1. Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

    This article has 18 authors:
    1. Carla Valenzuela Ripoll
    2. Zhen Guo
    3. Tripti Kumari
    4. Kana N. Miyata
    5. Mualla Ozcan
    6. Ahmed Diab
    7. Amanda Girardi
    8. Li He
    9. Attila Kovacs
    10. Carla Weinheimer
    11. Jess Nigro
    12. Jan Oscarsson
    13. Russell Esterline
    14. Joel Schilling
    15. Mikhail Kosiborod
    16. Christina Christoffersen
    17. Jaehyung Cho
    18. Ali Javaheri
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      SGLT2 inhibitors (SGLT2i) have assumed important roles in reducing cardiovascular risk, particularly in those with diabetes. It has become appreciated that its protective effects are likely beyond their ability to lower blood sugar levels. This research presents a novel approach to studying the SGLT2i mechanism of action which is yet to be fully elucidated.

    Reviewed by eLife

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