eLife

Latest preprint reviews

1. Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

   This article has 16 authors:

   1. Weijie Wu
   2. Miao Yu
   3. Qianchen Li
   4. Yiqian Zhao
   5. Lei Zhang
   6. Yi Sun
   7. Zhenbin Wang
   8. Yuqing Gong
   9. Wenjing Wang
   10. Chenying Liu
   11. Jing Zhang
   12. Yan Tang
   13. Xiaojie Xu
   14. Xiaojing Guo
   15. Jun Zhan
   16. Hongquan Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The research presents valuable findings on the impact of FRMD8 loss on tumor progression and resistance to tamoxifen therapy. Through a series of convincing and systematic experiments, the author thoroughly investigates the role of FRMD8 in breast cancer and its underlying regulatory mechanisms. The study confirms that FRMD8 holds potential as a therapeutic target for reversing tamoxifen resistance, offering helpful insights for future treatment strategies.

   Reviewed by eLife

2. Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system

   This article has 8 authors:

   1. Zeng-Hang Wang
   2. Ying An
   3. Ting Zhao
   4. Tong-Tong Pei
   5. Dora Yuping Wang
   6. Xiaoye Liang
   7. Wenming Qin
   8. Tao Dong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes how a single effector of the Type Six Secretion System (T6SS) has two distinct functions, which may contribute to bacterial survival and the development of novel antibacterials. The authors utilized various methods in biochemistry, microbiology, and microscopy to produce convincing data supporting their claims about the protein's function; however, they could clarify the implications for non-experts to enhance the accessibility of this work. This manuscript is of interest to those studying T6SS, particularly those interested in effectors and bacterial enzymes.

   Reviewed by eLife, Arcadia Science

3. Range geography and temperature variability explain cross-continental convergence in range and phenology shifts in a model insect taxon

   This article has 3 authors:

   1. Catherine Sirois-Delisle
   2. Susan CC Gordon
   3. Jeremy Kerr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The article presents important findings on the impact of climate change on odonates, integrating phenological and range shifts to broaden our understanding of biodiversity change. The study leverages extensive natural history data, offering a convincing analysis of temporal trends in phenology and range limit and their potential drivers.

   Reviewed by eLife

4. Protein-induced membrane strain drives supercomplex formation

   This article has 4 authors:

   1. Maximilian C Pöverlein
   2. Alexander Jussupow
   3. Hyunho Kim
   4. Ville RI Kaila

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important study, the authors conducted extensive atomistic and coarse-grained simulations as well as a lattice Monte Carlo analysis to probe the driving force and functional impact of supercomplex formation in the inner mitochondrial membrane. The study highlighted the major contribution from membrane mechanics to the supercomplex formation and revealed interesting differences in structural and dynamical features of the protein components upon complex formation. Upon revision, the analysis is considered solid, although the magnitude of estimated membrane deformation energies seem somewhat large. Overall, the study is thorough, creative and the impact on the field of bioenergetics is expected to be significant.

   Reviewed by eLife

5. Discovering root causal genes with high-throughput perturbations

   This article has 2 authors:

   1. Eric V Strobl
   2. Eric Gamazon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides an important framework for understanding the primary causes of disease. While the theoretical results rely on strong assumptions about the underlying causal mechanisms, the authors provide solid empirical evidence that the framework is robust to modest violations of these assumptions.

   Reviewed by eLife

6. Permissive and instructive Hox codes govern limb positioning

   This article has 20 authors:

   1. Yajun Wang
   2. Maik Hintze
   3. Jinbao Wang
   4. Hengxun Tao
   5. Patrick Petzsch
   6. Karl Köhrer
   7. Longfei Cheng
   8. Peng Zhou
   9. Jianlin Wang
   10. Zhaofu Liao
   11. Xu-Feng Qi
   12. Dongqing Cai
   13. Thomas Bartolomaeus
   14. Karl Schilling
   15. Joerg Wilting
   16. Stefanie Kuerten
   17. Georgy Koentges
   18. Ketan Patel
   19. Qin Pu
   20. Ruijin Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides the first putative evidence that alteration of the Hox code in neck lateral plate mesoderm is sufficient to induce ectopic development of forelimb buds at neck level. The authors use both gain-of-function (GOF) and loss-of-function (LOF) approaches in chick embryos to test the roles of Hox paralogy group (PG) 4-7 genes in limb development. The GOF data provide strong evidence that overexpression of Hox PG6/7 genes are sufficient to induce forelimb buds at neck level. However, the experiments using dominant negative constructs are lacking some key controls that are needed to demonstrate the specificity of the LOF effect rendering the work as a whole incomplete.

   Reviewed by eLife

7. Maternal behavior influences vocal practice and learning processes in the greater sac-winged bat

   This article has 4 authors:

   1. Ahana Aurora Fernandez
   2. Nora Serve
   3. Sarah-Cecil Fabian
   4. Mirjam Knörnschild

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides insights into the role of maternal behavior in the learning and ontogeny of vocalization. It finds evidence that the maternal behavior of sac-winged bats (Saccopteryx bilineata) can influence the learned territorial songs of their pups. The behavioral analyses are convincing, using longitudinal acoustic recordings and behavioral monitoring of individual mother-pup pairs across development and multiple wild bat colonies. The work will be relevant to a broad audience interested in the evolution and development of social behavior as well as sensory-motor learning.

   Reviewed by eLife

8. Prediction tendency, eye movements, and attention in a unified framework of neural speech tracking

   This article has 5 authors:

   1. Juliane Schubert
   2. Quirin Gehmacher
   3. Fabian Schmidt
   4. Thomas Hartmann
   5. Nathan Weisz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     These are valuable findings for those interested in how neural signals reflect auditory speech streams, and in understanding the roles of prediction, attention, and eye movements in this tracking. However, the evidence as it stands is incomplete. Further analyses are needed to clarify how the observed results relate to the relevant theoretical claims.

   Reviewed by eLife

9. Cholecystokinin modulates age-dependent thalamocortical neuroplasticity

   This article has 17 authors:

   1. Xiao Li
   2. Jingyu Feng
   3. Xiaohan Hu
   4. Peipei Zhou
   5. Tao Chen
   6. Xuejiao Zheng
   7. Peter Jendrichovsky
   8. Xue Wang
   9. Mengying Chen
   10. Hao Li
   11. Xi Chen
   12. Dingxuan Zeng
   13. Mengfan Zhang
   14. Zhoujian Xiao
   15. Ling He
   16. Stephen Temitayo Bello
   17. Jufang He

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study demonstrating that cholecystokinin is a key modulator of auditory thalamocortical plasticity during development and in young adult but not aged mice, though cortical application of this neuropeptide in older animals appears to go some way to restoring this age-dependent loss in plasticity. A strength of this work is the use of multiple experimental approaches, which together provide convincing support for the proposed involvement of cholecystokinin. This work is likely to be influential in opening up a new avenue of investigation into the roles of neuropeptides in sensory plasticity.

   Reviewed by eLife

10. Reprograming gene expression in ‘hibernating’ C. elegans involves the IRE-1/XBP-1 pathway

    This article has 5 authors:

    1. Melanie Lianne Engelfriet
    2. Yanwu Guo
    3. Andreas Arnold
    4. Eivind Valen
    5. Rafal Ciosk

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This useful study reveals that as C. elegans, a poikilothermic ("cold-blooded") animal, adapt to cold (4ºC), they display a drastic reduction in translation (assessed by polysome profiling and SUNSET). The remaining translation (by ribo-seq) correlates with mRNA levels (by RNA-seq), and the changes in gene expression at least partially require IRE-1, an established endoplasmic reticulum stress sensor. The reviewers consider the data assessing global translation and RNA expression upon cold exposure and the data demonstrating the requirement of ire-1 to be solid, but the conclusion that "transcription" is the major regulatory step and "lipid changes" can be a signal for IRE-1 activation in cold adapted worms needs substantially more evidence. Overall, this study demonstrated a good correlation between translation and RNA levels and yielded an inventory of gene changes as C. elegans adapt to cold, and will be of general interest to researchers interested in stress response and cold adaptation.

    Reviewed by eLife