eLife

Latest preprint reviews

1. Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

   This article has 10 authors:

   1. Judith Hüttemeister
   2. Franziska Rudolph
   3. Michael H Radke
   4. Claudia Fink
   5. Dhana Friedrich
   6. Stephan Preibisch
   7. Martin Falcke
   8. Eva Wagner
   9. Stephan E Lehnart
   10. Michael Gotthardt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers valuable information on how titin derived from different nuclei within the syncytium is organized and integrated during skeletal muscle development and remodeling. The authors developed a novel mCherry titin knock-in mice with the fluorophore mCherry inserted into titin's Z-disk region to track the titin during cell fusion. The approach using mcherry adds to understanding of the role and localization of titin in controlling stiffness of striated muscles and fine tuning contraction. The results demonstrate that the integration of titin into the sarcomere is tightly regulated, with its unexpected mobility aiding in the uniform distribution of titin post-cell fusion. Although the experimental approach is convincing, the work is very qualitative in its approaches, and the data needs rigorous statistical analysis. There is a need for some clarification concerning numbers of animals and control groups. Future studies will need more rigorous data analysis and interpretation.

   Reviewed by eLife

2. Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis

   This article has 8 authors:

   1. Jian Liu
   2. YuYing Jiang
   3. ZiYue Diao
   4. DanDan Chen
   5. RuiYuan Xia
   6. BingWei Wang
   7. Shuo Yang
   8. ZhiQiang Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study regarding the role of gasdesmin D in experimental psoriasis. The study contains solid evidence for such a role, involving neutrophils, from murine models of skin inflammation, as well as correlative data of elevated gasdermin D expression in human psoriatic skin. The findings will be of interest to researchers trying to unravel pathways of skin inflammation.

   Reviewed by eLife

3. Human brain ancestral barcodes

   This article has 1 author:

   1. Darryl Shibata

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable conceptual approach that cell lineage can be determined using methylation data. However, the evidence supporting the claims of the author remains incomplete after revision. If clarified further as described in the reviews, this approach could be of broad interest to neuroscientists and developmental biologists.

   Reviewed by eLife

4. AgRP1 modulates breeding season-dependent feeding behavior in female medaka

   This article has 9 authors:

   1. Yurika Tagui
   2. Shingo Takeda
   3. Hiroyo Waida
   4. Shoichi Kitahara
   5. Tomoki Kimura
   6. Shinji Kanda
   7. Yoshitaka Oka
   8. Yu Hayashi
   9. Chie Umatani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides fundamental new insight into the mechanisms linking photoperiod, reproduction function, and feeding activity, using medaka, a genetic model that itself exhibits photoperiodic responses. As well as identifying key neuropeptide genes that are regulated by photoperiod and involved in regulating feeding activity, the authors establish a knockout line for agrp1 using CRISPR Cas9 - based approach, profiting from the extensive use and development on this methodology in medaka. The combination of the RNAseq and quantitative in situ hybridization analysis with the knockout results as well as the study of ovariectomized fish provides compelling evidence implicating agrp1 in feeding regulation in response to photoperiod and reproductive status.

   Reviewed by eLife

5. The value of initiating a pursuit in temporal decision-making

   This article has 4 authors:

   1. Elissa Sutlief
   2. Charlie Walters
   3. Tanya Marton
   4. Marshall G Hussain Shuler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The paper presents a valuable theoretical treatment of the role of passage of time in optimal decision strategies in pursuit based tasks. The computational evidence and methodologies employed are novel, and the authors offer solid evidence for the majority of the claims.

   Reviewed by eLife

6. β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

   This article has 11 authors:

   1. Renaud Prevel
   2. Erwan Pernet
   3. Kim A Tran
   4. Abderrahmane Sadek
   5. Mina Sadeghi
   6. Elizabeth Lapshina
   7. Leonardo F Jurado
   8. Arnold S Kristof
   9. Mohieddine Moumni
   10. Jeremie Poschmann
   11. Maziar Divangahi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of maladaptive innate immune training. The experimental evidence supporting the conclusions is convincing and the expert reviewers strongly endorse the manuscript. The work will be of high interest to both researchers in the trained immunity field and clinician scientists.

   Reviewed by eLife

7. Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

   This article has 4 authors:

   1. Bhanu Shrestha
   2. Jiun Sang
   3. Suman Rimal
   4. Youngseok Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful contribution to our understanding of taste perception. The idea that specific receptors function in the pharynx to mediate responses to carboxylic acids is interesting, although the expression analysis is incomplete. Reviewers also have a number of other suggestions for improvement, including the request that authors provide more details about the methodology used. In general, the claims are supported by solid evidence and add to a growing body of literature on this topic.

   Reviewed by eLife, preLights

8. Structure of human PIEZO1 and its slow-inactivating channelopathy mutants

   This article has 7 authors:

   1. Yuanyue Shan
   2. Xinyi Guo
   3. Mengmeng Zhang
   4. Meiyu Chen
   5. Ying Li
   6. Mingfeng Zhang
   7. Duanqing Pei

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful revised manuscript that shows a set of data including the first cryo-EM structures of human PIEZO1 as well as structures of disease-related mutants in complex with the regulatory subunit MDFIC, which generate different inactivation phenotypes. The molecular basis of PIEZO channel inactivation is of great interest due to its association with several pathologies. This manuscript provides some structural insights that may help to ultimately build a molecular picture of PIEZO channel inactivation. While the structures are of use and clear conformational differences can be seen in the presence of the auxiliary subunit MDFIC, the strength of the evidence supporting the conclusions of the paper, especially the proposed role for pore lipids in inactivation, is incomplete.

   Reviewed by eLife

9. Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

   This article has 5 authors:

   1. Hans Kirschner
   2. Hanna M Molla
   3. Matthew R Nassar
   4. Harriet de Wit
   5. Markus Ullsperger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports effects of a single dose of methamphetamine vs placebo on a probabilistic reversal learning task with different levels of noise, in a large group of young healthy volunteers. The paper is well written and the methods are rigorous. The findings are important and have theoretical or practical implications beyond a single a subfield. The strength of the evidence is convincing, with the methods, data, and analyses broadly supporting the claims in the paper, which are sufficiently qualified given the lack of a significant effect of the binary baseline performance variable, and the nonlinear effect of individual differences in baseline performance.

   Reviewed by eLife

10. Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

    This article has 15 authors:

    1. Zhengming Tian
    2. Yuning Li
    3. Feiyang Jin
    4. Zirui Xu
    5. Yakun Gu
    6. Mengyuan Guo
    7. Qianqian Shao
    8. Yingxia Liu
    9. Hanjiang Luo
    10. Yue Wang
    11. Suyu Zhang
    12. Chenlu Yang
    13. Xin Liu
    14. Xunming Ji
    15. Jia Liu

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable paper analyses the role of endogenous CNS hemoglobin in protecting mitochondrial homeostasis in hypoxic conditions. The work is solid and opens the doors to future work in this field. However, it leaves many questions open regarding CNS-specific ischemia/hypoxia that should be considered in future work. In particular, a whole-body hypoxia model may liberate exosomes from other hypoxic organs, which may contribute to the protective effect. Overall, this work has the potential to be of broad interest to the neuroscience and hypoxia communities.

    Reviewed by eLife