Physiology

Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

1. Anika Shimonty
2. Fabrizio Pin
3. Matthew Prideaux
4. Gang Peng
5. Joshua Huot
6. Hyeonwoo Kim
7. Clifford J Rosen
8. Bruce M Spiegelman
9. Lynda F Bonewald

• Curated by eLife

  eLife assessment

  The study presents valuable findings on sexually dimorphic patterns of osteocytic transcriptomes and low calcium diet-induced osteocytic osteolysis in FNDC5-deficient mice. The authors present solid evidence for sex-specific changes in osteocyte morphology and gene expression under a calcium-demanding setting in this particular strain of mice, although the protective role of FNDC5-deficiency in lactation and low-calcium diet in female mice remains unclear due to lack of mechanistic studies. The study also lacks evidence that irisin, a proteolytically cleaved product of FNDC5, is responsible for the observed phenotypes, as irisin was not directly measured.

Reviewed by eLife

Changes in surface temperatures reveal the thermal challenge associated with catastrophic moult in captive Gentoo penguins

1. Agnès Lewden
2. Tristan Halna du Fretay
3. Antoine Stier

Reviewed by preLights

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification

1. Imran S. Khan
2. Christopher Molina
3. Xin Ren
4. Vincent C. Auyeung
5. Max Cohen
6. Tatsuya Tsukui
7. Amha Atakilit
8. Dean Sheppard

• Curated by eLife

  eLife assessment

  This study unveils important mechanistic insights into postnatal lung development and bronchopulmonary dysplasia (BPD) pathology. Using two BPD models enhances our comprehension of the disease, utilizing compelling evidence from single-cell sequencing and flow cytometry, revealing a myofibroblast loss. Pharmacological and genetic approaches convincingly argue against the presumed increase in TGFb signaling causing alveolar simplification; instead, it appears to be a compensatory response. The identified weakness is the absence of validation in tissue, leaving the question unanswered regarding whether myofibroblast loss is due to a lack of myofibroblast proliferation or myofibroblast differentiation/specification.

Reviewed by eLife

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

1. Martin Wohlwend
2. Pirkka-Pekka Laurila
3. Ludger JE Goeminne
4. Tanes Lima
5. Ioanna Daskalaki
6. Xiaoxu Li
7. Giacomo von Alvensleben
8. Barbara Crisol
9. Renata Mangione
10. Hector Gallart-Ayala
11. Amélia Lalou
12. Olivier Burri
13. Stephen Butler
14. Jonathan Morris
15. Nigel Turner
16. Julijana Ivanisevic
17. Johan Auwerx

• Curated by eLife

  eLife assessment

  This solid study presents valuable insights into the role of Cers1 on skeletal muscle function during aging, although further substantiation would help to fully establish the experimental assertions. It examines an unexplored aspect of muscle biology that is a relevant opening to future studies in this area of research.

Reviewed by eLife

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

1. Hong Chen
2. Lijun Sun
3. Lu Feng
4. Xue Han
5. Yunhua Zhang
6. Wenbo Zhai
7. Zehe Zhang
8. Michael Mulholland
9. Weizhen Zhang
10. Yue Yin

• Curated by eLife

  eLife assessment

  This study provides valuable findings showing the production of IL-22 from intestinal ILC3 during intermittent fasting promotes beigeing of white adipose tissue. The authors provided solid data and mechanistic insight by which IL-22-derived from ILC3 directly induces beigeing.

Reviewed by eLife

On-farm hatching and contact with adult hen post hatch induce sex-dependent effects on performance, health and robustness in broiler chickens

1. Laurence A Guilloteau
2. Aline Bertin
3. Sabine Crochet
4. Charlotte Bagnard
5. Alice Hondelatte
6. Laure Ravon
7. Catherine Schouler
8. Karine Germain
9. Anne Collin

Reviewed by Peer Community in Animal Science

Loss of CTRP10 results in female obesity with preserved metabolic health

1. Fangluo Chen
2. Dylan C. Sarver
3. Muzna Saqib
4. Leandro M Velez
5. Susan Aja
6. Marcus M. Seldin
7. G. William Wong

• Curated by eLife

  eLife assessment

  This manuscript presents a detailed characterization of male and female wild-type and CTRP10 knockout mice, revealing that knockout mice develop female-specific obesity that is largely uncoupled from metabolic dysfunction. The data are convincing, and the work is a valuable contribution to understanding how obesity is coupled to metabolic dysfunction, and how this can occur in a sex-specific manner.

Reviewed by eLife

Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

1. Rita De Gasperi
2. Laszlo Csernoch
3. Beatrix Dienes
4. Monika Gonczi
5. Jayanta K Chakrabarty
6. Shahar Goeta
7. Abdurrahman Aslan
8. Carlos A Toro
9. David Karasik
10. Lewis M Brown
11. Marco Brotto
12. Christopher P Cardozo

• Curated by eLife

  eLife assessment

  This convincing study demonstrates a potentially important role for the factor Numb in skeletal muscle excitation-contraction coupling, since a Numb knockout reduced contractile force. The authors thus demonstrate a novel role for Numb in calcium release in skeletal muscle.

Reviewed by eLife

Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

1. Jesus A Castor-Macias
2. Jacqueline A Larouche
3. Emily C Wallace
4. Bonnie D Spence
5. Alec Eames
6. Pamela Duran
7. Benjamin A Yang
8. Paula M Fraczek
9. Carol A Davis
10. Susan V Brooks
11. Krishna Rao Maddipati
12. James F Markworth
13. Carlos A Aguilar

• Curated by eLife

  eLife assessment

  This is a compelling study on pro-inflammatory and anti-inflammatory lipids in relation to skeletal muscle injury. It convincingly identifies pro-inflammatory lipids during recovery predisposing to fibrosis, and maresin 1 as an anti-inflammatory lipid reducing fibrosis, improved muscle regeneration, partially restoring contractile function, of fundamental potential clinical application.

Reviewed by eLife

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

1. Dylan C Sarver
2. Jean Garcia-Diaz
3. Muzna Saqib
4. Ryan C Riddle
5. G William Wong

• Curated by eLife

  eLife assessment

  This study discloses important physiological function for TMEM63 in regulating postnatal growth in mice. The data supporting the impaired body growth and skeletal phenotype as well as disrupted growth hormone/insulin-like growth factor-I (GH/IGF-I) signaling in TMEM63 knockout mice are compelling. However, to establish that alteration of hepatic GH/IGF-I signaling is the cause for observed growth and skeletal phenotype in TMEM63 knockout mice would need additional work.

Reviewed by eLife