eLife

Latest preprint reviews

1. Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration

   This article has 8 authors:

   1. Hyunggu Hahn
   2. Carole Daly
   3. John Little
   4. Nicole A Perry-Hauser
   5. Emmanuel Flores-Espinoza
   6. Asuka Inoue
   7. Bianca Plouffe
   8. Alex RB Thomsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that provides CCR7-APEX2 proximity labelling mass spectrometry data that is expected to provide new insights into CCR7 signaling partners and pathways. The study is technically easy to follow and the data is convincing. It will be interesting in the future to have complementary studies in lymphocytes/dendritic cells that endogenously express CCR7. This is of value to the community, and there are likely multiple opportunities to use the APEX2 data set to extend these findings, strengthen some claims, and even explore a new pathway identified in the APEX2 data set.

   Reviewed by eLife

2. GnRH pulse generator activity in mouse models of polycystic ovary syndrome

   This article has 8 authors:

   1. Ziyue Zhou
   2. Su Young Han
   3. Maria Pardo-Navarro
   4. Ellen G Wall
   5. Reena Desai
   6. Szilvia Vas
   7. David J Handelsman
   8. Allan E Herbison

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports findings on the GnRH pulse generator's role in androgen-exposed mouse models, providing further insights into PCOS pathophysiology and advancing the field of reproductive endocrinology. The experimental data were collected using cutting-edge methodologies and are solid. The findings, while interesting, are primarily applicable to mouse models, and their translation to human physiology requires cautious interpretation and further validation. This work will be of interest to endocrinologists and reproductive biologists.

   Reviewed by eLife

3. A scene with an invisible wall - navigational experience shapes visual scene representation

   This article has 5 authors:

   1. Shi Pui Donald Li
   2. Jiayu Shao
   3. Zhengang Lu
   4. Michael McCloskey
   5. Soojin Park

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides novel evidence that navigational experiences can shape perceptual scene representations. The evidence presented is incomplete and would benefit from clearer explanations of the experiment design and careful discussion of alternative interpretations such as contextual associations or familiarity. The work will be of interest to cognitive psychologists and neuroscientists working on perception and navigation.

     [Editors’ note: A revised version of this work has been published in the Journal of Cognitive Neuroscience (DOI: https://doi.org/10.1162/JOCN.a.2409).]

   Reviewed by eLife

4. UNC-6/Netrin promotes both adhesion and directed growth within a single axon

   This article has 3 authors:

   1. Ev L Nichols
   2. Joo Lee
   3. Kang Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     These studies make a fundamental contribution to our understanding of axon-guidance mechanisms, focusing on the role of UNC-6/Netrin in the long-range growth and targeting of axons. Using state-of-the-art genetics and in vivo imaging, the authors provide compelling support for the finding that UNC-6/Netrin can act via both chemotaxis and haptotaxis. This work will be of interest to a wide variety of cell and developmental biologists and neuroscientists.

   Reviewed by eLife

5. An anatomical and physiological basis for flexible coincidence detection in the auditory system

   This article has 6 authors:

   1. Lauren J Kreeger
   2. Suraj Honnuraiah
   3. Sydney Maeker
   4. Siobhan Shea
   5. Gordon Fishell
   6. Lisa Goodrich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Kreeger et al. convincingly demonstrate that octopus cells in the mouse cochlear nucleus, previously thought to rely primarily on excitatory inputs for coincidence detection, also receive glycinergic inhibitory synaptic inputs that influence their synaptic integration. Using advanced techniques, including genetic mouse models, optogenetics, microscopy, slice physiology, and computational modeling, this important study reveals that inhibition can shunt synaptic currents and alter the timing of dendritic EPSPs, both of which are significant for auditory processing. This research broadens the understanding of octopus cells' roles in sensory processing, highlighting the importance of inhibitory inputs in shaping fast, high-frequency neural response capabilities.

   Reviewed by eLife

6. Acquisition of auditory discrimination mediated by different processes through two distinct circuits linked to the lateral striatum

   This article has 13 authors:

   1. Susumu Setogawa
   2. Takashi Okauchi
   3. Di Hu
   4. Yasuhiro Wada
   5. Keigo Hikishima
   6. Hirotaka Onoe
   7. Kayo Nishizawa
   8. Nobuyuki Sakayori
   9. Hiroyuki Miyawaki
   10. Takuma Kitanishi
   11. Kenji Mizuseki
   12. Yilong Cui
   13. Kazuto Kobayashi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important understanding of the contribution of different striatal subregions, the anterior Dorsal Lateral Striatum (aDLS) and the posterior Ventrolateral Striatum (pVLS), to auditory discrimination learning. The authors have included robust behavior combined with multiple observational and perturbation techniques. The data provided are convincing of the relevance of task-related activity in these two subregions during learning.

   Reviewed by eLife

7. Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)

   This article has 43 authors:

   1. Michael W Reimann
   2. Sirio Bolaños-Puchet
   3. Jean-Denis Courcol
   4. Daniela Egas Santander
   5. Alexis Arnaudon
   6. Benoît Coste
   7. Fabien Delalondre
   8. Thomas Delemontex
   9. Adrien Devresse
   10. Hugo Dictus
   11. Alexander Dietz
   12. András Ecker
   13. Cyrille Favreau
   14. Gianluca Ficarelli
   15. Mike Gevaert
   16. Joni Herttuainen
   17. James B Isbister
   18. Lida Kanari
   19. Daniel Keller
   20. James King
   21. Pramod Kumbhar
   22. Samuel Lapere
   23. Jãnis Lazovskis
   24. Huanxiang Lu
   25. Nicolas Ninin
   26. Fernando Pereira
   27. Judit Planas
   28. Christoph Pokorny
   29. Juan Luis Riquelme
   30. Armando Romani
   31. Ying Shi
   32. Jason P Smith
   33. Vishal Sood
   34. Mohit Srivastava
   35. Werner Van Geit
   36. Liesbeth Vanherpe
   37. Matthias Wolf
   38. Ran Levi
   39. Kathryn Hess
   40. Felix Schürmann
   41. Eilif B Muller
   42. Henry Markram
   43. Srikanth Ramaswamy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports a detailed model of juvenile rat somatosensory cortex, consisting of 4.2 million morphologically and biophysically detailed neuron models, arranged in space and connected according to diverse experimental data - a valuable tool for the field. The construction of the model is based on a methodology with solid supporting evidence. It should be noted that, by necessity, such a large-scale model development involves many assumptions, interpolations, and decisions that could have compounding downstream effects on further analyses that may be difficult to disambiguate.

   Reviewed by eLife

8. Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain

   This article has 5 authors:

   1. Yue Li
   2. Qinyao Sun
   3. Shunli Zhu
   4. Congying Chu
   5. Jiaojian Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study compared the brain development trajectories of humans and macaque monkeys to quantify different evolutionary effects of convergent and divergent neural pathways between the two species. The cross-species evidence is solid, based on brain age prediction models that were carefully developed by using public MRI datasets of both humans and macaque monkeys. The findings will be of interest to neuroscientists, developmental biologists, and evolutionary biologists.

   Reviewed by eLife

9. Multimodal neural correlates of childhood psychopathology

   This article has 10 authors:

   1. Jessica Royer
   2. Valeria Kebets
   3. Camille Piguet
   4. Jianzhong Chen
   5. Leon Qi Rong Ooi
   6. Matthias Kirschner
   7. Vanessa Siffredi
   8. Bratislav Misic
   9. BT Thomas Yeo
   10. Boris C Bernhardt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study explores and delineates multivariate mappings between brain structure and functional measures with latent dimensions of psychopathology. This work provides solid evidence for the existence of such mappings and charts the relationship between different neurobiological measures and distinct dimensions of psychopathology. This work will be of broad interest within the neuroscience field.

   Reviewed by eLife

10. A rapid phylogeny-based method for accurate community profiling of large-scale metabarcoding datasets

    This article has 2 authors:

    1. Lenore Pipes
    2. Rasmus Nielsen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This potentially important work presents a tool for performing phylogenetic taxonomic classification of DNA sequences. In terms of methodology, the work is compelling. The authors perform a benchmark experiment against current state-of-the-art tools using real and simulated datasets to demonstrate where the novel tool stands in the context of existing methods. However, the experimentation is still incomplete. It would benefit from a more thorough exploration of existing methods as well as data sets that better represent real-world use cases.

    Reviewed by eLife