cells to promote their growth, migration and invasion. Additional experiments and analyses that supported the theoretical models for the interaction have been performed in response to the reviews. The overall findings and conceptual framework are important and the evidence is solid. A logical extrapolation of this work is to test the C1QBP mutants using functional assays to determine whether the mutations can decrease the protein stability mediated by the interaction with PA28g.

   Reviewed by eLife

10. The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

    This article has 7 authors:

    1. Jiayin Gao
    2. Jiawei Wang
    3. Shiyu Liu
    4. Jinzhu Song
    5. Chuanxin Zhang
    6. Boyang Liu
    7. Keliang Wu

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This useful study by Gao et al identifies Hspa2 as a heterogeneous transcript in the early embryo and proposes a plausible mechanism showing interactions with Carm1. The authors propose that variability in HSPA2 levels among blastomeres at the 4-cell stage skews their relative contribution to the embryonic lineage. Given only 4 other heterogeneous transcripts/non-coding RNA have been proposed to act similarly at or before the 4-cell stage, this would be a key addition to our understanding of how the first cell fate decision is made. While this is a solid study, further data are needed to fully support the conclusions.

    Reviewed by eLife