eLife

Latest preprint reviews

1. Dual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae

   This article has 5 authors:

   1. Ying Du
   2. Aiyang Lin
   3. Joshua A.R. Brown
   4. LeAnn J. Howe
   5. Wei Xiao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies an upstream repressive region in the Saccharomyces cerevisiae DDI2/3 promoter and shows that chemical stress induced by cyanamide or MMS is accompanied by reduced histone abundance and decreased nucleosome occupancy across the DDI2/3 locus. Genetic histone depletion is sufficient to enhance DDI2/3 expression, while MNase-seq and genetic analyses support a model in which the transcription factor Fzf1 both activates transcription through its established promoter-binding function and promotes chromatin changes that relieve nucleosome-mediated repression, helping to explain the unusually strong induction of DDI2/3 relative to other Fzf1 targets. The study is significant, as it provides a conceptually interesting extension of Fzf1-mediated stress regulation. The strength of the evidence is solid, although additional controls and a more cautious treatment of whether Fzf1 directly drives nucleosome eviction versus acting indirectly through transcriptional recruitment or chromatin-remodeling factors would further strengthen the mechanistic conclusions.

   Reviewed by eLife

2. Genomic variation and ancestry of Helicobacter pylori in the admixed population of Cabo Verde reveal host adaptation, limited host–pathogen ancestry concordance, and signatures of trans-Atlantic slave trade migrations

   This article has 18 authors:

   1. Timothy Archampong
   2. Yi Ling Tam
   3. Charlotte Davison
   4. Isra Boughanmi
   5. Sam Tallman
   6. Milani Rodrigues
   7. Neia Tavares
   8. Kleyde Simone Santos
   9. Francisco Barbosa Amado
   10. Isabel Ramos
   11. Antonieta Martins
   12. Richard Haigh
   13. Marco R. Oggioni
   14. Rui Manuel Ferreira
   15. Céu Figueiredo
   16. Fabian Freund
   17. Isabel Inês Araújo
   18. Sandra Beleza

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study characterizes the population structure and ancestry of Helicobacter pylori in Cabo Verde. Using a carefully sampled population-based cohort and paired host-bacterial genomic data, the authors identify distinct local lineages but with limited concordance between human and bacterial ancestry. The evidence is solid for the principal findings concerning bacterial diversity, ancestry and recent lineage expansion, while the support for the claim that this reflects host adaptation, enhanced transmission, reduced virulence or a mix thereof is weaker. The work has particular relevance for researchers interested in microbial population genomics, host-pathogen coevolution and the genetic consequences of human migration and admixture.

   Reviewed by eLife

3. Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling

   This article has 11 authors:

   1. Cristina Tuñí-Domínguez
   2. Giovanni Asole
   3. Pablo Monteagudo-Mesas
   4. Elena Cristina Rusu
   5. Lluc Cabús
   6. Lucila González
   7. Laura Sánchez
   8. Beatriz Neto
   9. Phil Sanders
   10. Marc Weber
   11. Julien Lagarde

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study addresses a timely problem that is of importance in the cfRNA field, and it provides a potentially valuable resource. The use of a common processing pipeline, publicly available code, and variance-partition analyses are notable strengths. However, several central conclusions, particularly those concerning protocol-level effects, the dominance of technical over biological variation, and the proposed universal QC criteria remain more general than the study design and available data can support. Therefore the evidence is currently incomplete and needs to be improved through the revision process.

   Reviewed by eLife

4. Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for LMNA -related Cardiomyopathy

   This article has 14 authors:

   1. Hananeh Fonoudi
   2. Ali Negahi Shirazi
   3. Hui-Hsuan Kuo
   4. Carlos G. Vanoye
   5. Xiaozhi Gao
   6. Susan Doody
   7. Mariam Jouni
   8. Brian Lenny
   9. Achal Neupane
   10. Janavi Kotamarthi
   11. Yadav Sapkota
   12. Jane E. Wilcox
   13. Alfred L. George
   14. Paul W. Burridge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable patient-derived human cell platform for investigating LMNA-associated cardiomyopathy and identifies cyproheptadine as a compound that improves abnormal calcium handling across multiple LMNA variants in vitro. The experimental approaches are generally rigorous and establish reproducible disease-associated cellular phenotypes; however, the evidence remains incomplete because the mechanistic basis of the observed rescue is not established, and the translational conclusions substantially exceed the presented data.

   Reviewed by eLife

5. Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice

   This article has 6 authors:

   1. Paola Montenegro
   2. Rachel Kim
   3. Mikayla Zedek
   4. Marianna Chicas
   5. Pamela Yeh
   6. Hermes Yeh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that prenatal alcohol exposure produces lasting changes in amyloid precursor protein processing, including altered APP C-terminal fragments and Notch intracellular domain levels, that persist into adulthood and track with progressive spatial learning and memory deficits, in both wild-type and 3xTg-AD mice. The convincing study was carefully designed and combined biochemical, histological, and behavioral approaches across multiple ages. The work will interest researchers studying fetal alcohol spectrum disorders, Alzheimer's disease risk, and the developmental origins of neurodegeneration. Nonetheless, reviewers identified opportunities to strengthen the conclusions with additional samples and controls.

   Reviewed by eLife

6. Multi-timescale dynamics organize descending pain modulation

   This article has 6 authors:

   1. Carl Ashworth
   2. Melissa Martenson
   3. Zhigang Shi
   4. Caitlynn C. De Preter
   5. Mary Heinricher
   6. Flavia Mancini

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     An intriguing set of electrophysiological and analytical results suggests that adult rat neurons in the medulla oblongata crucial for mediating descending pain modulation are embedded in a network that generates a specific pattern of oscillatory activity. These valuable findings may broaden our understanding of how descending pain modulation is achieved. The supporting evidence is incomplete, and the authors need to provide several methodological clarifications and additional data interpretations to strengthen the manuscript.

   Reviewed by eLife

7. S1PR1 signaling biases neutrophils toward long-lived low-inflammatory functional states

   This article has 15 authors:

   1. Yueh-Chien Lin
   2. Takahiro Seno
   3. Alan Y. Hsu
   4. Andréane Cartier
   5. Andrew Kuo
   6. Michel V Levesque
   7. Avishek Ghosh
   8. Ingo Fohmann
   9. Victoria A. Blaho
   10. Sylvain Galvani
   11. Reed Crocker
   12. Samuel W Kazer
   13. José Ordovás–Montañés
   14. Hongbo R. Luo
   15. Timothy Hla

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript examines how overexpression of sphingosine 1-phosphate receptor 1 in a mouse model affects neutrophil distribution, metabolism and function. Given the significance of S1PR1 in inflammatory mechanisms, this work is valuable for uncovering novel aspects of S1PR1 signaling in neutrophil dynamics and function. The evidence provided is solid as it integrates single-cell transcriptomics, flow cytometry, and multiple in vivo studies. This work also raises key questions about distinct physiological and pathophysiological roles of S1PR1 signaling in neutrophils that could become therapeutic targets.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.64898/2026.06.05.730398

9. We couldn't get details of this article at this time:
   10.64898/2026.07.03.736391

10. We couldn't get details of this article at this time:
    10.64898/2026.06.15.732329