eLife

Latest preprint reviews

1. Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity

   This article has 14 authors:

   1. Shaoyu Tu
   2. Yue Du
   3. Wei Liang
   4. Xiaoyi Xu
   5. Jiahui Zou
   6. Yuchao Yang
   7. Chuhan Xiong
   8. Yanglin Li
   9. Meijun Jiang
   10. Aotian Ouyang
   11. Tong Chen
   12. Meilin Jin
   13. Huanchun Chen
   14. Hongbo Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reveals a role for lactylation in influenza polymerase function and virus replication. The evidence supporting the claims is solid, although the direct involvement of ATAT1 and SIRT1 in this modification and the functional relevance of the identified sites can be further substantiated. These findings will appeal broadly to influenza virologists studying polymerase regulation, as well as researchers investigating the functional roles of lactylation.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.64898/2026.07.01.735787

3. We couldn't get details of this article at this time:
   10.64898/2026.06.01.729383

4. We couldn't get details of this article at this time:
   10.1101/2025.09.19.677475

5. We couldn't get details of this article at this time:
   10.64898/2026.03.29.715140

6. We couldn't get details of this article at this time:
   10.64898/2026.07.01.735930

7. Break-induced replication drives large-scale genomic amplifications in cancer cells

   This article has 4 authors:

   1. Mouadh Benamar
   2. Rebeka Eki
   3. Kang-Ping Du
   4. Tarek Abbas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important findings that genome-wide DNA double-strand breaks trigger large-scale genomic amplification (DIGA), which does not require origin re-licensing, but is dependent on some proteins that are involved in break-induced replication (BIR). While the findings and model are compelling, the evidence supporting the claims is largely incomplete, as it depends primarily on a single assay to examine amplification. This work will be of interest to scientists in the DNA repair, replication, and cell cycle fields, as well as cancer biologists.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.64898/2026.06.03.729765

9. We couldn't get details of this article at this time:
   10.1101/2025.09.01.673540

10. We couldn't get details of this article at this time:
    10.64898/2026.06.09.731162