eLife reviews preprints in the life sciences and medicine.

About Followers

Latest preprint reviews

  1. HAX1 drives assembly and activation of the mitochondrial intermembrane space chaperone CLPB

    1. Monifa A. V. Fahie
    2. Julia G. Hoffman
    3. Mimi S. Kay
    4. Julia R. Kardon

    • Curated by eLife

      eLife Assessment

      This in vitro study provides important evidence that the mitochondrial intermembrane space protein HAX1 functions as a direct activating cofactor of the AAA+ chaperone CLPB, resolving a longstanding question arising from the strong genetic, proteomic, and disease associations between these proteins. The convincing work advances our understanding of mitochondrial proteostasis by demonstrating that HAX1 promotes CLPB oligomerization and will potentially even enable the generation of small molecules that mimic the function of HAX1 in CLPB activation. The study will be of general interest to biochemists working on chaperones and/or mitochondrial biology.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Primary cilia in the growing limb are preferentially orientated, uncoupled from centriolar position

    1. T Johnson
    2. S Midha
    3. AM Julé
    4. G Randall
    5. K Apolinova
    6. J Miotla-Zarebska
    7. SN Sansom
    8. TL Vincent
    9. AKT Wann

    • Curated by eLife

      eLife Assessment

      This valuable study provides a detailed three-dimensional characterization of primary cilia organization in the postnatal mouse growth plate, revealing reproducible spatial patterns in ciliation, ciliary length, and orientation. The evidence supporting these descriptive findings is solid, based on high-quality quantitative imaging and complementary genetic, mechanical, and transcriptomic approaches. However, evidence for the broader mechanistic conclusions is incomplete, particularly regarding whether ciliary orientation is uncoupled from basal-body and cell orientation and whether its stability under altered mechanical loading reflects a cell-intrinsic program. The study provides a helpful foundation for understanding primary cilia organization and mechanobiology in the growing skeleton, while the mechanisms underlying these observations remain to be established.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  4. Invariant synaptic density across species

    1. André Ferreira Castro
    2. Albert Cardona

    • Curated by eLife

      eLife Assessment

      This is a potentially valuable study in the area of connectomics, comparing across species to obtain a uniform synaptic density of ~1 synapse per micron. While the methods add to the field, the datasets are limited and filtered, and the role of cell-type on spacing is passed over. Additionally, some of the analyses could be tightened; hence, overall, the findings remain incomplete.

    Reviewed by eLife

    2 evaluationsAppears in 1 listLatest version Latest activity
Page 1 of 866 Older