eLife reviews preprints in the life sciences and medicine.

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  1. Cooperative antibiotic response in coupled biofilm and planktonic E. faecalis communities

    1. Gabriela Fernandes Martins
    2. Keanu Alexander Guardiola-Flores
    3. Luis Zaman
    4. Jordan M. Horowitz
    5. Kelsey M. Hallinen
    6. Kevin Wood

    • Curated by eLife

      eLife Assessment

      This useful study combines experiments and mathematical modeling to show that antibiotic protection provided by resistant cells can extend across both surface-associated and freely growing bacterial populations. Notably, they show that treatment efficacy depends on population composition and density. The evidence supporting the main conclusions is incomplete, primarily because the biofilm context is not adequately characterized and demonstrated, raising the concern that it might represent only an aggregate of cells on the surface (rather than a biofilm) under the studied experimental conditions.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Astrocytic Nonsense-mediated mRNA decay regulates calcium signaling to support synapse function and restrain anxiety

    1. Pablo J. Lituma
    2. Aykut Deveci
    3. Estibaliz Barrio-Alonso
    4. Kun Tan
    5. Miles F. Wilkinson
    6. Pablo E. Castillo
    7. Dilek Colak

    • Curated by eLife

      eLife Assessment

      This important study provides the first in vivo evidence that nonsense-mediated mRNA decay (NMD) in mature astrocytes regulates astrocyte function, synaptic plasticity, and anxiety-related behavior. Using a broad range of approaches, the authors show that conditional deletion of Upf2 alters astrocyte morphology and calcium signaling while impairing synaptic transmission and plasticity, providing solid support for the central conclusion that astrocytic NMD influences neural circuit function. Some key mechanistic claims remain incompletely supported, including whether phenotypes reflect astrocyte remodeling versus loss, the interpretation of synaptic engulfment data, the link between NMD targets and calcium signaling, and the extent to which calcium dysregulation explains the observed synaptic and behavioral effects.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  3. CHOP promotes the transition to chronic integrated stress response signaling with suppression of hepatocyte identity

    1. Theo F. Velarde
    2. Kaihua Liu
    3. Zewei Zhang
    4. Reed C. Adajar
    5. Chaoxian Zhao
    6. Huojun Cao
    7. D. Thomas Rutkowski

    • Curated by eLife

      eLife Assessment

      This fundamental manuscript describes a key role for the integrated stress response-regulated transcription factor CHOP in regulating liver biology in response to endoplasmic reticulum stress through both the downregulation of transcription factors involved in regulating hepatic identity and altering the capacity for integrated stress response and unfolded protein response signaling to induce protective signaling. The data supporting this model is convincing, but including some additional discussion on the mechanism and importance of the work in the context of the published literature would be helpful to better define the complex importance of CHOP signaling. This work will be of interest to a wide range of biologists interested in liver biology, stress-responsive signaling, and ER stress.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Nanoscale organization of betaII-spectrin within segments of the membrane-associated periodic skeleton in mouse sciatic nerve axons

    1. Nahir Guadalupe Gazal
    2. Gonzalo Escalante
    3. Lucía F. Lopez
    4. Laurence Goutebroze
    5. Mariano Bisbal
    6. E. Axel Gorostiza
    7. Alan M. Szalai
    8. Fernando D. Stefani
    9. Nicolás Unsain

    • Curated by eLife

      eLife Assessment

      This is a valuable paper looking at nanoscale organization of the membrane associated periodic cytoskeleton in mouse sciatic nerve axons. Despite previous studies, the precise organisation of the structure remains unclear, especially in vivo, and this manuscript significantly adds to this knowledge with solid data. An unexpected observation is the presence of discrete nanoscale clusters, regularly distributed around sections of axons. However, the paper misses a description of these clusters along the longitudinal axis of the axons.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  5. Fourfold lifespan extension in C. elegans daf-2 mutant males

    1. Mike Russell
    2. Michelle Lin
    3. Alexander Tate Lasher
    4. Steven N Austad
    5. Liou Y Sun

    • Curated by eLife

      eLife Assessment

      This useful study reports on lifespan extension in C. elegans males that carry a mutation in a gene for an insulin receptor; while the observations are striking, the strength of evidence is currently incomplete. The central claim of male-specificity is undermined by the absence of direct hermaphrodite healthspan comparisons, and the reliance on a single mutant allele leaves open the possibility that background mutations, rather than daf-2 loss-of-function, drive the phenotype. Methodological details critical for reproducibility are also lacking, particularly regarding male housing density, censoring of plate-leaving animals, and the adequacy of replication for the key epistasis experiment. The work could be substantially strengthened by a targeted set of additional experiments and fuller engagement with the existing literature on sex-specific aging in C. elegans.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. PCNA-Polκ-Polδ/USP18 axes stabilize replication fork and restart to reduce cisplatin cytotoxicity

    1. Ipsita Subhadarsini
    2. Jugal Kishor Sahu
    3. Shweta Thakur
    4. Rupesh Dash
    5. Narottam Acharya

    • Curated by eLife

      eLife Assessment

      Building on earlier studies, this manuscript reports a role for pol kappa in cisplatin resistance in the very specific scenarios of head and neck squamous cell carcinoma, providing evidence that the PIP box of Pol kappa is critical for cisplatin resistance in these cells. The findings are of a highly focused relevance and will be useful in the field, but the conclusions are limited to very specific cancer cells. Conclusions cannot be generalized to all cisplatin resistance mechanisms and cell types and are based on incomplete evidence that presents uncertainties and discrepancies that need to be resolved.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  7. Primate Hippocampus Reveals Distinct Rules for Associative Synaptic Plasticity

    1. Anoop Manakkadan
    2. Krishna Kumar
    3. Yee Song Chong
    4. Wong Lik-Wei
    5. Sheeja Navakkode
    6. Yuk Peng Wong
    7. Soong Tuck Wah
    8. Camilo Libedinsky
    9. Sreedharan Sajikumar

    • Curated by eLife

      eLife Assessment

      This is a potentially important study comparing LTP mechanisms between primates and rodents. The experimental methods have some possible confounds, and the power (replicates) and design of the statistical methods could be strengthened, hence the support for the central claims of species differences is currently incomplete.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  8. Estimating the replicability of Brazilian biomedical science

    1. The Brazilian Reproducibility Initiative
    2. Olavo Bohrer Amaral
    3. Clarissa França Dias Carneiro
    4. Kleber Neves
    5. Ana Paula Wasilewska Sampaio
    6. Bruna Valério Gomes
    7. Mariana Boechat de Abreu
    8. Pedro Batista Tan
    9. Gabriel Paz Souza Mota
    10. Ricardo Netto Goulart
    11. Nathalia Raquel de Souza Fernandes
    12. Jimmy Hayden Linhares
    13. Adriana Mércia Guaratini Ibelli
    14. Adriano Defini Andricopulo
    15. Adriano Sebollela
    16. Adryano Augustto Valladão de Carvalho
    17. Airton Pereira e Silva
    18. Alana Silva Oliveira Souza
    19. Alessandra Catarina Chagas de Lima
    20. Alessandra Mara de Sousa
    21. Alexander Birbrair
    22. Alexandre Urban Borbely
    23. Aline Maria Machado
    24. Alinne do Carmo Costa
    25. Aliny Pereira de Vasconcelos
    26. Alvaro Henrique Bernardo de Lima Silva
    27. Amanda de Souza
    28. Ana Beatriz Rezende Paula
    29. Ana Carolina Caetano Nunes
    30. Ana Maria de Lauro Castrucci
    31. Ana Paula Almeida Bastos
    32. Ana Paula Farias Waltrick
    33. Ana Paula Herrmann
    34. Andre Gustavo Ferreira de Macedo
    35. Andrelson Wellington Rinaldi
    36. André Souza Mecawi
    37. Andrés Delgado Canedo
    38. Anna Paula Marçal
    39. Anna Paula Perin Vidigal
    40. Antonio Martins Monteiro
    41. Beatriz Gonçalves Silva Rocha
    42. Bianca Cruz Pachane
    43. Brenda da Silva Andrade
    44. Bruna Carla Casali
    45. Bruno Popik
    46. Camila Pasquini de Souza
    47. Camila da Silva Dos Santos
    48. Camilla Mendes Gonçalves
    49. Camilla Ribeiro Barroso do Nascimento
    50. Carla Pires Veríssimo
    51. Carlos Eduardo Neves Girardi
    52. Carmen Penido
    53. Carolina Batista
    54. Carolina Panis
    55. Carolina Saibro-Girardi
    56. Carolina da Silva Gouveia Pedrosa
    57. Caroline de Carvalho Picoli
    58. Cristiane Regina Guerino Furini
    59. Daniel Pens Gelain
    60. Daniel Sturza Lucas Caetano
    61. Daniela Costa Silva
    62. Daniele Cristina de Aguiar
    63. Demetrius Antonio Machado De Araújo
    64. Deoclécio Alves Chianca Júnior
    65. Dilza Balteiro Pereira de Campos
    66. Débora Aguirre Gonçalves
    67. Débora Santos da Silva
    68. Eduarda Godfried Nachtigall
    69. Eloiza Lopes Lira Tanabe
    70. Erika Seki Kioshima
    71. Fabio Rodrigues Ferreira Seiva
    72. Fabrício de Araujo Moreira
    73. Felipe Saceanu Leser
    74. Felipe Vanz
    75. Fernanda Cacilda dos Santos Silva
    76. Fernanda Magalhães Ferrão
    77. Fernanda Nogueira Lotz
    78. Flavia Fonseca Bloise
    79. Flavia Regina Souza Lima
    80. Flávio Alves Lara
    81. Franciana Aparecida Volpato
    82. Francieli Moro Stefanello
    83. Francisca Nathalia de Luna Vitorino
    84. Francisco Noé Fonseca
    85. Fábio Jorge Moreira da Silva
    86. Fábio de Almeida Mendes
    87. Gabriel Vasata Furtado
    88. Gilda Angela Neves
    89. Giovanna Zanetti
    90. Giulia Scarcella Cancelliero
    91. Graziele Fernanda Deriggi Pisani
    92. Guilherme Curi Aiub Casagrande
    93. Gustavo Roberto Villas-Boas
    94. Heitor Roque Oliveira Alvez da Cruz
    95. Helena Lobo Borges
    96. Heloisa Sobreiro Selistre De Araujo
    97. Helvécio Cardoso Corrêa Póvoa
    98. Hilana dos Santos Sena Brunel
    99. Hugo Bayer
    100. Igor Luchini Baptista
    101. Isabel Werle
    102. Isabela Alcântara Barretto Araújo Jardim
    103. Isabela Aparecida Divino
    104. Janaina Menezes Zanoveli
    105. Jane de Oliveira Peixoto
    106. Jaqueline de Carvalho Rinaldi
    107. Jeane Bachi Ferreira
    108. Jeferson Luis Franco
    109. Jeronimo Marteleto Nunes Rugani
    110. Jociane de Carvalho Myskiw
    111. Jorge Alberto Quillfeldt
    112. José Marcos Janeiro Pereira da Costa
    113. João Victor Roza Cruz
    114. Julia Helena Oliveira de Barros
    115. Julia Mello Barros
    116. Julia Pinheiro Chagas da Cunha
    117. Juliana Nunes Roson
    118. Júlia Dummer Rodrigues de Freitas
    119. Júlia Grigorini Mori Ayub
    120. Karen Steponavicius Cruz Borbely
    121. Karina Barbosa de Queiroz
    122. Karina Dutra Asensi
    123. Karoline dos Santos Rodrigues
    124. Kellyne de Castro Vieira
    125. Keyla Silva Nobre Pires
    126. Kétlyn Talise Knak Guerra
    127. Lays Adrianne Mendonça Trajano-Silva
    128. Leandro Jose Bertoglio
    129. Leonardo Vinicius Monteiro de Assis
    130. Leticia Menezes Vasconcelos
    131. Leticia Miranda Santos Lery
    132. Letícia de Oliveira Marinho da Silva
    133. Lorena de O Fernandes-Siqueira
    134. Lucas De Oliveira Alvares
    135. Lucas Gabriel Vieira
    136. Lucas Henrique de Melo Falcione
    137. Lucas Dos Santos da Silva
    138. Lucianne Fragel Madeira
    139. Luis Eduardo Duarte Nunes
    140. Luiz Gustavo de Almeida Chuffa
    141. Luiza Marques Prates Behrens
    142. Marcos Vinicius Esteca
    143. Maria Luiza Saraiva-Pereira
    144. Maria Nathália Moraes
    145. Maria Sueli Soares Felipe
    146. Mariana Saldanha Viegas Duarte
    147. Mariana Souza da Silveira
    148. Marimelia A Porcionatto
    149. Marisa Salvi
    150. Maryana Albino Clavero
    151. Mateus Lobato Ferreira
    152. Matheus Alves de Moura
    153. Matheus Gallas-Lopes
    154. Mauro César Isoldi
    155. Mayara Terra Villela Vieira Mundim
    156. Michael Andrades
    157. Micheline Freire Donato
    158. Milena Piaia Barboza
    159. Miliane Martins de Andrade Fagundes
    160. Miriane Avelino Silva
    161. Morgana Duarte da Silva
    162. Munira Muhammad Abdel Baqui
    163. Mychelle Pacheco de Souza
    164. Mônica Corrêa Ledur
    165. Nathalia Stark Pedra
    166. Natália Iorio Lopes Pontes Póvoa
    167. Natália Karla Bellini
    168. Nauana Somensi
    169. Nicolly Maria Payva Nunes
    170. Nícia Pedreira Soares
    171. Nívea Ferreira Silva
    172. Pablinny Moreira Galdino de Carvalho
    173. Paola Alejandra Cappelletti
    174. Patricia Pestana Garcez
    175. Patrícia Kellen Martins Oliveira Brito
    176. Patrícia Rocha Martins
    177. Paulo Roberto Moreira Lauar
    178. Priscila Nicolicht-Amorim
    179. Rafael Chitolina
    180. Raiana Andrade Quintanilha Barbosa
    181. Raul Alexander Gonzales Cordova
    182. Regina Coeli Dos Santos Goldenberg
    183. Rejane Giacomelli Tavares
    184. Renata Krogh
    185. Renata de Freitas Saito
    186. Roberto Andreatini
    187. Roberto Farina Almeida
    188. Rodrigo Cunha Alvim de Menezes
    189. Rodrigo Rorato
    190. Roger Chammas
    191. Rosangela Vieira de Andrade
    192. Roselia Maria Spanevello
    193. Rosiane Andrade Costa
    194. Rubens Lima do Monte-Neto
    195. Sabrina Alves dos Reis
    196. Scheila Iria Kraus
    197. Silvana Chedraoui Silva
    198. Simone Michelan-Duarte
    199. Stevens Kastrup Rehen
    200. Sylvana Izaura Salyba Rendeiro de Noronha
    201. Tania Maria Ortiga-Carvalho
    202. Tanira da Silveira Prieto
    203. Tatiane Renata Fagundes
    204. Thabatta Karollynne Estevam Nakamura
    205. Thadeu Estevam Moreira Maramaldo Costa
    206. Tharcísio Citrângulo Tortelli Junior
    207. Thays Barboza da Luz
    208. Thiago Aparecido da Silva
    209. Tiago Goss Dos Santos
    210. Vanessa Beijamini
    211. Victória Regina de Siqueira Monteiro
    212. Vinícius Alexandre Wippel
    213. Viviane Medeiros Oliveira Valença
    214. Wanessa Fernanda Altei

    • Curated by eLife

      eLife Assessment

      This important study assessed the replicability of a selection of lab-based biomedical experiments in papers published by authors based in Brazil. The study adds a unique perspective to the literature on replication, and provides rich data on the approach taken, the outcomes, and the challenges involved in conducting large-scale crowd-sourced research. The evidence supporting the claims is convincing, but there is scope for clarifying the presentation of the results and extending the discussion section.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. Yoda molecules agonize PIEZO2

    1. Tharaka D. Wijerathne
    2. Aneesh Chandrasekharan
    3. Aashish Bhatt
    4. Yun L. Luo
    5. Jérôme J. Lacroix

    • Curated by eLife

      eLife Assessment

      This study presents an important finding regarding the effect of Yoda molecules on PIEZO2 function, challenging the assumption that they selectively activate PIEZO1. The evidence supporting this claim is solid, but several methodological and conceptual issues need to be addressed. Overall, this work will be of broad interest to researchers working with PIEZO channels across various biological scales.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

    1. Go Kasuya
    2. Kaei Ryu
    3. Buntaro Zempo
    4. Emi Kawano-Yamashita
    5. Koichi Nakajo

    • Curated by eLife

      eLife Assessment

      In this manuscript, the authors describe a new member of the KCNE auxiliary subunits of potassium channels from a lamprey. This new subunit represents an early evolutionary member which confers new properties when expressed along with KCNQ channels. The authors present convincing evidence from several experimental approaches. The contents of this manuscript are important and should be relevant to understanding both the mechanism of modulation of KCNQ channels by KCNE subunits and the evolutionary history of these subunits, which this manuscript now extends to the divergence of early vertebrates.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity
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