eLife

Latest preprint reviews

1. Connectomic Analysis of Mitochondria in the Central Brain of Drosophila

   This article has 18 authors:

   1. Kit D. Longden
   2. Patricia K. Rivlin
   3. Michał Januszewski
   4. Erika Neace
   5. Louis K. Scheffer
   6. Christopher Ordish
   7. Jody Clements
   8. Elliott Phillips
   9. Natalie Smith
   10. Satoko Takemura
   11. Lowell Umayam
   12. Claire Walsh
   13. Emily A. Yakal
   14. Timothy F. Musial
   15. Michael J. Devine
   16. Michael B. Reiser
   17. Stephen M. Plaza
   18. Stuart Berg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable resource describing the size, density, and synaptic proximity of mitochondria across thousands of neurons in the Drosophila brain, drawn from a well-annotated electron microscopy dataset. The evidence supporting the main descriptive findings is mostly solid, though some measured parameters contain internal inconsistencies and the proposed links between mitochondrial properties and neural activity or energy use remain speculative. The work will interest neuroscientists studying mitochondrial biology, energetics, and connectomics, and lays a foundation for future studies connecting mitochondrial organization to neural circuit function.

   Reviewed by eLife

2. Pain is so close to pleasure: the same dopamine neurons can mediate approach and avoidance in Drosophila

   This article has 5 authors:

   1. Daniel Döringer
   2. Christian Rohrsen
   3. Benjamin de Bivort
   4. Wolf Huetteroth
   5. Björn Brembs

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable study that uses several operant paradigms to test Drosophila for the appetitive or aversive behavioral effects of self-activation of specific dopaminergic neuron (DAN) populations. The work provides solid data, although the range of paradigms and genetic driver lines will require more specific future evidence in case-by-case assays. The results suggest that a more nuanced view of the role of these neurons in ongoing behaviour and learning is necessary. The results will be of broad interest to the neuroscience community.

   Reviewed by eLife

3. Context makes the difference: Temporally Resolved Dopaminergic Teaching Signals Shape Associative Memory in Drosophila Larvae

   This article has 5 authors:

   1. Denise Weber
   2. Anna-Maria Jürgensen
   3. Juliane Kinnigkeit
   4. Martin P. Nawrot
   5. Andreas S. Thum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into how the timing of dopamine signals can influence associative learning and memory in fruit fly larvae at the single-cell level. Combining optogenetic manipulation of individual dopaminergic neurons and computational modeling of circuit computations provides some convincing evidence for the underlying circuit-level mechanisms. However, there are also aspects of incomplete evidence that require key control and validation experiments. The work will be of interest to researchers studying the neural mechanisms of learning and memory.'

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.64898/2026.07.20.739656

5. Correlative light–electron microscopy reveals fundamentally different axonal architectures for fast and modulatory transmission

   This article has 10 authors:

   1. KS Lee
   2. DA Sahlender
   3. JR Blanc
   4. A Jorstad
   5. C Gasselin
   6. S Clerc-Rosset
   7. F Markopoulos
   8. CCH Petersen
   9. A Holtmaat
   10. GW Knott

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper provides fundamental data on the ultrastructural signatures of neuromodulatory axons in mouse cortex obtained from exceptionally high-quality correlated light- and volume electron microscopy. They report unique vesicle and synapse configurations of cholinergic and serotonergic axons, providing compelling structural support for volume transmission.

   Reviewed by eLife

6. Extinction risk in terrestrial vertebrates is associated with niche limits that reflect climatic vulnerability

   This article has 2 authors:

   1. Matthew Nagy-Watson
   2. Jeremy T. Kerr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the relationship between climatic niche limits and extinction risk across more than 23,000 terrestrial vertebrate species. The large comparative dataset and phylogenetic analyses indicate solid evidence that species with lower upper thermal niche limits are more likely to be classified as threatened, whereas associations with aridity limits are less consistent. However, the treatment of data-deficient species and unclear definitions of niche metrics warrant further scrutiny, and the analyses do not establish that climate or land-use change drives the observed patterns. The findings will interest researchers in macroecology, global change biology, and conservation.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.09.15.751783

8. High-dimensional Characterization of Genome–Environment Fitness Landscapes in Klebsiella pneumoniae

   This article has 15 authors:

   1. Ge Zhou
   2. Georgia Williams
   3. Mathew T. Millner
   4. Raneem AlHirayban
   5. Wejdan Alosaimi
   6. Omniya Fallatah
   7. Adam J Hart
   8. Mohammed Malaikah
   9. Sara Iftikhar
   10. Huda Ahmad
   11. Mohammad Roghanian
   12. Ville Mustonen
   13. Rfeef AlYami
   14. Manuel Banzhaf
   15. Danesh Moradigaravand

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable mapping of how genomic variation from a large collection of Klebsiella pneumoniae clinical isolates shapes bacterial fitness across 214 conditions. Solid data describe that fitness is strongly condition-dependent and that features can be advantageous under selection. Though the predictive, plasmid causality and GWAS association findings would be further strengthened by additional analyses ruling out population-structure confounding, these findings are of value for our understanding of the power of genotype to predict phenotype for this important human pathogen.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.64898/2026.07.16.733837

10. Thermotaxis behavior of Drosophila melanogaster : A quantitative analysis of sensory-motor integration and heat avoidance

    This article has 5 authors:

    1. Zeinab Moradi
    2. Sara Jahedazad
    3. Ehsan Hosseinian
    4. Tayebeh Minaei
    5. Ali Sadighi

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study utilizes a two-choice assay to examine how groups of Drosophila melanogaster respond to temperature changes. The findings are useful, offering focused importance for the collective decision-making community. However, the strength of the evidence is incomplete, as the current data only partially support the primary claims and the work lacks the necessary integration into the existing literature to contextualize the findings.

    Reviewed by eLife