1. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

    This article has 11 authors:
    1. Chunlong Ma
    2. Michael Dominic Sacco
    3. Brett Hurst
    4. Julia Alma Townsend
    5. Yanmei Hu
    6. Tommy Szeto
    7. Xiujun Zhang
    8. Bart Tarbet
    9. Michael Thomas Marty
    10. Yu Chen
    11. Jun Wang

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro

    This article has 10 authors:
    1. Hongbo Liu
    2. Fei Ye
    3. Qi Sun
    4. Hao Liang
    5. Chunmei Li
    6. Siyang Li
    7. Roujian Lu
    8. Baoying Huang
    9. Wenjie Tan
    10. Luhua Lai

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Immunoglobulin fragment F(ab’)2 against RBD potently neutralizes SARS-CoV-2 in vitro

    This article has 15 authors:
    1. Xiaoyan Pan
    2. Pengfei Zhou
    3. Tiejiong Fan
    4. Yan Wu
    5. Jing Zhang
    6. Xiaoyue Shi
    7. Weijuan Shang
    8. Lijuan Fang
    9. Xiaming Jiang
    10. Jian Shi
    11. Yuan Sun
    12. Shaojuan Zhao
    13. Rui Gong
    14. Ze Chen
    15. Gengfu Xiao

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice

    This article has 6 authors:
    1. N.V Rajeshkumar
    2. Shinichi Yabuuchi
    3. Shweta G. Pai
    4. Anirban Maitra
    5. Manuel Hidalgo
    6. Chi V. Dang

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Nucleotide analogues as inhibitors of SARS‐CoV Polymerase

    This article has 10 authors:
    1. Jingyue Ju
    2. Xiaoxu Li
    3. Shiv Kumar
    4. Steffen Jockusch
    5. Minchen Chien
    6. Chuanjuan Tao
    7. Irina Morozova
    8. Sergey Kalachikov
    9. Robert N. Kirchdoerfer
    10. James J. Russo

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. AI-Aided Design of Novel Targeted Covalent Inhibitors against SARS-CoV-2

    This article has 9 authors:
    1. Bowen Tang
    2. Fengming He
    3. Dongpeng Liu
    4. Fei He
    5. Tong Wu
    6. Meijuan Fang
    7. Zhangming Niu
    8. Zhen Wu
    9. Dong Xu

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Local generation and efficient evaluation of numerous drug combinations in a single sample

    This article has 2 authors:
    1. Vlad Elgart
    2. Joseph Loscalzo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this manuscript, a method to test a large number of drug combinations in a single cell culture sample is presented. The strength of the evidence lies in their multiple experiments with different combinations of agents. The paper suggests that results from this application are feasible and the methodology could be applied in other laboratories to use drug combinations for defined outcomes.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  8. The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

    This article has 6 authors:
    1. Amy Louise Ball
    2. Carol E Jolly
    3. Mark G Lennon
    4. Jonathan J Lyon
    5. Ana Alfirevic
    6. Amy E Chadwick
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper is of potential interest to scientists within the field of drug-induced liver injury. The concept of the study is interesting by generating mitochondrial genotype-specific liver cell lines to evaluate idiosyncratic hepatotoxicity. While the proof-of-concept is clearly presented, the current data do not yet allow to draw broad conclusions about the significance of the study in terms of drug effects.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

    This article has 24 authors:
    1. Ziva Vuckovic
    2. Jinan Wang
    3. Vi Pham
    4. Jesse I Mobbs
    5. Matthew J Belousoff
    6. Apurba Bhattarai
    7. Wessel AC Burger
    8. Geoff Thompson
    9. Mahmuda Yeasmin
    10. Vindhya Nawaratne
    11. Katie Leach
    12. Emma T van der Westhuizen
    13. Elham Khajehali
    14. Yi-Lynn Liang
    15. Alisa Glukhova
    16. Denise Wootten
    17. Craig W Lindsley
    18. Andrew Tobin
    19. Patrick Sexton
    20. Radostin Danev
    21. Celine Valant
    22. Yinglong Miao
    23. Arthur Christopoulos
    24. David M Thal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study is important and carefully executed, providing important insights into the allosteric regulation of GPCRs with exceptional strength of evidence. This work will be of interest to a wide audience in drug discovery and receptor biology. The major strengths are the comprehensive structural and pharmacological characterization with only minor weaknesses, most notably a concern regarding the approach used to quantify efficacy.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance

    This article has 6 authors:
    1. Can Liu
    2. Jiawei Zhou
    3. Stephan Kudlacek
    4. Timothy Qi
    5. Tyler Dunlap
    6. Yanguang Cao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors have developed a useful model for how proteins that mediate a connection between invariant components of the T cell antigen receptor and leukaemic cells antigens, called bispecific engagers (BiTEs), mediate immunological synapse formation and impact T cell search for tumour cells in vivo. The model was compared against the in vitro experiments and in vivo data following a solid approach. The developed framework could provide a direction for employing computational mechanistic models for evaluating various strategies for BiTE treatments.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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