eLife

Latest preprint reviews

1. Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

   This article has 8 authors:

   1. Tarun Yadav
   2. Jonathan H. Borowsky
   3. Alvaro Jesus Narbona-Perez
   4. Bhavya Soni
   5. Corey N. Cunningham
   6. James Carrington
   7. Michael Grabe
   8. Jared Rutter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study provides theoretical and experimental evidence that aliphatic-to-threonine substitutions in transmembrane domains improve the translocation properties of mitochondrial proteins from the cytosol to mitochondria. The authors provide convincing evidence that substitutions within hydrophobic transmembrane regions of mitochondrial proteins may have contributed to their evolutionary adaptation following the transfer of their genes from the mitochondria to the nucleus. This study will be of interest to biologists and biochemists working on mitochondrial protein import and mitochondrial evolution.

   Reviewed by eLife

2. Spatiotemporal Dissociation of Human Amygdala Response to Negative Affect

   This article has 4 authors:

   1. Ke Bo
   2. Martin A. Lindquist
   3. Peter J. Gianaros
   4. Tor D. Wager

   This article has been curated by 1 group:

   • Curated by eLife

     Reviewer #1 (Public review):

     Summary:

     The authors aimed to re-analyse two fMRI datasets of studies investigating the effect of cognitive emotional regulation on amygdala response during the viewing of negative images, in order to assess whether such effects might have been missed in previous reports of the results of these studies. In order to accommodate potential non-typical response profiles in the amygdala, they used a modelling approach that is agnostic about the shape of the BOLD response (finite impulse response modelling). Furthermore, the authors sought to differentiate between amygdala subregions using i) two previously published probabilistic atlases of amygdala subnuclei; and ii) a data-driven analysis focusing on temporal response profiles, which identified four clusters that mostly overlapped with anatomical parcellations. The analyses confirmed their previous results insofar as they did not find any impact of emotional regulation on the amygdala response in any subregion. However, their approach revealed differences in temporal response profiles between amygdala subregions: the centromedial amygdala showed sustained activation extending into the post-stimulus rating period, whereas laterobasal and superficial subregions peaked earlier during stimulus presentation. Overall, this study helps to clarify whether cognitive emotional regulation during negative image viewing alters amygdala response, and demonstrates the value of flexible response modelling to differentiate between functional subregions of an important brain structure.

     Strengths:

     The strengths of this study lie in the amount of data used (a combined N of 358 participants is rather high), the flexibility of the modelling approach (FIR), the exploratory nature of the data-driven clustering based on temporal response profiles, and clarity of the text and of the findings. One weakness would be the fact that no fMRI data acquired at higher field strengths were used for the aim of differentiating responses of amygdala subunits.

     In my opinion, the authors achieved their aims of re-analysing these datasets with complementary methods, and helped to discover new aspects of the BOLD response in the amygdala during emotional regulation. The results support their conclusions.

     This work is likely to stimulate discussion of the response of amygdala subnuclei during emotional regulation, and might encourage researchers to resort to more flexible analysis methods by demonstrating the information gain achieved with the FIR approach.

     Weaknesses:

     There are 7T studies of the amygdala response that have looked at differences in BOLD response across subnuclei. While I don't know of any that have investigated emotional regulation, I think these studies should nevertheless be mentioned and discussed in the Discussion, at least to compare the differences observed across subnuclei.

   Reviewed by eLife

3. Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb

   This article has 10 authors:

   1. Nila R. Mönig
   2. Michał Januszewski
   3. Stephan Gerhard
   4. Bo Hu
   5. Nesibe Z. Temiz
   6. Ruth E. Montaño Crespo
   7. Tafheem Masudi
   8. Adrian A. Wanner
   9. Christel Genoud
   10. Rainer W. Friedrich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study carefully assesses the anatomical organization of the adult zebrafish olfactory bulb using a densely reconstructed electron microscopy dataset. The data were generated using a previously acquired state-of-the-art serial block-face scanning electron microscopy dataset, followed by manual classification of cells into distinct anatomical groups. The analysis is a convincing application of careful expert neuroanatomical understanding that reveals key details of the cell class and connectivity in the olfactory bulb, with helpful detailed descriptions of why each cell class was distinguished.

   Reviewed by eLife

4. RelB proximity proteomics and CRISPR screening define chromatin regulators of noncanonical NF-κB control of HIV latency and reactivation

   This article has 12 authors:

   1. Cameron R. Bussey-Sutton
   2. Carley N. Gray
   3. Benjamin J. Wu
   4. Jackson J. Peterson
   5. Samuel D. Burgos
   6. C. Allie Mills
   7. Laura E. Herring
   8. Edward P. Browne
   9. Anne-Marie W. Turner
   10. David M. Margolis
   11. Michael Emerman
   12. Brian D. Strahl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     By integrating RelB proximity labeling with targeted CRISPR screening, the authors identify several potential regulators of HIV latency and provide evidence implicating RelB, KAT7, and p300 in AZD5582-mediated HIV reactivation. While the study is important, the current work is incomplete, as it needs to establish physiological relevance. The findings require validation in primary latency models, and the unusually high basal RelB expression in the experimental system raises concerns about whether the observed effects accurately reflect endogenous mechanisms regulating HIV latency.

   Reviewed by eLife

5. Evidence for flexible regulation of movement and decision vigor in a reward-oriented task

   This article has 3 authors:

   1. Adrien Conessa
   2. Arnaud Boutin
   3. Bastien Berret

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study introduces an innovative task and framework for examining whether movement vigor and reward-seeking behavior are governed by common or separate processes. The behavioral findings provide solid evidence that these behaviors can be differentially influenced by effort and delay, but support for the proposed model and its mechanistic claims remains incomplete, requiring more rigorous validation and analyses to address potential confounds. The work will be of interest to researchers studying motor control, decision-making, and effort-based behavior.

   Reviewed by eLife

6. Two Interacting Neural Processes Support Speech Planning during Naturalistic Conversation

   This article has 3 authors:

   1. Hiroyoshi Yamasaki
   2. Philippe Blache
   3. Daniele Schön

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study shows that neural activity before a conversational response contains information about the duration and timing of the subsequent turn. The evidence that this information originates from speech-production planning is incomplete. Because the analyzed EEG is recorded during processing of the partner's speech, and because that speech causally determines the subsequent response, production planning and comprehension/context are confounded in the current analyses. It would strengthen the production interpretation considerably if the authors could show that the relationship with forthcoming duration survives richer controls for the preceding turn, or ideally after accounting for EEG variance driven by the incoming speech.

   Reviewed by eLife

7. Small circuit principles for learning in large worlds

   This article has 4 authors:

   1. Dhruva V. Raman
   2. Christopher R. Dunne
   3. Katie Davyson
   4. Timothy O’Leary

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study introduces Hetlearn, a novel learning algorithm that demonstrates that an ensemble of simple sub-learners with varying learning rates can effectively manage inference in complex, unstable environments. While the theoretical framework and its proposed application to parallel memory traces in the insect mushroom body are intriguing, the evidence supporting the core claims is currently incomplete. To fully validate the authors' conclusions, further exploration is needed to rigorously define the boundaries of the model's hyperparameter space, along with a deeper justification and clarification of its biological plausibility.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.64898/2026.07.13.737774

9. We couldn't get details of this article at this time:
   10.64898/2026.06.16.732723

10. We couldn't get details of this article at this time:
    10.64898/2026.06.11.730447