eLife reviews preprints in the life sciences and medicine.

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  1. Hippocampal and prefrontal contributions to memory-guided navigation depend on task epoch

    1. Tora Dohi
    2. Lucy Anderson
    3. György Buzsàki
    4. Ipshita Zutshi

    • Curated by eLife

      eLife Assessment

      Dohi et al. asked what role the dorsal hippocampus and medial prefrontal cortex play during different temporal epochs of a memory-guided navigation task, a long-standing question for neuroscientists studying hippocampal-prefrontal contributions to working memory. This useful study used a delayed, cue-guided T-maze task in mice and reported impaired choice accuracy when silencing occurred early in the central-arm run but not during the delay. However, the evidence for the study's claim is incomplete in its current form: the silencing windows are not duration-matched across epochs, key negative findings rest on three to four mice without power analysis or reported effect sizes, no non-mnemonic control task distinguishes disrupted memory-guided behavior from a general action-selection deficit, and no neural recordings accompany the causal manipulations to verify the manipulations' assumed mechanistic effects. The reported perseveration also reflects an increased directional bias rather than repetition of the previous choice, and the language should be revised accordingly.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Uncertainty-aware quantitative analysis of the structure and dynamics of T cell receptor repertoires

    1. Simo Kitanovski
    2. Kai Wollek
    3. Daniel Hoffmann

    • Curated by eLife

      eLife Assessment

      This study presents a valuable tool for comparing immune receptor data across multiple samples while properly accounting for statistical uncertainty and receptor similarity. The evidence supporting the tool is solid overall. However, some key concerns regarding potential sequencing artifacts in one of the validation datasets and an unclear strategy for false discovery rate control in the proposed framework remain to be addressed.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Reinforcement learning for closed-loop optimisation of spatiotemporal stimulation in patterned neuronal networks

    1. Benedikt Maurer
    2. Vaiva Vasiliauskaitė
    3. Julian Hengsteler
    4. Gino Cathomen
    5. Tobias Ruff
    6. Cedric Schmid
    7. János Vörös
    8. Stephan J. Ihle

    • Curated by eLife

      eLife Assessment

      This study presents an open-source reinforcement learning framework for the real-time, closed-loop optimization of spatiotemporal electrical stimulation in engineered neuronal networks. Using single-spike-resolution activity as continuous feedback, the authors provide solid evidence that their platform can identify stimulation patterns that drive specific activity motifs within a structurally constrained four-node circuit. While this reproducible system offers a valuable and accessible tool for interacting with biological neural networks in an adaptive manner, further validation is needed to determine how well these stimulation strategies generalize to larger, unstructured, or more conventional network architectures.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Top-down processing alone activates the early somatosensory nuclei

    1. Paige Howell
    2. Lynn Farner
    3. Finn Rabe
    4. Tim Emmenegger
    5. Maryam Seif
    6. Patrick Freund
    7. Nicole Wenderoth
    8. Sanne Kikkert

    • Curated by eLife

      eLife Assessment

      This important study provides convincing evidence that somatosensory relay nuclei remain engaged during attempted hand movements following chronic cervical spinal cord injury, including in individuals with severe motor impairment. The combination of functional and quantitative MRI with physiological controls supports the main findings and may have implications that are of importance in understanding sensorimotor processing after spinal cord injury. However, the interpretation of this activity as specifically reflecting top-down, and particularly corticocuneate, signaling may be overstated. The origin and anatomical route of the observed activity appears to remain less firmly established.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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