Physiology

FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells

1. Karin Uliczka
2. Judith Bossen
3. Ulrich M. Zissler
4. Christine Fink
5. Xiao Niu
6. Mario Pieper
7. Ruben D. Prange
8. Christina Vock
9. Christina Wagner
10. Mirjam Knop
11. Ahmed Abdelsadik
12. Sören Franzenburg
13. Iris Bruchhaus
14. Michael Wegmann
15. Carsten B. Schmidt-Weber
16. Peter König
17. Petra Pfefferle
18. Holger Heine
19. Thomas Roeder

• Curated by eLife

  eLife assessment

  This important study investigates, from Drosophila to mammals, the role of the Forkhead box O (FoxO) transcription factors in airway epithelial cells' response to stressors including hypoxia, temperature variations, and oxidative stress. The findings suggest a conserved role of FoxO in maintaining airway homeostasis across species. However, limitations in the specificity and concerns with the loss-of-function experiments render the evidence presented incomplete. Nonetheless, this study highlights FoxO's potential relevance in respiratory diseases like asthma and offers insights into potential therapeutic targets for conditions affecting airway health.

Reviewed by eLife

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

1. Arya Y Nakhe
2. Prasanna K Dadi
3. Jinsun Kim
4. Matthew T Dickerson
5. Soma Behera
6. Jordyn R Dobson
7. Shristi Shrestha
8. Jean-Philippe Cartailler
9. Leesa Sampson
10. Mark A Magnuson
11. David A Jacobson

• Curated by eLife

  eLife assessment

  This study characterizes how a point mutation in the TALK-1 potassium channel, encoded by the KCNK16 gene, causes MODY diabetes. The mutation, L114P, causes a gain-of-function to increase K+ currents and inhibit glucose-stimulated insulin secretion. Increased glucagon likely results from paracrine effects in the islets. The data are convincing and the work will be valuable for understanding islet function.

Reviewed by eLife

High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen

1. Wan-ping Yang
2. Mei-qi Li
3. Jie Ding
4. Jia-yan Li
5. Gang Wu
6. Bao Liu
7. Yu-qi Gao
8. Guo-hua Wang
9. Qian-qian Luo

• Curated by eLife

  eLife assessment

  This useful study reports that a week or more of hypoxia exposure in mice increases erythropoiesis and decreases the number of iron-recycling macrophages in the spleen, compromising their capacity for red blood cell phagocytosis – reflected by increased mature erythrocyte retention in the spleen. Compared to an earlier version, the study has been strengthened with mouse experiments under hypobaric hypoxia and complemented by extensive ex vivo analyses. Unfortunately, while some of the evidence is solid, the work as it currently stands only incompletely supports the authors' hypotheses. While the study would benefit from additional experiments that more directly buttress the central claims, it should be of interest to the fields of hemopoiesis and bone marrow biology and possibly also blood cancer.

Reviewed by eLife

Metformin protects the heart against chronic intermittent hypoxia through AMPK ‐dependent phosphorylation of HIF ‐1α

1. Sophie Moulin
2. Britanny Blachot‐Minassian
3. Anita Kneppers
4. Amandine Thomas
5. Stéphanie Paradis
6. Laurent Bultot
7. Claire Arnaud
8. Jean‐Louis Pépin
9. Luc Bertrand
10. Rémi Mounier
11. Elise Belaidi

Reviewed by Review Commons

Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice

1. Jinjing Chen
2. Ruoyu Wang
3. Feng Xiong
4. Hao Sun
5. Byron Kemper
6. Wenbo Li
7. Jongsook Kemper

• Curated by eLife

  eLife assessment

  Using unbiased transcriptional profiling, the study reports a fundamental discovery of a novel hepatic lncRNA, FincoR, which regulates FXR. The convincing findings have therapeutic implications in the treatment of MASH. The authors use state-of-the-art methodology and use unbiased transcriptomic profiling and epigenetic profiling, including validation in mouse models and human samples.

Reviewed by eLife

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

1. Anika Shimonty
2. Fabrizio Pin
3. Matthew Prideaux
4. Gang Peng
5. Joshua Huot
6. Hyeonwoo Kim
7. Clifford J Rosen
8. Bruce M Spiegelman
9. Lynda F Bonewald

• Curated by eLife

  eLife assessment

  The study presents valuable findings on sexually dimorphic patterns of osteocytic transcriptomes and low calcium diet-induced osteocytic osteolysis in FNDC5-deficient mice. The authors present solid evidence for sex-specific changes in osteocyte morphology and gene expression under a calcium-demanding setting in this particular strain of mice, although the protective role of FNDC5-deficiency in lactation and low-calcium diet in female mice remains unclear due to lack of mechanistic studies. The study also lacks evidence that irisin, a proteolytically cleaved product of FNDC5, is responsible for the observed phenotypes, as irisin was not directly measured.

Reviewed by eLife

Changes in surface temperatures reveal the thermal challenge associated with catastrophic moult in captive Gentoo penguins

1. Agnès Lewden
2. Tristan Halna du Fretay
3. Antoine Stier

Reviewed by preLights

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

1. Martin Wohlwend
2. Pirkka-Pekka Laurila
3. Ludger JE Goeminne
4. Tanes Lima
5. Ioanna Daskalaki
6. Xiaoxu Li
7. Giacomo von Alvensleben
8. Barbara Crisol
9. Renata Mangione
10. Hector Gallart-Ayala
11. Amélia Lalou
12. Olivier Burri
13. Stephen Butler
14. Jonathan Morris
15. Nigel Turner
16. Julijana Ivanisevic
17. Johan Auwerx

• Curated by eLife

  eLife assessment

  This solid study presents valuable insights into the role of Cers1 on skeletal muscle function during aging, although further substantiation would help to fully establish the experimental assertions. It examines an unexplored aspect of muscle biology that is a relevant opening to future studies in this area of research.

Reviewed by eLife

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

1. Hong Chen
2. Lijun Sun
3. Lu Feng
4. Xue Han
5. Yunhua Zhang
6. Wenbo Zhai
7. Zehe Zhang
8. Michael Mulholland
9. Weizhen Zhang
10. Yue Yin

• Curated by eLife

  eLife assessment

  This study provides valuable findings showing the production of IL-22 from intestinal ILC3 during intermittent fasting promotes beigeing of white adipose tissue. The authors provided solid data and mechanistic insight by which IL-22-derived from ILC3 directly induces beigeing.

Reviewed by eLife

On-farm hatching and contact with adult hen post hatch induce sex-dependent effects on performance, health and robustness in broiler chickens

1. Laurence A Guilloteau
2. Aline Bertin
3. Sabine Crochet
4. Charlotte Bagnard
5. Alice Hondelatte
6. Laure Ravon
7. Catherine Schouler
8. Karine Germain
9. Anne Collin

Reviewed by Peer Community in Animal Science