eLife reviews preprints in the life sciences and medicine.

About Followers

Latest preprint reviews

  1. Partial input loss differentially modifies neural pathways

    1. Joo Yeun Lee
    2. Jeffrey Yang
    3. Scott C. Harris
    4. Jeremiah V. John
    5. Natalia S. Stone
    6. Luca Della Santina
    7. David B. Kastner
    8. Felice A. Dunn

    • Curated by eLife

      eLife Assessment

      This study shows that partial cone photoreceptor loss induces pathway-specific circuit remodeling in the mouse retina, with alpha OFF-sustained and OFF-transient retinal ganglion cells adapting differently through changes in their pre- and postsynaptic circuits. The results are valuable because they provide a key understanding of the diversity of circuit remodeling in retinal degeneration. The data are convincing, although clearer reporting of the numbers of independent animals and retinas, a more rigorous distinction between compensation and circuit change, and discussion of the functional consequences would strengthen the mechanistic insights.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa

    1. Michael Telias
    2. Leonor Afrima
    3. Jared Endres
    4. Bristol Denlinger
    5. Richard H. Kramer

    • Curated by eLife

      eLife Assessment

      This study presents valuable findings regarding the role of the P2X7 receptor in retinoic acid signaling-mediated retinal remodeling following photoreceptor degeneration. However, the evidence supporting the main conclusions is currently incomplete, as key comparisons are confounded by differences in genetic background, and the cellular source of receptor expression is not sufficiently resolved. While the work offers mechanistic insights of interest to researchers studying retinal degeneration, additional experimental controls are needed to fully support the authors' claims.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. The stability of thought: using experience sampling and brain imaging to determine the contextually bound nature of human cognition

    1. Louis Chitiz
    2. Samyogita Hardikar
    3. Ian Goodall-Halliwell
    4. Raven Wallace
    5. Bridget Mullholland
    6. Samuel Ketcheson
    7. Bronte McKeown
    8. Michael Milham
    9. Ting Xu
    10. Daniel Margulies
    11. Nerissa Ho
    12. Theo Karapanagiotidis
    13. Giulia Poerio
    14. Robert Leech
    15. Elizabeth Jefferies
    16. Jonathan Smallwood

    • Curated by eLife

      eLife Assessment

      This important work considerably advances our understanding of the nature of ongoing thought across individuals and across task contexts. Using a combination of fMRI brain data and experience sampling, they find that activation of the MDN leads to greater stability of deliberate task-focused thoughts during task performance. The evidence supporting the claims is convincing and both analytically strong and creative, offering a novel approach to capture thought stability and its relationship to independent brain maps. The findings will be of broad interest to cognitive scientists and neuroimagers.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Error-driven representation learning in the mesolimbic system

    1. George Cai
    2. Max F. Scheller
    3. Wolfgang Kelsch
    4. Samuel J. Gershman

    • Curated by eLife

      eLife Assessment

      This important study presents compelling evidence for dopamine-based representation learning in the mouse olfactory tubercle. While this work suggests that gradient descent in deep networks serves as a helpful framework for understanding neural representations, the empirical evidence provided remains incomplete. Nonetheless, this work will be of significant interest to systems and computational neuroscientists, cognitive scientists, and machine learning theorists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival

    1. Magdalena A. Czubala
    2. Patricia Rodrigues
    3. Natacha Ipseiz
    4. Marcela Rosas
    5. Sandra Dimonte
    6. Iestyn Pope
    7. Christine Hinz
    8. Dina Fathalla
    9. Jorge Alvarez-Jarreta
    10. Victoria J. Tyrrell
    11. Wolfgang Langbein
    12. Paola Borri
    13. Robert Andrews
    14. Valerie B. O’Donnell
    15. Philip R. Taylor

    • Curated by eLife

      eLife Assessment

      This is an important study that provides evidence that GATA6-dependent programming of peritoneal macrophages helps to regulate lipid metabolism and influences eosinophil survival. The evidence linking GATA6 deficiency to altered lipid profiles and eosinophil accumulation is solid, although the proposed mechanistic pathway connecting sphingolipid remodelling, LTE4 production and eosinophil survival currently remains incomplete. Strengthening these links and/or appropriately calming the conclusions would help to increase the impact of the study.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Emergent particle collection by cyanobacteria through gliding motility and filament buckling

    1. Rebecca N. Poon
    2. Kelsey Cremin
    3. Alberto Scarampi
    4. Mary Coates
    5. Albane Théry
    6. Orkun S. Soyer

    • Curated by eLife

      eLife Assessment

      This manuscript presents important work on macrostructure formation in a freshwater filamentous cyanobacterium, focusing on its ability to aggregate and buckle. The authors employ a wide range of experiments and approaches, including time-lapse imaging and 3D theoretical modelling, to establish the physical dynamics of filaments, such as gliding motility and buckling. They demonstrate that, in addition to gliding motility, filament length and flexibility are essential for the ability of cyanobacteria to capture particles and form aggregates. Overall, the study provides convincing evidence and advances our understanding of the role of microbial motility in the environment. It will be of broad interest to biophysicists and environmental microbiologists.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
Page 1 of 865 Older