eLife

Latest preprint reviews

1. Prophase Chromosomes Relocalization to Nuclear Periphery in NPP-3/NUP205 Depletion Protects Genome Stability

   This article has 3 authors:

   1. Ling Jiang
   2. Yu Chung Tse
   3. Karen Wing Yee Yuen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the functional consequences of nuclear envelope rupture caused by the depletion of nuclear pore complex subunits on the behaviour and organisation of chromosomes during mitosis in C. elegans embryos. The experiments are generally well-designed and executed; however, the evidence for some of the main conclusions is incomplete. This work is of potential interest to cell biologists working on cell division.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.64898/2026.06.15.732353

3. Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic targets

   This article has 3 authors:

   1. Peter Chovanec
   2. Shiyang He
   3. Yi Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using sci-L3-Strand-seq, this study shows genome-wide, single-cell evidence that DSBs triggered by CRISPR/Cas9 are frequently resolved through sister chromatid exchange (SCE), which is undetectable with conventional whole-genome sequencing approaches. This important work provides helpful metrics quantifying the occurrence of SCE events at targeted and repetitive genomic loci that are of particular interest to those working in gene editing, DNA repair, genome instability, or repetitive genomic loci. However, the evidence supporting the proposed involvement of under-replicated region/replication-termination-zone resolution and TRAIP/URR-like pathways is currently incomplete and could be strengthened with an increased number of reciprocal daughter-cell pairs and by genetic or molecular perturbation, or alternatively, this can be addressed by changing the discussion.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2025.10.01.679817

5. We couldn't get details of this article at this time:
   10.64898/2026.05.31.729150

6. We couldn't get details of this article at this time:
   10.64898/2026.05.27.728092

7. We couldn't get details of this article at this time:
   10.64898/2026.05.13.724957

8. We couldn't get details of this article at this time:
   10.1101/2024.10.29.620866

9. We couldn't get details of this article at this time:
   10.64898/2026.04.27.721040

10. We couldn't get details of this article at this time:
    10.1101/2025.11.26.690816