Physiology

Involvement of TRPV4 in temperature-dependent perspiration in mice

1. Makiko Kashio
2. Sandra Derouiche
3. Reiko U Yoshimoto
4. Kenji Sano
5. Jing Lei
6. Mizuho A Kido
7. Makoto Tominaga

• Curated by eLife

  eLife assessment

  This useful studying implicates TRPV4 as a mediator of sweat, potentially based on TRPV4's expression and function on sweat glands. The data and methods are solid, with some limitations in terms of the approach. Overall, the work lends new insight into the physiologic basis of sweating using data from mice and humans.

Reviewed by eLife

A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

1. Brennan J Wadsworth
2. Marina Leiwe
3. Eleanor A Minogue
4. Pedro P Cunha
5. Viktor Engman
6. Carolin Brombach
7. Christos Asvestis
8. Shiv K Sah-Teli
9. Emilia Marklund
10. Peppi Koivunen
11. Jorge L Ruas
12. Helene Rundqvist
13. Johanna T Lanner
14. Randall S Johnson

• Curated by eLife

  eLife assessment

  The work by Johnson and co-workers has identified an important role of 2-Hydroxybutyrate in skeletal muscle oxidative capacity in the early stages of exercise. Mechanistically, they show convincing data to support a role of 2-Hydroxybutyrate in the regulation of BCAA metabolism via SIRT4, ADP-Ribosylation, and CEBP. However, whether this is the sole mechanism and if these translate to longer exercise training regimes requires future experiments.

Reviewed by eLife

Sweet and fatty symbionts: photosynthetic productivity and carbon storage boosted in microalgae within a host

1. A. Catacora-Grundy
2. F. Chevalier
3. D. Yee
4. C. LeKieffre
5. N. L. Schieber
6. Y. Schwab
7. B. Gallet
8. P.H. Jouneau
9. G. Curien
10. J. Decelle

Reviewed by Arcadia Science

The seminal vesicle is a juvenile hormone-responsive tissue in adult male Drosophila melanogaster

1. Yoshitomo Kurogi
2. Yosuke Mizuno
3. Naoki Okamoto
4. Lacy Barton
5. Ryusuke Niwa

Reviewed by Review Commons

Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

1. Jayati Gera
2. Marishia Agard
3. Hannah Nave
4. Farwa Sajadi
5. Leena Thorat
6. Shu Kondo
7. Dick R. Nässel
8. Jean-Paul V. Paluzzi
9. Meet Zandawala

• Curated by eLife

  eLife assessment

  This important study provides a comprehensive analysis of ITP and its role as an anti-diuretic and metabolic hormone in Drosophila. The evidence supporting the conclusion is solid in general with combined genetic, comparative genomic approaches, classical physiological techniques, and biochemical assays. However, the evidence of direct binding between ITPa and Gyc76C and their physiological functions is incomplete. This work represents a contribution to the field of neuropeptides and neurohormones in insects and other animals.

Reviewed by eLife

Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

1. Christopher TA Lewis
2. Elise G Melhedegaard
3. Marija M Ognjanovic
4. Mathilde S Olsen
5. Jenni Laitila
6. Robert AE Seaborne
7. Magnus Gronset
8. Changxin Zhang
9. Hiroyuki Iwamoto
10. Anthony L Hessel
11. Michel N Kuehn
12. Carla Merino
13. Nuria Amigo
14. Ole Frobert
15. Sylvain Giroud
16. James F Staples
17. Anna V Goropashnaya
18. Vadim B Fedorov
19. Brian Barnes
20. Oivind Toien
21. Kelly Drew
22. Ryan J Sprenger
23. Julien Ochala

• Curated by eLife

  eLife assessment

  The work by Lewis and co-workers presents important findings on the role of myosin structure/energetics on the molecular mechanisms of hibernation by comparing muscle samples from small and large hibernating mammals. The solid methodological approaches have revealed insights into the mechanisms of non-shivering thermogenesis and energy expenditure.

Reviewed by eLife

FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells

1. Karin Uliczka
2. Judith Bossen
3. Ulrich M. Zissler
4. Christine Fink
5. Xiao Niu
6. Mario Pieper
7. Ruben D. Prange
8. Christina Vock
9. Christina Wagner
10. Mirjam Knop
11. Ahmed Abdelsadik
12. Sören Franzenburg
13. Iris Bruchhaus
14. Michael Wegmann
15. Carsten B. Schmidt-Weber
16. Peter König
17. Petra Pfefferle
18. Holger Heine
19. Thomas Roeder

• Curated by eLife

  eLife assessment

  This important study investigates, from Drosophila to mammals, the role of the Forkhead box O (FoxO) transcription factors in airway epithelial cells' response to stressors including hypoxia, temperature variations, and oxidative stress. The findings suggest a conserved role of FoxO in maintaining airway homeostasis across species. However, limitations in the specificity and concerns with the loss-of-function experiments render the evidence presented incomplete. Nonetheless, this study highlights FoxO's potential relevance in respiratory diseases like asthma and offers insights into potential therapeutic targets for conditions affecting airway health.

Reviewed by eLife

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

1. Arya Y Nakhe
2. Prasanna K Dadi
3. Jinsun Kim
4. Matthew T Dickerson
5. Soma Behera
6. Jordyn R Dobson
7. Shristi Shrestha
8. Jean-Philippe Cartailler
9. Leesa Sampson
10. Mark A Magnuson
11. David A Jacobson

• Curated by eLife

  eLife assessment

  This study characterizes how a point mutation in the TALK-1 potassium channel, encoded by the KCNK16 gene, causes MODY diabetes. The mutation, L114P, causes a gain-of-function to increase K+ currents and inhibit glucose-stimulated insulin secretion. Increased glucagon likely results from paracrine effects in the islets. The data are convincing and the work will be valuable for understanding islet function.

Reviewed by eLife

High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen

1. Wan-ping Yang
2. Mei-qi Li
3. Jie Ding
4. Jia-yan Li
5. Gang Wu
6. Bao Liu
7. Yu-qi Gao
8. Guo-hua Wang
9. Qian-qian Luo

• Curated by eLife

  eLife assessment

  This useful study reports that a week or more of hypoxia exposure in mice increases erythropoiesis and decreases the number of iron-recycling macrophages in the spleen, compromising their capacity for red blood cell phagocytosis – reflected by increased mature erythrocyte retention in the spleen. Compared to an earlier version, the study has been strengthened with mouse experiments under hypobaric hypoxia and complemented by extensive ex vivo analyses. Unfortunately, while some of the evidence is solid, the work as it currently stands only incompletely supports the authors' hypotheses. While the study would benefit from additional experiments that more directly buttress the central claims, it should be of interest to the fields of hemopoiesis and bone marrow biology and possibly also blood cancer.

Reviewed by eLife

Metformin protects the heart against chronic intermittent hypoxia through AMPK ‐dependent phosphorylation of HIF ‐1α

1. Sophie Moulin
2. Britanny Blachot‐Minassian
3. Anita Kneppers
4. Amandine Thomas
5. Stéphanie Paradis
6. Laurent Bultot
7. Claire Arnaud
8. Jean‐Louis Pépin
9. Luc Bertrand
10. Rémi Mounier
11. Elise Belaidi

Reviewed by Review Commons