Physiology

Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

1. Rita De Gasperi
2. Laszlo Csernoch
3. Beatrix Dienes
4. Monika Gonczi
5. Jayanta K Chakrabarty
6. Shahar Goeta
7. Abdurrahman Aslan
8. Carlos A Toro
9. David Karasik
10. Lewis M Brown
11. Marco Brotto
12. Christopher P Cardozo

• Curated by eLife

  eLife assessment

  This convincing study demonstrates a potentially important role for the factor Numb in skeletal muscle excitation-contraction coupling, since a Numb knockout reduced contractile force. The authors thus demonstrate a novel role for Numb in calcium release in skeletal muscle.

Reviewed by eLife

Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

1. Jesus A Castor-Macias
2. Jacqueline A Larouche
3. Emily C Wallace
4. Bonnie D Spence
5. Alec Eames
6. Pamela Duran
7. Benjamin A Yang
8. Paula M Fraczek
9. Carol A Davis
10. Susan V Brooks
11. Krishna Rao Maddipati
12. James F Markworth
13. Carlos A Aguilar

• Curated by eLife

  eLife assessment

  This is a compelling study on pro-inflammatory and anti-inflammatory lipids in relation to skeletal muscle injury. It convincingly identifies pro-inflammatory lipids during recovery predisposing to fibrosis, and maresin 1 as an anti-inflammatory lipid reducing fibrosis, improved muscle regeneration, partially restoring contractile function, of fundamental potential clinical application.

Reviewed by eLife

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

1. Dylan C Sarver
2. Jean Garcia-Diaz
3. Muzna Saqib
4. Ryan C Riddle
5. G William Wong

• Curated by eLife

  eLife assessment

  This study discloses important physiological function for TMEM63 in regulating postnatal growth in mice. The data supporting the impaired body growth and skeletal phenotype as well as disrupted growth hormone/insulin-like growth factor-I (GH/IGF-I) signaling in TMEM63 knockout mice are compelling. However, to establish that alteration of hepatic GH/IGF-I signaling is the cause for observed growth and skeletal phenotype in TMEM63 knockout mice would need additional work.

Reviewed by eLife

Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila

1. Sophie A Fleck
2. Puja Biswas
3. Emily D DeWitt
4. Rebecca L Knuteson
5. Robert C Eisman
6. Travis Nemkov
7. Angelo D'Alessandro
8. Jason M Tennessen
9. Elizabeth Rideout
10. Lesley N Weaver

• Curated by eLife

  eLife assessment

  This valuable study shows that auxin exposure perturbs feeding behavior, survival rates, lipid metabolism, and gene expression patterns in adult Drosophila flies. The results are solid with proper methods and data analyses, and the evidence broadly supports the conclusions with only minor weaknesses. This work is relevant for fly geneticists who are interested in using the auxin-inducible gene expression system for inducing target protein degradation acutely.

Reviewed by eLife

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

1. Rabina Mainali
2. Nancy Buechler
3. Cristian Otero
4. Laken Edwards
5. Chia-Chi Key
6. Cristina Furdui
7. Matthew A Quinn

• Curated by eLife

  eLife assessment

  This work describes a connection between inflammation and metabolism, in which itaconate stabilizes the mitochondrial fatty acid uptake enzyme Cpt1a to enhance fatty acid oxidation. The mechanism for itaconate action may be generalizable to other protein targets. This is an important advance, which is supported by solid experimental data.

Reviewed by eLife

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

1. Gonzalo Hernandez-Hernandez
2. Samantha C O'Dwyer
3. Pei-Chi Yang
4. Collin Matsumoto
5. Mindy Tieu
6. Zhihui Fong
7. Timothy J Lewis
8. L Fernando Santana
9. Colleen E Clancy

• Curated by eLife

  eLife assessment

  The study is of importance for the cardiac modeling field by developing a novel mathematical model with sex difference. The data are compelling, and the model is helpful for mechanistic understanding, and thus is also important for experimental physiology. The model is based on experimental data and validated against some experimental data.

Reviewed by eLife

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

1. Xia Wang
2. Dawei chen
3. MengNan guo
4. Yao Ning
5. Jing Guo
6. Jiahui Gao
7. Xiaoran Xie
8. Dong Zhao
9. Lixiang Li
10. Shiyang Li
11. Yanqing Li
12. Xiuli Zuo
13. Jingxin Li

Reviewed by Review Commons

Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

1. Mingqi Zhou
2. Ian Tamburini
3. Cassandra Van
4. Jeffrey Molendijk
5. Christy M Nguyen
6. Ivan Yao-Yi Chang
7. Casey Johnson
8. Leandro M Velez
9. Youngseo Cheon
10. Reichelle Yeo
11. Hosung Bae
12. Johnny Le
13. Natalie Larson
14. Ron Pulido
15. Carlos HV Nascimento-Filho
16. Cholsoon Jang
17. Ivan Marazzi
18. Jamie Justice
19. Nicholas Pannunzio
20. Andrea L Hevener
21. Lauren Sparks
22. Erin E Kershaw
23. Dequina Nicholas
24. Benjamin L Parker
25. Selma Masri
26. Marcus M Seldin

• Curated by eLife

  eLife assessment

  This important paper provides web based interface for cross-tissue analysis of omics datasets from – so far – two different human populations, with compelling evidence that the tool can be used to make meaningful scientific discoveries. Conceptually, these analyses are relevant for any systems biologist or bioinformatician who is interested in integrating large population datasets. Currently, the resource is already of use for scientists studying the HMDP or using GTEx data, and we hope to see updates in the coming years that incorporate more populations and more datatypes, which could make it a general tool for a wide community.

Reviewed by eLife

CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice

1. Jenny Clarkson
2. Siew Hoong Yip
3. Robert Porteous
4. Alexia Kauff
5. Alison K Heather
6. Allan E Herbison

• Curated by eLife

  eLife assessment

  This important study provides convincing evidence of the criticality of estradiol – estrogen receptor-mediated upregulation of kisspeptin within neurons of the preoptic area to generate an ovulation-inducing luteinizing hormone surge. The use of in vivo CRIPSR-Cas9 is novel in this system and provides a road map for future studies in reproductive neuroendocrinology. This paper will be of interest to reproductive neuroscientists and endocrinologists.

Reviewed by eLife

Exercise training and cold exposure trigger distinct molecular adaptations to inguinal white adipose tissue

1. Maria Vamvini
2. Pasquale Nigro
3. Tiziana Caputo
4. Kristin I. Stanford
5. Michael F. Hirshman
6. Roeland J.W. Middelbeek
7. Laurie J. Goodyear

Reviewed by PREreview