Physiology

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways

1. Priyanka Das
2. Ravi
3. Jogender Singh

Reviewed by Review Commons

Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs

1. Qiufang Li
2. Xu Ping
3. Zhengwen Yu
4. Qin Yi
5. Chao Tang
6. Xiaoya Wang
7. Lan Zheng

• Curated by eLife

  eLife Assessment

  This study offers valuable insights into the role of miR-283 in ventral-lateral neurons (LNvs) and its impact on senescence, cardiac function, and aging in the Drosophila melanogaster model. However, the evidence supporting some of the conclusions remains incomplete, and further mechanistic studies are needed to clarify how miR-283 affects normal aging and influences exercise adaptations. Nonetheless, the work can be of interest to cell biologists studying miRNA biology, aging, and age-related diseases.

Reviewed by eLife

Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction

1. Yoshiko M Ikushima
2. Kuan-Chan Chen
3. Richard J. Sulston
4. Domenico Mattiucci
5. Eleanor J. Brain
6. Stefanie A Fung Xin Zi
7. Karla J. Suchacki
8. Benjamin J. Thomas
9. Andrea Lovdel
10. Matthew Bennett
11. Hiroshi Kobayashi
12. Phillip D. Whitfield
13. Keiyo Takubo
14. Andrew H. Baker
15. Nicholas M. Morton
16. Robert K. Semple
17. William P. Cawthorn

Reviewed by PREreview

Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice

1. Puqiao Lian
2. Artemiy Kovynev
3. Lei Wang
4. Amanda CM Pronk
5. Aswin Verhoeven
6. Martin Giera
7. Suzan Thijssen
8. Borja Martínez Téllez
9. Sander Kooijman
10. Patrick CN Rensen
11. Harro Timmerman
12. Harry J Wichers
13. Paul AJ Henricks
14. Gert Folkerts
15. Milena Schönke
16. Saskia Braber

• Curated by eLife

  eLife Assessment

  This valuable study examines how different exercise training intensities affect intestinal barrier function and gut microbiota composition over a 6-week period in mice. The evidence supporting the main claims about exercise-induced intestinal injury and microbiota changes is solid, featuring comprehensive histological analysis, molecular characterization, and metabolomic profiling, though key mechanistic insights and causal relationships remain to be established. The findings have practical implications for understanding exercise-induced gastrointestinal stress, particularly the observation that daily moderate exercise may be more damaging to intestinal integrity than vigorous exercise with rest days. Additional experimental validation would strengthen these conclusions.

Reviewed by eLife