Physiology

An acute microglial metabolic response controls metabolism and improves memory

1. Anne Drougard
2. Eric H Ma
3. Vanessa Wegert
4. Ryan Sheldon
5. Ilaria Panzeri
6. Naman Vatsa
7. Stefanos Apostle
8. Luca Fagnocchi
9. Judith Schaf
10. Klaus Gossens
11. Josephine Völker
12. Shengru Pang
13. Anna Bremser
14. Erez Dror
15. Francesca Giacona
16. Sagar Sagar
17. Michael X Henderson
18. Marco Prinz
19. Russell G Jones
20. John Andrew Pospisilik

• Curated by eLife

  eLife assessment

  This important study demonstrates a link between an acute high fat diet, microglial metabolism and improved higher cognitive function. The evidence supporting the proposed mechanism in vivo is incomplete at this stage due to non-trivial technical limitations but the authors provide convincing in vitro metabolic characterization of primary microglia cultures to support the model. This work will be of interest to a broad audience in the field of neuroscience, metabolism, and immunology.

Reviewed by eLife

Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases

1. Duk-Su Koh
2. Anastasiia Stratiievska
3. Subhashis Jana
4. Shauna C Otto
5. Teresa M Swanson
6. Anthony Nhim
7. Sara Carlson
8. Marium Raza
9. Ligia Araujo Naves
10. Eric N Senning
11. Ryan A Mehl
12. Sharona E Gordon

• Curated by eLife

  eLife assessment

  This study develops a new and important method for dissecting out two overlapping cell signaling pathways, phosphoinositide signaling and membrane protein trafficking. The combination of two state-of-the-art spectroscopic techniques provides compelling evidence for a reciprocal influence between an enzyme and a channel. The work will be of interest to the broader cell biology, biophysics and biochemistry communities.

Reviewed by eLife

Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers

1. Javier I Ottaviani
2. Virag Sagi-Kiss
3. Hagen Schroeter
4. Gunter GC Kuhnle

• Curated by eLife

  eLife assessment

  This important study, using three bioactive compounds as a model, demonstrates that estimating the intake of food components based on food composition databases and self-reported dietary data is highly unreliable. The authors present convincing data showing the differences in the estimated quantile of intake of three bioactive compounds between biomarker and 24-hour dietary recall with food-composition database. The work will be of broad interest to the clinical nutrition research community.

Reviewed by eLife

ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri

1. Vanessa R Ho
2. Greg G Goss
3. Sally P Leys

Reviewed by Arcadia Science

Involvement of TRPV4 in temperature-dependent perspiration in mice

1. Makiko Kashio
2. Sandra Derouiche
3. Reiko U Yoshimoto
4. Kenji Sano
5. Jing Lei
6. Mizuho A Kido
7. Makoto Tominaga

• Curated by eLife

  eLife assessment

  This useful studying implicates TRPV4 as a mediator of sweat, potentially based on TRPV4's expression and function on sweat glands. The data and methods are solid, with some limitations in terms of the approach. Overall, the work lends new insight into the physiologic basis of sweating using data from mice and humans.

Reviewed by eLife

A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

1. Brennan J Wadsworth
2. Marina Leiwe
3. Eleanor A Minogue
4. Pedro P Cunha
5. Viktor Engman
6. Carolin Brombach
7. Christos Asvestis
8. Shiv K Sah-Teli
9. Emilia Marklund
10. Peppi Koivunen
11. Jorge L Ruas
12. Helene Rundqvist
13. Johanna T Lanner
14. Randall S Johnson

• Curated by eLife

  eLife assessment

  The work by Johnson and co-workers has identified an important role of 2-Hydroxybutyrate in skeletal muscle oxidative capacity in the early stages of exercise. Mechanistically, they show convincing data to support a role of 2-Hydroxybutyrate in the regulation of BCAA metabolism via SIRT4, ADP-Ribosylation, and CEBP. However, whether this is the sole mechanism and if these translate to longer exercise training regimes requires future experiments.

Reviewed by eLife

Sweet and fatty symbionts: photosynthetic productivity and carbon storage boosted in microalgae within a host

1. A. Catacora-Grundy
2. F. Chevalier
3. D. Yee
4. C. LeKieffre
5. N. L. Schieber
6. Y. Schwab
7. B. Gallet
8. P.H. Jouneau
9. G. Curien
10. J. Decelle

Reviewed by Arcadia Science

The seminal vesicle is a juvenile hormone-responsive tissue in adult male Drosophila melanogaster

1. Yoshitomo Kurogi
2. Yosuke Mizuno
3. Naoki Okamoto
4. Lacy Barton
5. Ryusuke Niwa

Reviewed by Review Commons

Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

1. Jayati Gera
2. Marishia Agard
3. Hannah Nave
4. Farwa Sajadi
5. Leena Thorat
6. Shu Kondo
7. Dick R. Nässel
8. Jean-Paul V. Paluzzi
9. Meet Zandawala

• Curated by eLife

  eLife assessment

  This important study provides a comprehensive analysis of ITP and its role as an anti-diuretic and metabolic hormone in Drosophila. The evidence supporting the conclusion is solid in general with combined genetic, comparative genomic approaches, classical physiological techniques, and biochemical assays. However, the evidence of direct binding between ITPa and Gyc76C and their physiological functions is incomplete. This work represents a contribution to the field of neuropeptides and neurohormones in insects and other animals.

Reviewed by eLife

Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

1. Christopher TA Lewis
2. Elise G Melhedegaard
3. Marija M Ognjanovic
4. Mathilde S Olsen
5. Jenni Laitila
6. Robert AE Seaborne
7. Magnus Gronset
8. Changxin Zhang
9. Hiroyuki Iwamoto
10. Anthony L Hessel
11. Michel N Kuehn
12. Carla Merino
13. Nuria Amigo
14. Ole Frobert
15. Sylvain Giroud
16. James F Staples
17. Anna V Goropashnaya
18. Vadim B Fedorov
19. Brian Barnes
20. Oivind Toien
21. Kelly Drew
22. Ryan J Sprenger
23. Julien Ochala

• Curated by eLife

  eLife assessment

  The work by Lewis and co-workers presents important findings on the role of myosin structure/energetics on the molecular mechanisms of hibernation by comparing muscle samples from small and large hibernating mammals. The solid methodological approaches have revealed insights into the mechanisms of non-shivering thermogenesis and energy expenditure.

Reviewed by eLife