eLife

Latest preprint reviews

1. Enteropathogenic E. coli- mediated Fast and Coordinated Ca ^²⁺ responses regulate NF-κB activation

   This article has 6 authors:

   1. Fangrui Guo
   2. Roberto Ornelas Guevara
   3. Linda Oussaedine
   4. Geneviève Dupont
   5. Laurent Combettes
   6. Guy Tran Van Nhieu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports important advances in our understanding of how enteropathogenic E. coli (EPEC) interacts at the intestinal interface. Solid data describe a novel model of spatially coordinated calcium signaling to modulate NF-kB activation; additional data and clarification of methods would improve the strength of these conclusions. These findings, which integrate imaging, genetics, and computational modeling, provide a new way to consider host-pathogen interactions in EPEC infections that may lead to improved therapies.

   Reviewed by eLife

2. Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

   This article has 14 authors:

   1. Miles R Bryan
   2. Michael F Almeida
   3. Kyle Pellegrino
   4. Carli K Opland
   5. J Ethan Paulakonis
   6. Jake McGillion-Moore
   7. Hanna Trzeciakiewicz
   8. Diamond King
   9. Xu Tian
   10. Jui-Heng Tseng
   11. Jonathan C Schisler
   12. Nicholas G Brown
   13. Ben A Bahr
   14. Todd J Cohen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents compelling new data that combine two FTD-tau mutations, P301L/S320F (PL-SF), that reliably induce spontaneous full-length tau aggregation across multiple cellular systems. The findings are important for the field of neurodegenerative disease. The strength of evidence is solid; however, several conclusions would benefit from more validation.

   Reviewed by eLife

3. Decoding Spine Nanostructure in Mental Disorders Reveals a Schizophrenia-Linked Role for Ecrg4

   This article has 7 authors:

   1. Yutaro Kashiwagi
   2. Qingrui Liu
   3. Yasuhiro Go
   4. Ryo Saito
   5. Atsu Aiba
   6. Takanobu Nakazawa
   7. Shigeo Okabe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     By investigating spine nanostructure and dynamics across multiple genetic mouse models for neurodevelopmental disorders, this important study has the potential to uncover convergent or divergent synaptic phenotypes that may be specifically associated with autism versus schizophrenia risk. While the imaging and breadth are impressive, there are potential methodological concerns, especially around statistical analyses, which render the evidence incomplete and should be addressed. The purely in vitro nature of the study also slightly limits the generalisability of the findings.

   Reviewed by eLife

4. Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females

   This article has 2 authors:

   1. Puja Biswas
   2. Elizabeth J Rideout

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study provides a systematic and solid comparison of sex-biased enteroendocrine peptide expression, including AstC and Tk, to show that these peptides contribute to female-biased fat storage. The major research question of this study is based on the authors' previous papers, and therefore, the presented results are incremental. This study serves as a foundation for future investigation of regulatory mechanisms for the sex-biased fat content by AstC and Tk.

   Reviewed by eLife

5. Emergence of Functional Heart-Brain Circuits in a Vertebrate

   This article has 11 authors:

   1. Luis Hernandez-Nunez
   2. Joana Avrami
   3. Sky Shi
   4. Areni Markarian
   5. Areni Kim
   6. Jonathan Boulanger-Weill
   7. Virginia Rutten
   8. Arman Zarghani-Shiraz
   9. Misha B Ahrens
   10. Florian Engert
   11. Mark C Fishman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important manuscript, the authors establish a vertebrate model for studying the development of circuits that control heart rate. This contribution uses a combination of experimental techniques to provide compelling information for scientists looking to understand how heart rate regulation emerges during development.

   Reviewed by eLife

6. Non-decision time-informed collapsing threshold diffusion model: A joint modeling framework with identifiable time-dependent parameters

   This article has 5 authors:

   1. Amir Hosein Hadian Rasanan
   2. Lukas Schumacher
   3. Michael D Nunez
   4. Gabriel Weindel
   5. Jörg Rieskamp

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable advance in understanding how decision boundaries may change over time during simple choices by introducing a method that uses information about non-decision components to improve parameter estimates. The evidence supporting the main claims is convincing, with clear demonstrations on simulated and real data, although additional model comparison work would further strengthen confidence. The findings will be of interest to researchers studying human decision processes and the methods used to analyse them.

   Reviewed by eLife

7. Intersection of transient cell states with stable cell types in hippocampus

   This article has 3 authors:

   1. Jack A Olmstead
   2. Lauren E King
   3. Brenda L Bloodgood

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides a detailed analysis of the transcriptional landscape of the mouse hippocampus in the context of various physiological states. The main conclusions have solid support: that most transcriptional targets are generally stable, with notable exceptions in the dentate gyrus and with regard to circadian changes. There are some weaknesses and it would improve the manuscript to address them.

   Reviewed by eLife

8. Maximized field-of-view deep-brain calcium imaging through gradient-index lenses

   This article has 5 authors:

   1. Chenmao Wang
   2. Zongyue Cheng
   3. Yuting Li
   4. Jianian Lin
   5. Meng Cui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable and practical approach for one-photon imaging through GRIN lenses. By scanning a low numerical aperture (NA) beam and collecting fluorescence with a high NA, the method expands the usable field of view and yields clearer cellular signals. The evidence is solid overall, with strong qualitative demonstrations, but some claims would benefit from additional quantitative tests. The work will interest researchers who need simple, scalable tools for large‑area cellular imaging in the brain.

   Reviewed by eLife

9. Voltage imaging reveals the emergence of population activity in the spinal cord

   This article has 6 authors:

   1. Asuka Shiraishi
   2. Ayane Hayashi
   3. Narumi Fukuda
   4. Mari Hishinuma
   5. Hiroaki Miyazawa
   6. Sachiko Tsuda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents an important advance in genetically encoded voltage imaging of the developing zebrafish spinal cord in vivo, capturing voltage dynamics in neuronal populations, single cells, and subcellular compartments inaccessible to patch clamp, and diverse spike waveforms and subthreshold voltage dynamics inaccessible to calcium imaging. The work identifies a developmental progression from irregular voltage fluctuations to coordinated contralateral and ipsilateral activity, providing insight into how electrical dynamics and cellular morphology evolve during circuit formation. The strength of evidence is solid, with imaging data supporting the main conclusions, although the manuscript would be strengthened by more complete methodological documentation and clearer context relative to earlier calcium imaging studies. Overall, this study provides a resource that is of importance for researchers investigating neural development and circuit assembly, illustrating the value of voltage imaging as a general tool for probing bioelectric mechanisms in morphogenesis and circuit development.

   Reviewed by eLife

10. Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

    This article has 14 authors:

    1. Hanwen Chen
    2. Tian Xiong
    3. Baoxing Guan
    4. Jiaqi Huang
    5. Danrui Zhao
    6. Yao Chen
    7. Haoran Liang
    8. Yingwei Li
    9. Jingwen Wu
    10. Shaoping Ye
    11. Ting Li
    12. Wensheng Shu
    13. Jin-tian Li
    14. Yutao Wang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides important evidence that myristate, a fatty acid commonly present in soil environments, is taken up by arbuscular mycorrhizal fungi during symbiosis with a plant host. The evidence presented is solid, with multiple experimental approaches including stable isotope tracing, transcriptional analysis, and physiological measurements across different plant species and phosphorus conditions. However, the main claims are only partially supported.

    Reviewed by eLife