1. O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors

    This article has 11 authors:
    1. Zengdi Zhang
    2. Zan Huang
    3. Mohamed Awad
    4. Mohammed Elsalanty
    5. James Cray
    6. Lauren E Ball
    7. Jason C Maynard
    8. Alma L Burlingame
    9. Hu Zeng
    10. Kim C Mansky
    11. Hai-Bin Ruan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment:

      Bone marrow stromal cells (BMSCs) can differentiate into a variety of cell types such as osteoblasts, chondrocytes, and adipocytes. The authors of this important study provide compelling and strong evidence that ablating O-GlcNAc transferase (OGT) in BMSCs impairs bone formation but promotes marrow adiposity. The results show that the balance of osteogenic and adipogenic differentiation of BMSCs is controlled by reciprocal O-GlcNAc regulation of lineage-specifying transcription factors, and highlights the importance of an intracellular glycosylation process of specific proteins in bone formation and bone marrow adipocytes.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Distinct functions of cardiac β-adrenergic receptors in the T-tubule vs. outer surface membrane

    This article has 11 authors:
    1. Marion Barthé
    2. Flora Lefebvre
    3. Emilie Langlois
    4. Florence Lefebvre
    5. Patrick Lechêne
    6. Xavier Iturrioz
    7. Catherine Llorens-Cortes
    8. Tâp Ha-Duong
    9. Laurence Moine
    10. Nicolas Tsapis
    11. Rodolphe Fischmeister
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study describes an interesting approach using PEGylated isoprenaline to selectively activate beta-adrenergic receptors in the surface sarcolemma of ventricular myocytes. While the concept is compelling, and the core of an interesting and impactful study is presented, the results are preliminary and incomplete at this stage, and would benefit from more rigorous validation of the approach. The work will be of interest to cardiac cell biologists and pharmacologists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

    This article has 3 authors:
    1. Priscilla S-W Yeung
    2. Megumi Yamashita
    3. Murali Prakriya
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript reports novel and important findings on the mechanisms of regulation of CRAC channels. Collectively, the work represents an important conceptual advancement, showing that stromal interaction molecule-1 is not necessary for Ca2+-dependent inactivation of the Orai1 channel and that Orai1 likely contains a Ca2+ sensor for autoregulatio. The experiments are carefully conducted, and the data is of high quality and support the major conclusions of the authors.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

    This article has 23 authors:
    1. Alexandra Polyák
    2. Leila Topal
    3. Noémi Zombori-Tóth
    4. Noémi Tóth
    5. János Prorok
    6. Zsófia Kohajda
    7. Szilvia Déri
    8. Vivien Demeter-Haludka
    9. Péter Hegyi
    10. Viktória Venglovecz
    11. Gergely Ágoston
    12. Zoltán Husti
    13. Péter Gazdag
    14. Jozefina Szlovák
    15. Tamás Árpádffy-Lovas
    16. Muhammad Naveed
    17. Annamária Sarusi
    18. Norbert Jost
    19. László Virág
    20. Norbert Nagy
    21. István Baczkó
    22. Attila S Farkas
    23. András Varró
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable comprehensive data that underpin the enhanced ventricular arrhythmogenesis in elite trained athletes. The study is logistical challenge and the multiscale approaches used is a strength of the study. The data presented are strong and support most of the authors' claims.

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    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  5. Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis

    This article has 21 authors:
    1. Maria-Bernadette Madel
    2. Julia Halper
    3. Lidia Ibáñez
    4. Lozano Claire
    5. Matthieu Rouleau
    6. Antoine Boutin
    7. Adrien Mahler
    8. Rodolphe Pontier-Bres
    9. Thomas Ciucci
    10. Majlinda Topi
    11. Christophe Hue
    12. Jerome Amiaud
    13. Salvador Iborra
    14. David Sancho
    15. Dominique Heymann
    16. Henri-Jean Garchon
    17. Dorota Czerucka
    18. Florence Apparailly
    19. Isabelle Duroux-Richard
    20. Abdelilah Wakkach
    21. Claudine Blin-Wakkach
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this work, the authors provide convincing evidence about the existence of two distinct osteoclast populations with specific expression profiles and properties and show that the probiotic yeast S. boulardii may be useful in managing inflammation-mediated bone loss, including estrogen deprivation-mediated osteoporosis. The reported study aims to bring the concept of heterogeneous osteoclasts into a proof-of-principle therapeutic application, which may mean that the use of probiotics might combat osteoporosis towards a better bone quality than current therapies. The molecular mechanism of how the probiotic yeast S. boulardii treatment acts via the receptors remains obscure since it might act via changes in the gut permeability or by components directly released by the fungus.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta

    This article has 14 authors:
    1. Sima Stroganov
    2. Talia Harris
    3. Liat Fellus-Alyagor
    4. Lital Ben Moyal
    5. Romina Plitman Mayo
    6. Ofra Golani
    7. Dana Hirsch
    8. Shifra Ben-Dor
    9. Alexander Brandis
    10. Tevie Mehlman
    11. Michal Kovo
    12. Tal Biron-Shental
    13. Nava Dekel
    14. Michal Neeman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding of the role of under investigated pathway associated with development of placental oxygenation during pregnancy. The evidence supporting the claims of the authors is incomplete, although inclusion of a larger number of patient samples and an animal model have strengthened the study. The work will be of interest to developmental biologists working on placental function.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Impaired iron recycling from erythrocytes is an early hallmark of aging

    This article has 17 authors:
    1. Patryk Slusarczyk
    2. Pratik Kumar Mandal
    3. Gabriela Zurawska
    4. Marta Niklewicz
    5. Komal Chouhan
    6. Raghunandan Mahadeva
    7. Aneta Jończy
    8. Matylda Macias
    9. Aleksandra Szybinska
    10. Magdalena Cybulska-Lubak
    11. Olga Krawczyk
    12. Sylwia Herman
    13. Michal Mikula
    14. Remigiusz Serwa
    15. Małgorzata Lenartowicz
    16. Wojciech Pokrzywa
    17. Katarzyna Mleczko-Sanecka
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Slusarczyk et al demonstrate that red pulp macrophages (RPM), specialized splenic cells that clear senescent red blood cells through erythrophagocytosis, show diminished function in aging mice. This impairment leads to retention of hemolytic red blood cells and formation of extracellular aggregates which further exacerbate RPM demise. Iron restriction alleviates most of these symptoms in aging RPMs. They propose RPM collapse as an early indicator of aging that could be reversed through iron limitation.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  8. Vitamin B2 enables regulation of fasting glucose availability

    This article has 21 authors:
    1. Peter M Masschelin
    2. Pradip Saha
    3. Scott A Ochsner
    4. Aaron R Cox
    5. Kang Ho Kim
    6. Jessica B Felix
    7. Robert Sharp
    8. Xin Li
    9. Lin Tan
    10. Jun Hyoung Park
    11. Liping Wang
    12. Vasanta Putluri
    13. Philip L Lorenzi
    14. Alli M Nuotio-Antar
    15. Zheng Sun
    16. Benny Abraham Kaipparettu
    17. Nagireddy Putluri
    18. David D Moore
    19. Scott A Summers
    20. Neil J McKenna
    21. Sean M Hartig
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Masschelin et al. investigate the role of Vitamin B2 (riboflavin), an essential cofactor for FAD and FMN coenzymes involved in the electron transport chain and TCA cycle, in fasting glucose metabolism. This study phenotypes B2-deficient mice liver and provides valuable data on genes and metabolites that are changed with B2 depletion +/- Fenofibrate administration. The work employs solid methodology and will be of interest to liver physiologists interested in fasting in the context of PPAR.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning

    This article has 11 authors:
    1. Andrew McKay
    2. Emma K Costa
    3. Jingxun Chen
    4. Chi-Kuo Hu
    5. Xiaoshan Chen
    6. Claire N Bedbrook
    7. Rishad C Khondker
    8. Mike Thielvoldt
    9. Param Priya Singh
    10. Tony Wyss-Coray
    11. Anne Brunet
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      McKay, et al. describe development of a new wireless, network-enabled automated feeder system with which diet amount and schedule can be controlled across individually housed killifish. The system is constructed using open-source components and software and is amenable to manufacture by individual research groups and is highly scalable. The authors then use this system to explore dietary restriction effects on killifish lifespan and to develop an associative learning assay, two important goals in the KF /longevity field. The authors demonstrate that precise control of food allows automated investigation of lifespan extension under calorie restriction conditions. Secondly, they show an exciting modification of the system that involves only addition of a simple LED light. This modification allows use of the system in an associative learning / conditioning paradigm. Finally, using this paradigm, they demonstrate an age-dependent decline in learning.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice

    This article has 16 authors:
    1. Shogo Tsuji
    2. Cynthia S Brace
    3. Ruiqing Yao
    4. Yoshitaka Tanie
    5. Hirobumi Tada
    6. Nicholas Rensing
    7. Seiya Mizuno
    8. Julio Almunia
    9. Yingyi Kong
    10. Kazuhiro Nakamura
    11. Noboru Ogiso
    12. Shinya Toyokuni
    13. Satoru Takahashi
    14. Michael Wong
    15. Shin-ichiro Imai
    16. Akiko Satoh

    Reviewed by Review Commons, PREreview

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
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