eLife reviews preprints in the life sciences and medicine.

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  1. Dawn of segmented bilaterians unveiled by soft-bodied fossils in microbial pseudomorphs from the Basal Cambrian

    1. Xiaoguang Yang
    2. Deng Wang
    3. Farid Saleh
    4. Zhiliang Zhang
    5. Jie Sun
    6. Wenjing Hao
    7. Kentaro Uesugi
    8. Tsuyoshi Komiya
    9. Xing Wang
    10. Jian Han

    • Curated by eLife

      eLife Assessment

      This important manuscript reports exceptionally preserved, millimeter-scale segmented bilaterian microfossils from the early Cambrian Fortunian Kuanchuanpu Formation in South China. The authors propose that these non-biomineralized animals were preserved through microbial pseudomorphs rather than direct phosphatization, filling a critical taphonomic and evolutionary gap in early animal evolution. The physical preservation and high-resolution imaging of the fossils are convincing, but the theoretical grounds for establishing "true segmentation" versus superficial annulation/homonomy remain underdeveloped and need revision and further context. The new fossils and their taphonomy will be of broad interest to the paleontology community and those interested in early animal evolution.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. The cell cycle regulates cell-penetrating peptide cytosolic uptake via differential expression of KCNH1 potassium channel

    1. Francisco Tomás Ribeiro
    2. Ali Hallaj
    3. Roger Mora
    4. Anita Lüthi
    5. Evgeniya Trofimenko
    6. Christian Widmann

    • Curated by eLife

      eLife Assessment

      This study reveals valuable links between cell-penetrating peptide uptake and the cell cycle, membrane voltage and an endogenous potassium channel. The evidence is solid, and further experiments would strengthen the proposed mechanism and the degree of the mechanism's generalization. The findings will interest researchers working on delivery of therapeutic molecules into cells.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a g BRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

    1. Ezra Y. Rosen
    2. Marie-Claude Mathieu
    3. Gino B. Ferraro
    4. Philippe Mochirian
    5. Claude Godbout
    6. Hugo Poirier
    7. Sara Fournier
    8. Danielle Henry
    9. Hyeyeon Kim
    10. Robert Papp
    11. Shou Yun Yin
    12. Marie-Eve Leclaire
    13. Robert Houle
    14. Parham Nejad
    15. Joseph D. Schonhoft
    16. Karl E. Zahn
    17. W. Cameron Black
    18. Michel Gallant
    19. Insil Kim
    20. Danielle Ulanet
    21. Paul Basciano
    22. Artur Veloso
    23. Victoria Rimkunas
    24. Timothy A. Yap
    25. Robin Guo
    26. Nicholas Mai
    27. Maria Koehler
    28. Michael Zinda
    29. Anne Roulston
    30. Michal Zimmermann
    31. Stephen J. Morris
    32. Agnel Sfeir

    • Curated by eLife

      eLife Assessment

      Loss of POLQ function is synthetically lethal with BRCA1 or BRCA2 deficiency, as is pharmacological inhibition of its motor (ATPase) or polymerase activity. This important manuscript validates an inhibitor of the DNA polymerase theta (POLθ) motor domain in biochemical and cell-based assays and provides evidence of its efficacy against homologous recombination-deficient tumors in preclinical and clinical settings, particularly in combination with PARP inhibitors. The experiments are rigorous, the evidence is convincing, and the results are appropriately interpreted. This work will be of considerable interest to the ovarian cancer research community.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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