eLife reviews preprints in the life sciences and medicine.

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  1. Mechanics and fate stochasticity shape stem cell distribution in tissues

    1. Johannes C. Krämer
    2. Edouard Hannezo
    3. Jens Elgeti

    • Curated by eLife

      eLife Assessment

      This is a useful and clearly presented study showing how simple feedback between cell crowding and cell growth can maintain tissue balance and lead to the spontaneous formation of stem-cell clusters. The evidence supporting the behavior of the model is solid, but the significance of the clustering result would be strengthened by relating the emphasizing the differences to prior studies, and potentially relating the clustering mechanism to properties of critical birth-death processes in two dimensions.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. NUDT2 loss defines quantitative limits for dinucleoside polyphosphate action on the cGAS–STING–TBK1 axis

    1. Paul Weiland
    2. Renuka Dharani Shivakumar
    3. Ekaterina Jalomo-Khayrova
    4. Julia Schmidt
    5. Victor Zegarra
    6. Ying Wang
    7. Nicole Paczia
    8. Stephan Kiontke
    9. Andreas Burchert
    10. Gert Bange

    • Curated by eLife

      eLife Assessment

      This valuable study investigates the role of dinucleoside polyphosphates in regulating the cGAS-STING-TBK1 axis of innate immunity. The data collected using multiple biochemical and cellular assays, plus X-ray crystallography, are solid, but testing additional polyphosphates and using NUDT2KO cells will further strengthen the main conclusion. This paper will be broadly relevant to those studying various innate immune pathways.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Phylogenomics of free-living neobodonids reveals they are a paraphyletic group from which all other metakinetoplastids are descended

    1. Daryna Zavadska
    2. Julia A. Packer
    3. Daria Tashyreva
    4. Ryoma Kamikawa
    5. Alastair Simpson
    6. Daniel J. Richter

    • Curated by eLife

      eLife Assessment

      This valuable study substantially improves the phylogenetic framework for Kinetoplastea through greatly expanded sampling of free-living neobodonids; the phylogenomic analyses provide convincing evidence that neobodonids are paraphyletic and establish a substantially revised framework for deep relationships within Metakinetoplastina. The work forms the foundation for future comparative studies of kinetoplastid evolution and systematics, although its implications for the origins of parasitism should not be overstated. An 18S rRNA phylogeny documenting the placement of the newly sampled strains within previously recognized neobodonid lineages and/or confirmation of the principal topology using a well-documented phylogenomic set of marker genes would further strengthen the study. The work will be of particular interest to researchers studying protist evolution and the evolutionary context of trypanosomatids.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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