eLife reviews preprints in the life sciences and medicine.

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  1. Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells

    1. Shaimaa Hassan
    2. Maria Rodriguez-López
    3. StJohn Townsend
    4. Büşra Köksal
    5. Sezin Akkus
    6. Alessandro Ori
    7. Alessandro Cellerino
    8. Markus Ralser
    9. Jürg Bähler

    • Curated by eLife

      eLife Assessment

      This important study used several genome-wide approaches to compare dormancy in S. pombe spores and killifish diapause embryos. The findings include a trade-off between longevity and heat resistance in yeast spores and, in both these systems, a relatively higher expression of ribosomal-protein mRNAs but not proteins. While the evidence for the findings is overall solid, some interpretations should still be tempered. The large-scale datasets provide an excellent resource for future research in the dormancy field.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  3. Whole human organ clearing and multimodal mapping

    1. Héloïse Policet-Bétend
    2. Tomàs Jordà-Siquier
    3. Geraldine Cuenu
    4. Maeva Badré
    5. Sami Schranz
    6. Julien Da Costa
    7. Céline Brockmann
    8. Pascal Senn
    9. Daniel Huber
    10. Christophe M Lamy

    • Curated by eLife

      eLife Assessment

      This important paper introduces a generalisable tissue-clearing method to study human anatomy and the organisation of complex tissues and organs. The evidence for its broad applicability is compelling, based on results from 15 diverse human tissues, including highly heterogeneous specimens, with successful labelling using five antibodies and five fluorescent dyes. The method has broad potential applications across multiple disciplines.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Structures of LolB bound to LolA or lipoprotein resolve the final steps of bacterial lipoprotein trafficking

    1. Abigail E. Jepson
    2. Elise Kaplan
    3. Nicholas P. Greene
    4. Vassilis Koronakis

    • Curated by eLife

      eLife Assessment

      This is a valuable study that aims to resolve the mechanistic details of the final steps of bacterial lipoprotein trafficking. The evidence supporting the conclusions is mostly solid but support for other claims is incomplete. This work will be of interest to biochemists and microbiologists studying the bacterial cell envelope and those aiming to develop novel antibacterial molecules.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  6. Spatiotemporal Dissociation of Human Amygdala Response to Negative Affect

    1. Ke Bo
    2. Martin A. Lindquist
    3. Peter J. Gianaros
    4. Tor D. Wager

    • Curated by eLife

      eLife Assessment

      This study provides valuable new insights into the functional differentiation of human amygdala subnuclei during the observation of negative images and emotional reappraisal. The evidence is convincing, particularly regarding differences in the time course of evoked responses and their partial correspondence with broad anatomical subdivisions. The work will be of interest to researchers studying the amygdala, emotional processing, and emotion regulation.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity
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