Latest preprint reviews

  1. Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

    This article has 8 authors:
    1. Hadel Al Asafen
    2. Natalie M Clark
    3. Etika Goyal
    4. Sadia Siddika Dima
    5. Hung-Yuan Chen
    6. Thomas Jacobsen
    7. Rosangela Sozzani
    8. Gregory T Reeves
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study provides quantitative data and analysis to reveal that variations in Dorsal (Dl ) nuclear dynamics along the Dorso-ventral axis in the early Drosophila embryo are governed by Dl-Cactus nuclear interactions. The solid evidence partially supports a mechanism where nuclear localized Cactus contributes to the fraction of Dl that binds to DNA, but additional work will be necessary to confirm the claims and the biological significance of these findings.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Vesiculation pathways in clathrin-mediated endocytosis

    This article has 3 authors:
    1. Xinran Wang
    2. Julien Berro
    3. Rui Ma
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study proposes a theoretical model of clathrin coat formation based on membrane elasticity that seeks to determine whether this process occurs by increasing the area of a protein-coated patch with constant curvature, or by increasing the curvature of a protein-coated patch that forms in an initially flat conformation (so called constant curvature or constant area models). Identifying energetically favorable pathways and comparing the obtained shapes with experiments provides solid support to the constant-area pathway. This work will be of interest for biologists and biophysicists interested in membrane remodelling and endocytosis. It provides an innovative approach to tackle the question of constant curvature vs. constant area coat protein formation, although some of the model's assumption are only partially supported by experimental evidence.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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