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  1. IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2

    This article has 25 authors:
    1. John P. Miller
    2. Kyu Kwang Kim
    3. Cameron WA Snyder
    4. Negar Khazan
    5. Niloy A. Singh
    6. Megan E. Boyer
    7. Elizabeth Lamere
    8. Myla Strawderman
    9. Sonali Sharma
    10. Ronald Lakony
    11. Michelle Whittum
    12. Mark Anderson
    13. Rick Keenan
    14. Elizabeth Pritchett
    15. Cameron Baker
    16. John Ashton
    17. Manoj K. Khera
    18. Michael R. Elliott
    19. Christina M. Annunziata
    20. Jeevisha Bajaj
    21. Laura M. Calvi
    22. Michael W. Becker
    23. Rachael Rowswell-Turner
    24. Richard G. Moore
    25. Rakesh K. Singh
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study identifies the IL1R1-IRAK4 axis as a mediator of inflammation-associated ovarian cancer implantation. The evidence is convincing, supported by complementary genetic and pharmacological approaches across multiple in vivo models. These findings advance our understanding of how inflammatory signaling shapes metastatic niche formation and highlight IRAK4 as a potential therapeutic target.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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